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Biodiesel via Ultrasonically Improved (Trans-)Esterification
Biodiesel is synthesized via transesterification using a base-catalyst. However, if the raw material such as low-grade waste vegetable with a high free fatty acid content are used, a chemical pre-treatment step of esterification using an acid-catatlyst is required. Ultrasonication and…
https://www.hielscher.com/biodiesel-via-ultrasonically-improved-trans-esterification.htm
Acid-Catalyzed Esterification of FFAs Improved by Sonication
In biodiesel production and oleochemical processing, high levels of free fatty acids (FFAs) remain a persistent challenge. Conventional acid-catalyzed esterification is a well-established route to convert FFAs into valuable fatty acid alkyl esters, but the reaction is often limited by…
Power Ultrasound for Water-in-Diesel Emulsions
The use of water-in-fuel emulsions is a rapidly expanding due to tightened environmental regulations and the tougher competition in the transportation market. The ultrasonic emulsification technology enables for a more efficient use of fuels, such as heavy fuels or diesel,…
https://www.hielscher.com/power-ultrasound-for-water-in-diesel-emulsions.htm
Marine Diesel-Biodiesel: Efficient Fuel Blending for Supply Security and Sustainability
As the marine industry faces rising pressure from fuel volatility, stricter environmental expectations, and the urgent need for practical decarbonization strategies, marine diesel-biodiesel blends are gaining attention as a realistic and scalable solution. When these blends are produced using ultrasonic…
https://www.hielscher.com/marine-diesel-biodiesel-blending.htm
Biocide-free Sterilization and Dispersion of Water-Based Coatings
Water-based coatings are widely used because they support low-VOC formulations, safer handling, and more sustainable production. At the same time, their water content makes them highly susceptible to microbial contamination. Bacteria, yeasts, and molds can enter the product through raw…
https://www.hielscher.com/biocide-free-sterilization-and-dispersion-of-water-based-coatings.htm
Pasteurization & Homogenization of Liquid Egg
Liquid egg products (whole eggs, egg whites, yolks) must be pasteurized to ensure food safety. Ultrasonic homogenizers deliver intense cavitation and high shear forces to kill microbes. Especially when combined with elevated temperatures (∼50°C) and pressure (mano-thermosonication), power ultrasound delivers…
https://www.hielscher.com/ultrasonic-homogenization-of-liquid-egg.htm
Superior Efficiency and Quality in Nutmilk Production with Ultrasonics
Nutmilks and plant-based milk alternatives are a growing food segment. For the production of nutmilks and plant-based milk analogues, ultrasonic extraction and homogenization has shown great advantages over conventional techniques. High-power ultrasound increases yield, product stability, nutrient content and overall…
https://www.hielscher.com/superior-efficiency-and-quality-in-nutmilk-production-with-ultrasonics.htm
UltraSonicators for ASTM D2603 Shear Stability Testing
The ASTM D2603 standard describes the sonic shear stability testing of hydraulic fluids under ultra-sonically induced shear stress. Hielscher ultra-sonicators are used as reliable shear creating devices used for shear stability testing of hydraulic fluids in accordance to ASTM D2603…
https://www.hielscher.com/ultra-sonicators-for-astm-d2603.htm
Stepped Plate Resonator: Intense Acoustic Waves in Air
From ultrasonic drying and aerosol generation to precision cleaning and defoaming, the Hielscher stepped plate resonator (SPR) offers innovative solutions for a wide range of industrial processes. This stepped plate resonator is a specialized ultrasonic tool designed to generate high-intensity…
https://www.hielscher.com/stepped-plate-resonator-intense-acoustic-waves-in-air.htm
Probe-Type Sonicators for Reliable Lab Workflows
Hielscher Ultrasonics offers a comprehensive range of lab probe sonicators and ultrasonic lab homogenizers designed to meet the diverse needs of research, quality control, process development, and small-scale production. From compact devices for small sample volumes to high-power sonicators for…
Colorant Manufacturing using High-Performance Dispersers
The production of colorants and pigment suspensions requires reliable dispersion and mixing. Ultrasonic homogenizers are highly efficient when it comes to the production of liquid and paste-like masterbatches and colorant suspensions. Available at any industrial production scale, ultrasonic dispersers improve…
https://www.hielscher.com/colorant-manufacturing-using-high-performance-dispersers.htm
Cannabis Batch Extraction using Probe-Type Sonication
Extracting cannabinoids such as CBD, THC, CBN etc. from hemp and marijuana for production purposes involves a combination of chopping, grinding or crushing the cannabis plant, ultrasound-assisted solvent extraction, and subsequent isolation of the bioactive compounds. Here is a practical…
https://www.hielscher.com/cannabis-batch-extraction-using-probe-type-sonication.htm
High-Performance Paint Homogenizers
Ultrasonic mixers are a reliable tool to homogenize, disperse, and emulsify liquid paint and pigment formulations. Ultrasonic homogenizers not only produce highly stable, uniform paint emulsions and dispersions, but ultrasonicators are also used to mill and grind pigments, nanomaterials and…
https://www.hielscher.com/high-performance-paint-homogenizers.htm
Duckweed Protein Extraction
Duckweed (Lemna minor) is a fast growing aquatic plant rich in proteins and other nutritional compounds. Ultrasonic extraction is used as a highly efficient and reliable processing technology to release proteins, lipids and phyto-nutrients from duckweed. Sonication allows for the…
Ultrasound In The Food Industry
The application of power ultrasound is used for numerous application in food processing, including extraction, homogenization, pasteurization and fermentation. As a non-thermal treatment, ultrasonication improves food production processes by higher yields, higher quality, improved nutrient and flavour profiles as well…
Ultrasonic Protein Processing for Food and Nutritional Supplements
Sonication is a powerful process technology for improving the functionality, dispersibility, solubility, and stability of proteins used in foods and nutritional supplements. From plant proteins such as oat, pea, soy, hemp, and rice to dairy proteins and blended formulations, high-intensity…
https://www.hielscher.com/ultrasonic-protein-processing-for-food-and-nutritional-supplements.htm
Clean Endless Metal Tapes and Belts with Ultrasonic Inline Cleaners
Learn how ultrasonic inline wire and tape cleaners remove drawing soaps, lubricants, dust and residues from endless metal strips, belts, tapes and profiles with contact-less, high-speed cleaning and low chemical use. Continuous Metal Production Needs Continuous Cleaning Clean endless metal…
USCM700 Ultrasonic Inline Cleaning Machine
The ultrasonic wire cleaning machine USCM700 is a powerful and efficient device for the effective cleaning of continuous endless materials such as wires, rods and strips. The USCM700 features an optional belt filter, allowing for the avoidance of filter cartridges,…
https://www.hielscher.com/uscm700-ultrasonic-inline-cleaning-machine.htm
Rope Wire Cleaning in Continuous Production Lines
In wire rope manufacturing, clean wire surfaces are essential for stable production, reliable downstream processing, and consistent product quality. Lubricants, drawing soaps, metallic fines, dust, oxides, and process residues can accumulate on wires during drawing, transport, and handling. If these…
Heat Transfer Fluids – Superior Efficiency by Sonicated Nanofluids
Overcome the limits of thermal conductivity of heat transfer fluids! Create stable nanofluids with ultrasonic dispersion and elevate the thermal conductivity with nano-sized heat transfer fluids. Hielscher probe-type sonicators are highly-efficient and reliable disperser for the production of nanofluids. Benefits…
Ultrasonic Solubilization of Protein Pellets
In proteomics, sample preparation is never a minor detail. It is the foundation on which identification accuracy, quantification reliability, and reproducibility are built. One of the most persistent challenges in protein sample preparation is the efficient re-dissolution of protein pellets…
Sonication-Assisted Protein Extraction from Tumor Tissue – Protocol
This protocol describes a sonication-assisted protein extraction method for tumor tissue that advances the standard CPTAC urea lysis workflow by adding a controlled probe-sonication step during tissue disruption. Building on the established deep-scale CPTAC proteome and phosphoproteome preparation strategy, this…
https://www.hielscher.com/sonication-protein-extraction-from-tumor-tissue-protocol.htm
Biodiesel Production from Waste Oils and Fats with Ultrasonic Mixing
The production of biodiesel from waste vegetable oils, spent cooking oils and frying fats has become increasingly important for cost-efficient and sustainable fuel manufacturing. However, these low-cost feedstocks often present significant challenges in conventional biodiesel processing: poor phase mixing, slow…
https://www.hielscher.com/biodiesel-from-waste-oils-and-fats.htm
From UCO to Biodiesel using Ultrasonic Reactors
Used cooking oil (UCO) has become one of the most attractive feedstocks for sustainable biodiesel production. Converting UCO into biodiesel, or used cooking oil methyl ester, helps reduce waste, lowers raw material costs, and supports a more circular fuel economy.…
Assay Miniaturization Enabled by High-Throughput Sonication
Assay miniaturization is a defining trend in modern life science research. As laboratories seek to process larger sample numbers while reducing reagent consumption and experimental costs, smaller reaction volumes and microplate-based workflows are increasingly replacing traditional tube-based assays. This shift…
Proteomic Research – Why a Sonicator is Indispensable for Sample Preparation
Proteomic research gives deep insights into cell biology and widens our understanding of biological systems by enabling the comprehensive analysis of proteins and their functions. Central to the success of proteomic studies is the preparation of high-quality samples, which often…
Ultrasonic Reactors for Biodiesel Production
Ultrasonic reactors improve chemical reaction kinetics of the biodiesel conversion process. This leads to a faster transesterification, higher conversion yield, and it saves excess methanol and catalyst. Hielscher makes ultrasonic mixing reactors for the production of biodiesel at any scale.…
https://www.hielscher.com/biodiesel_ultrasonic_mixing_reactors.htm
Turning Waste Cooking Oil into Reliable Biodiesel for Diesel Engines
Waste cooking oil is one of the most attractive biodiesel feedstocks available today. It is low-cost, widely available, and helps solve a disposal problem. But it also presents a well-known processing challenge: poor feedstocks such as waste vegetable oils, used…
Biodiesel Production with Superior Process and Cost Efficiency
Ultrasonic mixing is the superior technology for highly efficient and cost-effective biodiesel production. Ultrasonic cavitation improves mass transfer drastically, thereby reducing production costs and processing duration. At the same time, poor-quality oils and fats (e.g., waste oils) can be used…
https://www.hielscher.com/superior-process-and-cost-efficiency-in-biodiesel-production.htm
Biodiesel Production from Oil Extracted from Spent Coffee Grounds
As global efforts to find sustainable and renewable energy sources intensify, the production of biodiesel from waste materials has gained significant attention. Among these materials, spent coffee grounds (SCG) present a promising opportunity. Sonication intensifies both, the extraction of oils…
https://www.hielscher.com/biodiesel-production-from-oil-extracted-from-spent-coffee-grounds.htm
Energy Efficiency and Methanol Savings in Biodiesel Production
Sonication is an energy-saving mixing technology that uses ultrasonic cavitation to create intense micro-mixing and rapid mass transfer between immiscible oil and methanol phases. In biodiesel processing, this effect drastically shortens reaction time - from hours to seconds - and…
https://www.hielscher.com/energy-efficiency-and-methanol-savings-in-biodiesel-production.htm
Ultrasonic Filter-Aided Sample Preparation (FASP): Enhancing Proteomics Workflows with Advanced Sonication
Ultrasonic filter-aided sample preparation (FASP) is emerging as a highly efficient and reproducible method in modern proteomics. By integrating controlled sonication into established FASP workflows, researchers can significantly improve protein extraction, digestion efficiency, and overall data quality. With increasing demand…
Endless Metal Tube and Pipe Cleaning with Ultrasonic Inline Cleaners
In modern metal processing, the demand for flawless surface quality extends far beyond wire manufacturing. Producers of endless metal tubes and pipes - used in industries ranging from automotive and construction to energy and precision engineering - face increasing pressure…
Ultrasonication Outcompetes Other Extraction Methods by Speed
The rapid procedure of ultrasonic extraction and the therefrom resulting time savings in extract production are one of many advantages of ultrasonic extraction of bioactive compounds from plants. Ultrasonic extraction has been scientifically compared to alternative extraction techniques such as…
https://www.hielscher.com/ultrasonication-outcompetes-other-extraction-methods-by-speed.htm
Ultrasonic Waste and Sludge Treatment
Biogas is generated from sources, such as municipal organic waste, sewage sludge, muck or manure. Ultrasonication improves the digestibility of such organic material leading to more biogas and less residual sludge. Biogas is a byproduct of the decomposition of organic…
Most Efficient Ultrasonic Dismembrators
Ultrasonic dismembrators are commonly used in the laboratory, bench-top and industry to prepare homogeneous colloidal suspensions such as emulsions and dispersions with droplet or particle sizes in the submicron- and nano-range. Furthermore, ultrasonic dismembrators are used for cell disruption, lysis,…
https://www.hielscher.com/most-efficient-ultrasonic-dismembrators.htm
Improve HPLC Analysis by Reliable Sample Preparation
High-performance liquid chromatography (HPLC) remains one of the most important analytical techniques for the identification and quantification of compounds in complex matrices. From pharmaceutical quality control to environmental monitoring and food analysis, HPLC methods are valued for their sensitivity, selectivity,…
Sonication-Assisted Protein Extraction for Phosphoproteomics
In modern life sciences, phosphoproteomics has emerged as a cornerstone technology for decoding cellular signaling pathways and understanding disease mechanisms at a systems level. As phosphorylation governs critical biological functions - from enzyme activity to protein–protein interactions - its precise…
Ultrasonic Inline Cleaning of Steel Wires
In the highly competitive wire manufacturing industry, maintaining consistent surface quality is no longer optional - it is a prerequisite for downstream processing, product performance, and regulatory compliance. Whether for drawing, coating, galvanizing, or welding applications, steel wires must be…
Chromatin Shearing with Sonication
Chromatin shearing is a critical step in many epigenetics and molecular biology workflows, particularly in chromatin immunoprecipitation (ChIP), ChIP-seq, and related assays. The goal is to fragment chromatin into reproducible DNA-protein complexes while preserving epitope integrity and minimizing sample loss.…
Assay Sonication – The Assay-at-Once Sonicator UIP400MTP
Sonication is an essential technique in laboratory protocols, particularly for applications like chromatin immunoprecipitation (ChIP) assays. By using ultrasonic energy to break down cells, shear DNA, and solubilize chromatin, sonication enables researchers to prepare samples more efficiently and reproducibly. The…
https://www.hielscher.com/assay-sonication-the-assay-at-once-sonicator-uip400mtp.htm
Mastering Lab Tasks with an Ultrasonic Homogenizer
Sonicators are essential lab tools used for a wide range of applications, such as homogenization and mixing, extraction, dispersing, emulsifying, dissolution, cell disruption, DNA fragmentation, and sonochemical reactions. Typically, probe-type sonicators are used to fulfill these common tasks in daily…
https://www.hielscher.com/mastering-lab-tasks-with-an-ultrasonic-homogenizer.htm
Renneting of Milk Enhanced by Ultrasonic Processing
Ultrasonic milk renneting is an innovative processing technique to improve product quality and production efficiency. Ultrasound treatment applied to milk prior to coagulation has shown strong potential to optimize the renneting stage in cheese manufacturing. Low-frequency, high-power ultrasound can alter…
Improved Cheese Manufacturing with Power Ultrasonics
Production of various cheese types such as hard cheeses, soft cheeses and curd, made from various milk sort (e.g., cow, goat, sheep, buffalo, camel milk etc.) can be efficiently improved by sonication. The application of high-intensity ultrasound accelerates homogenization, fermentation,…
https://www.hielscher.com/improved-cheese-manufacturing-with-power-ultrasonics.htm
Ultrasonic Inline Cleaning of Piano Wires in Production
Piano wire or music wire is among the highest-quality spring steels produced today. Used in applications such as piano strings, precision springs, medical components, and high-performance mechanical systems, music wire must meet strict requirements regarding surface quality, strength, and cleanliness.…
UP200St with VialTweeter for Simultaneous Sample Preparation
In laboratories, it is often necessary to prepare multiple samples simultaneously at the same process conditions. The VialTweeter enables for the simultaneous sonication of up to 10 vials at the same intensity. Thereby, the VialTweeter is a reliable lab homogenizer…
https://www.hielscher.com/up200st-with-vialtweeter-for-simultaneous-sample-preparation.htm
Video: VialTweeter Calibration
The short tutorial covers correct setup, including running the automatic 25–30 second calibration cycle via the touchscreen interface, and inserting sample vials such as 1.5mL Eppendorf tubes after calibration. You will also see how to reset and repeat calibration, which…
Integrating the UIP400MTP Microplate Sonicator into Lab Automation
The Hielscher UIP400MTP multi-well plate sonicator is engineered specifically for high-throughput, uniform ultrasonic processing of microtiter plates, addressing a critical need in automated sample preparation workflows spanning genomics, proteomics, diagnostics, and drug discovery. Its design, interface capabilities, and operational characteristics…
Sonoelectrolytic Hydrogen Production from Dilute Sulfuric Acid
Electrolysis of dilute sulfuric acid produces hydrogen gas and oxygen gas. Ultrasonication reduces the diffusion layer thickness at the electrode surface and improves mass transfer during electrolysis. Ultrasonication can increase hydrogen gas production rates in the electrolytic cell, significantly. Two…
https://www.hielscher.com/hydrogen-production-electrolysis.htm
Video: Ultrasonic Graphene Exfoliation
Master the art of producing high-quality single-layer graphene through ultrasonic exfoliation employing high-power probe-type sonicators. Sonication stands as a straightforward, efficient, and scalable technique for generating graphene dispersions with optimal yields and exceptional sheet quality. For further insights into ultrasonic…
https://www.hielscher.com/video-ultrasonic-graphene-exfoliation.htm
Sono-Electrochemical Synthesis of Prussian Blue Nanoparticles
Sono-electrochemical synthesis combines the principles of electrochemistry with the physical effects of high-intensity ultrasound to enable the controlled fabrication of nanomaterials, such as Prussian Blue nanoparticles. This hybrid technique uses the ultrasonic cavitation to enhance mass transport, initiate localized micro-turbulence,…
https://www.hielscher.com/sono-electrochemical-synthesis-of-prussian-blue-nanoparticles.htm
Sonoelectrochemical Deposition
Sonoelectrochemical deposition is synthesis technique, which combines sonochemistry and electrochemistry, for a highly efficient and environmental-friendly production of nanomaterials. Renown as fast, simple, and effective, sonoelectrochemical deposition allows for shape-controlled synthesis of nanoparticles and nanocomposites. Sono-Electrodeposition of Nanoparticles For sonoelectrodeposition…
https://www.hielscher.com/sonoelectrochemical-deposition.htm
Clean Water by Chemical-Free Sono-Electrocoagulation
Electrocoagulation (EC) is an electrochemical process that in situ generates coagulant species (e.g., Fe(OH)x, Al(OH)x) from sacrificial electrodes, capturing colloids, emulsions, metals, dyes, and emerging contaminants. Coupling EC with power ultrasound - "sono-electrocoagulation" (SEC) intensifies mass transfer, suppresses electrode passivation,…
https://www.hielscher.com/clean-water-by-chemical-free-sono-electrocoagulation.htm
Sono-Electrochemical Synthesis of Nanoparticles
The ultrasonically promoted electrochemical synthesis of nanoparticles is a highly efficacious and cost-efficient route to produce high-quality nanoparticles on large scale. The sono-electrochemical synthesis, also known as sonoelectrodeposition, allows to prepare nanostructures of various materials and shapes. Sonoelectrochemical Synthesis and…
https://www.hielscher.com/sono-electrochemical-synthesis-of-nanoparticles.htm
Electro-Sonication – Ultrasonic Electrodes
Electro-Sonication is the combination of the effects of electricity with the effects of sonication. Hielscher Ultrasonics developed a new and elegant method to use any sonotrode as electrode. This puts the power of ultrasound directly at the interface between ultrasonic…
https://www.hielscher.com/electro-sonication-ultrasonic-electrodes.htm
Sonoelectrochemistry Setup – 2000 Watts Ultrasound
Sonoelectrochemistry combines the benefits of electrochemistry with sonochemistry. The biggest advantage in these techniques is their simplicity, low cost, reproducibility and scalability. Hielscher Ultrasonics offers complete sonoelectrochemical setup for batch and inline use. It consists of: an advanced ultrasonic generator…
https://www.hielscher.com/sonoelectrochemistry-setup-2000-watts-ultrasound.htm
Sono-Electrochemistry and its Advantages
Here you will find all you need to know about ultrasonic electrochemistry (sonoelectrochemistry): working principle, applications, advantages and sono-electrochemical equipment - all relevant information about sonoelectrochemistry on one page. Why Applying Ultrasonics to Electrochemistry? The combination of low-frequency, high-intensity ultrasound…
https://www.hielscher.com/sono-electrochemistry-and-its-advantages.htm
UP50H – Compact Lab Homogenizer
The ultrasonic processor UP50H is typically used for the sonication of small lab samples. This homogenizer allows for the handheld or stand-mounted emulsification, dispersing, dissolving or cell disruption. The ultrasonic processor UP50H (50 watts, 30kHz) is the smallest model of…
UP100H – Compact Ultrasonic Laboratory Device
The ultrasonic processor UP100H (100W, 30kHz) is the perfect device for the sonication of small and medium size lab samples. This compact, yet powerful, lab homogenizer is commonly used for sample preparation, such as emulsifying, dispersing, dissolving and cell disruption.…
New Industrial Ultrasonic Processors: The hdT series
The new series of Hielscher industrial sonicators show their superiority: The industrial ultrasonic processors with 500W up to 4000W convince with the high ultrasound power and reliability, which Hielscher customers are accustomed to, but they excel by their new operational…
https://www.hielscher.com/new-industrial-ultrasonic-processors-the-hdt-series.htm
Decellularization of Extracellular Matrix with Sonication
Decellularization of the extracellular matrix (ECM) is a critical process in tissue engineering and regenerative medicine. The objective is to remove cellular components completely while preserving the structural, biochemical, and biomechanical properties of the native matrix. Maintaining this delicate balance…
https://www.hielscher.com/decellularization-of-extracellular-matrix-with-sonication.htm
Using Sonicators in Specialized Enclosures
Sonicators made by Hielscher can be used in specialized atmospheres, such as anaerobic enclosures, fume hoods, glove boxes, or purged cabinets. These controlled environments allow for precise manipulation of oxygen levels, humidity, and reactive gases, while also offering explosion protection…
Spring-Wire Cleaning – Intense Cleaning using Inline Ultrasonic Systems
Spring wires exit the drawing process with persistent surface contaminants, including lubricating oils, drawing soaps (commonly calcium or sodium stearates), metallic abrasion debris, and oxides. Ultrasonically assisted inline cleaning utilizes acoustic cavitation to reliably remove such contaminants - even from…
UP200St – Powerful Ultrasonic Lab Homogenizer
With the ultrasonic homogenizer UP200St (200W, 26kHz), the series of Hielscher 200 watt ultrasonicators is expanded by a very flexible and versatile unit. The new UP200St consists of a separated transducer UP200St-T and generator UP200St-G. Thereby, this sibling unit of…
https://www.hielscher.com/up200st-powerful-ultrasonic-lab-homogenizer.htm
Extracellular Matrix Extraction with the 96-Well Sonicator UIP400MTP
Traditional Extracellular Matrix (EM) extraction methods often involve multiple steps to disrupt the biofilm matrix. However, these techniques can be time-consuming and inconsistent, leading to variability in results. With the 96-well plate sonicator UIP400MTP, the EM extraction process is significantly…
Ultrasonic Extraction – Versatile and Usable for Any Botanical Material
Can I use my probe-type ultrasonicator for cannabis and psilocybin extraction? The answer is: Yes! You can use your ultrasonicator for numerous different raw materials to produce high-quality extracts. The beauty of the ultrasonic extraction technique lies in its compatibility…
https://www.hielscher.com/ultrasonic-extraction-versatile-and-usable-for-any-botanical-material.htm
Ultrasonic Wire Cleaner DRS2500-4S – De-Bottlenecking Wire Cleaning
The ultrasonic wire cleaning machine DRS2500-4S is a powerful and efficient machine for the effective inline cleaning of continuous endless materials such as wires, rods and strips. The DRS2500-4S is a robust system, that can be easily installed or retro-fitted…
Highly Efficient Water Extraction Using Power-Ultrasound
Water extraction of botanical compounds (e.g., cold or hot water extraction, pressurized water extraction and subcritical water extraction) can be efficiently improved by ultrasonication. The ultrasound-assisted water extraction not only gives higher yields and reduces processing time, but also results…
https://www.hielscher.com/highly-efficient-water-extraction-using-power-ultrasound.htm
Kava Kava – Superior Extraction using a Sonicator
Kava extracts are moste efficiently produced using ultrasonic extraction. Ultrasonic extraction is a cutting-edge technique that harnesses the power of energy-dense sound waves to create highly effective kava (Piper methysticum) extracts using water or aqueous ethanol. The ultrasonic extraction method…
https://www.hielscher.com/kava-kava-superior-extraction-using-a-sonicator.htm
Ultrasonic Cold Water Extraction of Psilocybin
Isolating psilocybin from fresh and dried magic mushrooms, e.g. psilocybe species, is known to be time-consuming and often quite inefficient. With ultrasonic extraction psilocybin, psilocin, baeocystin and norbaeocystin are rapidly extracted from fresh and dried psilocibe mushrooms. Ultrasonic extraction breaks…
https://www.hielscher.com/ultrasonic-cold-water-extraction-of-psilocybin.htm
Ayahuasca Extraction – Increased Yields with Sonication
Ayahuasca has attracted growing scientific and clinical interest due to its neuromodulatory, anti-inflammatory, and potential antidepressant properties. At the center of these effects are the β-carboline alkaloids derived from Banisteriopsis caapi, primarily harmine, harmaline, and tetrahydroharmine (THH). Efficient extraction of…
Liposomal Encapsulated Bioactive Molecules with Ultrasonics
Ultrasonication is well known to be highly efficient in the preparation of liposomal formulations. Typical liposome formulations encapsulate vitamin C, CBD, curcumin, quercitin, astaxanthin, peptides and manifiold other bioactive compounds using ultrasonication. Ultrasonic liposome encapsulation is a simple, fast and…
https://www.hielscher.com/liposomal-encapsulated-bioactive-molecules-with-ultrasonics.htm
Ultrasonically-Assisted Thin Film Hydration for Liposome Preparation
Liposomes are spherical vesicles composed of one or more phospholipid bilayers enclosing an aqueous core. Due to their ability to encapsulate hydrophilic, lipophilic, and amphiphilic compounds, liposomes are widely used in pharmaceutical, nutraceutical, cosmetic, and food applications. Their biodegradability, biocompatibility,…
https://www.hielscher.com/ultrasonically-assisted-thin-film-hydration-for-liposome-preparation.htm
Liposomes via Reverse-Phase Evaporation Method using Sonication
Liposomes are versatile nanocarriers used in drug delivery due to their biocompatibility and ability to encapsulate both hydrophilic and hydrophobic drugs. The reverse-phase evaporation method (also known as emulsification method or a solvent-evaporation method) is a prominent technique for liposome…
https://www.hielscher.com/liposomes-via-reverse-phase-evaporation-method-using-sonication.htm
Ultrasonic Liposome Preparation
Ultrasonically produced liposomes show a very high entrapment efficiency, high loading capacity and uniformly small spherical size. Thereby, ultrasonic liposomes offer excellent bioavailability. Hielscher Ultrasonics offers ultrasonicators for the reliable production of pharma-grade liposomes in batch and continuous mode. Advantages…
https://www.hielscher.com/ultrasonic-liposome-preparation.htm
Graphene Oxide – Ultrasonic Exfoliation and Dispersion
Ultrasonic exfoliation is a widely used technique to produce graphene oxide by breaking down graphite oxide into thin, single- or few-layer graphene sheets. Hielscher sonicators create intense acoustic cavitation, where energy-dense ultrasonic waves generate high-energy microbubbles in a liquid medium.…
https://www.hielscher.com/graphene-oxide-ultrasonic-exfoliation-and-dispersion.htm
Industrial-Scale Single-Layer Graphene using Ultrasonic Exfoliation
Graphene has become one of the most exciting materials of modern science - and for good reason. It is not just "another carbon material." Graphene is a single atomic layer of carbon arranged in a perfectly ordered honeycomb lattice, and…
Ultrasonic Leaching of Precious Metals
Power ultrasound is a effective technique to extract metals such as precious metals and rare earths. This process of ultrasonically assisted solid-liquid extraction is known as sono-leaching, lixiviation or washing. Robust industrial ultrasonicators can be easily installed to leach rare…
https://www.hielscher.com/ultrasonic-leaching-of-precious-metals.htm
Ultrasonic Dispersion of Graphene
To incorporate graphene into composites, it is essential to disperse or exfoliate the graphene into single nano-sheets uniformly throughout the formulation. The more thoroughly the graphene is deagglomerated, the better its extraordinary material properties can be utilized. Ultrasonic dispersion offers…
https://www.hielscher.com/ultrasonic-dispersion-of-graphene.htm
Graphene Nanoplatelets Synthesized and Dispersed via Probe-Sonication
Graphene nanoplatelets (GNPs) can be synthesized and dispersed with high efficiency and reliability using sonicators. High-intensity ultrasonication is employed to exfoliate graphite and obtain few-layer graphene, often referred to as graphene nanoplatelets. Sonication also excels in achieving excellent graphene nanoplatelet…
Industrial Production of Yerba Mate Beverages Using Sonication
Yerba mate has evolved from a traditional South American infusion into a globally recognized functional beverage. As demand grows for ready-to-drink (RTD) mate, clean-label energy drinks, and concentrated botanical extracts, manufacturers are seeking technologies that deliver consistent flavor, optimized phytochemical…
https://www.hielscher.com/industrial-production-of-yerba-mate-beverages-using-sonication.htm
Ultrasonically Cold-Brewed Tea
Power ultrasound is an established technique for the efficient extraction of flavors, polyphenols, and bioactive compounds from plant materials. Cold‑brewed tea provides numerous advantages, preserving a greater proportion of thermolabile bioactives while delivering a smoother, more refined flavor profile. As…
