Hielscher Ultrasonics
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Powerful Ultrasonicator UP400St (400 Watts)

The ultrasonicator UP400St is a robust, versatile ultrasonic homogenizer that delivers high performance, for professional liquid processing. This advanced 400 watts digital ultrasonicator is perfect for precision sonication of samples from 5mL to approximately 4 liters. The UP400St sonicator combines high power output with ease of use. It features a colored touch screen, integrated data recording, a temperature sensor, and much more. Hielscher Ultrasonics produces this UP400St sonicator and all other Hielscher sonicators entirely in Germany.
Use the UP400St for homogenizing, emulsifying, dispersing, deagglomeration and wet-milling, cell disruption, extraction, degassing, and sonochemical processes. This Hielscher ultrasonicator is built to run continuously at full power output in both research and small-scale production. For more details or a personalized proposal, please contact us! Our technical team will be happy to work with you on your sonication project.

Key Benefits of the UP400St Ultrasonicator

  • High Power and Versatility: 400 Watts homogenizer for effective sonication of volumes up to 4 liters (1.1 gallon).
  • User-Friendly Operation: Colored touch screen, integrated LEDs, and SD-card data recording.
  • Durable and Efficient: Continuous 24/7 operation at full load for lab use or small-scale production.
  • Flexible Setup: Compatible with sonotrodes from 3–40mm and flow cells for inline or batch processes.
  • Made in Germany: 100% German engineering and manufacturing at Hielscher Ultrasonics (Teltow, Germany)
UP400St Ultrasonic Homogenizer 400 watts for batch sonication

UP400St Ultrasonic Homogenizer 400 watts for batch sonication

Continuous Inline Sonication

In combination with a flow cell reactor, the UP400St can sonicate in continuous flow at approximately 20 to 200mL per minute. The stainless-steel flow cell is pressurizable up to 5 barg and has a cooling jacket, making it easy to maintain the ideal temperature during sonication.

The UP400St homogenizer handles larger sample volumes or consistent throughput with reproducible results. It is frequently used for nano-dispersion, emulsification, or extraction in fields ranging from pharmaceuticals to materials science. Please contact us directly for more information or assistance.

Video of the Hielscher UP400St - 400 Watts Ultrasonic Homogenizer, a probe type ultrasonicator for intense sample sonication

Video of UP400St - 400 Watts Ultrasonic Homogenizer

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UP400St Ultrasonicator with Touch-Screen Control

UP400St Ultrasonicator with Touch-Screen Control

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The Ultrasonicator UP400St in Action

The UP400St excels in laboratories, pilot-scale processes and small batch production. It enables continuous operation for hours under full load with real-time monitoring and automated data recording, ensuring reliable performance and reproducible results. This makes it an excellent choice for industries that require consistent outcomes, such as food processing, cosmetics, and materials science.

The video is demonstrating ultrasonic dispersion of red color using the UP400St sonicator with a 22mm probe.

Ultrasonic Red Color Dispersion using the UP400St

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UP400ST sonicator with sound enclosure SPB-L

UP400ST sonicator with a clear sound enclosure box

This powerful ultrasonic homogenizer streamlines workflows and shortens processing times. To request a quote or learn how the UP400St sonicator can fit your application, see the contact form or proposal request below.

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The Ultrasonic Processor UP400St in Research and Science

Below you can find a selection of scientific articles featuring the ultrasonic processor UP400St. The articles span from ultrasonic extraction over dispersion to electrochemistry. If you are looking for a specific application and related scientific references, please contact us.


Additional Technical Details

Full Color Touch-Screen

A color touch screen provides straightforward control of sonication amplitude and pulse operation. Numerical or bargraph displays can be selected. A BIG NUMBER mode is also available to ensure all settings are visible at a glance.

Browser Remote Control

The UP400St ultrasonicator can be accessed via any standard browser through its network web interface. No extra software is needed. An optional wireless router lets you control the device from a tablet or smartphone.

Built-In Network

Network operation streamlines setup and increases flexibility. Sonication data is automatically saved to an SD-card. A temperature sensor and LED illumination provide close monitoring of the sample.

Automatic Frequency Tuning

Like all Hielscher ultrasonicators, the UP400St automatically detects and tunes to the optimum operational frequency once switched on. This ensures high efficiency and reliability.

UP400St Ultrasonicator Dimensions

Dimensions of Hielscher ultrasonic homogenizer UP400St (400 watts)

UP400St sonicator dimensions

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