Ultrasonics: Applications and Processes

Ultrasonication is a mechanical processing method which creates extraordinarily intense acoustic cavitation and related physical forces such as high shear forces and high pressure differentials. These ultrasonically genrated forces are used for numerous applications such as mixing, homogenization, milling, dispersion, emulsification, extraction and sono-chemical reactions.
Below, you will find a selection of the most typical ultrasonic applications and processes.

Ultrasonic Homogenizing

UP400St Ultrasonic Homogenizer 400 watts for the sonication of beakers and batches.Ultrasonic homogenizers reduce small particles in a liquid to improve uniformity and dispersion stability. The particles (disperse phase) can be solids or liquid droplets suspended in a liquid phase. Ultrasonic homogenizing is very efficient for the reduction of soft and hard particles. Hielscher manufactures ultrasonicators for the homogenization of any liquid volume and for batch or inline processing. Laboratory ultrasonic devices can be used for volumes from 1.5mL to approx. 4L. Ultrasonic industrial devices can process batches from 0.5 to approx. 2000L or flow rates from 0.1L to 20 cubic meters per hour in process development and in commercial production.
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Ultrasonic Dispersing and Deagglomeration

Ultrasonication disrupts solid particles via acoustic cavitation.The dispersion and deagglomeration of solids into liquids is an important application of probe-type ultrasonicators. Ultrasonic / acoustic cavitation generates high shear forces that break particle agglomerates into individual, single dispersed particles. The mixing of powders into liquids is a common step in the formulation of various products, such as paint, varnish, cosmetic products, food and beverages, or polishing media. The individual particles are held together by attraction forces of various physical and chemical nature, including van-der-Waals-forces and liquid surface tension. Ultrasonication overcomes these attraction forces in order to deagglomerate and disperse the particles in liquid media. For the dispersing and deagglomeration of powders in liquids, high intensity ultrasonication is an interesting alternative to high pressure homogenizers, high shear mixers, bead mills or rotor-stator-mixers.
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The video is demonstrating ultrasonic dispersion of red color using the UP400St with a S24d 22mm probe.

Ultrasonic Red Color Dispersion using the UP400St

Ultrasonic Emulsification

Ultrasonication is a highly efficacious method for the production of nanoemulsions.A wide range of intermediate and consumer products, such as cosmetics and skin lotions, pharmaceutical ointments, varnishes, paints and lubricants and fuels are based wholly or in part on emulsions. Emulsions are dispersions of two or more immiscible liquid phases. Highly intensive ultrasound supplies enough intense shear to disperse a liquid phase (dispersed phase) in small droplets in a second phase (continuous phase). In the dispersing zone, imploding cavitation bubbles cause intensive shock waves in the surrounding liquid and result in the formation of liquid jets of high liquid velocity (high shear). Ultrasonication can be precisely adapted to the target emulsion size allowing thereby for the reliable production of micro-emulsions and nano-emulsions.
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Ultrasonic homogenizer UIP1000hdT for mixing, dispersion, emulsification and extraction.

The UIP1000hdT is 1000 watts powerful ultrasonicator for homogenization, milling and extraction applications.

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Ultrasonic Wet-Milling and Grinding

Ultrasonication is an efficient means for the wet-milling and micro-grinding of particles. In particular for the manufacturing of superfine-size slurries, ultrasound has many advantages. It is superior to traditional size reduction equipment, such as: colloid mills (e.g. ball mills, bead mills), disc mills or jet mills. Ultrasonication can process high-concentration and high-viscosity slurries – therefore reducing the volume to be processed. Of course, ultrasonic milling is suitable for processing micron-size and nano-size materials, such as ceramics, pigments, barium sulphate, calcium carbonate or metal oxides. Especially when it comes to nano-materials, ultrasonication excels in performance as its highly impactful shear forces create uniformly small nanoparticles.
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Titanium dioxide TiO2 particles after Ultrasonic milling show a drastically reduced diameter and a narrow size distribution.

Spray-dried TiO2 before and after ultrasonic milling

Ultrasonic Cell Disintegration and Lysis

Ultrasonically assisted extraction of compounds from herbs using an ultrasonic processor UP200SUltrasonic treatment can disintegrate fibrous, cellulosic material into fine particles and break the walls of the cell structure. This releases more of the intra-cellular material, such as starch or sugar into the liquid. This effect can be used for fermentation, digestion and other conversion processes of organic matter. After milling and grinding, ultrasonication makes more of the intra-cellular material e.g. starch as well as the cell wall debris available to the enzymes that convert starch into sugars. It does also increase the surface area exposed to the enzymes during liquefaction or saccharification. This does typically increase the speed and yield of yeast fermentation and other conversion processes, e.g. to boost the ethanol production from biomass.
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Ultrasonic Extraction of Botanicals

The extraction of bioactive compounds stored in cells and subcellular particles is an widely-used application of high-intensity ultrasound. Ultrasonic extraction is used to isolate secondary metabolites (e.g., polyphenols), polysaccharides, proteins, essential oils and other active ingredients from the cellular matrix of plants and fungi. Suitable for water- and solvent-extraction of organic compounds, sonication improves the yield of botanicals contained within plants or seeds significantly. Ultrasonic extraction is used for the production of pharmaceuticals, nutraceuticals / nutritional supplements, fragrances and biological additives. Ultrasonics is a green extraction technique also used for the extraction of bioactive components in biorefineries, e.g. release valuable compounds from non-utilized by-product streams formed in industrial processes. Ultrasonication is a highly effective technology for botanical extraction at lab and production scale.
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Ultrasonic botanical extraction gives higher yields. The Hielscher UIP2000hdT, 2000 watts homogenizer is powerful enough to extract batches from 10 liters to 120 liters easily.