https://www.hielscher.com/ultrasonically-cold-brewed-tea.htm
Powerful Ultrasonicator UP400St (400 Watts)
The ultrasonicator UP400St is a robust, versatile ultrasonic homogenizer that delivers high performance, for professional liquid processing. This advanced 400 watts digital ultrasonicator is perfect for precision sonication of samples from 5mL to approximately 4 liters. The UP400St sonicator combines…
https://www.hielscher.com/up400st-powerful-ultrasonicator.htm
UP200Ht – Handheld Ultrasonic Homogenizer
The UP200Ht (200W, 26kHz) handheld homogenizer is part of the digital device series of Hielscher's 200 watt ultrasonic homogenizers which come with broad range of new accessories. The new features include digital control and touch screen, automatic data recording, intuitive…
Ultrasonic Liposome Encapsulation of GLP-1 Peptides: Scalable Technology for Oral Peptide Delivery
Semaglutide and other GLP-1 peptides are transforming diabetes and obesity care, but most peptide drugs still require injections because oral delivery remains extremely challenging. Even approved oral semaglutide shows bioavailability below 1%, increasing dose requirements and cost. Encapsulating GLP-1 peptides…
https://www.hielscher.com/ultrasonic-liposome-encapsulation-of-glp-1-peptides.htm
Ultrasonic Production of Nano-Structured Cellulose
Nanocellulose, a remarkable high-performance additive, has gained prominence for its versatile applications as a rheology modifier, reinforcing agent, and key component in various advanced materials. These nano-structured fibrils, derived from any cellulose-containing source, can be efficiently isolated through high-power ultrasonic…
https://www.hielscher.com/ultrasonic-production-of-nano-structured-cellulose.htm
Ultrasonic Spraying, Nebulizing, and Atomizing
Ultrasonic vibrations can create very thin droplets. During ultrasonic spraying, the droplet size and distribution can be precisely controlled so that very small droplets and particles can be vaporized. Thereby, particles with high surface area are produced. The ultrasonic spay…
https://www.hielscher.com/ultrasonic-spraying-nebulizing-and-atomizing.htm
Ultrasound In Paper Manufacturing
Power ultrasound has emerged as a versatile and energy-efficient process technology in modern paper mills. By introducing high-intensity ultrasonic waves into liquid or slurry systems, mills can harness cavitation effects–microscopic bubble formation and collapse - to improve mixing, mass transfer,…
Ultrasonication and Its Manifold Applications in Food Processing
Power ultrasound offers manifold possibilities for effective and reliable food processing applications. The most common applications in the food industry include mixing & homogenization, emulsification, dispersing, cell disruption and extraction of intra-cellular material, activation or deactivation of enzymes (which is…
https://www.hielscher.com/ultrasonication-and-its-manifold-applications-in-food-processing.htm
Ultrasonic Extraction for Leghemoglobin Production
A cleaner, faster, and more scalable way to unlock the "meaty" molecule behind plant-based foods: Leghemoglobin - the heme-containing protein responsible for the aroma, color, and flavor of meat - has become one of the most valuable biomolecules in the…
https://www.hielscher.com/ultrasonic-extraction-for-leghemoglobin-production.htm
Ultrasonic Dispersion of Ceramic Slurries
Ultrasonic dispersers are an established and highly effective technology for the formulation and processing of ceramic slurries. In modern ceramics manufacturing, the quality and performance of the final product depend heavily on the homogeneity, stability, and particle size distribution of…
https://www.hielscher.com/ultrasonic-dispersion-of-ceramic-slurries.htm
Ultrasonic Extraction of Humic Acid: Faster, Greener, More Efficient
Humic acid is having a moment - and for good reason. From regenerative agriculture and soil remediation to animal feed, water treatment, and specialty fertilizers, this naturally derived compound is prized for improving nutrient availability, binding heavy metals, and enhancing…
https://www.hielscher.com/ultrasonic-extraction-of-humic-acid.htm
Ultrasonic Immersion Homogenizers
Ultrasonic immersion homogenizers are particularly valued in modern process engineering because they combine mechanical simplicity with extreme process effectiveness. By introducing ultrasonic energy directly into the liquid phase, probe-type sonicators eliminate intermediate transmission losses that are common in indirect systems.…
https://www.hielscher.com/ultrasonic-immersion-homogenizers.htm
Ultrasonic Agrochemicals Manufacturing
Formulating agrochemicals includes the dispersion, dissolving, emulsification, and homogenization of the compounds. Ultrasound is a reliable mixing technique for high quality chemical suspensions. Ultrasonic dispersing and dissolving allows to produce high load formulations at high dispersion speed. Ultrasonic formulating enables…
https://www.hielscher.com/ultrasonic-agrochemicals-manufacturing.htm
How to Make Silky Vegan Chocolate Mousse Using a Sonicator
Ultrasonic homogenization of mousse au chocolat utilizes high-intensity acoustic cavitation to create ultra-fine emulsions of fats and aqueous phases and works for conventional as well as vegan desserts. This ultrasound-based mixing technique disperses cocoa solids, proteins, and stabilizers at submicron…
Sonication for Cell Lysis: Cell Disruption and Extraction
Ultrasonic cell lysis is a widely applied sample‑preparation technique in modern biotech laboratories. Its primary purpose is to disrupt cellular membranes or entire cells in order to release intracellular components such as proteins, nucleic acids, or organelles. In daily lab…
https://www.hielscher.com/ultrasonic-lysis-cell-disruption-extraction.htm
Sono-Electro-Coagulation – High-Efficiency Flow-Through Processing
Sono-electro-coagulation (SEC) combines the principles of ultrasonication and electrocoagulation to enhance pollutant removal, particle destabilization, and reaction kinetics in liquid media. The integration of Hielscher Ultrasonic Electrodes within an inline sono-electrochemical flow cell reactor offers a significant advancement over conventional…
https://www.hielscher.com/sono-electro-coagulation-high-efficiency-flow-through-processing.htm
Hybrid Ultrasonics: Mano-, Thermo- and Electro-Sonication
Hybrid ultrasonics combines high-power sonication with controlled pressure, temperature, and electric fields to extend ultrasonic processing beyond conventional limits. By tuning cavitation intensity, reaction kinetics, and transport phenomena, hybrid ultrasonics enables faster extraction, finer emulsions, stronger dispersion, higher electrochemical efficiency,…
Ultrasonic Sample Preparation for Mass Spectrometry
Mass spectrometry (MS) is among the most powerful analytical techniques in modern research and industry. However, its performance is fundamentally dependent on one critical upstream factor: sample preparation. Ultrasonic sample preparation - particularly probe-type as well as non-contact sonication -…
https://www.hielscher.com/ultrasonic-sample-preparation-for-mass-spectrometry.htm
Sterile Sonication of Falcon Tubes
The VialTweeter VT26dxx is an ultrasonic sample homogenizer designed specifically for Falcon tubes. The VialTweeter VT26dxx sonicates the sample in a Falcon tube indirectly, avoiding the insertion of an ultrasonic probe into the sample. This allows cross-contamination and sample loss…
https://www.hielscher.com/sterile-sonication-of-falcon-tubes.htm
Overcome the Risks of Incomplete AAS Sample Digestion with Sonication
Incomplete sample digestion remains one of the most underestimated risks in atomic absorption spectroscopy (AAS). When solid matrices are not fully dissolved, analysts face biased results, poor recoveries, and reduced reproducibility - issues that directly undermine data quality and regulatory…
https://www.hielscher.com/overcome-the-risks-of-incomplete-aas-sample-digestion-with-sonication.htm
Efficient and Controlled Synthesis of Gold Nanoparticles
Gold nanoparticles of uniform shape and morphology can be efficiently synthesized via sonochemical route. The ultrasonically promoted chemical reaction of gold nanoparticle synthesis can be precisely controlled for particle size, shape (e.g., nanospheres, nanorods, nanobelts etc.) and morphology. The efficacious,…
https://www.hielscher.com/efficient-and-controlled-synthesis-of-gold-nanoparticles.htm
MBEC Assay Protocol Using the 96-Well Plate Sonicator UIP400MTP
The MBEC assay is used to determine the concentration of antimicrobial agents needed to eliminate biofilms formed on peg lids. To assess biofilm viability, the biofilms must first be detached from the peg lids of a 96-well plate. Sonication is…
EPA3550 Ultrasonic Extraction Guide
Ultrasonic extraction is a green, environmental-friendly method of extraction that can be applied to small lab samples as well as for the extraction of valuable compounds on commercial production scale. The United State Environmental Protection Agency (EPA) recommends a variety…
https://www.hielscher.com/epa3550-ultrasonic-extraction-guide.htm
Ultrasonic Soils Sample Processing for Environmental Analysis
Sonicators facilitate the preparation of soil samples, a critical step in environmental analysis, significantly. Given the heterogeneous and often recalcitrant nature of soil matrices, an efficient and reproducible technique is essential. Sonication helps to extract molecules in a gentle, yet…
ASTM E2799-22 Protocol for Antimicrobial Evaluation
The Hielscher UIP400MTP is a powerful and efficient multi-well plate sonicator designed to streamline the sonication step in the ASTM E2799-22 protocol. By delivering uniform ultrasonic energy across the entire microtiter plate, the UIP400MTP ensures consistent and reliable detachment of…
Ultrasonic Formulation of Niosomes
Niosomes are nano-sized vesicles, which can be used as carrier for drugs (e.g. cancer drugs) and other bioactive substances. Ultrasonic emulsification is a simple and rapid method to formulate small niosomes with a high drug load. Niosome Vesicles as Nano-Carrier…
https://www.hielscher.com/ultrasonic-formulation-of-niosomes.htm
Ultrasound-Assisted Niosome Production for Nanomedicine
Niosomes are nonionic surfactant–based vesicular systems that have gained increasing attention as versatile carriers for bioactive compounds and pharmaceutical agents. Their ability to encapsulate both hydrophilic and lipophilic molecules, combined with favorable biocompatibility and stability, makes them attractive alternatives to…
https://www.hielscher.com/ultrasound-assisted-niosome-production-for-nanomedicine.htm
Ultrasonic Mixing for the Cosmetic Industry
Hielscher sonicators are used in the cosmetics industry for manifold processes, e.g. for the manufacturing of lotions, sunscreen, creams, gels or ointments. Probe-type sonicators play a crucial role in enhancing the quality, stability, and efficacy of cosmetic and beauty products.…
Ultrasound-Enhanced Mineral Carbonation
Mineral carbonation is the reaction of carbon dioxide with alkaline minerals such as calcium or magnesium oxide. Mineral carbonation is used for the industrial production of solid particles in the pharmaceutical, polymer and fertilizer industry as well as for carbon…
https://www.hielscher.com/ultrasound-enhanced-mineral-carbonation.htm
Ultrasonic Sonotrodes, Flow Cells & Accessories
Hielscher Ultrasonics offers you a broad product range of ultrasonic accessories for the direct and indirect sonication of small lab samples to full commercial production. Find below an overview over our sonotrodes, flow-through reactors and accessories for both, direct and…
https://www.hielscher.com/ultrasonic-sonotrodes-flow-cells-accessories.htm
Sonochemical Synthesis of Latex
Ultrasound induces and promotes the chemical reaction for the polymerization of latex. By sonochemical forces, the latex synthesis occurs faster and more efficient. Even the handling of the chemical reaction becomes easier. How Sonication Improves the Synthesis of Latex Ultrasound…
https://www.hielscher.com/sonochemical-synthesis-of-latex.htm
How Does Probe and Bath Sonication Differ? – A Comparison of Efficiency
Ultrasonication is widely used across food science, biotechnology, and materials engineering to enhance extraction, dispersion, or cell disruption. Although both probe and bath sonicators rely on acoustic cavitation, their performance and control characteristics differ dramatically. The choice between them strongly…
https://www.hielscher.com/how-does-probe-and-bath-sonication-differ.htm
Ultrasonic-Enzymatic Oil Hydrolysis
Diacylglycerol (DAG) rich oils are a valuable ingredient for food, pharma and cosmetic products. Diacylglycerol can be produced by the hydrolysis of palm oil using a commercial lipase as a catalyst under ultrasonication. By the ultrasonic-enzymatic hydrolysis, DAGs can be…
https://www.hielscher.com/ultrasonic-enzymatic-oil-hydrolysis.htm
Ultrasonics for Improved Thawing and Peeling of Shrimp
Traditional brining-based maturation of shrimp can loosen the shell–meat connection but requires long soaking times and careful salt control to avoid color fading, sweetness loss, and compromised texture. Recent advancements demonstrate that power ultrasound can replace or enhance maturation by…
https://www.hielscher.com/ultrasonics-for-improved-thawing-and-peeling-of-shrimp.htm
Ultrasonic Extraction and Preservation
Ultrasonic extraction and preservation utilizes using power ultrasound for the disintegration of cell structures (lysis). Breaking cells with ultrasonics results in highly efficient extraction of intra-cellular compounds as well as microbial inactivation. Due to numerous advantages, ultrasonication is widely used…
Emulsifying by Ultrasonic Cavitation
A wide range of intermediate and consumer products, such as cosmetics and skin lotions, pharmaceutical ointments, varnishes, paints and lubricants and fuels are based wholly or in part on emulsions. Hielscher manufactures the world's largest industrial ultrasonic liquid processors for…
Faster Sprouting with Ultrasonics
Sprouts are a popular health food rich in vitamins, proteins, minerals and antioxidants. The sprouting process is laborious and time-consuming. Ultrasonic activation of seeds increases the germination rate, accelerates the sprouting process, improves the nutritional profile, and promotes the growth…
https://www.hielscher.com/faster-sprouting-with-ultrasonics.htm
The Effects of Sonication on Legumes and Seeds
Ultrasonic processing has become a valuable technology for modifying, conditioning, and analyzing plant materials such as lentils and legumes. Through acoustic cavitation and controlled mechanical forces, sonication enhances hydration, accelerates extraction, alters microstructures, and improves mass transfer. These effects are…
Ultrasonic Custom Processing Service
Hielscher Ultrasonics is specialist when it comes to ultrasonic processing. We are not only supplying powerful ultrasonicators for lab and industry, but we offer you the service to process your material as ultrasonic toll manufacturer at our headquarter in Germany,…
https://www.hielscher.com/ultrasonic-custom-processing-service.htm
Ultrasonic Coal Treatments for Energy Production
The sonication of coal slurries contributes to various processes during the energy production from coal. Ultrasound promotes the catalytic hydrogenation during the liquefaction of coal. Furthermore, sonication can improve the surface area and extractability of coal. Undesired chemical side-reactions during…
https://www.hielscher.com/ultrasonic-coal-treatments-for-energy-production.htm
Port Splitter RJ45-HUB for Ultrasonic Processors
The port splitter RJ45-HUB allows you to connect your ultrasonic processor to various additional components and to use all features of your digital ultrasonic processor optimally. At the same time, the functionality of the network is retained. The RJ45-HUB is…
https://www.hielscher.com/port-splitter-rj45-hub-for-ultrasonic-processors.htm
BIOMAN – Ultrasound for Biomass Digestion
Energy produced from biogas is one of the most important renewable resources and is conditioned by a supply of substrates and waste materials compatible with responsible use of arable lands, and safe food and feed production. BIOMAN is an EU…
https://www.hielscher.com/bioman-ultrasound-for-biomass-digestion.htm
Green Sonochemical Route to Silver Nanoparticles
Silver nanoparticles (AgNPs) are frequently utilized nanomaterials due to their anti-microbial properties, optical properties and high electrical conductivity. The sonochemical route using kappa carrageenan is a simple, convenient and environmental-friendly synthesis method for the preparation of silver nano particles. κ-carrageenan…
https://www.hielscher.com/green-sonochemical-route-to-silver-nanoparticles.htm
Ultrasonic Disintegration of Animal Manures before Anaerobic Digestion
Ultrasonic disintegration increases methane (CH4) yield, decreases solid retention time (SRT) and improves the overall performance of anaerobic digestion. This is the result of the disintegration of biosolids and bacterial cells in animal manures and the release of intracellular components…
https://www.hielscher.com/ultrasonic-disintegration-of-animal-manures-before-anaerobic-digestion.htm
Ultrasonic Freezing and Ice Crystallization of Food Products
Sonication increases the nucleation of ice crystals and provides thereby a faster freezing and control over the ice crystal size. Power ultrasound is beneficial to many food-freezing processes as shorter freezing times and leads to higher product quality. Ultrasonically assisted…
https://www.hielscher.com/ultrasonic-freezing-and-ice-crystallization-of-food-products.htm
Ultrasonic High Speed Batch Mixers
Wetting, hydration, homogenization, grinding, dispersion, emulsification and dissolving are common applications for Hielscher's ultrasonic high speed batch mixers. Ultrasonic batch mixing is carried out at high speed with reliable, reproducible results for outstanding process results at lab, bench-top and full…
https://www.hielscher.com/ultrasonic-high-speed-batch-mixers.htm
Ultrasonic Synthesis of Fluorescent Nano Particles
Artificially synthesized fluorescent nano particles have manifold potential applications in the manufacturing of electrooptics, optical data storage, as well as for biochemical, bioanalytical and medical applications. Sonication is an effective and reliable method to synthesize fluorescent nano particles of high…
https://www.hielscher.com/ultrasonic-synthesis-of-fluorescent-nano-particles.htm
Fuel Changeover System
Due to increasing fuel prices and new environmental emission regulations, innovative technologies are needed to operate vessels efficiently. The Fuel Changeover System operates through an intelligent control system which automatically performs the mix between both high and lower sulphur content…
Ultrasonic Dispersion of Xanthan and Guar Gums
Shear-thinning materials such as xanthan gum and guar gum are widely used as rheological modifiers. In order to take full advantage of the properties of xanthan gum or guar gum, the powders must be uniformly dispersed in the formulation. The…
https://www.hielscher.com/ultrasonic-dispersion-of-xanthan-and-guar-gums.htm
Ultrasonic Mixing Technology for Pharmacies
Ultrasonic lab homogenizers allow for fast and efficient emulsifying and dispersing of cremes, lotions, ointments, suspensions and tinctures. Power ultrasound is a reliable compounding technique for high quality pharmaceuticals Due to intense cavitational shear forces, ultrasonic mixing results in outstanding,…
https://www.hielscher.com/ultrasonic-mixing-technology-for-pharmacies.htm
Focused Ultrasonic Probes for Intense Cleaning
Hielscher Ultrasonics hand-held or stand-mounted ultrasonic probes direct highly intense ultrasonic waves to the openings of wire dies, wire guides, extruder dies, extruder plates or spinnerets. This cleans the fine channels and surfaces in seconds from: oils and fats dirt…
https://www.hielscher.com/focused-ultrasonic-probes-for-intense-cleaning.htm
Ultrasonic Nano-Structuring to Produce Porous Metals
Sonochemistry is a very effective tool for the engineering and functionalization of nano materials. In metallurgy, the ultrasonic irradiation promotes the formation of porous metals. The research group of Dr. Daria Andreeva developed an effective and cost-efficient ultrasound-assisted procedure to…
https://www.hielscher.com/ultrasonic-nano-structuring-to-produce-porous-metals.htm
Sonochemical Reduction of Palladium Nanoparticles
Palladium (Pd) is well known for its catalytic functions but is also often used in materials research and the production of electronics, medicine, hydrogen purification, and other chemical applications. Via sonochemical route, mono-dispersed as well as aggregated palladium nano particles…
https://www.hielscher.com/sonochemical-reduction-of-palladium-nanoparticles.htm
Sono-Synthesis of Nano-Hydroxyapatite
Hydroxyapatite (HA or HAp) is a highly frequented bioactive ceramic for medical purposes due to its similar structure to bone material. The ultrasonically assisted synthesis (sono-synthesis) of hydroxyapatite is a successful technique to produce nanostructured HAp at highest quality standards.…
https://www.hielscher.com/sono-synthesis-of-nano-hydroxyapatite.htm
Improve your Scavengers by Ultrasonic Mixing
A scavenger is a chemical substance that is added to a mixture in order to remove or deactivate impurities and marring by-products. ln many reactions, an excess of starting materials is used to drive a solution phase reaction to completion.…
https://www.hielscher.com/improve-your-scavengers-by-ultrasonic-mixing.htm
Mixing H2S Scavengers for Phase-Transfer-Reaction
Hydrogen sulfide (H2S) is a colorless gas that occurs in crude oil and natural gas. H2S is poisonous, corrosive, flammable and explosive. It can be removed from oil and gas by scavengers, hydrodesulfurization, activated carbon filtration or reaction with iron…
https://www.hielscher.com/mixing-h2s-scavengers-for-phase-transfer-reaction.htm
InnoREX – Ultrasonically Improved PLA Extrusion
Ultrasonic mixing, dispersing and emulsification improves the extrusion of polylactic acids (PLA). Implementing ultrasonication into extrusion lines increases yield and quality of the produced PLA. Polylactide Synthesis Polylactid acids or polylactide (PLA) is a thermoplastic aliphatic polyester, which is synthesized…
https://www.hielscher.com/innorex-ultrasonically-improved-pla-extrusion.htm
Algae Grow Lab – Ultrasonic Algae Extraction
Algae Cultivation Algae Grow Lab developed a series of tubular and flat photobioreactors for algae cultivation as well as a process of cell ultrasonic destruction based on Hielscher ultrasonic processors equipped with flow cells. The general flow diagram of the…
MultiPhaseCavitator-Insert for Ultrasonic Flow Cell
The MultiPhaseCavitator Insert (InsertMPC48) is designed to improve the ultrasonic processing of liquid/liquid or liquid/gas mixes. 48 very fine cannulas inject liquid or gas into a liquid phase right in the cavitation zone. This creates very small suspended droplets or…
https://www.hielscher.com/multiphasecavitator-insert-for-ultrasonic-flow-cell-reactor.htm
Ultrasonication Accelerates the Suzuki Coupling Reaction
The Suzuki Cross-Coupling (also known as Suzuki-Miyaura Coupling) is an organic reaction with the aim to synthesize biphenyl derivatives, vinyl aromates (e.g. styrenes), poly-olefins, as well as alkyl bromides. The reaction base materials are an aryl- or vinyl-boronic acid with…
https://www.hielscher.com/ultrasonication-accelerates-the-suzuki-coupling-reaction.htm
Ultrasonically Induced and Enhanced Phase Transfer Catalysis
High power ultrasound is well-known for its contribution to various chemical reactions. This is the so-called sonochemistry. Heterogeneous reactions – and especially phase transfer reactions – are highly potential application fields for power ultrasound. Due to the mechanical and sonochemical…
https://www.hielscher.com/ultrasonically-induced-and-enhanced-phase-transfer-catalysis.htm
Ultrasonically Assisted Catalytic Extraction
Hielscher ultrasonic reactors are used in many industries to assist and improve the catalytic extraction processing (CEP) or so-called phase-transfer extraction (PTE). Catalytic extraction involves a heterogeneous immiscible phase system, such as liquid-liquid or liquid-solid. Ultrasonic high shear and cavitational…
https://www.hielscher.com/ultrasonically-assisted-catalytic-extraction.htm
Closed Ultrasonic Reactor for Pharmaceutical Batch Processing
Many processes as mixing, dispersing and extraction of high-value materials are carried out as batch process. Hielscher's closed ultrasonic reactor is ideal for an integrated ultrasonic processing under closed and precisely controlled conditions. Hielscher's closed ultrasonic reactor is perfectly suitable…
https://www.hielscher.com/closed-ultrasonic-reactor-for-pharmaceutical-batch-processing.htm
Video: Flexible Plate Sonicator UIP400MTP
Hielscher offers adaptable inlays for the UIP400MTP plate sonicator. Fast swaps, no proprietary plates, and full workflow flexibility. For more information about multi-well plate sonication, please click here!
https://www.hielscher.com/video-flexible-plate-sonicator.htm
Hielscher News
Hielscher News highlights the latest research, innovations, and applications in ultrasonic processing. From extraction and formulation to particle size reduction and cell disruption, our news articles provide concise insights into current scientific findings, industrial trends, and real-world use cases. Stay…
Overcome the Challenges of Ohmic Heating
Ultrasonic Ohmic heating combines the rapid, uniform volumetric heating of electrical currents with the intense mechanical effects of sonication. This synergy enhances heat transfer, reduces thermal gradients, and promotes efficient mass transfer at the microscale. As a result, it minimizes…
https://www.hielscher.com/overcome-the-challenges-of-ohmic-heating.htm
Ultrasonic Homogenizers As Essential Tool in Cosmetic Production
In modern cosmetic manufacturing, the demand for stable, high-performance formulations is persistently high. Consumers expect creams that glide smoothly, serums with fine texture, and emulsions that remain stable over time. Achieving these characteristics requires precise control over droplet size, dispersion…
https://www.hielscher.com/ultrasonic-homogenizers-in-cosmetic-production.htm
Ultrasonic Cavitation in Liquids
Ultrasonic waves of high intensity ultrasound generate acoustic cavitation in liquids. Cavitation causes extreme effects locally, such as liquid jets of up to 1000km/hr, pressures of up to 2000 atm and temperatures of up to 5000 Kelvin. These ultrasonically-generated forces…
https://www.hielscher.com/ultrasonic-cavitation-in-liquids-2.htm
Biodiesel from Algae using Ultrasonication
Algae oil is an interesting sustainable feedstock for biodiesel manufacturing. It is an alternative to popular feedstocks, like soybean, canola and palm. Ultrasonication improves the extraction of oil from the algae cells and the conversion to biodiesel. In comparison to…
Ultrasonication Saves Energy and Costs
Switching from conventional homogenizers, hydrodynamic mixers and agitated mills to ultrasonic cavitational processing adds both cost savings and makes processing environmentally friendly. Due to the recent and continued rise in energy prices energy consumption has a direct and substantial effect…
Ultrasonic Preparation of Metal-Organic Frameworks (MOFs)
Metal-Organic Frameworks are compounds formed from metal ions and organic molecules so that a one-, two, or three-dimensional hybrid material is created. These hybrid structures can be porous or non-porous and offer manifold functionalities. The sonochemical synthesis of MOFs is…
https://www.hielscher.com/ultrasonic-preparation-of-metal-organic-frameworks-mofs.htm
Supramolecular Structures Assembled via Sonication
Sonication is a powerful and versatile tool in supramolecular chemistry, enabling precise control over noncovalent assembly processes that are often sensitive to kinetic and thermodynamic parameters. The application of power ultrasound to a liquid medium affects molecular interactions, accelerating self-assembly,…
https://www.hielscher.com/supramolecular-structures-assembled-via-sonication.htm
Ultrasonic Synthesis of SnOx Nanoflakes
Two-dimensional (2D) nanomaterials continue to attract considerable interest in material science, owing to their high surface area, tunable electronic properties, and unique interactions with light and matter. Among these, tin-oxide based systems (generally SnO₂, or mixed SnO/SnO₂ phases) are of…
https://www.hielscher.com/ultrasonic-synthesis-of-snox-nanoflakes.htm
Ruthenium Oxide Nanosheets via Ultrasonic Exfoliation
Ruthenium oxide monolayer nanosheets can efficiently produced using probe-type ultrasonication. Major advantages of ultrasonic nanosheet exfoliation are process efficiency, high yields, short treatment and facile, safe operation. Due to its high efficiency and superior quality of produced nanosheets, ultrasonication is…
https://www.hielscher.com/ruthenium-oxide-nanosheets-via-ultrasonic-exfoliation.htm
Ultrasonic CupHorn
The Hielscher Ultrasonic CupHorn is the world's most advanced ultrasonic cuphorn. The ultrasonic intensity of the Hielscher CupHorn exceeds conventional ultrasonic baths by a thousand times. Precise control and user-friendliness ensure reliable and repeatable outcomes and comfortable operation. That's why…
Nanocomposite Hydrogel Synthesis using Ultrasonication
Nanocomposite hydrogels or nanogels are multi-functional 3D structures with high efficacies as drug carriers and controlled-release drug delivery systems. Ultrasonication promotes the dispersion of nano-sized, polymeric hydrogel particles as well as the subsequent inclusion/incorporation of nanoparticles into these polymer structures.…
https://www.hielscher.com/nanocomposite-hydrogel-synthesis-using-ultrasonication.htm
Careers at Hielscher Ultrasonics
We are glad that you are interested in joining our company! On this page, you can find all currently open vacancies. For the reinforcement of our team we are always in the search for engaged and skilled coworkers and trainees.…
https://www.hielscher.com/careers-at-hielscher-ultrasonics.htm
Sonicator UIP1000hdT (1000 Watts) – Powerful and Versatile
The UIP1000hdT (1000W, 20kHz) is a powerful and adaptable probe-type sonicator for lab testing and the industrial sonication of liquids. It is used for applications, such as emulsification, dispersing, particle fine milling, lysis, extraction, dissolving and sonochemical reactions. Color touch…
Stable Paraffin Wax Emulsions via Sonication
Ultrasonic emulsification provides significant advantages in the preparation of stable paraffin wax emulsions, enhancing the quality and stability of the final product. Sonication effectively overcomes the key challenges of paraffin emulsification by utilizing high-intensity ultrasonic waves to generate intense cavitation…
https://www.hielscher.com/stable-paraffin-wax-emulsions-via-sonication.htm
Nanoparticle-in-Wax Dispersions – Make Stable Formulations!
Dispersing nanoparticles into wax matrices is an important, yet challenging application in coatings, cosmetics, pharmaceuticals, and phase-change materials. Given the intrinsic viscosity of molten waxes, their hydrophobicity, and the tendency of nanoparticles to agglomerate due to high surface energies, the…
https://www.hielscher.com/nanoparticle-in-wax-dispersions-make-stable-formulations.htm
Video: 50mL VialTweeter – Dispersing Carbon Nanotubes
Using the Hielscher VialTweeter, you can achieve rapid and uniform dispersion of carbon nanotubes (CNTs), including multi-walled carbon nanotubes (MWCNTs), in a wide range of solvents such as ethanol, isopropanol, and water. The powerful ultrasonic energy delivered by the VialTweeter…
https://www.hielscher.com/video-ultrasonic-dispersing-cnt-50ml-test-tube.htm
Ultrasonic Ohmic Heating in Food Processing
The demand for gentle yet effective processing technologies in the food sector has intensified, driven by the need to balance microbial safety with the preservation of nutritional and sensory qualities. Conventional thermal treatments often rely on surface-to-core heat transfer, which…
https://www.hielscher.com/ultrasonic-ohmic-heating-in-food-processing.htm
Ultrasonic Ohmic Heating for Intensified Botanical Extraction
Ultrasonic ohmic heating combines ultrasound-induced cavitation with rapid, uniform ohmic heating to intensify the extraction of bioactive compounds from botanicals. Compared with conventional and single-mode methods, it yields more phyto-chemicals in significantly less time while reducing energy use by up…
https://www.hielscher.com/ultrasonic-ohmic-heating-for-intensified-botanical-extraction.htm
Book Your Accommodation for Your Visit at Hielscher Ultrasonics!
