Ultrasonicators and Probes for Liquid Processing

Hielscher Ultrasonics offers a complete range of high-performance sonicators – from compact lab devices to robust industrial systems. Engineered for precision and reliability, our ultrasonic processors deliver reproducible results for sample preparation, particle size reduction, extraction, and chemical processing.

Hielscher Ultrasonics is a leading manufacturer of probe-type ultrasonic processors for sample preparation, particle size reduction, extraction, emulsification, and chemical processing.
From compact laboratory sonicators to powerful industrial ultrasonic homogenizers, our systems deliver reproducible results with maximum energy efficiency.
Engineered in Germany, Hielscher sonicators are trusted worldwide in material science, chemistry, biology, pharmaceuticals, and food technology. Whether you process microliter volumes or thousands of liters per hour, we offer a scalable ultrasonic solution tailored to your application.

Complete Range of Hielscher Sonicators

Laboratory Sonicators

Ideal for research and small-batch processing, our lab devices combine precision control with versatility. Models like the UP100H, UP200St and UP400St are compact yet powerful – ideal for direct probe-type sonication for volumes from 0.1 mL to several liters.

 

Multi-Sample Sonicators

For parallel sample processing, our VialTweeter and UIP400MTP systems allow contamination-free sonication of multiple vials or microtiter plates simultaneously. These solutions are ideal for analytical labs, high-throughput screening, and pharmaceutical workflows where reproducibility is essential.

Typical lab applications include:

• Cell disruption & lysis for DNA/RNA extraction
• Homogenization of suspensions and emulsions
• Particle size reduction to the nano-scale
• Solvent-based and solvent-free extractions

 

Pilot-Scale Sonicators

Bridge the gap between lab development and industrial production with our UIP1000hdT and UIP2000hdT systems. These units are perfect for process optimization, scale-up studies, and medium-scale manufacturing.

 
 

Industrial Ultrasonic Systems

Our industrial processors, such as the UIP4000hdT, UIP6000hdT, and UIP16000hdT, handle continuous operation under full load, with processing capacities of up to several cubic meters per hour. Robust design ensures reliability in demanding environments, from chemical reactors to food processing lines.

 

Key Features and Advantages

• Probe-Type Sonication Technology: Direct energy transfer into the medium for superior efficiency. Learn why probe-type sonication excels ultrasonic baths!
• Digital Control & Data Logging: Precision amplitude adjustment, temperature monitoring, and automatic process recording.
• Linear Scalability: Identical processing parameters from the smallest lab sample to full-scale production.
• Versatile Applications: Emulsification, dispersion, extraction, degassing, sonochemistry, cell lysis.
• Durability: Built for continuous 24/7 operation in laboratory and industrial settings.

Applications of Hielscher Sonicators

Nanomaterials & Particle Size Reduction
Produce stable suspensions and nanoscale dispersions with controlled particle size distribution – critical for advanced materials, coatings, and energy storage technologies.
Cell Disruption & Lysis
Efficiently break cell walls to release intracellular compounds, ideal for molecular biology, proteomics, and pharmaceutical research.
Emulsification
Create nanoemulsions with enhanced stability for pharmaceuticals, cosmetics, and functional foods.
Chemical Processing
Harness sonochemistry for synthesis, catalysis, and functionalization, increasing reaction rates and yields.
Extraction of Bioactives
Recover valuable compounds from plant materials using solvent-based or green extraction methods, with improved yield and reduced processing time.

 

Custom Solutions and Support
Hielscher offers customized ultrasonic processing systems to meet specific industry requirements. Our application lab can conduct process feasibility studies and optimize your parameters before scaling up to production.

Accessories include:

• Flow cells for continuous processing
• Sonotrodes/probes of various diameters
• Temperature and pressure sensors
• Cooling solutions for temperature-sensitive materials

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Frequently Asked Questions about Sonicators

What is a probe-type sonicator?

A probe-type sonicator transmits ultrasonic energy directly into a liquid medium via a titanium probe (sonotrode), ensuring high-intensity cavitation and efficient mixing or disruption.

How do I scale sonication from lab to production?

Hielscher systems are designed for parameter transferability, allowing identical results across different device sizes.

Which applications benefit most from ultrasonication?

Any process requiring intense mixing, emulsification, particle size reduction, or cell disruption can benefit, from nanoparticle production to botanical extraction.

Applications of Hielscher Sonicators

The list of ultrasonic processes below links directly to detailed topic pages, where you can explore each specific application in depth – including key process information, performance benefits, and guidance on selecting the most suitable Hielscher sonicator for your requirements.

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Scientific Literature and Reports featuring Hielscher Ultrasonicators

The following list features a small selection of scientific articles, in which Hielscher ultrasonic probes were successfully used for various applications. Please ask us for literature concerning specific applications of your particular interest!

• Petigny L., Périno-Issartier S., Wajsman J., Chemat F. (2013): Batch and Continuous Ultrasound Assisted Extraction of Boldo Leaves (Peumus boldus Mol.). International Journal of Molecular Science 14, 2013. 5750-5764.
• Zahra Hadian, Mohammad Ali Sahari, Hamid Reza Moghimi; Mohsen Barzegar (2014): Formulation, Characterization and Optimization of Liposomes Containing Eicosapentaenoic and Docosahexaenoic Acids; A Methodology Approach. Iranian Journal of Pharmaceutical Research (2014), 13 (2): 393-404.
• Shah Purvin, Parameswara Rao Vuddanda, Sanjay Kumar Singh, Achint Jain, Sanjay Singh (2014): Pharmacokinetic and Tissue Distribution Study of Solid Lipid Nanoparticles of Zidov in Rats. Journal of Nanotechnology, Volume 2014.
• Antonia Tamborrino, Agnese Taticchi, Roberto Romaniello, Claudio Perone, Sonia Esposto, Alessandro Leone, Maurizio Servili (2021): Assessment of the olive oil extraction plant layout implementing a high-power ultrasound machine. Ultrasonics Sonochemistry, Volume 73, 2021.
• Bruno G. Pollet; Faranak Foroughi; Alaa Y. Faid; David R. Emberson; Md.H. Islam (2020): Does power ultrasound (26 kHz) affect the hydrogen evolution reaction (HER) on Pt polycrystalline electrode in a mild acidic electrolyte? Ultrasonics Sonochemistry Vol. 69, December 2020.