Ultrasonic Extraction of Botanicals - 30 Liter / 8 Gallon Batch

Ultrasonication is known to improve transesterification reactions thereby giving e.g. higher methyl esters and polyols. Hielscher Ultrasonics manufactures industrial ultrasonic probes and reactors for high throughputs.

Ultrasonic reactor with 16,000 watts for ultrasonically enhanced liquid processing.

Sonochemical Application of Ultrasonics

cavitation_2_p0200Sonochemistry is the application of ultrasound to chemical reactions and processes. The mechanism causing sonochemical effects in liquids is the phenomenon of acoustic cavitation. The sonochemical effects to chemical reactions and processes include increase in reaction speed or output, more efficient energy usage, performance improvement of phase transfer catalysts, activation of metals and solids or increase in the reactivity of reagents or catalysts.
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Ultrasonic Transesterification of Oil to Biodiesel

Ultrasonication increases the chemical reaction speed and yield of the transesterification of vegetable oils and animal fats into biodiesel. This allows changing the production from batch processing to continuous flow processing and it reduces investment and operational costs. One of the major advantages of ultrasonic biodiesel manufacturing is the use of waste oils such as spent cooking oils and other poor-quality oil sources. Ultrasonic transesterification can convert even low-quality feedstock into high-quality biodiesel (fatty acid methyl ester / FAME). The manufacturing of biodiesel from vegetable oils or animal fats, involves the base-catalyzed transesterification of fatty acids with methanol or ethanol to give the corresponding methyl esters or ethyl esters. Ultrasonication can achieve a biodiesel yield in excess of 99%. Ultrasound reduces the processing time and the separation time significantly.
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Ultrasonic Degassing and De-Aeration of Liquids

Degassing of liquids is another important application of probe-type ultrasonicators. Ultrasonic vibrations and cavitation cause the coalescence of dissolved gases in a liquid. As the minute gas bubbles coalesce, they form thereby larger bubbles which float quickly to the top surface of the liquid from there they can be removed. Thus, ultrasonic degassing and deaeration can reduce the level of dissolved gas below the natural equilibrium level.
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This video demonstrate the efficient degassing of viscous oil (40cP). Ultrasonication removes small suspended gas-bubbles from the liquid and reduces the level of dissolved gas below the natural equilibrium level.

Ultrasonic Inline Degassing & Defoaming of Oil (40cP)

Ultrasonic Wire, Cable and Strip Cleaning

coil of cableUltrasonic cleaning is an environmentally friendly alternative for the cleaning of continuous materials, such as wire and cable, tape or tubes. The effect of the powerful ultrasonic cavitation removes lubrication residues like oil or grease, soaps, stearates or dust from the material surface. Hielscher Ultrasonics offers various ultrasonic systems for the inline cleaning of continuous profiles.
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Working Principle and Use of Ultrasonic Processing

Ultrasonication is a commercial processing technology, which has been adopted by numerous industries for large scale production. High reliability and scaleablility as well as low maintenance costs and high energy efficiency make ultrasonic processors a good alternative for traditional liquid processing equipment. Ultrasound offers additional exciting opportunities: Cavitation – the basic ultrasonic effect – produces unique results in biological, chemical and physical processes. For instance, ultrasonic dispersion and emulsification easily produces stable nano-sized formulations. Also in the field of botanical extraction, ultrasound is a non-thermal technique to isolate bioactive compounds.

While low-intensity or high-frequency ultrasound is mainly used for analysis, non-destructive testing and imaging, high-intensity ultrasound is used for the processing of liquids and pastes, where intense ultrasound waves are used for mixing, emulsifying, dispersing and deagglomeration, cell disintegration or enzyme deactivation. When sonicating liquids at high intensities, the sound waves propagate through the liquid media. This results in alternating high-pressure (compression) and low-pressure (rarefaction) cycles, with rates depending on the frequency. During the low-pressure cycle, high-intensity ultrasonic waves create small vacuum bubbles or voids in the liquid. When the bubbles attain a volume at which they can no longer absorb energy, they collapse violently during a high-pressure cycle. This phenomenon is termed cavitation. During the implosion very high temperatures (approx. 5,000K) and pressures (approx. 2,000atm) are reached locally. The implosion of the cavitation bubble also results in liquid jets of up to 280 meters per second velocity.

Ultrasonic cavitation in liquids can cause fast and complete degassing; initiate various chemical reactions by generating free chemical ions (radicals); accelerate chemical reactions by facilitating the mixing of reactants; enhance polymerization and depolymerization reactions by dispersing aggregates or by permanently breaking chemical bonds in polymeric chains; increase emulsification rates; improve diffusion rates; produce highly concentrated emulsions or uniform dispersions of micron-size or nano-size materials; assist the extraction of substances such as enzymes from animal, plant, yeast, or bacterial cells; remove viruses from infected tissue; and finally, erode and break down susceptible particles, including micro-organisms. (cf. Kuldiloke 2002)

High-intensity ultrasound produces violent agitation in low-viscosity liquids, which can be used to disperse materials in liquids. (cf. Ensminger, 1988) At liquid/solid or gas/solid interfaces, the asymmetric implosion of cavitation bubbles can cause extreme turbulences that reduce the diffusion boundary layer, increase the convection mass transfer, and considerably accelerate diffusion in systems where ordinary mixing is not possible. (cf. Nyborg, 1965)

Ultrasonic reactor for chemical synthesis, e.g. transesterification, esterification, or acetylation processes.

Ultrasonic reactor with 4x 2000 watts probes (8kW) for sonochemical processes.


High performance ultrasonics! Hielscher's product range covers the full spectrum from the compact lab ultrasonicator over bench-top units to full-industrial ultrasonic systems.

Hielscher Ultrasonics manufactures high-performance ultrasonic homogenizers from lab to industrial size.