To facilitate your travel plannings, Hielscher Ultrasonics has partnered with GINN Hotels. When you book a room through the link below and use the corporate code "CGINN24" for 15% discount on the actual daily rate. GINN Hotel in Teltow -…
Ultrasonic Wet-Precipitation of Prussian Blue Nanocubes
Prussian Blue or iron hexacyanoferrate is a nano-structured metal organic framework (MOF), that is used in sodium‐ion battery manufacturing, biomedicine, inks and electronics. Ultrasonic wet-chemical synthesis is efficient, reliable and rapid pathway to produce Prussian Blue nanocubes and Prussian blue…
https://www.hielscher.com/ultrasonic-wet-precipitation-of-prussian-blue-nanocubes.htm
Nanodiamonds Dispersed in Aqueous Suspension with Sonication
Nanodiamond dispersions can be prepared rapidly and efficiently using Hielscher sonicators. In aqueous suspension, ultrasonic deaggregation ensures reliable breakdown of aggregates and the formation of stable colloids. When combined with simple salt addition for pH adjustment, the method provides a…
https://www.hielscher.com/nanodiamonds-dispersed-in-aqueous-suspension-with-sonication.htm
Ultrasonic Synthesis of Nanodiamonds
Due to its intense cavitational force, power ultrasound is a promising technique to produce micron- and nano-sized diamonds from graphite. Micro- and nano-crystalline diamonds can be synthesized sonicating a suspension of graphite in organic liquid at atmospheric pressure and room…
https://www.hielscher.com/ultrasonic-synthesis-of-nanodiamonds.htm
Nanodiamond Dispersion: Accurate Sample Preparation with Sonication
Efficient dispersion and deagglomeration of nanodiamonds are critical prerequisites for reliable analysis, as these materials exhibit a pronounced tendency to form strongly bound aggregates due to their high surface energy and extensive hydrogen bonding networks. Poorly dispersed suspensions can obscure…
https://www.hielscher.com/nanodiamond-dispersion-accurate-sample-preparation-with-sonication.htm
RNA Sequencing with UIP400MTP High Throughput Sonicator
In genomics research, next-generation sequencing (NGS) offers unparalleled insights into genetic information. The success of NGS depends on the quality of RNA samples. This is where the Hielscher UIP400MTP multi-well-plate sonicator is essential. This advanced ultrasonication technology of the UIP400MTP…
https://www.hielscher.com/rna-sequencing-with-uip400mtp-high-throughput-sonicator.htm
Ultrasonic DNA Fragmentation for Next Gen Sequencing
Next Generation Sequencing (NGS) requires the reliable shearing and fragmentation of genomic DNA in order to sequence genomic DNA strands and to create genome libraries. The controlled fragmentation of DNA into DNA fragments is an essential sample preparation step required…
https://www.hielscher.com/ultrasonic-dna-fragmentation-for-next-gen-sequencing.htm
Ultrasonic Pomace Extraction – Sustainable Recovery of Bioactive Compounds
Fruit processing by-products, especially pomace, represent an untapped reservoir of bioactive compounds with potential applications in nutraceuticals, food fortification, and pharmaceuticals. Yet, the efficient and sustainable recovery of these compounds remains a technical challenge. Among emerging green extraction technologies, ultrasound-assisted…
Grape Seed Extraction with Ultrasound: Yield, Speed, Sustainability
Ultrasonic extraction is a highly efficient and scalable technique for recovering polyphenols from grape seeds - a rich source of condensed tannins, flavan-3-ols, and proanthocyanidins. The mechanical effects of acoustic cavitation generated by high-power ultrasound significantly enhance mass transfer, disrupt…
https://www.hielscher.com/grape-seed-extraction-with-ultrasound.htm
96-Well Plate Sonicator UIP400MTP for High-Throughput Sample Prep
96-well plates, microplates, multi-well plates, microtiter plates or ELISA plates are used for the mass sample cultivation and processing of biological samples. With the microtiter plate ultrasonicator UIP400MTP, Hielscher offers a unique ultrasonic solution of the uniform and reliable sample…
https://www.hielscher.com/microtiter-plate-mass-sample-preparation-by-ultrasonication.htm
Ultrasonic Dissolving of Solids in Liquids
The preparation of solutions is an important step for lab samples as well as for industrial production. In general, lab samples must be liquified before analysis. Ultrasonic homogenization and dissolving is a quick and reliable means to prepare samples of…
https://www.hielscher.com/ultrasonic-dissolving-of-solids-in-liquids.htm
Oleogels: How Sonication Improves Oleogel Formulations
Oleogels are versatile materials with applications in a wide range of industries, offering unique benefits in terms of texture, stability, and functionality. Using probe-type sonicators significantly improves the synthesis and performance of oleogels, making them more suitable for various industrial…
https://www.hielscher.com/oleogels-how-sonication-improves-oleogel-formulations.htm
Ultrasonic Precipitation Process
Particles, e.g. nanoparticles can be generated bottom-up in liquids by means of precipitation. In this process, a supersaturated mixture starts forming solid particles out of the highly concentrated material that will grow and finally precipitate. In order to control the…
Buffer Solutions Prepared with Ultrasonication
Lysis buffers can be efficiently and quick prepared using ultrasonic tissue homogenizers. Since ultrasonicators are a dream tool for mixing, dissolving and dispersing, they allow for a reliable and user-friendly preparation of lysis buffers. Ultrasonic Preparation of Lysis Buffers Ultrasonic…
https://www.hielscher.com/buffer-solutions-prepared-with-ultrasonication.htm
NOx-Reduction by Oil/Water-Emulsification
Nitrogen oxides (NOx) are known to be immediately dangerous to human and environmental health. Mobile and stationary diesel and gasoline engines are contributing largely to the worldwide NOx emissions. Emulsification of the fuel with water is a way to reduce…
Dissolving: High-Performance Dissolvers
Ultrasonic dissolvers are powerful mixing tools used in various industries to disperse and homogenize powder-liquid slurries with unparalleled efficiency. Unlike traditional mixing methods, ultrasonic dissolvers utilize high-intensity ultrasound waves to create intense cavitation and micro-turbulence within the liquid. These effects…
https://www.hielscher.com/dissolving-high-performance-dissolvers.htm
Ultrasonic Mixing For High-Performance Concrete
The use of micro- and nanosilica or nanotubes leads to improvements in the compressive strength of high-performance concrete. Ultrasonication is an effective means for the mixing, wetting and dispersing of nanomaterials in cement or concrete. Micro silica is widely…
Ultrasonically Improved Kombucha Fermentation
Sonication promotes fermentation in ultrasonically fermented foods such as kombucha, kimchi and other fermented vegetables by enhancing mass transfer, disrupting microbial cells, activating enzymes, and improving homogeneity, ultimately leading to accelerated fermentation rates and the production of a superior-quality product.…
https://www.hielscher.com/ultrasonically-improved-kombucha-fermentation.htm
Improved Insect Protein Production with Ultrasonics
Insects are a sustainable, easy-to-grow source for high-quality nutritional proteins and lipids. In order to separate proteins and lipids from the insects, ultrasonic extraction is used as highly efficient and reliable technology. Ultrasonication has been proven for high extraction rates,…
https://www.hielscher.com/improved-insect-protein-production-with-ultrasonics.htm
Production of Hand Sanitizers with Industrial Ultrasonic Mixers
To produce hand sanitizers and disinfecting solutions, a powerful mixing technology is required to obtain a consistent mixture. Ultrasonic mixers and agitators are the most reliable and efficient mixing technology for blending and emulsifying two or more phases in order…
https://www.hielscher.com/production-of-hand-sanitizers-with-industrial-ultrasonic-mixers.htm
About Hielscher Ultrasonics
Hielscher Ultrasonics is a family owned business, located in Teltow near Berlin (Germany). The main emphasis of its activities is the conception, development and production of ultrasonic devices for the use in laboratory and for manifold industrial applications. Technological innovations…
UP400S – Powerful Sonication of Larger Samples
400 Watts ultrasonic power - The UP400S (400W, 24kHz) is a powerful and reliable ultrasonic device for the sonication of larger samples in the lab. Typical application include: Homogenization, deagglomeration, lysis and cell disintegration, protein extraction and the emulsification of…
Higher Pectin Yields with Ultrasonic Extraction
Ultrasonic extraction results in high yields of superior quality pectins. Using sonication, valuable pectins can be efficiently produced from fruit waste (e.g., by-products from juice processing) and other biological raw material. Ultrasonic pectin extraction excels other extraction techniques by producing…
https://www.hielscher.com/higher-pectin-yields-with-ultrasonic-extraction.htm
Pectin Extraction from Grapefruit Peel using a Sonicator
Pectins from fruit by-products such as peels or pulp are highly efficiently extracted using ultrasonic extractors. As a reliable simple and safe to operate pectin extraction method, sonication increases the pectin yield and pectin quality at accelerated production speed. Below,…
https://www.hielscher.com/pectin-extraction-from-grapefruit-peel-using-a-sonicator.htm
Ultrasonic Pectin Extraction from Fruit and Bio-Waste
Pectins are a very frequently used food additive, mainly added for its gelling effects. Ultrasonic extraction increases the yield and quality of pectin extracts significantly. Sonication is known for its process intensifying effects, which are already used in manifold industrial…
https://www.hielscher.com/ultrasonic-pectin-extraction-from-fruit-and-bio-waste.htm
Sono-Electrochemical Deposition of Nano-Enhanced Coatings
Sono-electrochemical deposition couples high-intensity ultrasound with electroplating to create dense, adherent, nano-enhanced coatings with controlled microstructure.The vigorous ultrasonic agitation and micro-streaming continuously refreshes the diffusion layer, and cleans/activates the electrode surface; as a result, ion transport and nucleation rates increase,…
https://www.hielscher.com/sono-electrochemical-deposition-of-nano-enhanced-coatings.htm
UIP2000hdT – 2000 Watts Powerful Industrial Ultrasonicator for Full Process Control
The new digital probe-type sonicator UIP2000hdT (20kHz, 2000W) is a powerful ultrasound processor for liquid treatments on bench-top and industrial scale. Common applications include homogenization, emulsification, dispersing and particle fine milling, lysis and extraction, dissolving or sonochemical reactions, such as…
Ultrasonicators and Probes for Liquid Processing
Hielscher Ultrasonics offers a complete range of high-performance sonicators - from compact lab devices to robust industrial systems. Engineered for precision and reliability, our ultrasonic processors deliver reproducible results for sample preparation, particle size reduction, extraction, and chemical processing. Hielscher…
Molecular Cuisine and other Culinary Applications
Sonication is transforming the way chefs and food scientists prepare foods and beverages: ultrasonic extraction, infusion, emulsification and homogenization are key applications of sonicators for culinary creations. From rapid extractions to silkier emulsions and intensified aromas, ultrasound waves develop outstanding…
https://www.hielscher.com/ultrasonic-homogeniser-for-culinary-applications.htm
Food Emulsions – Better by Sonication
Emulsion technology is ubiquitous in food formulations: frozen desserts with a velvety mouthfeel, creamy salad dressings, perfectly homogenized milk products, spreads, margarines, and even high‑end flavor concentrates. Emulsions are complex dispersions of immiscible liquids, typically oil and water, stabilized to…
Cold Mix Asphalt – Produce Better Quality Using Sonication
Cold mix asphalt emulsions depend critically on controlling droplet size distribution, viscosity, and stability while minimizing the energy input required for processing. Hielscher sonicators break droplets efficiently, shorten processing time, and allow you to hit tighter specs with less surfactant…
https://www.hielscher.com/cold-mix-asphalt-produce-better-quality-using-sonication.htm
Ultrasonic Wire Draw Cleaning
For ultrasonic wire draw cleaning, high-intensity ultrasound waves are superimposed on conventional wire dies. Intense vibrations are generated by high amplitudes of an ultrasonic processor and directly coupled via wire die into the metal working piece (e.g., wires, rods, tubes).…
Ultrasonic Preparation of Calcium Bromide Fluids for Oil and Gas
Calcium bromide brines are indispensable in modern well construction, completion, work-over, and long term service because they deliver high density without suspended solids, mix cleanly with companion halide systems, and exhibit strong shale and clay inhibition in water sensitive formations.…
https://www.hielscher.com/ultrasonic-preparation-of-calcium-bromide-fluids-for-oil-and-gas.htm
Clear Halide Brines by Ultrasonication
High-power ultrasonication lets engineers dissolve and degas brine salts in minutes, producing uniform, low-oxygen brines on demand. Clear halide brines are single-phase, solids-free aqueous solutions of chloride or bromide salts that deliver precise hydrostatic pressure while minimizing formation damage. Densities…
https://www.hielscher.com/clear-halide-brines-by-ultrasonication.htm
Sonicator – Hielscher Ultrasonics | Lab to Industrial Scale
Sonicator power breaks tough cells, drives nano dispersions, forms fine nano emulsions, and turns promising lab work into real products. Whether you run daily prep, chase particle size distributions, test ultrasonics in class, or design a startup process, Hielscher Ultrasonics…
Ultrasonic Polymerization of Hydrogels: Protocol and Scale-Up
Ultrasound-induced polymerization offers a radical-free, initiator-free approach to synthesizing hydrogels from water-soluble vinyl monomers and macromonomers. This methodology exploits the sonochemical generation of radicals via cavitation and is ideally suited for biomedical applications where initiator residues must be avoided. Hydrogels…
Multiwell Plate Sonicator
The Hielscher UIP400MTP is the most advanced and most powerful multiwell plate sonicator on the market. It is designed to deliver unparalleled sonication efficiency, precision and reproducibility across a wide range of applications. It works with your multiwell plates, PCR…
Universal Compatibility: Sonicate Multi-well Plates with the UIP400MTP
The UIP400MTP multi‑well plate sonicator is engineered for universal compatibility, enabling efficient, non‑contact ultrasonic processing across virtually all standardized microplate formats without the need for proprietary consumables. It accepts and operates seamlessly with 6‑, 12‑, 24‑, 48‑, 96‑, and 384‑well…
Video: UIP400MTP – Uniform Microplate Sonication
The UIP400MTP microplate sonicator delivers uniform sonication results within short processing times. The multi-well plate sonicator UIP400MTP demonstrates remarkable uniformity of ultrasonic energy distribution across all wells, as validated by standardized test procedures. In the video, a thin sheet…
https://www.hielscher.com/video-uip400mtp-uniform-microplate-sonication.htm
Stepped Plate Sonicators for Ultrasonically-Assisted Freeze-Drying
Freeze-drying, or lyophilization is a dehydration technique used to preserve heat-sensitive biological and food materials. Freeze-drying is widely applied in food and pharma manufacturing as this method maintains compound structures and nutritional values. Yet traditional freeze-drying systems often suffer from…
https://www.hielscher.com/stepped-plate-sonicators-for-ultrasonically-assisted-freeze-drying.htm
Ultrasonic Bentonite Dispersion
Bentonite clays, such as sodium bentonite, calcium bentonite and potassium bentonite, are mainly used as additive for drilling fluids, binder, purifier, adsorbent, and as a groundwater barrier. Due to strong bonding and van der Waals forces, the dispersibility of bentonite…
https://www.hielscher.com/ultrasonic-bentonite-dispersion.htm
Ultrasonic Mixers for Drilling Muds and Packer Fluids
Drilling fluid (drilling mud) is used to aid the drilling of oil wells, natural gas wells, exploratory wells (wildcat wells) or water wells. Ultrasonic reactors are an effective technology for the mixing, dispersing, emulsification and degassing of water-based mud (WBM,…
https://www.hielscher.com/ultrasonic-mixers-for-drilling-muds-and-packer-fluids.htm
Ultrasonic Cooking: Mixers & Recipes
Ultrasonictors are powerful blenders and homogenizers, whose application is not limited to lab and industry. Since a few years, ultrasonicators have found their way into the gourmet kitchens, too. Prestigious star-arwarded gourmet restaurants, small gems of finest food, cooking school…
https://www.hielscher.com/ultrasonic-cooking-basics-recipes.htm
Cement Particle Deagglomeration using Power Ultrasonics
Probe-type sonicators are frequently used for the deagglomeration of cement particles. This method eliminates the need for grinding media, simplifies the process by making filtration and intensive cleaning unnecessary, and provides efficient particle size reduction. Additionally, sonication reduces the reliance…
https://www.hielscher.com/cement-particle-deagglomeration-using-power-ultrasonics.htm
Reliable Nanoparticle Dispersion for Industrial Applications
High power ultrasonication can efficient and reliably break-up particle agglomerates and even disintegrate primary particles. Due to its high-performance dispersion performance, probe-type ultrasonicators are used as preferred method to create homogeneous nanoparticle suspensions. Reliable Nanoparticle Dispersion by Ultrasonication Many industries…
https://www.hielscher.com/reliable-nanoparticle-dispersion-for-industrial-applications.htm
Ultrasonic Homogenizers for Nanomaterial Deagglomeration
Hielscher sonicators provide precise and reliable deagglomeration of nanomaterials, whether in lab beakers or on a production scale. They help researchers and engineers achieve consistent results in nanotechnology applications. Nanomaterial Deagglomeration: Challenges and Hielscher Solutions Nanomaterial formulations often face agglomeration…
https://www.hielscher.com/ultrasonic-nanomaterial-deagglomeration.htm
Video: Sonication of Carrot Juice for Stability and Better Taste
This video demonstrates how sonication stabilizes fresh organic carrot juice by disrupting cell structures and releasing flavors, shown via a refrigerated time-lapse. Using a purely mechanical process, Hielscher sonicators enhance stability, texture, and shelf life of juices, smoothies, purees,…
https://www.hielscher.com/video-sonication-of-carrot-juice-for-stability-and-better-taste.htm
Video: UP200Ht and UP200St – Lab Sonicators
This video features the Hielscher 200 Watts sonicators UP200Ht and UP200St with a digital touch interface to deliver precise, reproducible homogenization with integrated temperature monitoring. For more information about these sonicators, please click here!
https://www.hielscher.com/video-up200ht-and-up200st-lab-sonicators.htm
Video: Sonicator UP400St – 400 Watts
The Hielscher UP400St is your perfect sonicator for a wide range of ultrasonic processes in research and development as well as for the production of smaller batches. For more information about this sonicator, please click here!
https://www.hielscher.com/video-sonicator-up400st-400-watts.htm
Micro-Algae Harvesting Improved by Sonication
Microalgae is rich in lipids, protein and micronutrient, which makes microalgae a valuable source for nutrients. Given the structural resilience of algal cell walls and the need for downstream extraction of intracellular compounds - particularly lipids and micronutrients - a…
https://www.hielscher.com/micro-algae-harvesting-improved-by-sonication.htm
Ultrasonication to Improve Algae Cell Disruption and Extraction
Algae, macro- and microalgae, contain many valuable compounds, which are used as nutritional foods, food additives or as fuel or fuel feedstock. In order to release the target substances from the algae cell a potent and efficient cell disruption technique…
https://www.hielscher.com/ultrasonication-to-improve-algae-cell-disruption-and-extraction.htm
Ultrasonic Algae Extraction for Nutritional Supplements
Ultrasonic extraction is the superior method to disrupt algae cells effectively and rapidly. Sonication can release the complete amount of the bioactive compounds, which makes the ultrasonic technique highly efficient. How To Extract Proteins, Lipids and Phenolics from Algae with…
https://www.hielscher.com/ultrasonic-algae-extraction-for-nutritional-supplements.htm
Ultrasonic Alternative to Hydrodesulfurization
Oil refineries are facing increasing supplied of sulfurous crude oil, so-called sour crude, whilst at the same time environmental regulations pressure for lower sulfur content of gasoline. Simultaneously, the costs of conventional hydrodesulfurization (HDS) are rising because of the hydrogen…
Ultrasonically Assisted Oxidative Desulfurization (UAODS)
Sulfur-containing compounds in crude oil, petroleum, diesel and other fuel oils include sulfides, thiols, thiophenes, substituted benzo- and dibenzothiophenes (BTs and DBTs), benzonaphthothiophene (BNT), and many more complex molecules, in which the condensed thiophenes are the most common forms. Hielscher…
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The Effects of an Ultrasonic Disperser on Inline Measurements
For the characterization and measurement of primary particles, the particles should be well dispersed as agglomerates falsify the measurement results. Ultrasound is a reliable tool to destroy agglomerates and to create conditions where the primary particles are hold in adequate…
https://www.hielscher.com/the-effects-of-an-ultrasonic-disperser-on-inline-measurements.htm
The Solution to Electrode Surface Fouling
Electrode surface fouling is a serious problem in many electrochemical production processes and in electrochemical sensors. Electrode fouling can affect the performance and energy efficiency of an electrochemical cell. Ultrasonication is an effective means to avoid and remove electrode fouling.…
https://www.hielscher.com/solution-to-electrode-surface-fouling.htm
Realtime Excel Logger for Hielscher Sonicator XML Data
This realtime Excel logger for Hielscher sonicators is a lightweight VBA-based solution that allows users to visualize live sonication data streamed in XML format. It automatically connects to a sonicator via its local IP, reads out live process data, logs…
Ultrasonic-Enzymatic Diacylglycerol Production
Diacylglycerol (DAG) rich oils have shown a high nutritional value since they are digested and metabolized in a way, which significantly reduces body weight. Diacylglycerol can be produced by the hydrolysis of palm oil using a commercial lipase as a…
https://www.hielscher.com/ultrasonic-enzymatic-diacylglycerol-production.htm
Threaded Spindle Cleaning for Improved Manufacturing
The manufacturing process of threaded spindles and thread rods involves the removal of drawing oils and dirt. Hielscher ultrasonic inline cleaners remove any process residues in a highly efficient cleaning process from threaded endless profiles without halting or slowing the…
Ultrasonic Extraction of Nut Oils and Lipids
Ultrasonic extraction is a powerful, non-thermal technique to isolate valuable lipids and oils from plant-derived materials. This page provides a comprehensive overview of the ultrasonic extraction of nut oils, including the underlying principles, chemical composition of nut lipids, and detailed…
https://www.hielscher.com/ultrasonic-extraction-of-nut-oils-and-lipids.htm
Video: Ultrasonic Solvent Extraction of Nut Oils and Lipids
Ultrasonic ethanol extraction of nut oils and lipids with vacuum filtration, UV-Vis profiling, and rotary evaporation for high-quality, thermo-sensitive extracts. For more information about this extraction process and protocol, please click here!
https://www.hielscher.com/video-ultrasonic-solvent-extraction-of-nut-oils-and-lipids.htm
Video: Falcon Tube Sonicator
Experience how the Hielscher VialTweeter delivers powerful, contamination-free sonication inside a sealed 50 mL Falcon tube to accelerate workflows ranging from microbiology to formulation development. For more information about this Falcon tube sonicator, please click here!
Video: 5mL VialTweeter® Sonicator
The Hielscher VialTweeter® offers sonication of closed, sterile test tubes, without cross-contamination, sample loss, or aerosols. For more information about this 5mL VialTweeter® sonicator, please click here!
https://www.hielscher.com/video-5ml-vialtweeter-sonicator.htm
Ultrasonic Mixing of Asphalt Rejuvenators
Asphalt rehabilitators and rejuvenators enable to recycle existing asphalt pavements by applying rejuvenating agents to the construction material. Ultrasonic dispersers are a powerful technique to mix nano-particles and nano-droplets into asphalt and bitumen emulsions. Power ultrasound is used to manufacture…
https://www.hielscher.com/ultrasonic-mixing-of-asphalt-rejuvenators.htm
Ultrasonic Soxhlet Extraction
Ultrasonics improves the conventional Soxhlet extraction. Ultrasonically assisted Soxhlet, also known as Sono-Soxhlet, extraction leads to higher yields and shorter extraction times. Hielscher probe-type sonicators can be easily integrated into any classic Soxhlet extractor setup. Soxhlet Extraction using Ultrasonication Soxhlet…
Ultrasonic Process Optimization & Consulting
Over 20 years of experience in ultrasonic processing makes Hielscher the leading expert for industrial ultrasonic processes. We guide our customers from their first process ideas through process optimization to the final scale-up to commercial production - developping the perfect…
https://www.hielscher.com/ultrasonic-process-optimization-consulting.htm
PT100 Thermo Couples for Ultrasonic Homogenizers
Liquid temperature is an important factor for ultrasonic processes. For temperature monitoring, controlling and recording, Hielscher offers two PT100 temperature sensors (PT100 and PT100-0G5) for use with all its ultrasonic devices with Touch control. Please see the compatibility chart for…
https://www.hielscher.com/pt100-thermo-couples-for-ultrasonic-homogenizers.htm
Ultrasonic Degassing of Aluminium Alloy Melts
Aluminium and alloy melts can be efficiently degassed using high-performance ultrasonication. Powerful ultrasound waves promote the coalescence of hydrogen and other unwanted gases so that they can be removed efficiently from the metal melt. Ultrasonic degassers are available for the…
https://www.hielscher.com/ultrasonic-degassing-of-aluminium-alloy-melts.htm
Gravity Die Casting – Optimized Solidification by Sonication
Ultrasound offers a scalable, energy-efficient pathway to optimize the microstructure of gravity-cast metals - bridging the gap between casting economy and high-performance demands. In gravity die casting, the control of solidification is essential to achieving high-performance metal components. Sonication of…
Frequently Asked Questions on Ultrasonics
Below you will find answers to the most common questions regarding ultrasonication. If you do not find an answer to your question, please do not hesitate to ask us. We will be glad to assist you. Can I sonicate solvents?…
Submarine Cables – Efficient Cleaning at High-Speed With Inline Ultrasonics
Submarine communication cables are the infrastructure of global connectivity - transmitting over 99% of intercontinental digital traffic. These cables must operate reliably in some of the most demanding environments on earth: deep ocean trenches, high-pressure saltwater exposure, and decades of…
Aluminium Wire Cleaning
In high-throughput wire production, surface cleanliness is critical. Hielscher ultrasonic inline cleaners remove residual lubricants, oxides, and particulate contaminants from aluminum wires, rods, and profiles. Thorough cleaning is crucial for endless aluminium profiles used in electrical, structural, or high-precision applications.…
Welding Wire Cleaning Inline in Production
Hielscher Ultrasonics offers advanced inline ultrasonic cleaning systems specifically engineered for high-performance welding wire production. Designed for integration into continuous manufacturing lines, these systems deliver non-contact, high-performance cleaning that effectively removes drawing lubricants, metal fines, and oxide residues from stainless…
Sterile Sonication of 5mL Test Tubes
By transmitting ultrasonic energy directly through the walls of closed 5mL test tubes, this Hielscher VialTweeter® offers precise and contamination-free sample processing. Unlike traditional sonication methods that involve direct contact with probes or open containers, this closed-vial approach eliminates the…
https://www.hielscher.com/sterile-sonication-of-5ml-test-tubes.htm
Ultrasonic Wire Cleaning
Manufacturing wire and cable, rods, tapes, tubes and fasteners requires lubrication. Before further processing, such as galvanizing, extrusion or welding, the lubricant residues need to be cleaned off. Hielscher Ultrasonics offers you a unique ultrasonic cleaning process for efficient inline…
Ultrasonic Inline Cleaning of Wire Saws and Cutting Wires
Clean wire surfaces are important when it comes to wire saws and diamond wire saws. Only clean, well-maintained wires produce precise cuts (e.g., silicon wafers, semiconductors, minerals and stones) ans provide high efficiency and quality. Ultrasonic inline wire saw cleaning…
https://www.hielscher.com/ultrasonic-inline-cleaning-of-wire-saws-and-cutting-wires.htm
Cleaning Copper Wires with Ultrasonic Inline Cleaners
Cleaning copper wires is an important step in the production of copper wires and conductors. Whether for electrical applications, electronics, automotive wiring, or high-frequency signal transmission cables, the removal of drawing lubricants, oxides, metal dust, and other residues is essential…
Ultrasonic Cleaning Modules for Wire, Tube and Cable
Hielscher manufactures ultrasonic cleaning systems for the removal of contamination, such as lubricants, drawing oil, dust, dirt, soap or stearate from continuous profiles, such as wire, tube, flat strip or cable. USCM - A Modular Cleaning System The USCM series…
https://www.hielscher.com/ultrasonic-cleaning-modules-for-wire-tube-and-cable.htm
Cocoa Shell Extracts with Power Ultrasound
Cocoa waste such as cocoa fruit pulp and cocoa shells can be easily valorized by extracting cocoa butter, fruit sugar and bioactive compounds. Ultrasonic extraction has been proven to be a highly efficient technique to isolate valuable components from cocoa…
https://www.hielscher.com/cocoa-shell-extracts-with-power-ultrasound.htm
Ultrasonic Processor UIP2000hd – High-Efficiency
The ultrasonic processor UIP2000hd (20kHz, 2000W) is a powerful and adaptable ultrasonic device for the industrial processing of liquids. It is used for applications, such as emulsification, dispersing & particle fine milling, lysis & extraction or homogenizing. Despite the enormous…
Ultrasonic Inline Cleaning of Solder Wires
In solder wire manufacturing, surface cleanliness is critical to ensure optimal performance during soldering. Hielscher ultrasonic inline wire cleaners effectively eliminate contaminants such as drawing lubricants, oxides, dust, or metal particles in a continuous, contact-free process. The result: exceptionally clean…
Sample Preparation with the VialTweeter Sonicator
Sample preparation before analysis can require various pre-analytical processes such as tissue homogenization, lysis, extraction of proteins, DNA, RNA, organelles and other intracellular substances, dissolving and degassing. The VialTweeter is a unique sonicator that prepares multiple sample tubes simultaneously under…
https://www.hielscher.com/sample-preparation-with-the-ultrasonic-vialtweeter.htm
Ultrasonic Priming and Sprouting
Ultrasonic seed priming is a useful pre-sowing technique to replenish seeds with water and nutrients and to stimulate germination. Sonication is an efficient technique for breaking seed dormancy and improving the germination characteristics. Hielscher ultrasonic equipment can be precisely controlled…
https://www.hielscher.com/ultrasonic-priming-and-sprouting.htm
Accelerating Grass Seed Germination for Rolled Turf Production
Rolled turf manufacturing is challenging. Fast germination, dense grass, and short cultivation cycles are essential for an efficient turnover and profitability. Sonication is a highly effective technique to boost turf grass cultivation. Controlled exposure to high-intensity, low-frequency ultrasound facilitates nutrient…
How To Use Hielscher Ultrasonic Tissue Homogenizers
Before purifying or characterizing intracellular macromolecules such as proteins, organelles, enzymes, or active compounds, it is essential to employ an efficient method for tissue lysis and cell disintegration. Ultrasonication is a highly effective technique for cell preparation, quickly releasing intracellular…
https://www.hielscher.com/how-to-use-hielschers-ultrasonic-tissue-homogenizers.htm
Coolants Based on Thermoconductive Nanofluids
Ultrasonically synthesized nanofluids are efficient coolants and heat exchanger liquids. Thermoconductive nanomaterials increase heat transfer and heat dissipation capacity significantly. Sonication is well established in the synthesis and functionalization of thermoconductive nanoparticles as well as the production of stable high-performant…
https://www.hielscher.com/coolants-based-on-thermoconductive-nanofluids.htm
How to Make Nanofluids
A nanofluid is an engineered fluid that consist of a base fluid containing nanoparticles. For the synthesis of nanofluids, an efficacious and reliable homogenization and deagglomeration technique is required to ensure a high degree of uniform dispersion. Ultrasonic dispersers are…
Cavitation Erosion Testing ASTM G32-92
Controllable and reproducible ultrasonication is needed to perform cavitation erosion testing in accordance with ASTM Standard G32-92. Hielscher ultrasonic devices can be used for the direct and indirect erosion testing of samples. Hielscher manufactures ultrasonic processors, that have a fixed…
Ultrasonics for Gourmet Restaurants
Ultrasonic devices made by Hielscher are used by chefs of high-class restaurants for innovative, high-quality cooking. This includes flavor extraction, emusification or modification of texture. Hielscher ultrasonic devices are used for manifold applications and proven for their performance, reliability and…
https://www.hielscher.com/gourmet_restaurant_ultrasonic_extraction.htm
Efficient Hydrogen Production with Ultrasonics
Hydrogen is an alternative fuel that is preferable due to its environmental-friendliness and zero carbon dioxide emission. However, conventional hydrogen generation is not efficient for economical mass production. The ultrasonically promoted electrolysis of water and alkaline water solutions results in…
https://www.hielscher.com/efficient-hydrogen-production-with-ultrasonics.htm
Deparaffinization and Protein Extraction from FFPE
Facilitate protein extraction from formalin-fixed paraffin-embedded (FFPE) tissue sections using an optimized combination of deparaffinization, solubilization, and sonication with a VialTweeter multi-tube ultrasonicator. This protocol supports downstream mass spectrometry–based proteomics and is compatible with SP3 cleanup and enzymatic digestion workflows.…
GDmini2 – Ultrasonic Inline Micro-Reactor
The GDmini2 is an ultrasonic micro-reactor for the indirect, temperature-controlled sonication of liquid media. Applications include: Homogenization, emulsification, particle synthesis, solvent extraction, cell lysis and fragmentation. The GDmini2 is an ultrasonic homogenizer in the shape of a straight glass tube.…
https://www.hielscher.com/gdmini2-ultrasonic-inline-micro-reactor.htm
Ultrasonic Lactose Crystallization
In many dairy processes, large volumes of whey — also referred to as milk permeate — are generated as a by-product. This effluent is rich in lactose, but its disposal is both costly and environmentally burdensome. By applying ultrasound to…
https://www.hielscher.com/ultrasonic-lactose-crystallization.htm
Lactose Inline Crystallization – from Lab to Industry
Ultrasonic-assisted crystallization is an efficient technique for enhancing solid formation under continuous flow conditions. Below we present you a study that focuses on the inline crystallization of lactose from a lactose/water/isopropanol ternary system, utilizing the Hielscher UP200St-TD-FlowCell sonication chamber. The…
https://www.hielscher.com/lactose-crystallization-up200st-td.htm
Ultrasonically Improved Crystallization of Cocoa Butter
Cocoa butter crystallization plays a crucial role in chocolate manufacturing, directly impacting texture, gloss, and shelf stability. The size, number, and polymorphic form of cocoa butter crystals determine key quality attributes such as snap, mouthfeel, and resistance to fat bloom.…
FFPE High-Throughput Sample Prep: Protein Extraction and Nucleic Acid Shearing
With the high-throughput ultrasonicator UIP400MTP, Hielscher Ultrasonics addresses the challenges of formalin fixation and paraffin embedded (FFPE) tissue preparation. Learn how ultrasonication processes FFPE sample in large numbers for FFPE deparaffinization, tissue lysis, homogenization, protein extraction and DNA/RNA shearing! Take…
Lilac-Infused Spirits and Cocktails with Sonication
Ultrasonic extraction and infusion is used for capturing the delicate floral essence of lilac flowers, enhancing a variety of spirits, cocktails and culinary creations. Whether releasing the flavour compounds of lilac into spirits like gin and cocktails or concocting non-alcoholic…
https://www.hielscher.com/lilac-infused-spirits-and-cocktails-with-sonication.htm
Glycerine as Solvent for Ultrasonic Extraction
Glycerine or glycerol can be used as purely (100%) or as mixture of glycerine and water or ethanol for botanical extraction. Learn about the advantages of utilizing glycerine as extraction solvent in sonication processes. Botanical Extraction in Glycerine using Sonication…
https://www.hielscher.com/glycerine-as-solvent-for-ultrasonic-extraction.htm
Advantageous Hydrogel Production via Ultrasonication
Sonication is a highly efficacious, reliable and simple technique for the preparation of high-performance hydrogels. These hydrogels offer excellent material properties such as absorption capacities, viscoelasticity, mechanical strength, compression modulus, and self-healing functionalities. Ultrasonic Polymerization and Dispersion for Hydrogel Production…
https://www.hielscher.com/advantageous-hydrogel-production-via-ultrasonication.htm
Ultrasonic Encapsulation Transforms Wound Care with Aloe Vera Nanocapsules
In the pursuit of advanced wound dressing solutions, researchers have discovered the remarkable potential of Aloe vera nanocapsules, harnessing the healing properties of Aloe vera extract and embedding them within cotton fabric using a highly efficient ultrasonic extraction and encapsulation…
Probe-Type Sonication for Sample Preparation: A Comprehensive Guide
Probe-type sonication is a powerful tool for disrupting cells, shearing DNA, and dispersing particles in liquid samples. Like all techniques in life science, microbiology and clinical analysis, sonication requires careful optimization to avoid sample damage, particularly when working with heat-sensitive…
https://www.hielscher.com/probe-type-sonication-for-sample-preparation-a-comprehensive-guide.htm
Antibody Elution using High-Throughput Sonication
Affinity chromatography is a powerful technique for protein purification, which requires Ultrasonically-assisted non-specific elution is a reliable sample preparation technique to obtain antibodies from affinity chromatography. The efficient and reproducible elution of target antibodies bound to affinity matrices is significantly…
https://www.hielscher.com/antibody-elution-by-sonication-using-high-throughput-sonication.htm
Sonication for Juice Preservation and Nutrient Enhancement
In modern food processing, preserving freshness while enhancing nutritional value is a central challenge. High-performance ultrasonication — using probe-type sonicators — has gained traction as a powerful non-thermal processing method. This article presents findings from a scientific study investigating how…
https://www.hielscher.com/sonication-for-juice-preservation-and-nutrient-enhancement.htm
Eggnog Emulsification and Pasteurization using Ultrasonics
Eggnog is a creamy beverage mainly consisting in dairy and egg yolk. In order to obtain a homogeneously blended and long-term stable eggnog beverage, a reliable and efficient emulsification technique is required. Ultrasonic homogenization and emulsification provides the necessary mixing…
https://www.hielscher.com/eggnog-emulsification-and-pasteurization-using-ultrasonics.htm
Industrial Probe-Type Sonicators: The Ultimate Solution for Challenging Processes
Industrial probe-type sonicators use ultrasonic energy to create intense mixing, disruption, extraction and emulsification for industrial applications. Commonly used in chemical processing, pharmaceuticals, food production, and nanotechnology, they perform essential functions like particle size reduction, cell lysis, and dispersion. Key…
Ultrasonic Solvent-Free Garlic Extraction
Garlic (Allium sativum) is rich in organosulfur compounds (e.g. allicin, glutathione), which promote many health benefits. Ultrasonic extraction is a reliable and efficient technique to produce highly concentrated garlic extracts. Ultrasonication results in high yields of high quality, full spectrum…
https://www.hielscher.com/ultrasonic-solvent-free-garlic-extraction.htm
Acoustic vs Hydrodynamic Cavitation for Mixing Applications
Cavitation for Mixing and Blending: Is there a difference between acoustic and hydrodynamic cavitation? And why might one cavitation technology be better for your process? Acoustic cavitation - also known as ultrasonic cavitation - and hydrodynamic cavitation are both forms…
https://www.hielscher.com/acoustic-vs-hydrodynamic-cavitation-for-mixing-applications.htm
Ultrasonic Emulsions for Water-in-Diesel Combustion
Power generators, ship engines and railway engines, which are fuelled with diesel, can be run more efficiently when water-in-diesel emulsions are used. Water-diesel emulsion fuels reduce the fuel consumption, lower the combustion temperature, burn cleaner and reduce emissions, such as…
https://www.hielscher.com/ultrasonic-emulsions-for-water-in-diesel-combustion.htm
Ultrasonic Dispersion of Nanomaterials (Nanoparticles)
Nanomaterials have become an integral component of products as diverse as high-performance materials, sunscreens, performance coatings, or plastic composites. Ultrasonic cavitation is used to disperse nano-size particles into liquids, such as water, oil, solvents or resins. Ultrasonic Dispersion of Nanoparticles…
Industry-Specific Ultrasonic Solutions
Hielscher ultrasonic devices are used in many industries, such as renewable fuels & biomass, food & beverage, paint & ink, coatings, wire and cable, or chemical processing. Algae Growth and Algae Oil Extraction Hielscher ultrasonic devices are applied to continuous…
Ultrasonic Size Reduction of Ink (e.g. for Inkjet)
Ultrasonic cavitation is an effective means for the dispersing and microgrinding (wet milling) of ink pigments. Ultrasonic dispersers are successfully used in research as well as in industrial manufacturing of UV-, water- or solvent-based inkjet inks. Nano-Dispersed Inkjet Inks Ultrasound…
Ultrasonic Extraction and its Working Principle
Ultrasonic extraction is the preferred technique to isolate bioactive compounds from botanicals. Sonication achieves a complete extraction and thereby superior extract yields are obtained in a very short extraction time. Being such an efficient extraction method, ultrasonic extraction is cost-…
https://www.hielscher.com/ultrasonic-extraction-and-its-working-principle.htm
Sonication of Wine – Innovative Applications of Ultrasound in Wineries
Ultrasound is a non-thermal processing method, which is already widely used in the food industry due to its mild application but significant effects on the product. For the wineries, sonication offers various applications such as the extraction of flavours, phenolics…
https://www.hielscher.com/sonication-of-wine-innovative-applications-of-ultrasound-in-wineries.htm
Ultrasonic Stem Cell Isolation
Sonication is a highly efficient mechanical method for isolating stem cells from human adipose tissue. The ultrasonically isolated stromal vascular fraction (SVF) demonstrates significant regenerative potential for medical applications. Hielscher Ultrasonics provides a range of direct and indirect sonication options…
https://www.hielscher.com/ultrasonic-stem-cell-isolation.htm
Ultrasonic Milling of Thermoelectrical Nano-Powders
Research has shown that ultrasonic milling can be successfully used for fabrication of thermoelectric nanoparticles and has the potential to manipulate the surfaces of the particles. Ultrasonically milled particles (e.g. Bi2Te3-based alloy) showed a significant size reduction and fabricated nano-particles…
https://www.hielscher.com/ultrasonic-milling-of-thermoelectrical-nano-powders.htm
Ultrasonic Deacetylation of Chitin to Chitosan
Chitosan is a chitin-derived biopolymer which has many applications in pharma, food, agriculture and industry. Ultrasonic deacetylation of chitin to chitosan intensifies the treatment significantly - leading to an efficient and fast process with a high chitosan yield of superior…
https://www.hielscher.com/ultrasonic-deacetylation-of-chitin-to-chitosan.htm
Homogenizers – Working Principle, Use and Scale-Up
Homogenizers are a type of mixers, which apply mechanical forces to blend, emulsify, disperse, and dissolve liquid-liquid and solid-liquid systems. Depending on the homogenizer model rotational shear, nozzles or high-power ultrasound are used to create the required forces to disintegrate…
https://www.hielscher.com/homogenizers-working-principle-use-and-scale-up.htm
Application of Power Ultrasound using Ultrasonic Horns
Ultrasonic horns or probes are used widely for manifold liquid processing applications including homogenization, dispersing, wet-milling, emulsification, extraction, disintegration, dissolving, and de-aeration. Learn the basics about ultrasonic horns, ultrasonic probes and their applications. Ultrasonic Horn vs Ultrasonic Probe Often, the…
https://www.hielscher.com/application-of-power-ultrasound-using-ultrasonic-horns.htm
Ramp-up Slow and Insufficient Manufacturing Processes
Ultrasonication is a well-established process intensifying technique, which is used in many kinds of liquid applications such as homogenization, mixing, dispersing, wet-milling, emulsification as well as improving heterogeneous chemical reactions. If your production process is underperforming and does not achieve…
https://www.hielscher.com/ramp-up-slow-and-insufficient-manufacturing-processes.htm
Fruit-Dairy Drink Innovation: The Role of Sonication
The production of fruit-infused dairy beverages (e.g. fruit-milk) undergoes significant improvements using sonication, a food processing technology that offers remarkable benefits over traditional methods. Ultrasonic processing using Hielscher probe-type sonicators enhances the quality and stability of these beverages by reducing…
Sonication Devices for your Lab Tasks
Sonication devices, particularly probe-type sonicators, are highly specialized tools widely employed in both laboratory and industrial settings. These instruments harness the power of ultrasound to efficiently process various materials. By transmitting ultrasonic energy through a probe (or horn) into a…
https://www.hielscher.com/sonication-devices-for-your-lab-tasks.htm
Nano-Propolis: Ultrasonic Extraction and Nano-Sizing
Nanopropolis and propolis-loaded nanocarriers prepared by sonication represent a significant advancement for the therapeutic potential of propolis. Ultrasonic nano-sizing of propolis addresses critical formulation challenges, delivering enhanced solubility, stability, and bioavailability. Its scalability and versatility make sonication a valuable tool…
Alpha-Synuclein Fragmentation using the VialTweeter Sonicator
α-synuclein fibrils and ribbons are fragmented in scientific research to generate smaller fibril snippets or even individual protein molecules, which can be more readily analyzed using various experimental techniques. The VialTweeter Sonicator is one of the most commonly used ultrasonicators…
https://www.hielscher.com/alpha-synuclein-fragmentation-using-the-vialtweeter-sonicator.htm
Amyloid Fibril Formation using the UIP400MTP Microplate Sonicator
Amyloid fibrils, much like crystals, form through a process of nucleation and subsequent growth. However, due to the high free-energy barrier of nucleation, spontaneous amyloid fibril formation occurs only after a prolonged lag phase. Ultrasonication has emerged as a powerful…
https://www.hielscher.com/amyloid-fibril-formation-using-the-uip400mtp-microplate-sonicator.htm
Magnetic Nanoparticle Synthesis: From Lab to Production
Magnetic nanoparticles (MNPs) are a crucial component in various scientific and industrial applications, including biomedical imaging, targeted drug delivery, catalysis, and environmental remediation. The precise control of magnetic nanoparticle properties such as size, shape, magnetic behavior, and surface functionality is…
Synthesizing Nano-Silver with Honey and Ultrasonics
Nano-silver is use for its anti-bacterial properties to reinforce materials in medicine and material science. Ultrasonication allows for a rapid, efficacious, safe, and environmental-friendly synthesis of spherical silver nanoparticles in water. Ultrasonic nanoparticle synthesis can be easily scaled from small…
https://www.hielscher.com/synthesizing-nano-silver-with-honey-and-ultrasonics.htm
Ultrasound-Assisted Extraction
Ultrasound-assisted extraction is a very efficient and easy-to-use method for the extraction of bioactive compounds from botanicals. This extraction technique is known for its efficiency, and the ability to preserve the integrity of bioactive compounds during extraction. Ultrasound-assisted extraction leverages…
https://www.hielscher.com/ultrasound-assisted-extraction.htm
Propolis Tincture – Increase Potency with Sonication
Propolis, a resinous substance collected by bees from plant exudates, has gained significant interest due to its antimicrobial, anti-inflammatory, and antioxidant properties. Typically extracted in ethanol or other solvents to produce tinctures, propolis presents challenges related to solubility and bioavailability.…
Dandelion Extraction – Potent Tinctures with Sonication
Ultrasonic extraction of dandelion plant parts is a highly efficient and effective method to obtain bioactive compounds under mild extraction conditions - yielding a high-quality extracts and tinctures. Learn how to apply ultrasonication to maximize extraction yields while preserving the…
https://www.hielscher.com/dandelion-extraction-potent-tinctures-with-sonication.htm
Nettle Extraction – Potent Tinctures with Ultrasonics
Nettle (Urtica dioica) is a plant rich in bioactive compounds such as polyphenols, antioxidants, carotenes, and terpenoids, which are used as pharmaceutical, therapeutic and nutraceutical substances. The ultrasonic extractor is a high-efficient industry-established tool for the production of nettle extracts…
https://www.hielscher.com/nettle-extraction-potent-tinctures-with-ultrasonics.htm
Ultrasonic Dispersion of Monolayer Amorphous Carbon (MAC) in Liquids
Monolayer amorphous carbon (MAC) is a novel carbon-based nanomaterial with exceptional mechanical strength, flexibility, and conductivity. Its integration into liquid matrices is critical for applications in high-performance composites, energy storage, coatings, and electronic materials. However, achieving a uniform and stable…
Uniformly Dispersed CNTs by Ultrasonication
To exploit the exceptional functionalities of carbon nanotubes (CNTs), they must be homogeneously dispersed. Ultrasonic dispersers are the most common tool to distribute CNTs into aqueous and solvent-based suspensions. The ultrasonic dispersing technology creates sufficiently high shear energy to achieve…
https://www.hielscher.com/uniformly-dispersed-nanotubes-by-sonication.htm
Effects of Sonication on Conductivity and pH Value of Water
Conductivity and pH value of water can be efficiently influenced by treating water with high-intensity, low-frequency ultrasound. Sonication of water results in increased conductivity and pH values in water. Influence of Power Ultrasound on Electric Conductivity Tests were performed using…
https://www.hielscher.com/effects-of-sonication-on-conductivity-and-ph-value-of-water.htm
Sonicators in Mixology: Learn from the Master Dario Comini
Dario Comini, one of the most famous bartenders - also known as Italy's Godfather of Molecular Mixology - uses a sonicator to create exceptional cocktails. He uses the power of high-intensity ultrasound to extract essences, infuse spirits, age alcohol and…
https://www.hielscher.com/sonicators-in-mixology-learn-from-the-master-dario-comini.htm
Ultrasonic Vanilla Extraction – A Non-Thermal Method
Vanilla extract is a flavour solution extracted from vanilla pods in a solution of ethanol and water. To produce high-quality vanillin as aroma, flavour and fragrance component, an efficient, yet mild extraction technique is required to prevent decomposition. Ultrasonic extraction…
https://www.hielscher.com/ultrasonic-vanilla-extraction-a-non-thermal-method.htm
Ultrasonic Kratom Extraction
Ultrasonication is a highly effective, simple and reliable technique to produce alkaloid-rich extracts from kratom leaves (Mitragyna speciosa). Sonication releases bioactive compounds such as mitragynine and 7-hydroxymitragynine from the plant cells so that they can be isolated. Ultrasonic extraction provides…
Ultrasonic Dispersion of Polishing Agents (CMP)
Non-uniform particle size and inhomogeneous particle size distribution causes severe damages to the polished surface during a CMP process. Ultrasonic dispersion is a superior technique to disperse and deagglomerate nano-sized polishing particles. The uniform dispersion achieved by sonication results in…
https://www.hielscher.com/ultrasonic-dispersion-of-polishing-agents-cmp.htm
GENO-break – Ultrasonic Water Disinfection
The Gruenbeck GENO-break®-System IV water treatment combines a Hielscher ultrasonic processor with intense UV-C light for continuous hot water system disinfection. Hot water supplies and pools can bear Legionella bacteria, pathogens and other micro-organisms. Legionella is known to cause Legionellosis.…
Ultrasonic Effects on Precipitation and Froth Flotation
Industrial waste waters are often heavily acidified due to the excessive use of sulphuric acid. Acidified wastewater containing heavy metals are commonly treated by chemical precipitation after coagulation and flocculation. Ultrasonic conditioning before the flotation resulted in a significant improved…
https://www.hielscher.com/ultrasonic-effects-on-precipitation-and-froth-flotation.htm
VialTweeter – Sonoreactor for Trace Mineral Extraction from Soil
For monitoring the health and pollution of soil, pollutants such as trace minerals must be extracted and measured. The VialTweeter facilitates pre-analytical extraction in laboratory workflows significantly. The extraction of trace minerals from soil samples is a great example showing…
https://www.hielscher.com/vialtweeter-trace-mineral-extraction.htm
VialTweeter – Intensive Sonication of Small Volumes
Sonication is a very effective method for the mixing, homogenizing, emulsifying, dispersing, disintegration, and degassing of liquids by means of ultrasonic cavitation. The VialTweeter applies this technology to vials, such as autosampler vials, storage vials and reagent vials without the…
Nail Polish Production – Find the Ideal Mixing Tool!
Being one of the most advanced mixing techniques, sonication has significantly improved the production process of nail polishes, also known as nail varnishes or enamels. As a beauty product, nail polish comes in a wide variety of colors and finishes,…
Functionalized Surfaces with Nanoparticles
The PANADUR GmbH (www.panadur.de) provides functional coating systems on the basis of Polyurea for surfaces of all types, for example, the "In-Mould Coating" process (IMC) can be used. "In-Mould Coatings" by PANADUR can be easily combined with many methods of…
Probe-Type Sonicators vs. Ultrasonic Baths
Understanding the differences between a probe-type sonicator and an ultrasonic bath helps you choose the most efficient option for your application. Hielscher probe-type sonicators focus intense ultrasonic energy directly into your sample, which reduces processing times and ensures consistent, reproducible…
https://www.hielscher.com/probe-type-sonication-vs-ultrasonic-bath-an-efficiency-comparison.htm
Cleaning Medical Wires with Ultrasonic Inline Cleaners
Medical fine wires require especially intense and thorough cleaning procedures. Ultrasonic inline cleaning is a highly efficient and reliable method to remove any residues from fine and ultra-fine wires used for medical purposes. Medical Wire Cleaning using Hielscher Ultrasonics Inline…
https://www.hielscher.com/cleaning-medical-wires-with-ultrasonic-inline-cleaners.htm
Video: Mushroom Extraction – Ultrasonic Bath vs Probe Sonicator
https://www.youtube.com/watch?v=sdramBljq4E This video compares the extraction efficiency of an ultrasonic bath and the Hielscher UP100H ultrasonic probe. Both methods are tested using crushed Chaga mushrooms in a water-ethanol mixture to extract bioactive compounds like betulin and phytosterols. Non-thermal extraction at…
https://www.hielscher.com/video-mushroom-extraction-ultrasonic-bath-vs-probe-sonicator.htm
50 mL Falcon Tube Sonicator
This VialTweeter sonicator delivers up to 200 watts of focused sonication power to closed 50 mL Falcon tubes, centrifuge tubes or conical sample vials. The high amplitude and intense sonication enables rapid and uniform treatment in a closed Falcon tube. It ensures…
Most Efficient Extraction Method for Botanicals
Are you looking for a powerful and reliable extraction setup to produce high-quality botanical extracts? Here you can find a comparison of common extraction techniques including ultrasonic extraction, supercritical CO2 extraction, ethanol extraction, maceration amongst others and their advantages as…
https://www.hielscher.com/most-efficient-botanical-extracts.htm
ZnO Nanostructures Grown by Ultrasonic Synthesis
Ultrasonic nanoparticle synthesis has gained increasing attention due to its ability to produce nanomaterials with controlled size, morphology, and crystallinity under mild reaction conditions. The technique leverages acoustic cavitation to generate localized high temperatures and pressures, promoting enhanced nucleation and…
https://www.hielscher.com/zno-nanostructures-grown-by-ultrasonic-synthesis.htm
Ultrasonic Processing of Fruit and Vegetable Purees
In the competitive world of food production, besides the flavor of a product the sensory attributes of plant-derived products — especially texture and viscosity — play a crucial role in determining consumer acceptance. This is particularly true for tomato-based products…
https://www.hielscher.com/ultrasonic-processing-of-fruit-and-vegetable-purees.htm
Video: CBD Nano-Emulsion
https://www.youtube.com/watch?v=Nm00Xck_KGA We create a CBD-rich hemp oil nano-emulsion using a Hielscher UP400St sonicator and verify its particle size with a NANO-flex DLS. Combining CBD hemp oil, StuphCorp emulsifier, and water at 60°C produces a translucent nano-emulsion in just a few…
Improved Energy Efficiency of High-Pressure Processing
High-Pressure Processing (HPP) is a non-thermal food preservation method that ensures microbial safety and extends shelf life while maintaining food quality, though its energy inefficiencies due to entrapped air and gas present operational challenges for sustainable implementation. Ultrasonic degassing the…
Video: Sono-Reactors for Biodiesel Production
Ultrasonic mixing has revolutionized biodiesel production since the early 2000s, delivering higher yields, faster reaction times, and better-quality biodiesel. Hielscher sonicators shorten transesterification time and save energy. The innovative MultiPhaseCavitator flow cell insert further enhances these benefits by introducing…
https://www.hielscher.com/video-sono-reactors-for-biodiesel-production.htm
Protocol using Hielscher Multi-Sample Sonicators in Biofilm and Proteomic Analysis
The use of multi-sample sonicators, such as the VialTweeter Multi-Tube Sonicator and the UIP400MTP Microplate Sonicator, streamlines laboratory workflows for high-throughput applications. Both devices allow precise and uniform ultrasonic processing across multiple samples, minimizing variability and enhancing reproducibility. This is…
Ultrasonic Levitation and its Industrial Applications
Ultrasonic / acoustic levitation is an industrially-proven option for non-contact bearing of light-weight sensitive materials as well as for contact-free sample handling. Learn more about ultrasonic levitation and its applications in industry and science! Applications of Ultrasonic Levitation Acoustic levitation…
https://www.hielscher.com/ultrasonic-levitation-and-its-industrial-applications.htm
Proteomic Workflows with High-Throughput Protein Digestion
Proteomics is an essential field for understanding biological processes and systems, with protein digestion forming a critical step in its workflows. Traditionally, protein digestion is carried out in solution using proteolytic enzymes like trypsin, which specifically hydrolyzes peptide bonds at…
https://www.hielscher.com/proteomic-workflows-with-high-throughput-protein-digestion.htm
Video: Stepped Plate Resonator
This video shows the Hielscher stepped plate resonator, which delivers high-performance ultrasonic waves for drying, defoaming, and precision cleaning without contact or contamination. Its advanced stepped geometry amplifies and focuses sound, making it ideal for delicate and complex industrial…
Improved Food Thawing by Air-Borne Ultrasonics
The food industry consistently seeks innovations to optimize processes, reduce waste, and preserve quality. Thawing frozen foods efficiently while maintaining their integrity is a significant challenge, especially at scale. Conventional thawing methods — such as water baths, air circulation, or…
PMCA for High-Throughput Detection of Prions using the UIP400MTP Sonicator
The UIP400MTP multi-well plate sonicator offers a powerful solution for high-throughput sample preparation in protein misfolding cyclic amplification (PMCA). By delivering uniform energy distribution across multiple wells and maintaining precise sonication parameters, this system enables the simultaneous processing of numerous…
Minimum Inhibitory Concentration (MIC) Assay Protocol
The Biofilm-Based Minimum Inhibitory Concentration (MIC) assay is an essential method for evaluating the effectiveness of antimicrobial agents against biofilm-associated microorganisms, which exhibit heightened resistance due to their protective extracellular matrix. A crucial step in this assay is the disruption…
Staphylococcus Biofilm Cultivation and Detachment Protocol
Standardized methods are essential for reliable research outcomes. Here you can find a cultivation and detachment protocol for staphylococcal biofilms. This protocol focusses on streamlined high-throughput sample preparation using UIP400MTP multi-well plate sonicator for efficient, high-throughput biofilm detachment in 96-well…
https://www.hielscher.com/staphylococcus-biofilm-cultivation-and-detachment-protocol.htm
High-Throughput Sample Preparation for Mitochondrial Diagnostics
Mitochondrial diagnostics in research and clinics are performed using various techniques such as sequencing, PCR, and biochemical assays. These methods are used to identify DNA mutations and measure mitochondrial function. Sequencing helps detect genetic mutations, while PCR can quantify specific…
PCR Plate Sonicator UIP400MTP
The PCR Plate Sonicator UIP400MTP is designed to optimize workflows involving PCR plates, streamlining PCR tests with precision and efficiency. This innovative equipment enables uniform ultrasonic treatment of entire multi-well plates, making it ideal for tasks such as sample preparation,…
Ultrasonic Cell Detachment
Ultrasonic cell detachment is a highly effective and reliable sample preparation technique used in various fields of cell biology and biotechnology. Using ultrasonic waves, the multi-well plate sonicator UIP400MTP detaches adherent cells from culture surfaces and prepares cell suspensions for…
Replace Cell Scraping with the UIP400MTP High-throughput Sonicator
The detachment and extraction of adherent cell lines from multi-well plates for multi-omics analysis is a daily task in labs. High-throughput cell detachment using the multi-well plate sonicator UIP400MTP replaces manual cell scraping leading to higher yields of RNA, total…
Focused Sonicators for High-Throughput Sample Processing
Focused sonicators are the solution for high-throughput sample preparation. The 96-Well Plate Sonicator UIP400MTP reliably processes samples in multi-well plates, 96-well plates, Petri dishes or test tubes and are specifically designed to meet the rigorous demands of laboratories and research…
https://www.hielscher.com/focused-sonicators-for-high-throughput-sample-processing.htm
Improve Heterogeneous Chemical Reaction Kinetics by Sonication
Sonication offers innovative ways to improve heterogeneous chemical reaction kinetics in liquid‐liquid and liquid‐solid processes. Unlike ordinary stirring, ultrasonic waves generate microscopic bubbles that implode and create intense mixing zones. These zones help disperse solids and droplets more evenly, boost…
https://www.hielscher.com/improve-heterogeneous-chemical-reaction-kinetics-by-sonication.htm
Ultrasonic Lysis of E. Coli
E. coli bacteria are the most commonly used bacteria in microbiology and biotechnology. Ultrasonic cell disruptors deliver reliable and reproducible results for the lysis of E. coli. Intense yet precisely controllable cavitation and shear forces result in complete disruption and…
Ultrasonic Lysis: Step-by-Step Guide to Perfecting Cell Disruption
Do you want to master the science of cell lysis? Look no further! In this step-by-step guide, we will walk you through the process of ultrasonic cell disruption and ensure that your cell lysis technique gets you optimal results. Whether…
https://www.hielscher.com/ultrasonic-lysis-step-by-step-guide-to-perfecting-cell-disruption.htm
Ultrasonic Disintegration of Cells
Ultrasonication is an effective means of disintegrating cell structures. Therefore, sonicators are widely used in laboratories to break open cells, extract intracellular molecules, proteins and organelles for research and analysis. On industrial scale, ultrasonic disintegration and lysis is used to…
Sterile Homogenization using Sonification
For sterile homogenization, a sample is placed into a sterile container which then is agitated in order to obtain a homogeneous blend. Ultrasonification is a highly efficient and reliable technique to treat one or multiple samples under sterile conditions and…
https://www.hielscher.com/sterile-homogenization-using-sonification.htm
Ultrasonic Preparation of C. Elegans Samples
C. elegans, a nematode worm, is a widely used model organism in biology. Sample preparation before analysis requires lysis, protein and lipid extraction as well as RNA fragmentation, which can be reliably performed via sonication. Ultrasonic cell disruptors are reliable,…
https://www.hielscher.com/ultrasonic-preparation-of-c-elegans-samples.htm
Ultrasonic Elderberry Extraction
Elderberry extracts are well-known for their antiviral properties and thereby heavily used as natural remedy to relieve flu symptoms such as fever, cough, and sore throat. To produce elderberry extracts with a high polyphenol and antioxidant content, a mild yet…
https://www.hielscher.com/ultrasonic-elderberry-extraction.htm
Juice and Smoothie Homogenization using Power Ultrasonics
Juices, smoothies and beverages require reliable and efficient homogenization to provide a desirable flavour and texture as well as long-term stability. Ultrasonic high-shear homogenizers are widely used in the food and beverage industry to produce juices, drinks, purees and sauces…
https://www.hielscher.com/juice-and-smoothie-homogenization-using-power-ultrasonics.htm
Video: Multi-Sample Sonicator
Effortless Chromatin, DNA, RNA, and Protein Shearing with Unmatched Consistency. The UIP400MTP multi-sample sonicator delivers superior sonication performance with short processing times, outstanding uniformity and at minimal operating costs. The Hielscher UIP400MTP multi-sample sonicator is a versatile, high-performance ultrasonic…
Video: Soxhlet Extraction
This video demonstrates the setup, operation, and applications of a Soxhlet extractor, focusing on extracting nicotine from tobacco using ethanol. In this video we extract nicotine from tobacco using ethanol as the solvent, showcasing each step of the process.…
Ultrasonic Honey Processing
Honey enjoys great demand as food and medicine. Ultrasonic processing is an effective means to destroy undesirable components, such as crystals and microbial cells in honey. As a non-thermal processing technology, ultrasonic honey decrystallization prevents undesired increase in HFM as…
Video: Botanical Extraction
In this presentation we explain botanical extraction. We explain the challenges of producing high-quality botanical extracts and how a sonicator can help you to overcome these challenges. This presentation will show you how ultrasonic extraction works. You will learn,…
Video: Sonicator Setup Tutorial – UP400St
This is a step-by-step guide to setting up your Hielscher UP400St sonicator. The video covers everything from unboxing the device and reviewing its components to essential safety steps and initial preparation, including reading the manual and inserting the SD…
https://www.hielscher.com/video-sonicator-setup-tutorial-up400st.htm
Ultrasonic Extraction of Caffeine
Using ultrasonics is an effective method for the extraction of caffeine and other active compounds from coffee. Powerful sonicators assist the extraction process whilst maximizing yield and shortening processing time. Learn how Hielscher sonicators promote caffeine extraction as well as…
https://www.hielscher.com/ultrasonic-extraction-of-caffeine-and-other-active-compounds.htm
Ultrasonic Nanoparticle Functionalization for HPLC Columns
High-performance liquid chromatography (HPLC) is the key technology the separation and analysis of complex mixtures, being a cornerstone in fields like pharmaceuticals, biochemistry, and environmental sciences. A critical factor in HPLC efficacy lies in the design and functionalization of its…
https://www.hielscher.com/ultrasonic-nanoparticle-functionalization-for-hplc-columns.htm
Ultrasonic Particle Modification for HPLC Columns
The challenges in HPLC are a fast and efficient separation for a wide range of samples. Sonication allows to modify and functionalize nano particles, e.g. silica or zirkonia microspheres. Ultrasonication is a very successful technique to synthesize core–shell silica particles,…
https://www.hielscher.com/ultrasonic-particle-modification-for-hplc-columns.htm
Support Videos
This page is a collection of third-party party support videos for Hielscher ultrasonic equipment. Here you will find a comprehensive collection of tutorials and guides designed to help you get the most out of your Hielscher ultrasonic devices. Whether you…
Sonication of Bottles and Cans for Leak Detection
Hielscher ultrasound is being used in bottling and filling machines for the on-line container leak testing of bottles and cans. The instantaneous release of carbon dioxide is the decisive effect of ultrasonic leakage tests of containers filled with carbonated beverages.…
Ultrasonic Soldering – Flux-Free Joining of Hard Metals to Steel
Ultrasonic soldering is revolutionizing the way hard metals are joined, offering a cleaner, more efficient alternative to traditional methods. By applying high-intensity ultrasonic waves, this advanced technique eliminates the need for toxic fluxes, which are commonly used to break down…
Microbiome Research and Clinical Analysis Streamlined by Sonication
Sonication is a powerful technique widely used in microbiome research and clinical analysis facilitating a high-throughput sample preparation. The ultrasonic method is particularly effective for processing complex biological samples, such as those containing microorganisms. The use of sonication facilitates cell…
https://www.hielscher.com/microbiome-reasearch-sonication.htm
Metabolomics Facilitated by High-Throughput Sonication
Metabolomics is the research field that employs high-throughput techniques to characterize and quantify small molecules in various biofluids, such as urine, serum, plasma, feces, and saliva, unveiling unique metabolic signatures. The high-throughput sonicator UIP400MTP, designed for multi-well plates, is a…
Chromatin Shearing: High-Throughput and Non-Contact Precision
Chromatin shearing is a critical step in many molecular biology workflows, enabling the fragmentation of chromatin into precise sizes for applications like ChIP and NGS. The UIP400MTP multi-well plate sonicator revolutionizes this process with its high-throughput, non-contact technology, offering unmatched…
Cleaning of Bondwires with Superior Efficiency
High-power ultrasound is highly efficient in removing oxide layers from bondwires. Hielscher ultrasonic wire cleaners remove any contamination and residues from the surface of the bonding wires without mechanical or chemical treatment of sensitive wire structures. Intense yet Gentle Cleaning…
https://www.hielscher.com/cleaning-of-bondwires-with-superior-efficiency.htm
High-Shear Mixers for Pet Food Manufacturing
Pet food manufacturing requires reliable high-shear mixing equipment to prepare homogeneous mixtures of various ingredients. Ultrasonic mixers provide ultras-high shear forces that can process highly viscous slurries and doughs. Furthermore, ultrasonic mixers are used to produce stable nano-emulsions and to…
https://www.hielscher.com/high-shear-mixers-for-pet-food-manufacturing.htm
Extraction of Beta-Glucans From Mushrooms Using Ultrasonication
Extracting beta-glucans from mushrooms for lab testing or production purposes involves a combination of chopping, grinding or crushing the mushrooms, ultrasonically assisted extraction, and precipitation of beta-glucans. Here is a simplified outline of the beta-glucan extraction process, along with example…
https://www.hielscher.com/extraction-of-beta-glucans-from-mushrooms-using-ultrasonication.htm
Horse Care Products Formulated by Ultrasonic Homogenization
Horse owners demand the highest quality when it comes to care products for their equine companions. This is especially true for sport horses, which often require meticulously crafted formulations to meet their unique needs. Organic, eco-friendly solutions that deliver ultimate…
Our Social Responsibility
Hielscher Ultrasonics and the Hielscher family are strongly committed to social responsibility in business and personal life. To us, corporate social responsibility (CSR) means conducting business ethically and with sensitivity towards social, cultural, economic, and environmental issues. As part of…
Ultrasonic Mixing of Cement Paste For Concrete
The ultrasonic mixing of cement paste offers great benefits for precast molding, drycast, and concrete plants. These benefits include shorter initial and final set times, lower dosage of superplasticizer, faster and more complete hydration, as well as higher compressive strength.…
https://www.hielscher.com/cement_paste_ultrasonic_mixing.htm
Ultrasonic Nanoliposomes for Stabilised Allicin Formulations
Allicin is a bioactive compound, which can be extracted from fresh garlic cloves. Allicin is prone to degradation and must be therefore formulated into a stabilised supplement form in order to obtain a long-term potent formula. Ultrasonic encapsulation of allicin…
https://www.hielscher.com/ultrasonic-nanoliposomes-for-stabilised-allicin-formulations.htm
Ultrasonics Makes Lithium-Ion Battery Recycling More Efficient
Lithium is a scarce and highly valuable material present in high-performance batteries, such as Li-ion batteries. Lithium is the most valuable material that is recovered in Li-ion battery recycling, but also other minerals and metals such as cobalt, manganese, nickel,…
https://www.hielscher.com/ultrasonics-makes-lithium-ion-battery-recycling-more-efficient.htm
Ultrasonic Leaching Transforms Battery Recycling and Urban Mining
Used batteries and electronic waste are packed with valuable materials like lithium, nickel, manganese, and cobalt, essential for the growing demand in renewable energy and electric vehicle sectors. Urban mining — the process of reclaiming these metals from discarded batteries…
https://www.hielscher.com/ultrasonic-leaching-metal-recycling.htm
Cement Particle Wet-Milling Using Probe-Type Sonicators
Cement particle wet milling is a crucial process in the production of high-quality cement. The objective is to reduce the particle size to enhance the properties of cement, such as its reactivity and strength. Traditional milling techniques, such as ball…
https://www.hielscher.com/cement-particle-wet-milling-using-probe-type-sonicators.htm
Ultrasonic Extraction of Mycoprotein
Fulfilling the demands for sustainable and nutritious food alternatives, mycoprotein has emerged as a revolutionary ingredient, derived from fungi and primarily used in the creation of meat substitutes, often referred to as "fake meat." This protein source offers a promising…
https://www.hielscher.com/ultrasonic-extraction-of-mycoprotein.htm
Ultrasonic Bioreactors for Fermentation
Ultrasonics is an effective means to stimulate microorganisms by mechanical vibrations and cavitation. In a sonobioreactor / ultrasonic fermenter, the ultrasonic treatment of cells and tissue becomes highly controllable since the environmental factors can be exactly determined. With ultrasonic bioreactors,…
https://www.hielscher.com/ultrasonic-bioreactors-for-fermentation.htm
Ultrasonic DNA Shearing
During DNA and RNA shearing, long DNA molecules are fragmented into smaller pieces, a crucial step in preparing samples for next-generation sequencing (NGS) library construction. Ultrasonic DNA shearing employs acoustic cavitation forces to break DNA or RNA into fragments ranging…
Wax Emulsions with Power Ultrasonics
When wax is dispersed as nano droplets with a very homogeneous distribution, a stable wax emulsions is obtained. Ultrasonic homogenizers generate high shear forces and are reliable and robust systems to produce stable wax nano-emulsions. Hielscher Ultrasonics high-shear homogenizers deliver…
https://www.hielscher.com/wax-emulsions-with-power-ultrasonics.htm
Ultrasonic Crystallization and Precipitation
Ultrasound initiates and promotes the nucleation and crystallization of organic molecules. Having control over this process is vital to make sure the final product is of high quality. The advantages of using sonication for crystallization and making solids from liquids…
https://www.hielscher.com/ultrasonic-crystallization-and-precipitation.htm
Ultrasonic Hydrodistillation of Essential Oils
The conventional extraction of essential oils is expensive and time-consuming. Ultrasonic extraction gives higher yields and superior extract quality. Ultrasonic can be carried out as solvent- or water-based extraction method. Alternatively, sonication can be combined with traditional extraction systems to…
https://www.hielscher.com/ultrasonic-hydrodistillation-of-essential-oils.htm
Maceration and Aromatisation by Sonication
Ultrasonic aromatisation and flavoring of edible oils is based on the ultrasonic extraction of flavor compounds from botanicals such as herbs, spices, fruits etc. Ultrasonic maceration is a process intensifying method, which extracts bioactive components into the oil. As a…
https://www.hielscher.com/maceration-and-aromatisation-by-sonication.htm
Ultrasonic Extraction of Extra Virgin Olive Oil
Ultrasonically-assisted extraction and malaxation make the production of extra virgin olive oil more efficient. The ultrasonic process intensification results in higher EVOO yield, higher nutritional quality and shorter malaxation. Simultaneously, sonication increases the antioxidant and polyphenol content in extra virgin…
https://www.hielscher.com/ultrasonic-extraction-of-virgin-olive-oil.htm
Improved Industrial Tomato Processing
Tomato paste is a common ingredient in food products and is a staple raw material in numerous food products such as ketchup, soups, sauces, juices and purees. Ultrasonic tomato processing is a mild, non-thermal treatment that gives the final tomato…
Ultrasonic Production of Flavor Ingredients
Ultrasonic flavor extraction is a highly efficient and sustainable process that increases yield while significantly reducing processing time. Utilizing safe, green solvents, ultrasound technology offers a green extraction method with enhanced energy efficiency, making it an eco-friendly alternative to traditional…
https://www.hielscher.com/ultrasonic-production-of-flavour-ingredients.htm
96-Well Sonicators – Streamline High-Throughput Sample Preparation
The 96-well sonicator UIP400MTP is a high-power ultrasound device designed specifically for the effective sonication of multi-well plates. The UIP400MTP is designed to enable precise, uniform focused sonication across all wells in microtiter plates, widely used in laboratory settings for…
UIP250MTP – Sonication of Microtiter Plates
The ultrasonic processor UIP250MTP allows for the consistent sonication of an entire microtiter plate within the sonotrode. It can be used for the homogenizing, dispersing, degassing or for disruption of cells. This model of the UIP250MTP has been discontinued and…
Ultrasonic Sample Prep for ELISA Assays
Assays such as ELISA are widely used for in-vitro diagnostics, disease-related protein detection and quality control (e.g. monitoring food allergens). Ultrasonic sample preparation is a rapid, reliable and reproducible technique to lyse cell and isolate intracellular proteins, DNA, RNA and…
https://www.hielscher.com/ultrasonic-sample-prep-for-elisa-assays.htm
Ultrasonic Modification of Starch Granules Slurries
Starch is easily extractable from native sources, such as potato, maize or corn. Modification of starch is necessary to improve the physical and chemical properties. Hielscher ultrasonic reactors promote physical, chemical, and enzymatic modification of starch that leads to better…
https://www.hielscher.com/ultrasonic-modification-of-starch-granules-slurries.htm
OSA-Starch Production – Improved Esterification by Sonication
Esterification of starches with octenyl succinic anhydride (OSA) is a widely applied modification technique, especially relevant in the food industry for creating functional starches with improved properties. However, traditional OSA starch modification under alkaline conditions is time-consuming and can limit…
https://www.hielscher.com/osa-starch-production-improved-esterification-by-sonication.htm
Sonicator UIP1500hdT – High Ultrasonic Processing Power
The probe-type sonicator UIP1500hdT (20kHz, 1500W) combines high processing power with flexibility and user-comfort. This 1.5kW powerful ultrasonic homogenizer is suitable for process development, optimization and for production processes. This includes emulsifying, dispersing and sono-chemistry, lysis and extraction or homogenizing.…
Ultrasonic Extraction of Ayurvedic Herbs
Herbs and spices contain many bioactive compounds, which are used as remedy and therypeutics in Ayurveda practices. Ultrasonication is a superior extraction technique to produce high-quality extracts. The advantages of ultrasonic extraction are very high yields, rapid extraction and a…
https://www.hielscher.com/ultrasonic-extraction-of-ayurvedic-herbs.htm
Sonochemical Effects on Sol-Gel Processes
Ultrafine nano-sized particles and spherical shaped particles, thin film coatings, fibers, porous and dense materials, as well extremely porous aerogels and xerogels are highly potential additives for the development and production of high performance materials. Advanced materials, including e.g. ceramics,…
https://www.hielscher.com/sonochemical-effects-on-sol-gel-processes.htm
Why Nanoformulated Medicines?
Ultrasonic nanoemulsions excel as drug carrier due to a significantly higher solubilization capacity than simple micelle solutions. Their thermodynamic stability offers advantages over unstable systems such as macro-sized emulsions, dispersions and suspensions. Hielscher ultrasonicators are used to prepare nanoemulsions with…
Ultrasonic Henna Extraction
Henna extracts are widely used in cosmetic, nutritional and medical products. The ultrasonic extraction method increases the yield of the active compounds such as antioxidants, phenolics, and colorants. Ultrasonic processing is a mild non-thermal technique to intensify the Henna extract…
Genomic Research Facilitated by Sonication
Genomic research has revolutionized our understanding of biological systems, enabling the elucidation of complex genetic mechanisms underlying various diseases and traits. Sonication, a technique originally developed for the disruption of cellular membranes, has found extensive utility in genomic research. This…
https://www.hielscher.com/genomic-research-facilitated-by-sonication.htm
Mayonnaise – Emulsification using a Sonicator
Oil and water don't mix, right? In fact, oil and water can be efficiently mixed using power ultrasound. Mayonnaise is a prominent example of an emulsion in culinary applications. Learn how sonication facilitates the production of a stable, creamy, and…
https://www.hielscher.com/mayonnaise-emulsification-using-a-sonicator.htm
Power Ultrasound for the Improvement of Juices & Smoothies
Researches from the Technical University Berlin found that ultrasonication is a very effective processing method to improve fruit and vegetable juices as well as smoothies. Being a non-thermal food process technique, ultrasound provides a mild but effective treatment that intensifies…
https://www.hielscher.com/power-ultrasound-for-the-improvement-of-juices-smoothies.htm
Ultrasonic Exfoliation of Water-Dispersible Graphene
Mono- and bi-layer graphene nanosheets can be produced rapidly via ultrasonic exfoliation with high throughput and at low cost. Ultrasonically exfoliated graphene can be functionalized with biopolymers in order to obtain water-dispersible graphene. By ultrasonic cavitation, the synthesized graphene can…
https://www.hielscher.com/ultrasonic-exfoliation-of-water-dispersible-graphene.htm
Improved Fruit and Vegetable Gelation by Ultrasonics
Thickening sauces, juices, jams and other foods by gelation is a common process in the production of liquid foods. Ultrasonic extraction of pectins and natural intracellular sugars from fruits and vegetables is a highly efficient method to promote the gelation…
https://www.hielscher.com/improved-fruit-and-vegetable-gelation-by-ultrasonics.htm
Mano-Thermo-Sonication: Synergies in Ultrasonic Processing
Sonication is a non-thermal processing technique used for numerous applications such as homogenization, emulsification, dispersion, extraction and preservation in food, pharma, biology, chemistry and material science. The use of ultrasound alone is a very efficient processing method and completes processing…
https://www.hielscher.com/mano-thermo-sonication-synergies-in-ultrasonic-processing.htm
Spagyric Herbal Tincture Production with Ultrasound
Ultrasound waves are a powerful method to intensify herbal extraction. Ultrasonic extraction results in a full-spectrum extract which contains the whole range of bioactive compounds. Applying ultrasound waves during spagyric tincture preparation makes the process significantly more efficient since sonication…
https://www.hielscher.com/spagyric-herbal-tincture-production-with-ultrasound.htm
Deep Eutectic Solvents for Highly Efficient Extraction
Deep eutectic solvents (DESs) and natural deep eutectic solvents (NADES) offer advantages as extraction solvents on many levels and are thereby a promising alternative to conventional organic solvents. Deep eutectic solvent work excellent in combination with ultrasonic extraction and give…
https://www.hielscher.com/extraction-with-deep-eutectic-solvents.htm
Crafting Sakura Vodka and Syrup through Ultrasonic Infusion
Cherry blossoms, also known by the Japanese term Sakura, do not only look beautiful, they also used to give spirits a bittersweet flavour notes of almond and cherry. We introduce you to the technique of ultrasonic maceration and infusion, which…
https://www.hielscher.com/crafting-sakura-vodka-and-gin-through-ultrasonic-infusion.htm
Scale-up of Ultrasonic Extraction Processes
In order to increase production capacities, extraction processes must be scaled to larger volumes / higher throughputs. Ultrasonically-assisted extraction is a highly efficacious method to isolate botanical compounds from plant material. Additionally, sonication applications can be linearly scaled to larger…
https://www.hielscher.com/scale-up-of-ultrasonic-extraction-processes.htm
Strategies for Higher Yields in Botanical Extraction
In order to produce premium-quality extracts from botanicals with high efficiency, i.e. high yields of premium quality extracts within a short extraction time, a high-performance extraction technique is required. Ultrasonic extraction is a process intensifying technique, which allows to use…
https://www.hielscher.com/strategies-for-higher-yields-in-botanical-extraction.htm
Sonication Enhanced Geopolymerisation
Geopolymers present a promising alternative to traditional cement-based materials, offering environmental, mechanical, and durability advantages. Ultrasonic dispersing is a highly efficient technique to produce geopolymers with excellent material characteristics. Sonication represents a highly efficient mixing method enabling the economical production…
https://www.hielscher.com/sonication-enhanced-geopolymerisation.htm
Gin Infusion by Ultrasonically-Intensified Maceration
Gin is an alcoholic beverage infused with juniper and other botanical compounds. Ultrasonic extraction enhances and intensifies the maceration process of pot distilled gin as well as compound gin. The advantages of ultrasonically-infused include the production of flavour-rich, aromatic beverages…
https://www.hielscher.com/gin-infusion-by-ultrasonically-intensified-maceration.htm
Alkaloid Extraction using a Probe-Ultrasonicator
Alkaloids are bioactive compounds, which can be efficiently extracted from plants using ultrasonication. Alkaloids exhibit a wide array of biological effects and are thereby used as pharmaceuticals and therapeutics. Ultrasonic extraction is the preferred technique to produce high quality alkaloid…
https://www.hielscher.com/alkaloid-extraction-using-a-probe-ultrasonicator.htm
Continuously Stirred-Tank Reactors Agitated with Ultrasound
Continuously stirred tank reactors (CSTR) are widely applied for various chemical reactions including catalysis, emulsion chemistry, polymerization, synthesis, extraction and crystallization. Slow reaction kinetics is a common problem in CSTR, which can easily be overcome by the application of power-ultrasonication.…
https://www.hielscher.com/continuously-stirred-tank-reactors-agitated-with-ultrasound.htm
Ultrasonic Deagglomeration of Silica Nanoparticles
Silica nanoparticles such as fumed silica (e.g. Aerosil) are a widely used additive in various industries. In order to obtain fully functional nanosilica with the desired material characteristics, the silica nano-particles must be deagglomerated and distributed as single-dispersed particles. Ultrasonic…
https://www.hielscher.com/ultrasonic-deagglomeration-of-silica-nanoparticles.htm
Ultrasonicators for ASTM D5621 Sonic Shear Stability of Hydraulic Fluids
The ASTM D5621 standard test method describes the sonic shear stability testing of hydraulic fluids and their viscosities at 40°C and 100°C, respectively. In order to test and determine the viscosity stability of hydraulic fluids under shear, a reliable testing…
Ultrasonically Aged and Matured Spirits and Liquors
Distilleries are using high-performance ultrasonication to improve the quality of distilled spirits within hours thereby skipping or reducing the time-consuming barrel-ageing, which takes up to several years. Ultrasonics promote the mechanical and chemical reactions, which take several years under conventional…
https://www.hielscher.com/ultrasonically-aged-and-matured-spirits-and-liquors.htm
Ultrasonically Improved Ice Cream Production
The application of power ultrasound has several beneficial effects on the production of high-quality ice cream. The major advantages of sonication include the reduction of the crystal size and the acceleration of freezing in ice cream. Thereby, ultrasonication improves the…
https://www.hielscher.com/ultrasonically-improved-ice-cream-production.htm
Reduced Asphaltene Deposition with Power Ultrasonics
Asphaltene precipitation initiates numerous problems in oil production through reducing the permeability, changing the reservoir rock wetability, well bore blockage as well as creating a significant pressure drop around the production well. Ultrasonic asphaltene deagglomeration and dispersion prevents and remediates…
https://www.hielscher.com/reduced-asphaltene-deposition-with-power-ultrasonics.htm
Water-Based Graphene Exfoliation
Ultrasonic exfoliation allows to produce few-layer graphene without the use of harsh solvents using pure water only. High-power sonication delaminates graphene sheets within a short treatment. The avoidance of solvents turns graphene exfoliation in a green, sustainable process. Graphene Production…
https://www.hielscher.com/water-based-graphene-exfoliation.htm
Organic Mushroom Extracts with Ultrasound
Produce premium-quality organic mushroom extracts, e.g. from chaga, reishi, psilocybe cubensis (magic mushrooms), lion’s mane, maitake, and many other mushroom species using ultrasonic extraction. The mild extraction method of power ultrasound can be combined with organically certified (bio-certified / eco-certified)…
Highly Efficient De-Aeration of Liquids using Ultrasonics
Whilst degassing or outgassing is often an extremely time-consuming process step, ultrasonication can accelerate the coalescence of gas bubbles and their rise significantly. Ultrasonic outgassing can be used in batch and inline setups and can be also combined with conventional…
https://www.hielscher.com/highly-efficient-de-aeration-of-liquids-using-ultrasonics.htm
Sonochemistry: Application Notes
Sonochemistry is the effect of ultrasonic cavitation on chemical systems. Due to the extreme conditions that occur in the cavitational "hot spot", power ultrasound is an very effective method to improve reaction outcome (higher yield, better quality), conversion and duration…
https://www.hielscher.com/sonochemistry-application-notes.htm
Ultrasonic Graphene Production
Ultrasonic synthesis of graphene via graphite exfoliation is the most reliable and advantageous method to produce high-quality graphene sheets on industrial scale. Hielscher high-performance ultrasonic processors are precisely controllable and can generate very high amplitudes in 24/7 operation. This allows…
https://www.hielscher.com/ultrasonic-graphene-preparation.htm
Sonochemical Reactions and Synthesis
Sonochemistry is the application of ultrasound to chemical reactions and processes. The mechanism causing sonochemical effects in liquids is the phenomenon of acoustic cavitation. Hielscher ultrasonic laboratory and industrial devices are used in a wide range of sonochemical processes. Ultrasonic…
Ultrasonic Process Test Facility
The effect of ultrasonication on various materials can be tested easily. Hielscher Ultrasonics offers you its ultrasound process facility, fully equipped with ultrasonic homogenizers, process accessories and analytic equipment, for the feasibility testing and process optimization of your application. We…
UIP500hdT – Industrial Processing in Small Scale
The ultrasonic processor UIP500hdT (20kHz, 500W) is an industrial grade device for pilot testing and small scale processing of liquids. Amongst the most common applications of the UIP500hdT are homogenization, dispersing, emulsification, cell disintegration and sonochemical reactions. A full color…
Ultrasound in Coating Formulation
Various components, such as pigments, fillers, chemical additives, crosslinkers and rheology modifiers go into coating and paint formulations. Ultrasound is an effective means for the dispersion and emulsifying, deagglomeration and milling of such components in coatings. Ultrasound is used in…
Ultrasonic Degassing of Anti-Freeze and Cooling Liquids
Ultrasonic degassing is a highly effective and efficient method for removing dissolved gases from coolants and anti-freeze liquids. Its application in industrial settings, particularly through the use of probe-type sonicators, ensures that these critical fluids perform optimally, safeguarding the equipment…
https://www.hielscher.com/ultrasonic-degassing-of-anti-freeze-and-cooling-liquids.htm
Special topics on our website
Find information about some of our special topics and concerns:
Accelerated Dewatering of Cellulose Nanofibers for Paper Production
Sonication in combination with lactic acid (LA) modification is an eco-friendly approach to accelerate the dewatering process of cellulose nanofibers (CNFs) for paper production. Cellulose nanofibers are known for their high water retention, causing significant delays in the drainage process,…
https://www.hielscher.com/accelerated-dewatering-of-cellulose-nanofibers.htm
Power Ultrasound for the Production of Cosmetics
Ultrasonic processing stands at the forefront of innovation in the dynamic realms of cosmetics and personal care development and manufacturing. Its versatile applications in the cosmetic industry encompass the creation of emulsions, dispersions, particle size reduction, liposome preparation, and the…
https://www.hielscher.com/power-ultrasound-for-the-production-of-cosmetics.htm
Ultrasonic Cold Brew Coffee
Cold brew coffee prepared using a sonicator is a process in which ultrasound waves are used as cold brewing technique. Instead of heat, powerful ultrasound waves extract flavor compounds from coffee grounds. Cold brew coffee offers a flavor profile that…
Green Coffee Extraction and Cold Brewing
Sonication, or the application of power ultrasound to agitate particles in a sample, has altered various industries, including food and beverage production. In particular, probe-type sonication has emerged as a superior method for the extraction and cold brewing of green…
https://www.hielscher.com/green-coffee-extraction-and-cold-brewing.htm
Food Homogenizers
Homogenizers are essential mixing equipment widely used in the food and beverage industry to naturally enhance flavor, consistency, and shelf life. As food and beverages constitute a significant part of the global economy, ensuring their quality and stability is paramount.…
Ultrasonicators for Life Science
Ultrasonicators play a critical role in the extraction and processing of biological samples for genomics, proteomics, and diagnostic applications. By effectively disrupting a wide range of cell and tissue types, ultrasonicators facilitate the isolation and analysis of DNA, RNA, and…
https://www.hielscher.com/ultrasonicators-for-life-science.htm
Soxhlet Extraction – What is it? How does it work?
The Soxhlet extractor is a fundamental tool for extracting specific compounds from solid samples using a continuous solvent extraction process. It involves repeated washing with a solvent over an extended period, typically 6-48 hours, making it very time-consuming. Long-term exposure…
https://www.hielscher.com/soxhlet-extraction-setup-and-function.htm
Biofilm Dislodging using the High-Throughput Sonicator UIP400MTP
High-throughput sonicators designed for multi-well plates and 96-well plates are essential tools in biofilm research, particularly for dislodging and removing biofilms from wells, tubes, pins, and Petri dishes. These sonicators facilitate the processing of numerous samples simultaneously, improving efficiency and…
https://www.hielscher.com/biofilm-dislodging-using-the-high-throughput-sonicator-uip400mtp.htm
Cannabis Oil / CBD Nanoemulsion by Ultrasonics
Making clear, translucent cannabis nanoemulsions is a real challenge. Ultrasonic emulsifiers are a highly efficient technique to produce clear, long-time stable nanoemulsion encapsulating cannabinoids. Ultrasonically nano-emulsified CBD, CBG or THC have a significantly higher bioavailability. Make CBD Nano-Emulsions using an…
https://www.hielscher.com/ultrasonic-cannabis-oil-emulsion.htm
Please Contact Us for More Information
Contact Hielscher Ultrasonics by phone, email, or visit our headquarters in Teltow, Germany. Whether you are looking to purchase an ultrasonic lab homogenizer for research or an industrial sonicator for production, we provide the ideal system for your needs. Our…
Oil-in-Water Emulsions
In oil-in-water emulsions, the oily phase is mixed into the aqueous phase. Ultrasonic emulsifiers are ideal for creating these emulsions, offering uniform droplet dispersion and long-term stability, making them popular in labs and production. Benefits of Hielscher Sonicators for Oil-in-Water…
Ultrasonic Exfoliation of Xenes
Xenes are 2D monoelemental nanomaterials with extraordinary properties such as very high surface area, anisotropic physical / chemical properties including superior electric conductivity or tensile strength. Ultrasonic exfoliation or delamination is an efficient and reliable technique to produce single-layer 2D…
https://www.hielscher.com/ultrasonic-exfoliation-of-xenes.htm
Liposomal Vitamin C Production with Ultrasonics
Liposomal vitamin formulations are known for their higher bioavailability and absorption rate. Vitamin C, an antioxidant, is a common supplement used in nutritional and medical drugs to support the immune system of the human body. Ultrasonication is a reliable and…
https://www.hielscher.com/liposomal-vitamin-c-production-with-ultrasonics.htm
Ultrasonic Priming of Seeds: How Sonication Improves Germination
Ultrasonic priming of seeds and grains result in a more complete and faster germination and higher crop yields. Ultrasonication perforates the seed testa (seed coating) and increases the uptake of water, nutrients and oxygen into the seed grains. The ultrasonic…
https://www.hielscher.com/ultrasonic-priming-of-seeds-how-sonication-improves-crop-germination.htm
Non-Contact Sonicators
Ultrasonicators play a critical role in the extraction and processing of biological samples for genomics, proteomics, and diagnostic applications. By effectively disrupting a wide range of cell and tissue types, ultrasonicators facilitate the isolation and analysis of DNA, RNA, and…
Ultrasonic Margarine Production
The basic production step during the manufacturing of margarine consists in emulsifying a blend of vegetable oils and fats with water and additives. Ultrasonic emulsification a a reliable, proven technique to prepare stable, fine-size food emulsions. The ultrasonic emulsion process…
https://www.hielscher.com/ultrasonic-margarine-production.htm
Ultrasonic Cold-Water Extraction of Mogrosides from Monk Fruit
Monk fruit (S. grosvenorii) extract and particularly its compound mogroside V is used as a natural non-caloric sweetener. Mogrosides. Ultrasonic extraction is a simple, rapid, reproducible, and reliable extraction method successfully applied to produce natural non-caloric sweetener from monk fruit.…
https://www.hielscher.com/ultrasonic-cold-water-extraction-of-mogrosides-from-monk-fruit.htm
A Comprehensive Guide to Temperature Control during Sonication
Temperature control in ultrasonic processing and sonochemical reactions is essential for maintaining sample integrity, protecting heat-sensitive compounds, optimizing reaction conditions, ensuring uniform sonication, and enhancing overall safety. All digital models of Hielscher sonicators come with a pluggable temperature sensor and…
https://www.hielscher.com/a-comprehensive-guide-to-temperature-control-during-sonication.htm
Thank you for your Inquiry!
We would like to thank you for your interest in our ultrasonic products. Your information request will be processed as soon as possible. In a hurry? Feel free to contact any of our offices. We will be glad to assist…
Solvents for Ultrasonic Extraction from Plants
Ultrasonic extraction features many advantages such as high yields, fast extraction rates, environmental-friendliness and low energy consumption. One of the strongest benefits is the use of water as extraction medium. However, sonication can be used with manifold solvent systems to…
https://www.hielscher.com/solvents-for-ultrasonic-extraction-from-plants.htm
All-In-One Sample Preparation Unit UP200St_TD
The 200 watts ultrasonic device UP200St_TD offers a broad versatility as this basic unit allows for three completely different setups. The basic system consists in the top-down transducer UP200St_TD that is driven by the 200 watt generator (UP200St-G) suppling the…
https://www.hielscher.com/all-in-one-sample-preparation-unit-up200st_td.htm
Ultrasonic Production of Liposomal Omega-3 Fatty Acids
Nanoliposomes are highly effective drug carriers used to enhance the bioavailability of bioactive compounds such as omega-2 fatty acids, vitamins, and other substances. Ultrasonic encapsulation of bioactive compounds is a fast and simple technique to prepare nanoliposomes with high drug…
https://www.hielscher.com/ultrasonic-production-of-liposomal-omega-3-fatty-acids.htm
High-Throughput Sample Preparation for Biomarker Diagnostics: Ultrasonic Protein Extraction
The integration of high-throughput sonicators in biomarker diagnostics offers substantial advantages, enhancing the efficiency, consistency, and scalability of sample preparation processes. By enabling the rapid and uniform extraction of biomolecules from diverse sample types, the Multiwell-Plate Sonicator UIP400MTP supports the…
Ultrasonically Improved Frying of Food
Fried foods such as french fries, potato chips and other deep-fried foods can benefit from sonication before or during frying. Learn how ultrasonics leads to healthier fried food as they contain less oil and less acrylamide. Simultaneously, the frying time…
https://www.hielscher.com/ultrasonically-improved-frying-of-food.htm
Flower Extraction – Mild Processing, High Yields by Sonication
Whether you want to make an absolute, flower-infused water or blossom hydrolat, sonication helps you to increase the yield of your flower extract. Learn why sonication is the ideal extraction technique to isolate the delicate biomolecules and essential oils from…
https://www.hielscher.com/flower-extraction-mild-processing-high-yields-by-sonication.htm
Polyol Synthesis via Ultrasonic Transesterification
Polyols are synthetic esters produced mainly via a transesterification of triglycerides from vegetable oils or animal fats. These polyols are raw material for the production of polyurethans, biolubricants and other cemicals. Ultrasonication is used to enhance transesterification reactions by applying…
https://www.hielscher.com/polyol-synthesis-via-ultrasonic-transesterification.htm
Ultrasonic Extraction of Active Compounds from Grape and Wine By-Products
Grapes (Vitis vinifera), vine and wine by-products are rich in polyphenols and other bioactive substances, which are valuable compounds for the production of medicinal and nutritional supplements. Ultrasonic extraction allows for the simple and highly efficient isolation of grape- and…
Rosemary Extraction using Power Ultrasound
Rosemary is a fragrant, evergreen herb rich in bioactive compounds and essential oils, which are used in medicinal, food and cosmetic products. Ultrasonic extraction is a mild, yet highly efficient technique to isolate bioactive compounds and essential oils from rosemary…
https://www.hielscher.com/rosemary-extraction-using-power-ultrasound.htm
SonoStation – Hielscher’s Ultrasonic Pump Solution Setup
Ultrasonic processes are widely used in manifold industries for mixing, dispersing, homogenisation and extraction. Whilst small volumes easily can be sonicated in batch mode, for larger volume processes a sophisticated inline setup is recommended. The SonoStation is a complete self-standing…
https://www.hielscher.com/sonostation-hielschers-ultrasonic-pump-solution-setup.htm
Hielscher Ultrasonics Videos
This page is a collection of videos.
Nano-Conductive Adhesives for High-Performance Electronics
Ultrasonic dispersers are used as reliable mixing and milling technique in the production of high-performance adhesives for high-performance electronics and nano-electronics. In production of high-performance electronics, adhesives such as nano-conductive adhesives are in high demand. Such high-performance adhesives are used…
https://www.hielscher.com/nano-conductive-adhesives-for-high-performance-electronics.htm
Ultrasonic Preparation of Reinforced Rubber
Reinforced rubbers show higher tensile strength, elongation, abrasion resistance and better aging stability. Fillers such as carbon black (e.g. CNTs, MWNTs), graphene, or silica must be homogeneously dispersed in the matrix to provide the desired material properties. Power ultrasonics gives…
https://www.hielscher.com/ultrasonic-preparation-of-reinforced-rubber.htm
Ultrasonic Dispersing of Activated Charcoal
Activated charcoal and active carbons are widely used in cosmetic, medical and industrial products. For best results, active charcoal must be uniformly dispersed: The smaller the particle size, the larger the particle surface, the better the activity. Ultrasonic dispersion gives…
https://www.hielscher.com/ultrasonic-dispersing-of-activated-charcoal.htm
Ultrasonic Production of Conductive Inks on Large Scale
Uniformly dispersed nanoparticles such as silver, graphene or CNTs with an precisely tailored particle size are crucial for production highly conductive inks. Powerful ultrasonic dispersers allow to synthesize, deagglomerate and distribute metallic (e.g. Ag), carbon-based (e.g. CNTs, graphene) nanoparticles as…
https://www.hielscher.com/ultrasonic-production-of-conductive-inks-on-large-scale.htm
Ultrasonic Homogenizers
Ultrasonic homogenizers are powerful tools to mix and homogenize solid-liquid and liquid-liquid suspensions. Ultrasonic homogenization is a mechanical process to reduce particles in a liquid so that they become uniformly small and evenly distributed. Hielscher offers powerful ultrasonic homogenizers for…
Ultrasonic Dispersing and Deagglomeration
The dispersing and deagglomeration of solids into liquids is an important application of power ultrasound and probe-type sonicators. Ultrasonic cavitation generates extraordinarily high shear that breaks particle agglomerates into single dispersed particles. Due to its locally focused high shear forces,…
Ultrasonic Flow Reactors – Design, Applications and Advantages
Ultrasonic reactors allow for a continuous inline treatment of liquids and slurries applying powerful ultrasound waves. Ultrasonic reactors are used for homogenisation, mixing, emulsification, dispersing, extraction, cell disintegration, pasteurization, degasification, dissolving and the intensification of chemical reactions such as synthesis…
https://www.hielscher.com/ultrasonic-flow-reactors-design-applications-and-advantages.htm
Sonochemistry and Sonochemical Reactors
Sonochemistry is the field of chemistry where high-intensity ultrasound is used to induce, accelerate and modify chemical reactions (synthesis, catalysis, degradation, polymerization, hydrolysis etc.). Ultrasonically generated cavitation is characterized by unique energy-dense conditions, which promote and intensify chemical reactions. Faster…
https://www.hielscher.com/sonochemistry-and-sonochemical-reactors.htm
Chitin and Chitosan Production from Mushrooms
Ultrasonication is a highly efficient method to release chitin and chitosan from fungal sources such as mushrooms. Chitin and chitosan must be depolymerized and deacetylated in down-stream processing in order to obtain a high-quality biopolymer. Ultrasonically-assisted depolymerization and deacetylation is…
https://www.hielscher.com/chitin-and-chitosan-production-from-mushrooms.htm
Ultrasonic Astaxanthin Extraction for Higher Yields
Astaxanthin is a highly potent antioxidant used in pharmaceuticals and nutritional supplements. In order to produce high-quality astaxanthin from natural sources such as algae, a high-performance extraction technique is required. Ultrasonic extraction is a mechanical treatment, which gives high yields…
Ultrasonic Preparation of Bitters
Bitters are very intensely infused alcoholic mixture used to flavour cocktails and other alcoholic drinks. Ultrasonic extraction and infusion helps to create an intense flavour profile in bitters. Whilst the traditional infusion of bitters is a time-consuming process, ultrasonic infusion…
https://www.hielscher.com/ultrasonic-preparation-of-bitters.htm
Synthesis and Functionalization of Zeolites using Sonication
Zeolites including nano-zeolites and zeolite derivatives can be efficiently and reliable synthesized, functionalized and deagglomerated using high-performance ultrasonication. Ultrasonic zeolite synthesis and treatment excels conventional hydrothermal synthesis by efficiency, simplicity, and simple linear scalability to large production. Ultrasonically synthesized zeolites…
https://www.hielscher.com/synthesis-and-functionalization-of-zeolites-using-sonication.htm
Ultrasonic Degassing and Defoaming of Liquids
Degassing and defoaming of liquids using ultrasonic is a very effective process. Ultrasonication removes small suspended gas-bubbles from the liquid and reduces the level of dissolved gas below the natural equilibrium level. The degassing and defoaming of liquids is required…
Ultrasonic Laboratory Devices
Hielscher lab sonicators are compact, easy-to-use and extremely versatile. They can be used for the processing of a variety of organic and inorganic materials in a wide range of volumes. Powerful ultrasonic homogenizers are available for intense direct and indirect…
Get in Touch with Kathrin Hielscher
Kathrin Hielscher: Marketing Manager at Hielscher Ultrasonics GmbH Kathrin Hielscher, born and raised in Bavaria, Germany, is the Marketing Manager at Hielscher Ultrasonics GmbH, a family-owned and operated company renowned for its high-power ultrasonic devices. After completing her studies and…
Thank you for your Inquiry!
We would like to thank you for your interest in our ultrasonic products. Your information request will be processed as soon as possible. In a hurry? Feel free to contact any of our offices. We will be glad to assist…
Ultrasonic Formulation of Nanostructured Lipid Drug Carriers
Nanostructured lipid carriers (NLCs) are an advanced form of nano-sized drug delivery systems featuring a lipid core and a water-soluble shell. NLCs have a high stability, protect the active bio-molecules against degradation and offer sustained drug release. Ultrasonication is a…
https://www.hielscher.com/ultrasonic-formulation-of-nanostructured-lipid-drug-carriers.htm
Saponification – Soap Making Process with Ultrasonics
Saponification is the chemical process of soap making. It is the reaction in which the raw material of fats or oils (triglycerides) react with an alkali reactant in order to form soap. Ultrasonication improves the phase transfer catalysis resulting in…
Saccharification: Benefits of Sonication
Saccharification is a fundamental biochemical process involving the transformation of complex carbohydrates such as starch and cellulose into simpler, more fermentable sugars like glucose. Ultrasonic reactors offer a significant enhancement in the efficiency and efficacy of these processes, leveraging high-performance…
https://www.hielscher.com/saccharification-benefits-of-sonication.htm
Imprint & Copyright
Imprint Hielscher Ultrasonics GmbH (Gesellschaft mit beschränkter Haftung) Oderstr. 53 D-14513 Teltow, Germany Tel.: +49 3328 437 420 Fax: +49 3328 437 444 Email: [email protected] Managing Director: Thomas Hielscher Commercial Registry Potsdam: HRB 19012 V.A.T.-No. (§27a UStG): DE 814 563…
Lion’s Mane Extract Made with Ultrasonics
Extracts from the fungus species Hericium erinaceus, known as lion’s mane mushroom, are most efficiently produced using ultrasonication. Ultrasonic extractors rapidly break open the fungal cell matrix and allow for the complete extraction of bioactive compounds from the lion's mane…
https://www.hielscher.com/lions-mane-extract-made-with-ultrasonics.htm
Ultrasonic Solutions for Improved Vaccine Production
Sonication is used in various steps of vaccines preparation: for cell lysis, to homogenize cell suspensions, to stimulate cell growth, for encapsulation, for adjuvant protein binding etc. Hielscher sonicators are used in the antigen production, encapsulation and formulation as well…
https://www.hielscher.com/ultrasonic-solutions-for-improved-vaccine-production.htm
Ultrasonic Sieve Shakers for Laboratories
The ultrasonic sieve shaker for laboratory sieves from Hielscher sieves, fractionates, classifies or separates powders quickly and reliably. The ultrasonic ring is simply clamped between standard lab sieves or test sieves. The ultrasonic vibrations are transmitted to all sieves in…
Compact Ultrasonic Wire Cleaning System for Feasibility Tests
Ultrasonic cleaning systems are very efficient for the inline cleaning of endless materials such as wires, cables, rods and continuous profiles. In order to test the ultrasonic cleaning effects on your specific material and contamination, Hielscher has developed the compact…
https://www.hielscher.com/ultrasonic-wire-cleaning-test-set.htm
Cleaning of Endless Punched Metal Strips With Power Ultrasonics
Stamped metal tapes and belts, perforated metal strips, shaped wires as well as stamped / punched terminals, pins, or SMA actuators are produced as endless materials. The cleaning of these metals, which often serve as electronic components, is an especially…
https://www.hielscher.com/cleaning-of-stamped-endless-metal-belts-with-power-ultrasonics.htm
Cleaning of Corrugated Hoses and Pipes
Ultrasonic inline cleaning is a highly efficient and reliable method to remove dust, dirt, grease and other processing residues from the outer surface of corrugated hoses and pipes. Hielscher ultrasonic inline cleaners can be easily integrated into existing production plants…
https://www.hielscher.com/cleaning-of-corrugated-hoses-and-pipes.htm
Compact Inline Wire Cleaning System WTC950
The WTC950 is the most compact inline wire cleaning system for endless materials such as wires, cables, rods, fibres, and stamped profiles. At only one meter in length, the WTC950 includes an extremely intensive ultrasonic cleaner, a temperature-controlled 17 liter…
https://www.hielscher.com/compact-inline-wire-cleaning-system-wtc950.htm
Ultrasonic Extraction of Edible Oils
Edible oils are used for manifold applications in cooking and food production. Mechanical extraction of edible oils prevents the oils from degradation. Ultrasonic extraction of edible oils is a superior method to release oils from seeds, kernels and fruits. As…
https://www.hielscher.com/ultrasonic-extraction-of-edible-oils.htm
UIPEVO – Ultrasonic Olive Oil Extractor for Higher Yields
The Hielscher UIPEVO is an ultrasonic extraction system for extra virgin olive oil that improves malaxation and extraction. The use of ultrasound for olive oil extraction increases yield and quality producing superior extra virgin olive oil. Due to the gentle…
https://www.hielscher.com/uipevo-ultrasonic-olive-oil-extractor-for-higher-yields.htm
Ultrasonic Tissue Homogenizers
Ultrasonication is a safe & efficient method of tissue homogenization. Ultrasonic applications include the preparation tissue and suspensions, the extraction of proteins, DNA/ RNA and active compounds, as well as the activation / inactivation of enzymes and yeasts. The precise…
https://www.hielscher.com/ultrasonic-tissue-homogenizers.htm
Mixology: Ultrasonic Homogenizer for Cocktail Bars
Nowadays, sophisticated bars work with highly innovative tools to create unique cocktails and drinks. Inspired by the molecular cuisine, bartenders use ultrasonic homogenizers to infuse drinks, blend emulsions and age wine or spirits. The Hielscher UP200Ht is the most popular…
https://www.hielscher.com/mixology-ultrasonic-homogenizer-for-cocktail-bars.htm
Improved Mustard Production with Power Ultrasound
Mustard condiment is produced from mustard flour and water or vinegar. Ultrasonic processing of mustard is a rapid and efficient method to release the full flavour spectrum from the ground mustard seeds. In a non-thermal, mild shear process, ultrasonic cavitation…
https://www.hielscher.com/improved-mustard-production-with-power-ultrasound.htm
Ultrasonic Dispersing of Carbon Nanotubes (CNT)
Carbon nanotubes are strong and flexible but very cohesive. They are difficult to disperse into liquids, such as water, ethanol, oil, polymer or epoxy resin. Ultrasound is an effective method to obtain discrete - single-dispersed - carbon nanotubes. Carbon nanotubes…
Highly Filled Resins produced with Power Ultrasound
Ultrasonic dispersion allows for the efficient and homogeneous incorporation of nano fillers into resins. Ultrasonic dispersers can easily handle high solid concentration in order to produce highly filled resins with a uniform particle distribution. Sonication is compatible with all kind…
https://www.hielscher.com/highly-filled-resins-with-power-ultrasound.htm
Solvent-Free Stevia Extraction with Ultrasound
The conventional extraction of the sweet components such as stevioglycosides from Stevia rebaudiana uses toxic solvents. In order to obtain a healthy, high-quality food product, a solvent-free extraction method is required. The ultrasonic extraction technique avoids the use of solvents…
https://www.hielscher.com/solvent-free-stevia-extraction-with-ultrasound.htm
UIP4000hdT – 4kW High Performance Ultrasonics
The UIP4000hdT delivers up to 4kW ultrasound power and is a reliable production machine even under demanding conditions. It is designed for industrial processes with a higher energy demand and large volumes. The UIP4000hdT is a robust and powerful ultrasonic…
https://www.hielscher.com/uip4000hdt-4kw-high-performance-ultrasonics.htm
UIP6000hdT – 6kW High-Performance Ultrasonicator
The UIP6000hdT delivers 6kW of ultrasound power and is a reliable production machine for heavy-duty applications and in demanding environments. Designed for industrial processes with a higher energy demand and large volumes such as particle milling, nano-material processing and food…
https://www.hielscher.com/uip6000hdt-6kw-high-performance-ultrasonicator.htm
Ultrasound for Dispersing and Grinding: Paint & Pigments
Power ultrasound is well known for its intense and precisely controllable milling and dispersing effects. This makes ultrasonic homogenizers ideal for the production of pigment paste and paint formulations. Industrial ultrasonicators provide a highly uniform particle size distribution in the…
https://www.hielscher.com/ultrasound-for-dispersing-and-grinding-paint-pigments.htm
Large-Scale Mushroom Extraction using Probe-Type Batch Sonication
Extracting bioactive compounds from mushrooms for production purposes involves a combination of cutting, grinding or crushing the mushrooms, ultrasonically-assisted solvent extraction, and subsequent isolation of the bioactive compounds such as beta-glucans. Here is a practical instruction of ultrasonic mushroom extraction…
https://www.hielscher.com/large-scale-mushroom-extraction-using-probe-type-batch-sonication.htm
Terpene Extraction by Ultrasonics
Ultrasonic terpene extraction has been proven to give high yields of terpene caryophyllene oxide, e.g. from cannabis and hops. Caryophyllene oxide is a terpene found in cannabis, hops, pepper, basil and rosemary. As an active compound, extracted terpene caryophyllene oxide…
Highly Efficient Cannabidiol (CBD) Extraction from Cannabis
Hielscher ultrasonic extractors are the state-of-art technique when it comes to the reliable and efficient extraction of hemp and CBD oils. Ultrasonication is well-known as a highly potent extraction technique to release valuable compounds from botanicals. In comparison to other…
https://www.hielscher.com/highly-efficient-ultrasonic-cannabidiol-cbd-extraction-from-cannabis.htm
Ultrasonic Dispersion of Tattoo Ink
Tattoo inks are specialty inks used for the artificial pigmentation of the skin. Mixing and dispersing tattoo inks with a probe-type sonicator offers advantages such as homogenization, particle size reduction, ingredient dispersion, reduced processing time, sterilization, and controlled process parameters.…
https://www.hielscher.com/ultrasonic-dispersion-of-tattoo-ink.htm
Ultrasonic Extraction of Olive Leaf Polyphenols
Olive leaf extracts are a potent dietary supplement and therapeutic as it contains strong antioxidants such as the polyphenols oleuropein, hydroxytyrosol and verbascoside. Ultrasonic extraction is highly efficient technique to release and isolate bioactive compounds such as polyphenols, flavones and…
https://www.hielscher.com/ultrasonic-extraction-of-olive-leaf-extract.htm
Ultrasonic Nanostructuring of Antibiotics
Ultrasonically-assisted production of antibiotics can increase their effectiveness, even against drug-resistant bacteria: The increasing number of antibiotic-resistant bacteria strains is a still unsolved problem making bacterial infections, which have been successfully treated with antibiotics within the last decades, a worldwide…
https://www.hielscher.com/ultrasonic-nanostructuring-of-antibiotics.htm
Soldier Fly Larvae Protein Extraction Improved by Sonication
Probe-type sonicators have become one of the most common processing techniques for Soldier Fly Larvae (SFL) protein processing due to their efficiency, mild processing conditions, scalability, and versatility. Sonication enables the disintegration of soldier fly larvae biomass and extraction of…
https://www.hielscher.com/soldier-fly-larvae-protein-extraction-improved-by-sonication.htm
Support and Trouble Shooting for Your Ultrasonic Device
Hielscher ultrasonic devices are built to the highest industry standards. Should you face any trouble or defect, please let us know! Our support team will be glad to assist you in getting your ultrasonic unit operational again, quickly. Perform a…
https://www.hielscher.com/support-and-trouble-shooting-for-your-ultrasonic-device.htm
Ultrasonically Assisted Fermentation for Bioethanol Production
Ultrasonically-assisted fermentation can enhance bioethanol production by promoting the breakdown of complex carbohydrates into simpler sugars, making them more readily available for yeast to convert into ethanol. Simultaneously, sonication also improves the efficiency of yeast cell wall permeability, allowing for…
https://www.hielscher.com/ultrasonically-assisted-fermentation-for-bioethanol-production.htm
Ultrasonic Homogenization of Soy Milk
The challenges of soy milk production lie in the production of a tasty, nutritional high-quality soy-based drink under high efficiency process conditions. Ultrasonic homogenization and pasteurization offers the advantages of a healthy soy milk with high nutritional values & shelf-stable…
https://www.hielscher.com/ultrasonic-homogenization-of-soy-milk.htm
Ultrasonically Assisted Drawing of Wires, Pipes and Profiles (UAD)
Hielscher Ultrasonics manufactures an ultrasonically vibrating wire die holder that works with standard wire dies of up to 42mm outer diameter. The ultrasonic agitation reduces the line tension required for the diameter reduction significantly. This can be used to increase…
https://www.hielscher.com/ultrasonically-assisted-drawing-of-wires-pipes-and-profiles-uad.htm
Verbena-Infused Tequila Blanco – A Bar Fritz’n Signature Drink
Potsdam‘s Bar Fritz’n cultivate an upscale cocktail culture and strive to bring their clientele novel drinks using carefully selected ingredients. This means also that the Bar Fritz’n bartenders are not shy to use innovative techniques. For instance, they use a…
https://www.hielscher.com/verbena-infused-tequila-blanco-a-bar-fritzn-signature-drink.htm
Pickering Emulsions with Power Ultrasonics
Pickering emulsions are stabilized by solid particles. Pickering emulsions convince by their “emulsifier-free” character and their enhanced stability. Ultrasonic is the perfect tool to create Pickering emulsions by firstly dispersing the stabilizing particles into the water phase and secondly to…
https://www.hielscher.com/pickering-emulsions-with-power-ultrasonics.htm
Ultrasonic Treatment of Nanoparticles for Pharmaceuticals
Probe-type sonicators play a crucial role in pharmaceutical research and manufacturing by providing a powerful and controlled means of achieving particle size reduction, cell disruption, and homogenization. Sonicators utilize ultrasonic waves to generate cavitation, resulting in the formation and collapse…
https://www.hielscher.com/ultrasonic-treatment-of-nanoparticles-for-pharmaceuticals.htm
Ultrasonic Lysis for Western Blotting
The western blot is an analytical procedure for the detection of specific proteins in a sample of tissue homogenate or cell extract. To run a Western blot or to measure enzyme activity, many assays require access to the materials (e.g.…
https://www.hielscher.com/ultrasonic-lysis-for-western-blotting.htm
Ultrasonic Anthocyanin Extraction
Anthocyanins are widely used as natural colorant and nutritional additive in food products. Ultrasonic extraction is a highly efficient and simple technique to obtain high-quality anthocyanins. The use of probe-type sonicators promotes the release of high-quality anthocyanins from plants resulting…
https://www.hielscher.com/ultrasonic-anthocyanin-extraction.htm
Ultrasonically Emulsified Creams and Cosmetic Products
Skin care products such as creams, lotions, moisturizers, balms and ointments are generally based on stable submicron- and nano-sized emulsions. Ultrasonic emulsification creates high-shear forces and is well-established as a potent and reliable blending technique for skin care and cosmetic…
https://www.hielscher.com/ultrasonically-emulsified-cremes-and-cosmetic-products.htm
Ultrasonic Extraction Using Hemp as Raw Material
For the cannabis sativa plant, two species can be differentiated: marijuana and hemp. Ultrasonic is well known as superior method to isolate cannabinoids from both, marijuana and hemp. Ultrasonic Extraction of Cannabinoids The ultrasonic extraction technology is highly efficient to…
https://www.hielscher.com/ultrasonic-extraction-using-hemp-as-raw-material.htm
Ultrasonic Production of Highly Purified Schizophyllan Beta-Glucans
Schizophyallan is a fungal β-glucan with immunomodulating properties. For highly active medicinal effects, schizophyllan must have a low molecular weight in order to show improved bioavailability. Ultrasonication has been proven to reduce the molecular weight of schizophyllan. As reliable and…
https://www.hielscher.com/ultrasonic-production-of-highly-purified-schizophyllan-beta-glucans.htm
UIP16000 – Most Powerful Ultrasonic Processor
16,000 watts of ultrasonic power make the UIP16000 the most powerful ultrasonic processor in the world. It is designed to work in clusters of three or more units, for large volume processing, such as to homogenize, disperse or deagglomerate. Industrial…
Sonochemically Nanostructured Implants Improving Osseointegration
Implants, orthopedic prostheses and dental implants are made mainly from titanium and alloys. Sonication is used to create nanostructured surfaces on metallic implants. Ultrasonic nanostructuring allows to modify metallic surfaces generating uniformly distributed nano-sized patterns on implant surfaces. These nanostructured…
https://www.hielscher.com/sonochemically-nanostructured-implants-improving-osseointegration.htm
Sonicators for ASTM E1979-21 Lead Extraction
ASTM E1979 describes the standard practice for ultrasonic extraction of paint, dust, soil, and air samples for subsequent determination of lead. Ultrasonic extraction is a main sample preparation step to make lead contamination available for subsequent analysis. Ultrasonic Extraction of…
https://www.hielscher.com/sonicators-for-astm-e1979-21-lead-extraction.htm
Ultrasonic Dispersion of C60 into Supplements
Ultrasonic dispersion is the superior method to blend C60 homogeneously into stable oil-based and liposomal supplements. The mild, precisely controllable ultrasonic treatment ensures that the C60 molecules are kept intact for best results. The ultrasonically blended nano-structured formulation results in…
https://www.hielscher.com/ultrasonic-dispersion-of-c60-into-supplements.htm
Ultrasonically Polyhydroxylated C60 (Fullerenol)
Water-soluble polyhydroxylated C60 fullerene, called fullerenol or fullerol, is a strong free radical scavenger and is therefore used as an antioxidant in supplements and pharmaceuticals. Ultrasonic hydroxylation is a rapid and simple one-step reaction, which is used to produce water-soluble…
https://www.hielscher.com/ultrasonic-polyhydroxylated-c60-fullerenol.htm
Biodiesel Production & Biodiesel Conversion
When you make biodiesel, slow reaction kinetics and poor mass transfer are lowering your biodiesel plant capacity as well as your biodiesel yield and quality. Hielscher ultrasonic reactors improve the transesterification kinetics significantly. Therefore lower excess methanol and less catalyst…
https://www.hielscher.com/biodiesel_transesterification_01.htm
Ultrasonic Avocado Oil Extraction
Ultrasonic extraction and malaxation increases yield of extra virgin avocado oil production. Sonication is a gentle non-thermal process and thereby is appropriate to produce the highest grade of extra virgin avocado oil. The ultrasonically assisted oil pressing not only improves…
https://www.hielscher.com/ultrasonic-avocado-oil-extraction.htm
Ultrasonics Improve Biodiesel Process Efficiency
Hielscher ultrasonic mixing reactors improve your biodiesel production process. Ultrasonication produces higher transesterification conversion yields in less time. Ultrasonic mixing increases production capacity and reduces methanol and catalyst usage. Efficient Biodiesel Processing Today, making biodiesel is not just about making…
https://www.hielscher.com/biodiesel_processing_efficiency.htm
Frost & Sullivan Technology Innovation of the Year
It is in recognition of Hielscher Ultrasonics innovative application of ultrasonics technology to biodiesel manufacturing that Frost & Sullivan is pleased to acknowledge the company’s work with the prestigious Award for Technology Innovation of the Year. "It (Hielscher Ultrasonics) specializes…
Biodiesel Pumps & Tanks
The tables below lists suppliers of pumps and tanks for the manufacturing of biodiesel. Pumps for Biodiesel Systems Company Pumps PumpBiz Inc. 1955 Shermer Av., Northbrook, IL 60062 Phone: 847-291-1357, Fax: 847-589-3935 [email protected], www.pumpbiz.com Centrifugal Rotary Viking Pump Inc. 406…
Aqua-Fuels – NOx Reduction by Ultrasonic Emulsification
Aqua-fuels are water-in-fuel blends, which provide a cleaner, more efficient burning fuel type. Ultrasonic emulsification are used for instance to mix heavy fuel oils with water, that are used on marine vessels to reduce the emission of nitrous oxide (NOx),…
https://www.hielscher.com/enermulsion-nox-reduction-by-ultrasonic-emulsification.htm
Ultrasonically Promoted Enzymatic Plastic Recycling
Polyethylene terephthalate (PET) is a huge waste source coming mostly from used water and beverage bottles. Until recently, recycling of PET resulted in low quality plastics. A new mutant enzyme promises the degradation of PET into pristine raw material, which…
https://www.hielscher.com/ultrasonically-promoted-enzymatic-plastic-recycling.htm
Cannabis Extraction Equipment – The Advantage of Sonication
Ultrasonic extraction equipment has many advantages which makes it the superior extraction method for hemp and marijuana. Although extraction of bioactive compounds such as THC and CBD from cannabis can be performed with different techniques, sonication offers numerous advantages. Due…
https://www.hielscher.com/cannabis-extraction-equipment-the-advantage-of-sonication.htm
Ultrasonic Curcurmin Extraction
Curcumin is a pharmacological and nutritional phytochemical present in the rhizomes of Curcuma longa. In order to obtain high curcumin yields, ultrasonic extractors is used as most efficient extraction technique. Ultrasonic extraction results in curcumin of superior quality and very…
https://www.hielscher.com/ultrasonic-cucurmin-extraction.htm
Dissolving Cannabinoids in Alcoholic Beverages
The production of cannabis-infused beverages of both, alcoholic and non-alcoholic drinks, is a challenging task. In order to achieve long-term stability, clear appearance and a desired development of flavours requires an efficient and reliable mixing technology and a compatible emulsifying…
https://www.hielscher.com/dissolving-cannabinoids-in-alcoholic-beverages.htm
Ultrasonic Refinement of Metal Melts
Power ultrasound in molten metals and alloys shows various beneficial effects such as structuring, degassing, and improved filtration. Ultrasonication promotes the non-dendritic solidification in liquid and semi-solid metals. Sonication has significant benefits on the microstructural refinement of dendritic grains and…
https://www.hielscher.com/ultrasonic-processing-of-metal-melts.htm
Ultrasonic Capsaicin Extraction from Hot Chili Peppers
Capsaicin is the main flavour and spice compound in hot peppers, also known as chilies. To produce high-quality capsaicin as aromatic flavour and medicinal ingredient, an efficient, yet mild extraction technique is required to prevent degradation. Ultrasonic extraction is a…
https://www.hielscher.com/ultrasonic-capsaicin-extraction-from-hot-chili-peppers.htm
Flow Cells and Inline Reactors for Lab Ultrasonicators
Ultrasonic lab homogenizers can be used for batch and inline processing of liquids and slurries. Typical applications include homogenization, dispersing, emulsification, dissolving as well as sonochemical reactions. For the continuous inline sonication, flow cells and in-line reactors in various sizes…
https://www.hielscher.com/flow-cells-and-inline-reactors-for-lab-ultrasonicators.htm
Superior Catechin Extracts with Ultrasonics
Catechin such as epigallocatechin gallate (EGCG), epigallocatechin (EGC), epicatechin gallate (ECG), and epicatechin (EC) are polyphenols, which show significant health benefits. Whilst catechin are found in smaller amounts in green tea, cocoa, fruits and some other foods, for high dose…
https://www.hielscher.com/superior-catechin-extracts-with-ultrasonics.htm
Ultrasonic Protein Extraction from Tissue and Cell Cultures
Protein extraction is an essential sample preparation step in proteomics. Proteins can be extracted from plant and animal tissue, yeasts and microorganisms. Sonication is a reliable, efficient protein extraction method giving high protein yields within a short extraction time. Protein…
https://www.hielscher.com/ultrasonic-protein-extraction-from-tissue-and-cell-cultures.htm
Ultrasonic Tobacco Extraction
Conventional tobacco extraction is a slow, time-consuming process, which involves the use of toxic solvents at high temperatures, which makes the process hazardous. Ultrasonically-assisted extraction of alkaloids from tobacco can be run using water or mild solvents in a rapid…
Ultrasonic Extraction of Medicinal Mushrooms
Medicinal mushrooms are known since ancient times for their exceptional health benefits. Recently, medicinal fungi turn into a mainstream commodity to improve health and to boost energy. In order to experience the full spectrum of health supporting effects of medicinal…
https://www.hielscher.com/ultrasonic-extraction-of-medicinal-mushrooms.htm
Ultrasonic Extraction of Piperine from Pepper
Piperine is a bioactive substance that is found in pepper corns and valued for its pharmacological properties. Ultrasonic is an efficient, simple, and rapid extraction technique to isolate high-quality piperine. Ultrasonic extraction is a reliable and proven method, already widely…
https://www.hielscher.com/ultrasonic-extraction-of-piperine-from-pepper.htm
Ultrasonically Assisted Saffron Extraction
Ultrasound is well known for its extraction capacity. The ultrasonically assisted extraction of active compounds, flavours and spices from plant material is a very successful application as ultrasonically generated cavitation disruptes plant cells and enhances mass transfer so that the…
https://www.hielscher.com/ultrasonically-assisted-saffron-extraction.htm
Ultrasonically-Assisted Cloud Point Extraction
Cloud point extraction (CPE) is an pre-analytical procedure to separate and pre-concetrate analytes. In combination with ultrasonication, cloud point extraction can be intensified making the process more efficient, faster, and environment-friendlier. Ultrasonically-assisted cloud point extraction reduces solvent consumption and extraction…
https://www.hielscher.com/ultrasonically-assisted-cloud-point-extraction.htm
Efficient Production of Hops Extracts by Sonication
Hops and hop extracts are essential ingredients for the production of beer. The alpha-acids a-caryophyllene (humulone) and beta-caryophyllene (humulene) are important flavour compounds, which give beer its bitterness and contribute to its aroma, foam structure, and microbiological stability. Ultrasonic extraction…
https://www.hielscher.com/efficient-production-of-hops-extracts-by-sonication.htm
Ultrasonic Extraction of Polysaccharides from Astragalus Membranaceus Root
The roots of Astragalus membranceus (also called Astragalus propinquus) contain the saponin cycloastragenol, which may activate telomerase and thereby extend the length of telomeres. Telomere length is associated with longevity. Ultrasonic extraction is the superior technique to isolate cycloastragenol and…
Ultrasonically Enhanced Three-Phase Partitioning
Three-phase partitioning (TPP) is a technique to extract, separate and purify components, e.g lipids, enzymes, polysaccharides and other biomolecules, from biological material. Ultrasonically-assisted Three-Phase Partitioning excels the conventional three-phase partitioning by higher yield, improved purity and exceptional speed. Ultrasonic Three-Phase…
https://www.hielscher.com/ultrasonically-enhanced-three-phase-partitioning.htm
Ultrasonicators for Forensic Investigations
Ultrasonic devices are used for two major applications in forensic labs: for extraction and cleaning. Ultrasonic extraction is used to obtain targeted substances such as DNA, drug components or other active compounds. Ultrasonic cleaning is an effective tool to remove…
https://www.hielscher.com/ultrasonicators-for-forensic-investigations.htm
Cell Lysis of BL21 Cells by Ultrasonication
BL21 cells are a strain of E. coli that is widely used in research laboratories, biotechnology and industrial production due to their capability to express proteins highly efficient. Ultrasonic cell disruption, lysis and protein extraction is the common method to…
https://www.hielscher.com/cell-lysis-of-bl21-cells-by-ultrasonication.htm
Preparation of Cannabis Glycerin Extract with Ultrasonics
Cannabis extraction in glycerin is a comfortable way to extract cannabinoids directly from the dry plant material. Cannabis glycerin concentrates can be easily formulated in any kind of cannabis-infused product such as tinctures, vapes, baking ingredient, lotions etc. Ultrasonic extraction…
https://www.hielscher.com/preparation-of-cannabis-glycerin-extract-with-ultrasonics.htm
Hexane Extraction with Improved Efficiency by Ultrasonication
Probe-type ultrasonication can improve conventional hexane extraction by intensifying the process and making it significantly more efficient. Ultrasonic extraction improves mass transfer and disrupts cells to release targeted bioactive substances into the solvent, resulting in higher extraction yields compared to…
https://www.hielscher.com/hexane-extraction-with-improved-efficiency-by-ultrasonication.htm
Genetic Transformation in Plant Cells using Ultrasonics
Sonication-Assisted Agrobacterium-Mediated Transformation (SAAT) is an efficient method to infect plant cells with foreign genes using Agrobacterium as transporter. Ultrasonic cavitation causes sonoporation, which can be described as targeted micro-wounding of plant tissue. Via these ultrasonically creates micro-wounds, DNA and…
https://www.hielscher.com/genetic-transformation-in-plant-cells-using-ultrasonics.htm
Ultrasonic Lysis of Drosophila Melanogaster Samples
Drosophila melanogaster is widely used in laboratories as model organism. Therefore, pre-analytical preparation steps such as lysis, cell disruption, protein extraction and DNA shearing of Drosophila melanogaster samples must be frequently carried out. Ultrasonic dismembrators are reliable and efficient and…
https://www.hielscher.com/lysis-of-drosophila-melanogaster-samples.htm
Ultrasonic Extraction of Medicinal Herbs
Herbs, spices and other plant materials are rich in phytochemicals, which are valued components for medicinal and nutritional products. Sonication breaks the cell structure and releases the bioactive compounds - resulting in higher yields and faster extraction rates. As a…
https://www.hielscher.com/ultrasonic-extraction-of-medicinal-herbs.htm
Ultrasonic Psilocybin Extraction from Mushrooms
Psilocybin is the hallucinogenic substance present in magic mushrooms. For convenient consumption and reliable dosing, psilocybin is normally extracted and used in form of tinctures or enriched foods. As ultrasonic extraction gives high psilocybin yield in a very rapid extraction…
https://www.hielscher.com/ultrasonic-psilocybin-extraction-from-mushrooms.htm
Ultrasonic Quercetin Extraction
Quercetin is a plant compound of the group of polyphenols, which is known for manifold health beenfits. In order to produce high-quality quercetin for food additives and supplements, an efficient, yet mild extraction technique is required to prevent decomposition. Ultrasonic…
https://www.hielscher.com/ultrasonic-quercetin-extraction.htm
Ultrasonics for Vaccine Production
Ultrasonics is a proven method to destroy or inactivate viruses, bacteria and yeast. Additionally, sonicators are reliable for the lysis of cells, e.g. viral or bacterial cells and the release of intracellular matter, e.g. proteins, DNA/RNA, enzymes and bioactives. Therefore,…
https://www.hielscher.com/ultrasonics-for-vaccine-production.htm
Ultrasonic Extraction of Polyphenols from Baggibuti (Stachys parviflora)
Extracts of the Baggibuti (Stachys parviflora L.) plant are valued as herbal medicine used as treatment of cramps, arthralgia, epilepsy, falling sickness, and dracunculiasis. Ultrasonic extractors are successfully applied for the isolation of polyphenols and other phytochemicals from Stachys parviflora.…
https://www.hielscher.com/ultrasonic-extraction-of-polyphenols-from-baggibuti-stachys-parviflora.htm
Highly Efficient Artemisinin Extraction with Sonication
Artemisinin can be efficiently extracted using high-performance sonication. Ultrasonic extraction gives very high yields of artemisinin using mild solvents. The process of extraction applying ultrasound is accelerated drastically. The processing conditions in ultrasonic extractors are precisely controllable, which allows to…
https://www.hielscher.com/highly-efficient-artemisinin-extraction-with-sonication.htm
Tire Rubber Recycling with High-Performance Ultrasound
Waste tire rubber is a toxic, non-biodegradable material making its disposal an environmental and economical problem. Ultrasonic devulcanization is a fast and efficient method to recycle waste tire rubber allowing to reuse waste tires. Ultrasonic tire rubber recycling is relatively…
https://www.hielscher.com/tire-rubber-recycling-with-high-performance-ultrasound.htm
Nano-Sized Magnesium Hydride as Efficient Hydrogen Storage
Sonication is applied to magnesium hydride in order to accelerate the hydrolysis of magnesium hydride to enhance hydrogen generation. Additionally, ultrasonically nanostructured magnesium hydride, i.e. MgH2 nanoparticles, show improved hydrogen storage capacity. Magnesium Hydride for Hydrogen Storage Magnesium hydride, MgH2,…
https://www.hielscher.com/magnesium-hydride-synthesis-via-hydrolysis.htm
Support – Software Upgrade Check
Support - Software Update Check Dear Customer, Your ultrasonic device may be eligible for a free software-upgrade. If so, we strongly suggest to use this opportunity to keep your unit up-to-date and to make use of any improvements and added…
Ultrasonic Extraction of Spirulina Pigments
Ultrasonic extraction has been proven to be highly efficient for the isolation of superior quality extracts of microalgae. Spirulina pigments such as phycocyanin are known as superfood, which contribute to health benefits due to their high content of antioxidants, vitamins…
https://www.hielscher.com/ultrasonic-extraction-of-spirulina-pigments.htm
Ultrasonics for the Recycling of Lithium Ion Batteries
Lithium-ion batteries used in electric cars are just now coming to the mass market and with it, recycling capacities must be developed. Ultrasonic leaching is an efficient, environmental-friendly technique to recover metals such as Li, Mg, Co, Ni etc. from…
https://www.hielscher.com/ultrasonics-for-the-recycling-of-lithium-ion-batteries.htm
Spirits and Liquors – Rich Flavours by Ultrasonic Infusion
Infusing alcoholic beverages such as spirits, liquors and cocktails with flavours can be improved significantly by application of power ultrasound. The sonication process transfers flavours and aromas to alcoholic beverages creating a rich and smooth flavour profile. How does Ultrasonic…
https://www.hielscher.com/spirits-and-liquors-rich-flavours-by-ultrasonically-infusion.htm
Ultrasonic Dispersion of Silica (SiO2)
Silica, also known as SiO2, nano-silica or micro-silica is used in toothpaste, cement, synthetic rubber, high-performance polymer or in food products as a thickener, adsorbent, anti-caking agent, or carrier for fragrances and flavors. Below you will learn more about the…
Protocol for SARS-CoV-2 Coronavirus Inactivation with Sonication
The Hielscher VialTweeter is a unique ultrasonic multi-sample preparation unit, which is used to inactivate the coronavirus SARS-COV-2. The VialTweeter allow to prepare up to 10 sample vials simultaneously and is thereby the ideal unit for mass sample processing. Inactivation…
https://www.hielscher.com/protocol-for-sars-cov-2-coronavirus-inactivation-with-sonication.htm
Solvent-free Decaffeination with Power-Ultrasound
The conventional decaffeination process of coffee and tea requires the use of toxic solvents. Ultrasonic decaffeination is an efficient intensification method the that allows to remove caffeine in a water-based extraction procedure without the use of harsh solvents. Ultrasonic decaffeination…
https://www.hielscher.com/solvent-free-decaffeination-with-power-ultrasound.htm
Ultrasonic Pasteurization of Liquid Foods
Ultrasonic pasteurization is a non-thermal sterilization process to inactivate microbes such as E.coli, Pseudomonas fluorescens, Listeria monocytogenes, Staphylococcus aureus, Bacillus coagulans, Anoxybacillus flavithermus amongst many others to prevent microbial spoilage and achieve long-term stability of food and beverages. Non-Thermal Pasteurization…
https://www.hielscher.com/ultrasonic-pasteurization-of-liquid-foods.htm
Coronavirus (COVID-19, SARS-CoV-2) and Ultrasonics
Ultrasonication is a powerful tool used in biology, molecular chemistry and biochemistry as well as in the production of pharmaceuticals. Bio-sciences use ultrasonic homogenizers to lyse cells and extract proteins and other intracellular materials, the pharma industry applied ultrasonics to…
https://www.hielscher.com/coronavirus-covid-19-sars-cov-2-and-ultrasonics.htm
Ultrasonic Applications in MonkeyPox Virus
Ultrasonication is an important processing method for the isolation of the monkeypox virus (MPXV) from analytical samples, for virus DNA fragmentation as well as in monkeypox vaccine manufacturing. For sample preparation before diagnostics and analysis (PCR, ELISA etc.) ultrasonication is…
https://www.hielscher.com/ultrasonic-applications-in-monkeypox-virus.htm
Ultrasonic High-Shear In-Line Mixers
High-shear ultrasonicators for inline mixing processes offer various advantages when compared to conventional colloid homogenizers. Using high-power ultrasound for mixing enables Hielscher ultrasonic high-shear mixers to produce uniformly dispersed colloidal suspensions and emulsions in the nano-range. Ultrasonic inline homogenizers can…
Dispersion of Carbon Nanotubes in 3D-Printable Inks
A uniform dispersion of CNTs in 3D-printable inks can enhance the properties of ink and enable new applications in various fields. Probe-type ultrasonication is a highly reliable dispersing technique to produce stable nanosuspensions of CNTs in polymers. Efficient and Stable…
https://www.hielscher.com/dispersion-of-carbon-nanotubes-in-3d-printable-inks.htm
Ultrasonics: Applications and Processes
Ultrasonication is a mechanical processing method which creates acoustic cavitation and highly intense physical forces. Therefore, ultrasonics is used for numerous applications such as mixing, homogenization, milling, dispersion, emulsification, extraction, degassing, and sono-chemical reactions. Below, you will learn all about…
Ultrasonic Production of Stable Nanoemulsions
Nanoemulsions - also known as miniemulsions or submicron emulsions - are used in a wide range of applications in chemistry, paints, coatings, cosmetics, pharmaceuticals and food. Ultrasonicators are known as a highly efficient and reliable technique for the production of…
https://www.hielscher.com/ultrasonic-production-of-stable-nanoemulsions.htm
Ultrasonic Viscosity Reduction of Protein Suspensions before Spray Drying
Ultrasonics is the solution to enhance efficiency and reduce costs for the spray drying process of whey slurries, e.g. WPC. Ultrasonic shear forces lower the viscosity of the whey solution and allows thereby for a higher protein concentration. Hielscher Ultrasonics…
https://www.hielscher.com/ultrasonic-spray-drying-of-proteins-for-viscosity-reduction.htm
Ultrasonic Preparation of Brines
Brines are a solution of salts, e.g. NaCl, KCl, KNO3, KClO3, CaCl3 in water, which are prepared for the food industry, fish farming or drilling fluids. The process of dissolving salts in water can be time-consuming, when no or insufficient…
https://www.hielscher.com/ultrasonic-preparation-of-brines.htm
Ultrasonic Precipitation of Curcumin Superparticles
Since turmeric contains only 2-9 wt% of curcuminoids, a efficient extraction or synthesis technique is necessary to obtain a medically potent powder. Ultrasonically assisted antisolvent precipitation is a highly efficient method to synthesise curcumin particles. The ultrasonic antisolvent precipitation can…
https://www.hielscher.com/ultrasonic-precipitation-of-curcumin-superparticles.htm
Ultrasonic Formulation of Reinforced Composites
Composites show unique material properties such as significantly enhanced thermo-stability, elastic modulus, tensile strength, fracture strength and are therefore widely used in the manufacturing of manifold products. Sonication is proven to produce high-quality nanocomposites with highly dispersed CNTs, graphene etc.…
https://www.hielscher.com/ultrasonic-formulation-of-reinforced-composites.htm
Ultrasonic Extraction of Sugar from Sugar Beet Cossettes
Ultrasonic extraction enhances the yield of extracted sucrose from sugar beet cossettes and reduces the extraction process duration significantly. Sonication is a simple and safe technique, which can be easily combined with the current counter-current flow extraction technology in order…
https://www.hielscher.com/ultrasonic-extraction-of-sugar-from-sugar-beet-cossettes.htm
Sonochemically Improved Diels-Alder Reactions
Diels-Alder reactions are widely used for chemical syntheses, where atomic carbon-carbon bonds must be formed. Ultrasonication and its sonochemical effects are highly efficacious in driving and promoting Diels-Alder reactions resulting in higher yields, significantly reduced reaction time and at the…
https://www.hielscher.com/sonochemically-improved-diels-alder-reactions.htm
Perovskite Synthesis by Ultrasonication
Ultrasonically induced and intensified reactions offer a facile, precisely controllable and versatile synthesis method for the production of light-activated materials, which often cannot prepared by conventional techniques. The ultrasonic crystallization and precipitation of perovskite crystals is a highly effective and…
https://www.hielscher.com/perovskite-synthesis-by-ultrasonication.htm
Peptide Synthesis made Efficient using Sonication
Solid Phase Peptide Synthesis (SPPS) is the common method for peptide synthesis. Ultrasonication is a reliable tool to intensify solid phase peptide synthesis resulting in higher yields, improved purity, no racemization and significantly accelerated reaction speed. Hielscher Ultrasonics offers various…
https://www.hielscher.com/peptide-synthesis-made-efficient-using-sonication.htm
Nano-Encapsulated Intranasal Vaccine Against S. Pneumoniae with Ultrasonics
Nanoparticle-based drug carriers are an evolving technology, which allows to formulate vaccine delivery systems with a high protection rate against various diseases. Ultrasonic emulsification and encapsulation is a highly efficient method to prepare loaded nano-structured drug carriers such as nanoparticles,…
Ultrasonics for Oil, Gas and Renewable Fuels
Oil prices and greenhouse gases as well as the sustainability of fuel sources became a focal point of interest in the oil & gas industry. Hielscher ultrasonic devices are used in research facilities and processing plants for many applications. Ultrasonic…
Producing Biodegradable Nanospheres
Biodegradable micro- and nanospheres can be produced in a continuous, contact- and contamination-free process that can be readily run under sterile conditions. Introduction Biodegradable micro- and nanospheres (MS, NS) made of poly(lactide-coglycolide) (PLGA) or other materials are very potent drug…
Biosynthetic Production of Human Milk Oligosaccharides
The biosynthesis of human milk oligosaccharides (HMOs) via fermentation or enzymatic reactions is a complex, consuming and often low-yielding process. Ultrasonication increases the mass transfer between substrate and cell factories ans stimulates cell growth and metabolism. Thereby, sonication intensifies fermentation…
How to Ultrasonically Fat-Wash Spirits
A fat-washed spirit is an alcoholic beverage infused with oil or fat. High-power ultrasound waves produce very fine emulsions and it increases the mass transfer between the two phases. Ultrasonic fat washing, infuses the spirit with the flavor profile of…
https://www.hielscher.com/how-to-ultrasonically-fat-wash-spirits.htm
How To Disperse Single-Walled Carbon Nanotubes Individually
Single-Walled Carbon Nanotubes (SWNTs or SWCNTs) have unique characteristics, but to express them they must be individually dispersed. To make full use of the exceptional characteristics of single-walled carbon nanotubes, the tubes must be detangled most completely. SWNTs as other…
https://www.hielscher.com/how-to-disperse-single-walled-carbon-nanotubes-individually.htm
Electrode Recycling – Highly Efficient with Ultrasonic Delamination
Ultrasonic delamination of electrodes allows to recover active materials such as lithium, nickel, manganese, cobalt etc. within seconds. Thereby, ultrasonic electrode delamination makes the recovery of reusable materials from batteries faster, green, and significantly less energy-intensive. Research has already proven…
https://www.hielscher.com/electrode-recycling-highly-efficient-with-ultrasonic-delamination.htm
Clean Beauty Product Formulation with Ultrasonics
Natural, organic ingredients (INCIs) combined with high effectiveness and bioavailability are the features of innovstive clean beauty products. Ultrasonication is used as highly efficient and reliable technique to mix, blend, disperse, nano-emulsify and nano-encapsulate cosmetic ingredients. Why Should You Use…
https://www.hielscher.com/clean-beauty-product-formulation-with-ultrasonics.htm
Boron Nitride Nanotubes – Exfoliated and Dispersed using Sonication
Ultrasonication is successfully applied to the processing and dispersion of boron nitride nanotubes (BNNTs). High-intensity sonication provides homogeneous detangling and distribution in various solutions and is thereby a crucial processing technique to incorporate BNNTs into solutions and matrices. Ultrasonic Processing…
https://www.hielscher.com/boron-nitride-nanotubes-exfoliated-and-dispersed-using-sonication.htm
Ultrasonic Cleaning of Photo-Bioreactors
Microalgae can be grown in shallow ponds or photo-bioreactors. In bioreactors, an algae film tends to grow on the inner reactor surface, blocking sunlight and restricting photosynthesis. Ultrasonic cleaning - applied from the outside - removes this algae film efficiently.…
Pharmaceuticals Encapsulated in Lipid Nanoparticles with Ultrasonics
Nano-size drug carriers are widely used to deliver pharmaceutically active compounds into the targeted cells. In order to encapsulate the active substances into a drug carrier with a high bioavailability, solid lipid nanoparticles are used. Ultrasonic nano-emulsification and encapsulation is…
https://www.hielscher.com/pharmaceuticals-encapsulated-in-lipid-nanoparticles-with-ultrasonics.htm
Sonocatalysis – Ultrasonically Assisted Catalysis
Ultrasonication affects the catalyst reactivity during catalysis by enhanced mass-transfer and energy input. In heterogeneous catalysis, where the catalyst is in a different phase to the reactants, ultrasonic dispersion increases the surface area available to the reactants. Background of Sonocatalysis…
Ultrasonic Synthesis of Molecularly Imprinted Polymers (MIPs)
Molecularly Imprinted Polymers (MIPs) are artificially designed receptors with a predetermined selectivity and specificity for a given biological or chemical molecule structure. Ultrasonication can improve various synthesis pathways of molecularly imprinted polymers making the polymerization more efficient and reliable. What…
https://www.hielscher.com/ultrasonic-synthesis-of-molecularly-imprinted-polymers-mips.htm
Improved Remdesivir Solubility by Sonication
Remdesivir (GS-5734) is an anti-viral drug, which is under research for treating the Ebola virus disease and COVID-19, which is caused by the Sars-CoV-2 coronavirus. Remdesivir is pharmaceutical solution, which is administered intravenously. Whilst short ultrasonic dissolving alone enhances the…
https://www.hielscher.com/improved-remdesivir-solubility-by-sonication.htm
Ultrasonic Milling for Lipstick Manufacturing
Lipstick manufacturing involves the grinding and mixing of waxes and colour pigments on a precisely controllable level to ensure a certain colour and texture profile of the lipstick. Ultrasonic grinding and mixing is a reliable, efficient, and exactly controllable technique…
https://www.hielscher.com/ultrasonic-milling-for-lipstick-manufacturing.htm
Ultrasonic Malting and Malt Germination
Malting is a time-consuming process: the soaking and hydration of the grain seeds takes a lot of time and achieves mostly uneven results. By ultrasonication, the germination speed, rate and yield of barley can be significantly improved. Malt Production Malt…
Ultrasonic Sample Preparation for THC Analysis
Ultrasonic extraction is a proven method for the production of THC, but it can be used for analytical purposes, too. Ultrasonication is a common sample prep method used for analysis of the total content of THC in cannabis products. Ultrasonic…
https://www.hielscher.com/ultrasonic-sample-preparation-for-thc-analysis.htm
Highly Efficient Chaga Extraction via Sonication
Chaga mushrooms (Inonotus obliquus) are rich in very potent phyto-chemicals (e.g. polysaccharides, betulinic acid, triterpenoids), which are known to contribute to health and to fight diseases. Using high-power ultrasonic frequency for chaga extraction is the preferred technique to produce superior…
https://www.hielscher.com/highly-efficient-chaga-extraction-via-sonication.htm
Nootropics and Smart Drugs Formulations with Ultrasonics
Smart drugs and nootropic supplements are consumed as “cognitive enhancers” in order to increase cognitive function, brain capacity, concentration, memory and creativity, to boost motivation and mental energy as well as to support brain health. To promote the transport of…
https://www.hielscher.com/nootropics-and-smart-drug-formulations-with-ultrasonics.htm
Non-Destructive Crack Detection by Ultrasound-Thermography
Ultrasound-excited thermography (also known as vibrothermography) is a superior method for the detection of cracks in wood boards, panels and surfaces. The ultrasonic thermography provides a highly accurate, precise and fast detection without destructing the inspected material. As non-destructive detection…
https://www.hielscher.com/non-destructive-crack-detection-by-ultrasound-thermography.htm
Ultrasonically Accelerated Gypsum Crystallization
Ultrasonic mixing and dispersing accelerates the crystallization and setting reaction of gypsum (CaSO4･2H2O). Application of power ultrasonics to the gypsum slurry accelerates crystallization thereby reducing the setting time. Besides a faster setting, the produced wall boards exhibit a reduced density.…
https://www.hielscher.com/ultrasonically-accelerated-gypsum-crystallization.htm
High Shear Mixing with Ultrasonics
High shear mixers apply high shear forces into liquids and slurries in order to provide the uniform dispersing, blending, and emulsification of two or more liquid-solid or liquid-liquid phases. Ultrasonication generates high shear forces via acoustic cavitation, which occurs when…
https://www.hielscher.com/high-shear-mixing-with-ultrasonics.htm
Ultrasonically Assisted Draw-Peeling of Wire Rods (UADP)
The draw-peeling of wire rods improves the surface quality significantly by the peeling of material from the outer material perimeter. It is a widely known alternative to rotary-peeling, sandblasting or grinding. Ultrasonically assisted draw-peeling uses a high-frequency vibration of the…
https://www.hielscher.com/ultrasonically-assisted-draw-peeling-of-wire-rods-uadp.htm
Ultrasonic Spray Pyrolysis
Ultrasonic Spray Pyrolysis (USP) is one of the important techniques to synthesize nano materials and to coat substrates with thin film coatings. Ultrasonic spraying and atomization allows for full process control resulting in homogeneous high-quality output. Ultrasonic spray pyrolysis excels…
Ultrasonic Nano-Emulsification for Microencapsulation before Spray-Drying
In order to microencapsulate active ingredients via spray-drying, a fine-sized stable micro- or nanoemulsion must be prepared. Ultrasonic emulsification is a facile and reliable technique to produce stable micro- and nano-emulsions As alternative surfactant, biopolymers such gum arabi or WPI…
Ultrasonic Borophene Synthesis on Industrial Scale
Borophene, a two-dimensional nanostructured derivative of boron, can be efficiently synthesized via a facile and low-cost ultrasonic exfoliation. Ultrasonic liquid-phase exfoliation can be used to produce large quantities of high-quality borophene nanosheets. The ultrasonic exfoliation technique is widely used to…
https://www.hielscher.com/ultrasonic-borophene-synthesis-on-industrial-scale.htm
Ellagitannin Extraction from Pomegranate
Ellagitannins are a precursor for the age-defying compound urolithin A, which is converted from ellagitannins by the gut microbiome. Ultrasonic extraction promotes the release of ellagitannins from fruit and vegetal cells to produce supplements and pharmaceuticals with a highly concentrated…
https://www.hielscher.com/ellagitannin-extraction-from-pomegranate.htm
Ultrasonics for the Spinning of Polymer Fibers
Spinning of polymer fibers for use in textiles and fabrics is a specialized form of extrusion, that uses a spinneret to form multiple continuous synthetic filaments. Ultrasonics can be used for various types of spinning: dry, jet-wet, melt and gel…
https://www.hielscher.com/ultrasonics-for-the-spinning-of-polymer-fibers.htm
Ultrasonic Meat Tenderizing
Ultrasonic tenderizing of meat is a quick and easy mechanical method. Ultrasonic tenderization is successfully used in kitchens and industrial processing lines. Hielscher Ultrasonics offers two options: compact sonicators for the easy and convenient tenderization in restaurants. high-power ultrasonic systems…
Ultrasonically Promoted Michael Addition Reaction
Asymmetric Michael reactions are a type of organocatalytic reactions, which can benefit heavily from sonication. The Michael reaction or Michael addition is widely used for chemical syntheses, where carbon-carbon bonds are formed under mild conditions. Ultrasonication and its sonochemical effects…
https://www.hielscher.com/ultrasonically-promoted-michael-addition-reaction.htm
Superior Nano-Fuels by Ultrasonic Dispersion
Ultrasonic dispersion is used to produce nanofuels or diesohol, a fuel blend of ethanol and diesel, which is improved by the addition of CNTs or nanoparticles. Power ultrasonics produces super-fine, nano-fuel emulsions and dispersions. Ultrasonically dispersed nanoparticles in fuels improve…
https://www.hielscher.com/superior-nano-fuels-by-ultrasonic-dispersion.htm
Ultrasonic Ballast Water Disinfection
The ultrasonic treatment system has demonstrated to be effective in the killing of bacteria, plankton, and larger organisms. The ultrasonic disinfection of ballast water is a mechanical/ physical treatment, which avoids the dosing of any strong and expensive active chemicals…
https://www.hielscher.com/ultrasonic-ballast-water-disinfection.htm
Ultrasonic Wet-Milling and Micro-Grinding
Ultrasonication is an efficient means for the wet-milling and micro-grinding of particles. Besides dispersing and deagglomerating, the wet milling is an important application of Hielscher ultrasonic devices. In particular for the manufacturing of superfine-size slurries, ultrasound has many advantages, when…
Cavitation Erosion Testing
Cavitation erosion occurs on material surfaces that are exposed to intense ultrasonic cavitation. Cavitation erosion testing is a fast method to measure erosion resistance of materials or coatings to intense stress and other erosion factors. It provides an easy quantitative…
Technical Training and Service
Hielscher offers extensive service to support your ultrasonic process R&D, engineering, process testing and optimization as well as installation support and maintenance training. Hielscher's service and training programs save customers time and money. A wide range of service options are…
Ultrasonics in Vinegar Manufacturing and Aging
Vinegar, such as balsamic is an important condiment in cuisine. Hielscher ultrasonic devices are used for many processes in the manufacturing and maturation of vinegar. Background on Vinegar Production The production of vinegar, especially of high quality products, such as…
Ultrasonically-Assisted Ultrafiltration
Ultrafiltration (UF) is frequently used in the dairy industry for the concentration of whey. Ultrasonically-assisted ultrafiltration processes enhance the efficiency of whey separation processes during ultrafiltration of whey solutions. Hielscher Ultrasonics offers various options to integrate high power ultrasonics into…
https://www.hielscher.com/ultrasonically-assisted-ultrafiltration.htm
Sonication Improves Fenton Reactions
Fenton reactions are based on the generation of free radicals such as hydroxyl •OH radical and hydrogen peroxide (H2O2). The Fenton reaction can be significantly intensified when combined with ultrasonication. The simple, but highly efficacious combination of Fenton reaction with…
https://www.hielscher.com/sonication-improves-fenton-reactions.htm
Ultrasonic Resveratrol Inclusion Complex
Resveratrol is a polyphenol, which promises many health benefits, e.g. prolonging life span, and to treat heart disease, diabetes, cancer, Alzheimer's as well as other chronic conditions. However, resveratrol has a low bioavailability and shows a rapid clearance from the…
https://www.hielscher.com/ultrasonic-resveratrol-inclusion-complex.htm
Ultrasonic Disintegration: Wetting, Dissolving, Dispersing
Ultrasonic integrators are widely used to wet, disperse or dissolve particles and powders into liquids. High-performance ultrasonicators create intense shear forces, which break and shatter aggregates, agglomerates and primary particles to microscopic or nano size. The uniform particle processing in…
https://www.hielscher.com/disintegration-wetting-dissolving-dispersing.htm
Why is a Probe-Type Ultrasonicator Best for Mushroom Extraction?
Are you wondering why your mushroom extraction using an ultrasonic bath or an ultrasonic cleaning tank does not give you the desired extract yield? Learn here all you need to know about the rigid chitin-containing cell walls of mushrooms, the…
https://www.hielscher.com/why-is-a-probe-type-ultrasonicator-best-for-mushroom-extraction.htm
Fast And Simple Ultrasonic Cannabis Extraction
To meet the rising demand and to supply cannabinoids of high quality, an efficient and reliable cannabis extraction method is substantial. Ultrasonic extraction is proven to shorten the extraction time and to increase yield considerably. With power ultrasound, cannabis extraction…
https://www.hielscher.com/fast-simple-ultrasonic-cannabis-extraction.htm
Lubricants with Nanoparticle-Improved Functionalities
Lubricating oils can greatly benefit from nano-additives, which help to reduce friction and wear. It is however crucial, that nano-additives such as nanoparticles, graphene monolayers or core-shell nanospheres are uniformly and single-dispersed in the lubricant. Ultrasonic dispersion has been proven…
https://www.hielscher.com/lubricants-with-nanoparticle-improved-functionalities.htm
W.Last – High Quality Extracts with Sonication
W.Last is an experienced company based in South Africa, which specializes in the production of premium extracts and tinctures from botanicals. W.Last uses ultrasonic extraction to manufacture their high-quality extracts, which are used for medicinal purpose, food flavouring and in…
https://www.hielscher.com/w-last-high-quality-extracts-with-sonication.htm
Silymarin Extraction from Milk Thistle – Most Efficient with Ultrasonication
Silymarin is a standardized extract from milk thistle seeds and contains mainly several flavonolignans such as silibin. Silymarin is well-known for various medicinal effects and thereby used in pharmaceuticals and supplements. Ultrasonic extraction has been proven to be the most…
Sonication for Drug Testing and Drug Potency Analysis
Ultrasonic homogenization and extraction is a common sample preparation technique before drug analysis, e.g. for quality tests, evaluation of raw materials and potency tests. Probe-type ultrasonicators are widely used for the release of active substances such as APIs, bioactive plant…
https://www.hielscher.com/sonication-for-drug-testing-and-drug-potency-analysis.htm
Pharmaceutical Nanosuspensions with Improved Bioavailability
Nanosuspensions prepared by sonication show a significant improved pharmacological bioavailability. Especially drug molecules with poor water-solubility, which reduces its bioavailability and effect onset, benefit from the nanosizing technique of ultrasonication. Ultrasonication is used reduce drug particles and crystals to nanometer…
https://www.hielscher.com/pharmaceutical-nanosuspensions-with-improved-bioavailability.htm
Click Chemistry – How to Enhance Click Reactions with Sonication
Click chemistry reactions such as copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions can greatly benefit from the application of power ultrasound. Sonochemical effects increase yield and conversion rate. Additionally, the overall efficiency of click chemistry reactions is improved. As a technique of…
https://www.hielscher.com/click-chemistry-how-to-enhance-click-reactions-with-sonication.htm
Ultrasonic Extraction of Cellular Matter
Ultrasonic extraction or sono-extraction is a process intensifying technology, which works by the coupling of high power ultrasonics into a slurry of plant or cell tissue. Hielscher Ultrasonics supplies reliable ultrasonicators for cell disruption and extraction from small lab samples…
https://www.hielscher.com/ultrasonic-extraction-of-cellular-matter.htm
Ultrasonic Disintegrators
Cell disintegration is a common task in biotechnology and in many applications that involve processing cells and intracellular material. Ultrasonic cell disintegrators are efficient and reliable, when it comes to breaking cell wall or membranes of plant cells, mammalian tissue,…
Power Ultrasound for Particle Treatment: Application Notes
To express their characteristics completely, particles must be deagglomerated and evenly dispersed so that the particles' surface is available. Powerful ultrasound forces are known as reliable dispersing and milling tools that beak particles down to submicron- and nano-size. Furthermore, sonication…
https://www.hielscher.com/power-ultrasound-for-particle-treatment-application-notes.htm
High-Shear Mixers for Toothpaste Manufacturing
Toothpaste manufacturing is a demanding process that requires mixing equipment capable to handle viscous pastes, high solid concentrations and abrasive particles. Ultrasonic high-shear mixers provide high-intensity shear forces that provide thorough wetting of powders, uniform homogenisation of colloidal slurries and…
Efficient Biorefineries via Ultrasonic Process Intensification
Ultrasonication is a process intensifying technique, which is implemented into various processes in biorefineries. Typical processes that benefit significantly from ultrasonic treatment are extraction, slow heterogeneous reactions as well as other applications that involve intense mixing, homogeniaztion and dispersing. Ultrasonication…
https://www.hielscher.com/more-efficient-biorefineries-by-ultrasonic-process-intensification.htm
Nasal Spray Formulations Emulsified with Ultrasound
Nasal sprays and mouth sprays are widely used drug administering solutions to apply active ingredients to the respiratory mucosa. Ultrasonic emulsification is a highly efficient and reliable technique to produce highly efficacious nasal and mouth spays with very high bioavailability,…
https://www.hielscher.com/nasal-spray-formulations-emulsified-with-ultrasound.htm
Optimized Chemical Reactor Efficiency by High-Power Ultrasonication
Ultrasonication is well known to intensify and/or initiate chemical reactions. Therefore, the integration of high-performance ultrasound is considered as reliable tool to promote chemical reactors for improved reaction outcomes. Hielscher Ultrasonics offers various reactor solutions to tweak your chemical process.…
https://www.hielscher.com/optimized-chemical-reactor-efficiency-by-high-power-ultrasonication.htm
Supercritical Fluid Extraction Improved by Power Ultrasonics
Ultrasonic extraction alone or in combination with alternative extraction methods such as solvent extraction or supercritical CO2 extractors is successfully used to extract the full spectrum of cannabinoids from the cannabis plant (hemp and marijuana). In marijuana, the main cannabinoid…
https://www.hielscher.com/supercritical-fluid-extraction-improved-by-power-ultrasonics.htm
How to Mix Varnishes with Nanofillers
Varnish production requires powerful mixing equipment that can handle nano-particles and pigments, which must be uniformly dispersed into the formulation. Ultrasonic homogenizers are highly efficient and reliable dispersing technique which provide a homogeneous distribution of the nanoparticles into polymers. Varnish…
https://www.hielscher.com/how-to-mix-varnishes-with-nanofillers.htm
High-Performance Adhesive Formulations – Improved by Ultrasonic Dispersion
High-performance adhesives are composed from epoxy, silicone, polyurethane, polysulfide, or acrylic systems containing various (nano-)fillers and additives, which give the adhesive special performance such as bond strength, light weight, durability, heat-resistance, and sustainability. Efficient and reliable mixing is required to…
Ageing and Oaking of Wines with Ultrasound
Wine ageing and oaking contribute heavily to the final taste and quality of wine. Both processes are known to undertake long time, often the maturation process goes over serval years. Ultrasound is a highly efficacious and rapid technology, which intensifies…
https://www.hielscher.com/ageing-and-oaking-of-wines-with-ultrasound.htm
Cleaning and Sanitizing Wine Barrels Efficiently with Ultrasound
Oak barrels for wine ageing can be efficiently cleaned and sanitized using power ultrasound. By sonication, tartrate is removed and microorganisms such as yeast (Brettanomyces, Dekkera) are killed. Additionally, wooden aroma compounds become more available when the barrels are used…
https://www.hielscher.com/cleaning-and-sanitizing-wine-barrels-efficiently-with-ultrasound.htm
Polyphenol-Rich Wines with Power-Ultrasound
Ultrasonication improves the extraction of phenolic compounds from grape to must, which contributes to the total polyphenol content - thereby improving the further ageing process of wine. The application of power ultrasound gives higher extraction yields and accelerates the maturation…
https://www.hielscher.com/polyphenol-rich-wines-with-power-ultrasound.htm
Sonofragmentation – The Effect of Power Ultrasound on Particle Breakage
Sonofragmentation describes the breakage of particles into nano-sized fragments by high power ultrasound. In contrast to the common ultrasonic deagglomeration and milling - where particles are mainly grinded and separated by inter-particle collision - , sono-fragementation is distinguished by the…
https://www.hielscher.com/sonofragmentation-the-effect-of-power-ultrasound-on-particle-breakage.htm
Sonochemically Improved Mannich Reactions
Mannich reaction are important carbon–carbon bond forming reactions, which are widely used in industries such as the pharmaceutical production and the synthesis of natural products. Whilst most of one-pot Mannich reactions are very slow, the positive effects of ultrasonication on…
https://www.hielscher.com/sonochemically-improved-mannich-reactions.htm
Plasmid Preparation using Ultrasonication
Ultrasonication is a reliable technique to fragment plasmid DNA. Precisely controllable amplitude, pulsation mode and temperature control are most important features of an ultrasonicator for non-damaging plasmid fragmentation. Additionally, the use of certain agents help to protect against plasmid degradation.…
https://www.hielscher.com/plasmid-preparation-using-ultrasonication.htm
MultiSonoReactor for High-Throughput Inline Sonication
The Hielscher MultiSonoReactor is an ultrasonic flow-through reactor for large scale processing of liquids and slurries. Depending on the configuration, the MultiSonoReactor can process liquids and slurries with up to 30kW ultrasound power. Optimized flow conditions within the reactor ensure…
https://www.hielscher.com/multisonoreactor-for-high-throughput-inline-sonication.htm
Ultrasonic Emulsifiers
An emulsion is a two-phase system of two immiscible liquids, where one phase, the so-called internal or dispersed phase, is distributed as small droplets into the other, so-called external or continuous, phase. To prepare an emulsion, generally energy input into…
UTR200 – Powerful Ultrasonic Cup Horn
The UTR200 is a powerful ultrasonic device with a cup-horn shaped sonotrode. It can be used as a high intensity ultrasonic bath or - when closed - as an ultrasonic reactor for inline sonication. The UTR200 is mostly used for…
Ultrasonic Marine Fuel Desulphurization
Marine fuels are affected by new regulations, which require a sulphur content of 0.5%m/m or less. Ultrasound-assisted oxidative desulfurization (UAOD) is an established method that accelerates the oxidation reaction and is an economical and safe process. UAOD processes can be…
https://www.hielscher.com/ultrasonic-marine-fuel-desulphurization.htm
Ultrasonic Extraction of Bioactive Compounds from Bitter Melon
Bitter melons (also known as bitter apple, bitter gourd, bitter squash, balsam-pear) is a fruit high in health-beneficial compounds such as antioxidants, flavonoids, phytosterols, and saponins. Sonication is well known to intensify the extraction of bioactive substances from botanicals. Ultrasonic…
https://www.hielscher.com/ultrasonic-extraction-of-bioactive-compounds-from-bitter-melon.htm
Hemp Extraction by Ultrasonic Equipment
Hemp extraction using ultrasonic solvent extraction equipment is a simple, cost-efficient and very scaleable method to extract CBD (cannabidiol) from hemp. Ultrasonic hemp extractors are easy to install and can extract hemp in batches or inline for higher throughput. Ultrasonic…
https://www.hielscher.com/hemp-extraction-by-ultrasonic-equipment.htm
Highly Efficient Ginger Extraction by Sonication
Ultrasonic extraction of essential oils and active compounds from ginger convinces by high efficiency and high yields. Ultrasonic extraction is a mild, non-thermal process which yields in high quality extracts. Whilst other extraction methods are limited in their upscaling capability,…
https://www.hielscher.com/highly-efficient-ginger-extraction-by-sonication.htm
Surfactant-Free Cosmetic Emulsions by Power Ultrasonics
Due to the increasing demand for eco-friendly cosmetics, the cosmetic industry is focussing on the formulation of surfactant-free emulsions. Pickering emulsions are surfactant-/emulsifier-free w/o- or o/w-mixtures stabilized by particles. Ultrasonic mixing and emulsification is an excellent technique to formulate highly…
https://www.hielscher.com/surfactant-free-cosmetic-emulsions-by-power-ultrasonics.htm
Ultrasonic Powder Compacting
Hielscher Ultrasonics makes devices for the ultrasonic agitation of containers, vials, reactors or columns. The ultrasonic vibrations can shake powder particles after filling, in order to obtain a denser and or uniform powder packing. Bulk density or packing density of…
Sonochemical Synthesis of Electrode Materials for Battery Production
In the production of high-performance battery cells, nanostructured materials and nanocomposites play an important role providing superior electric conductivity, higher storage densities, high capacity and reliability. In order to attain full functionalities of nanomaterials, nano-particles must be individually dispersed or…
https://www.hielscher.com/sonochemical-synthesis-of-electrode-materials-for-battery-production.htm
SonoStep – Sample Preparation in a Single-Step
The SonoStep combines ultrasonication, stirring and pumping of samples in a compact design. It is easy to operate and can be used to deliver sonicated samples to analytic devices, e.g. for particle size measurement. Ultrasonication helps to disperse agglomerated particles…
Ultrasonic Lysis of Bioengineered Cells in Industrial Production
Bioengineered bacteria species such E. coli as well as genetically modified mammalian and plant cell types are used widely in biotech to express molecules. In order to release these synthesized bio-molecules, a reliable cell disruption technique is required. High-performance ultrasonication…
https://www.hielscher.com/ultrasonic-lysis-of-bioengineered-cells-in-industrial-production.htm
Ultrasonically Agitated Syringe Filter for Higher Throughputs
Ultrasonically agitated syringe filters enable to work at higher flow rates and loading capacities. Samples with higher solid contents can be reliable and efficiently processed using an ultrasonically vibrated syringe filters. This allows for higher throughputs. Ultrasonically agitation of syringe…
https://www.hielscher.com/ultrasonically-agitated-syringe-filter-for-higher-throughputs.htm
Various Solutions for Phosphorus Recovery from Municipal Sewage Sludge
Phosphorus is a critical resource mineral, which natural supply is diminishing rapidly. Consequently, the German government enacted by decree that from 2029 phosphorus must be largely recovered from sewage sludge. The implementation of power ultrasound opens various options to intensify…
https://www.hielscher.com/various-solutions-for-phosphorus-recovery-from-municipal-sewage-sludge.htm
UP200H / UP200S – Ultrasonic Power for the Lab
The ultrasonic lab devices UP200H (200W, 24kHz) and UP200S (200W, 24kHz) are well suited for all general ultrasonic applications in small and medium scale. The applications include: Homogenization, disintegration, emulsification, cell disruption, degassing or sonochemistry. The production of these models…
Organocatalytic Reactions Promoted by Sonication
In organic chemistry, organocatalysis is a form of catalysis in which the rate of a chemical reaction is increased by an organic catalyst. This "organocatalyst" consists of carbon, hydrogen, sulfur and other nonmetal elements found in organic compounds. The application…
https://www.hielscher.com/organocatalytic-reactions-promoted-by-sonication.htm
Ultramicronization and Nano-Formulation of Palmitoylethanolamide (PEA)
The fatty acid amide palmitoylethanolamide (PEA) is used as oral drug administered for its anti-inflammatory and neuroprotective effects. However, being a lipid and expressing a large particle size, the bioavailability and bioaccessibility of palmitoylethanolamide (PEA) is limited due its poor…
https://www.hielscher.com/ultramicronization-and-nano-formulation-of-palmitoylethanolamide-pea.htm
Ultrasonic Preparation of Catalysts for Dimethyl Ether (DME) Conversion
Dimethyl ether (DME) is a favourable alternative fuel, which can be synthesised from methanol, CO2 or syngas through catalysis. For the catalytic conversion to DME, potent catalysts are required. Nano-sized mesoporous catalysts such as mesoporous acidic zeolites, decorated zeolites or…
https://www.hielscher.com/ultrasonic-preparation-of-catalysts-for-dimethyl-ether-dme-conversion.htm
Industrial Ultrasonic Devices
Hielscher industrial ultrasonic devices are powerful, efficient and reliable. They are built to operate continuously at high load in industrial environments. With up to 16 kilowatts per device, Hielscher is the leading ultrasonics supplier for industrial liquid processes. Ultrasonic liquid…
Sonication in Multi-Neck Flasks
Sonication is widely used for chemical and biochemical reactions. Hielscher supplies standardized ground joint adapters to insert the ultrasonic sonotrode into reaction vessels such as round-bottom flasks, multi-neck flasks and other lab glass ware. For a sophisticated setup of an…
https://www.hielscher.com/sonication-in-multi-neck-flasks.htm
Ultrasonic Collagen Extraction from Jellyfish
Jellyfish collagen is a high-quality collagen, which is unique but exhibits similar properties to type I, II, III and type V collagen. Ultrasonic extraction is a purely mechanical technique, that increases yield, accelerates the process and produces high molecular weight…
https://www.hielscher.com/ultrasonic-collagen-extraction-from-jellyfish.htm
Ultrasonic Collagen Extraction
Collagen is rich in proteins and is widely used in manifold industrial applications, e.g. food, pharma, additives etc. Sonication can be easily combined with enzymatic or acid extraction of collagen. The implementation of ultrasonics into the collagen extraction process results…
https://www.hielscher.com/ultrasonic-collagen-extraction.htm
Ultrasonic Tank Agitators
Ultrasonic tank agitators are mechanical agitators. Ultrasonic agitation mixes liquids with other liquids or solids to improve process kinetics in chemical, food, pharmaceutical and cosmetic manufacturing. Hielscher Ultrasonics agitators range in size from lab agitators to industrial tank agitators for…
Water-Soluble Nano-THC Formulations With Sonication
The formulation of THC-enhanced beverages is challenging. - THC-infused drinks must be nano-emulsified in order to provide a high bioavailability and thereby potency, long-term stability and clear appearance. Ultrasonic nano-emulsification of THC into beverage is highly efficient and efficacious resulting…
https://www.hielscher.com/water-soluble-nano-thc-formulations-with-sonication.htm
Remote Foot Switch / Pedal for Ultrasonic Homogenizers
Foot switches are available for almost all of our ultrasonic devices. Please see the compatibility chart for details. The switches can be used to control the devices remotely by activating the foot pedal. This keeps your hands free, e.g. to…
https://www.hielscher.com/remote-foot-switch-pedal-for-ultrasonic-homogenizers.htm
UPcontrol V2.3 WIN – PC-Interface
As an option, our ultrasonic processors can be equipped or retrofitted with an UPcontrol package. This PC-control gives automation of the ultrasonic process parameters, such as amplitude, pulse/cycle, operating time or alternatively the actual energy input. It serves for the…
Sanitary Pressure Sensor / Transmitter for Ultrasonic Homogenizers
Liquid pressure is a significant influence on sonication process efficiency. For this reason, Hielscher offers sanitary pressure sensors (PS7D and PS70) for use with all its ultrasonic devices with Touch control. Please see the compatibility chart for details. In combination…
https://www.hielscher.com/sanitary-pressure-sensor-for-ultrasonic-homogenizers.htm
Centrifugal Ultrasonic Reactor for Separation
Hielscher Ultrasonics designs custom ultrasonic reactors for special processes. The centrifugal reactor is used for ultrasonically assisted separation processes. This includes the separation of gas or solids from liquids. The liquid media enters the reactor tangentially at high speed on…
https://www.hielscher.com/centrifugal-ultrasonic-reactor-for-separation.htm
Ultrasonics in Virus Research
Ultrasonic lysis and extraction is a reliable and long-time established method for the disruption of cells and the subsequent release of viruses, viral proteins, DNA, and RNA. Ultrasonics in Coronavirus Research The extraction of viruses from organ tissue is an…
Clear Nano-Emulsions with Stuph and Ultrasonics
Clear nano-emulsions have a wide range of applications in food, beverage and cosmetic formulations. Stuph Corp supplies is various food-grade, high-quality emulsifiers for the preparation of clear nano-emulsions for the use in food, drinks, tinctures, concentrates as well as skin…
https://www.hielscher.com/clear-nano-emulsions-with-stuph-and-ultrasonics.htm
Improved Fischer-Tropsch Catalysts with Sonication
Improved Synthesis of Fischer-Tropsch Catalysts with Ultrasound: Ultrasonic treatment of catalyst particles is used for several purposes. Ultrasonic synthesis helps to create modified or functionalized nano-particles, which have a high catalytic activity. Spent and poisoned catalysts can be easily and…
https://www.hielscher.com/improved-fischer-tropsch-catalysts-with-sonication.htm
Improved Textile Fiber Dyeing with Ultrasonics
Ultrasonically assisted dyeing of fibers and fabrics improves the penetration of the dye into the fiber pores and increases colour strength and colour fastness significantly. Ultrasonic dyeing is a rapid process, which can be run under mild conditions and low…
https://www.hielscher.com/improved-textile-fiber-dyeing-with-ultrasonics.htm
Ultrasonic Phosphor Recovery from Sewage Sludge
The worldwide demand for phosphor is increasing, whilst the supply of natural phosphorus resources are getting scarce. Sewage sludge and sewage sludge ash are rich in phosphorus and can be therefore used as source to reclaim phosphorus. The ultrasonic wet-chemical…
https://www.hielscher.com/ultrasonic-phosphor-recovery-from-sewage-sludge.htm
Ultrasonic Hemp Fibre Processing
Ultrasonic retting of fibrous materials such as hemp and flax fibers allows for a fast and efficient fiber modification. Ultrasonically processed bast fibers are fibrillated and show a significantly higher specific surface, increased tensile strength and flexibility. Ultrasonic fiber processing…
https://www.hielscher.com/ultrasonic-hemp-fibre-processing.htm
Ultrasonic Extraction of Quillaja Saponins
Saponin extracts of the Quillaja saponaria Molina tree are the main source of saponins for industrial applications. Ultrasonic extraction of Quillaja saponins yields in high quality saponins. Ultrasonic extraction is a highly efficient method to produce high yields of Quillaja…
https://www.hielscher.com/ultrasonic-extraction-of-quillaja-saponins.htm
Ultrasonic Steeping of E-Liquids
Ultrasonic steeping enhances the flavour of e-liquids / e-juices significantly. The ultrasonic steeping treatment offers two major benefits: First, ultrasonic steeping gives a unique flavour profile, which is characterized by a full, round and smooth taste. Secondly, with an industrial…
https://www.hielscher.com/ultrasonic-steeping-of-e-liquids.htm
Ultrasonic Preparation of Platelet Rich Serum
Platelet-rich plasma (PRP) is blood plasma that has been enriched with platelets, which is used for medical and estethic treatments. Ultrasonic lysis and conditioning is an very effective method to prepare platelet-rich plasma. Hielscher Ultrasonics offers various ultrasonic systems matching…
https://www.hielscher.com/ultrasonic-preparation-of-platelet-rich-serum.htm
Ultrasonically Intensified Fixed Bed Reactors
Ultrasonic mixing and dispersion activates and intensifies the catalytic reaction in fixed bed reactors. The sonication improves the mass transfer and increases thereby efficiency, conversion rate and yield. An additional benefit is the removal of passivating fouling layers from the…
https://www.hielscher.com/ultrasonically-intensified-fixed-bed-reactors.htm
Custom Development for Ultrasonic Process Solutions
Hielscher Ultrasonics has a highly experienced R&D team of technical designers and engineers, which allows to offer the development and customized manufacturing of high-power ultrasound systems and processes. Our development services include the following services: Our technical engineer services, which…
https://www.hielscher.com/custom-development-of-ultrasonic-equipment-processes.htm
Power-Ultrasound for Advanced Microbial Stability of Paints
Microbial deterioration can damage both water- and solvent-borne paint formulations. Environmental regulations restrict the use of biocides. Sonication is an environmental-friendly, effective method of paint preservation. Power ultrasound allows even for the recycling of microbially spoilt paints and coatings. Ultrasonic…
https://www.hielscher.com/power-ultrasound-for-advanced-microbial-stability-of-paints.htm
Hielscher – We Manufacture Ultrasonics!
To deliver you with the best quality and service for your process, we at Hielscher Ultrasonics manufacture our range of products ourselves. From idea, development and CAD drawings to machining, assembly and testing, we take great satisfaction and have an…
Hielscher Cascatrode – High Surface Sonication Probe
Hielscher Cascatrodes™ are special design sonotrodes (ultrasonic probes) for the effective sonication at elevated ultrasonic power levels at low or medium sonication intensities - typically below 60W/cm² and below 60 micron amplitude. Hielscher developed the Cascatrode™ for industrial processing applications.…
Crystallization of Cannabinoids with Sonication
Crystallization is a necessary process step in order to produce crystalline CBD isolate. Ultrasonic nano-crystallization (sono-crystallization) is widely used to prepare crystalline isolates such as CBD isolate from a supersaturated solution. By high-power ultrasound frequency waves, intense agitation promotes the…
https://www.hielscher.com/crystallization-of-cannabinoids.htm
Ultrasonic Decarboxylation of Cannabinoids
Decarboxylated cannabinoids such as CBD, THC and CBG amongst many others are known as the active form, which shows more impactful and successful effects in the human body (i.e. endocannbinoid system). Ultrasonication is a highly effective technique to extract an…
https://www.hielscher.com/ultrasonic-decarboxylation-of-cannabinoids.htm
Turbo Extraction of Cinnamon with Ultrasonics
Traditional cinnamon extraction is time-consuming and relatively inefficient. Ultrasonic extraction is a simple, yet highly efficient process intensifying technique wich reduces the extraction time to a few hours and increases simultaneously the cinnamon essential oil yield. Improved Cinnamon Extraction with…
https://www.hielscher.com/turbo-extraction-of-cinnamon-with-ultrasonics.htm
UIP1000-Exd – 1.0kW ATEX Ultrasonic Mixer
The UIP1000-Exd (20kHz, 1000W) is designed for the ultrasonication of flammable liquids, e.g. solvents in hazardous environments (ATEX). It is used for applications, such as emulsifying, dispersing & particle fine milling, or homogenizing. The ATEX certified UIP1000-Exd is manufactured for…
Ultrasonication and Renewable Fuels
Biodiesel, bioethanol and biogas are three ways to convert organic material into green fuels. Ultrasonication improves energy yield and conversion efficiency. Renewable fuels enjoy increasing demand as oil prices mark new heights. The application of ultrasonic technology to the production…
Worldwide Power Plugs for Ultrasonic Devices
Type Voltage Picture Country / Specification B 115V~ USA NEMA 5-15P Canada CSA CAN/CSA-22.2 No.21-95 Japan JIS C 8303 Taiwan CNS 6797 Thailand D 230V~ South Africa SABS 164-1 F 230V~ Belgium NBN C 61-112-1 Brazil NBR 14136 Denmark Afsnit…
Ultrasonic Mini Flow Cell
Usually intensive ultrasound is transmitted into small volumes via a titanium sonotrode immersed into the liquid. This method is very efficient but has the side effect that there is also cavitation at the sonotrode, which results in a small contamination…
UIP10000 – High Power Ultrasonic Clusters
With its 10,000 watts, the UIP10000 is the second largest ultrasonic processor. It is designed to work in clusters of four or more units, for large volume processing, such as homogenizing, dispersing and deagglomeration. Ultrasonic applications can be scaled up…
UIP4000 – High Ultrasonic Output Power
The UIP4000 (4,000 watts, 20kHz) is used mainly for the industrial processing of liquids such as homogenizing, dispersing, disintegrating or deagglomerating. The powerful ultrasonic processor UIP4000 is used when high power is needed for continuous operation. It is controlled by…