Special topics and frequent searches on our website
Find information about some of our special topics and concerns or
have a look at the most frequent search requests on our website:
Utrasonic topic: "The Advantages of Ultrasonic Extraction"
Ultrasonic extraction or sono-extraction is a process intensifying technology, which works by the coupling of high power ultrasonics into a slurry of plant or cell tissue. Hielscher Ultrasonics supplies reliable ultrasonicators for cell disruption and extraction from small lab samples up to high volumes in industrial processing. The appeal of the ultrasonically assisted extraction lies in the non-thermal treatment of the material, its easy application and the scaleability from test to production scale. Hielscher’s ultrasonic devices generate high intense ultrasound that can be exactely controlled to your process requirements.
Utrasonic topic: "Ultrasonic Processing in the Pharma Industry"
Power ultrasonics is a highly efficient and reliable tool for the production of vaccines, nano-formulated drugs and drug carriers (e.g. liposomes). Hielscher Ultrasonics’ lab, pilot and industrial systems produce pharma-grade micron- and nano-emulsions / -dispersions, liposomes as well as vaccines. Hielscher’s ultrasonic systems are equipped with CIP (clean-in-place) and SIP (sterilize-in-place) and guarantee thereby safe and efficient production according to pharmaceutical standards. All specific ultrasonic processes can be easily tested in lab or bench-top scale and then be linearly scaled up to industrial production.
Utrasonic topic: "Ultrasonic Processing in the Food Industry"
The application of powerful ultrasound waves to liquid food products is used to homogenise and disperse them evenly, to extract aromatic and bioactive compounds (e.g. flavours, vitamins, natural colorants) and to improve microbial stability. As a non-thermal treatment, ultrasonication avoids the thermal decomposition of temperature-sensitive substances and is thereby a mild processing method. Hielscher Ultrasonics offers a wide product range of high-performance ultrasonic food processing systems, which can be operated in batch mode or continuous inline setup using an ultrasonic flow-through reactor.
Learn more about powerful ultrasonic food processing and its benefits!
Utrasonic topic: "The Benefits of Ultrasonic Process Intensification"
Process intensification makes the reactions and the production of materials more efficient. Ultrasonic processing is well known to speed-up processes and to improve the output (e.g. superior quality, higher yields). Hielscher Ultrasonics manufactures superior ultrasonic equipment for homogenization, dispersion & wet-milling, emulsification, extraction, lysis, and sonochemical reactions. Learn more about how ultrasonication can intensify your process and make it more efficient!
Utrasonic topic: "Ultrasonication: Applications and Benefits"
Ultrasonication is the application of intense ultrasound waves into liquids and slurries. The acoustic cavitation generated by intense sonication creates energy-dense conditions such as high pressure and temperature differentials as well as high shear forces and turbulences. Those forces agitate particles, break droplets and disrupt cells causing homogenisation, dispersion, emulsification and extraction effects. Read more about ultrasonication and its multiple applications!
Utrasonic topic: "Sonication - Applications and Advantages"
Sonication (also termed ultrasonication) is the application of low frequency, high intensity ultrasound waves into a liquid or pastes medium. Acoustic cavitation generated by intense sonication creates energy-dense conditions such as high pressure and temperature differentials as well as high shear forces and turbulences. Those ultrasonically generated forces break particles and droplets, disrupt cells and initiate chemical reaction. Due to these effects, sonication is used for homogenisation, wet-milling & dispersing, emulsification, extraction and sonochemistry. Read more about the manifold advantages of sonication and learn how your process can benefit from the application of power ultrasound!
Utrasonic topic: "What are Ultrasonic Extractors Used for?"
Ultrasonic extractors are the superior tool when it comes to the intensification of ultrasonic extraction processes. As a non-thermal method, sonication prevents the degradation of temperature-sensitive substances (e.g. vitamins, flavours, antioxidants, CBD etc.). The application of high-power ultrasound waves causes the perforation and disruption of cells and tissues and promotes mass transfer. This means the intracellular material (i.e. the targeted substances) is released from the inner cell and transferred into the solvent. Ultrasonic extraction intensifies the extraction process resulting in higher yields, superior extract quality and rapid processing. At the same time, ultrasonic extraction is an environmental-friendly, green method.
Read more about how sonication can improve your extraction process!
Utrasonic topic: "Ultrasonic Nanomaterial Processing"
High-performance sonication is a well-established technique for particle size reduction in nano-sized dispersions and emulsions. Besides the fine-size distribution of particles, ultrasonic processors are used to synthesise nano-structured materials such as nanodiamonds or to precipitate nanoparticles (e.g. magnetite (Fe3O4)).
Hielscher’s ultrasonic processors are available from lab to industrial size and can be used for batch and continuous inline sonication. Learn how sonication can improve your nano-material processing!
Utrasonic topic: "liposomes"
A liposome is a spherical vesicle with at least one lipid bilayer. Liposomes are widely used as vehicles for drug and nutrient delivery. Due to its composition and size, liposomes offer a great bioavailability and absorption rate in the body. Sonication is the preferred technique to prepare loaded liposomes, such as small, unilamellar vesicles (SUV) with diameters in the range of 15-50nm or large, multilamellar vesicles (LMV) with a size of with a mean diameter of 120-140nm. The majority of liposomes is composed of phospholipids, e.g. phosphatidylcholine, but other lipids, such as egg phosphatidylethanolamine, are successfully used too, if compatible with lipid bilayer structure.
Hielscher ultrasonicators are reliable tools to produce nano-sized liposomes and to formulate liposomal products. To ensure reproducibility and highest quality standards of the liposomal products, Hielscher ultrasonicators can be precisely controlled. The most important ultrasonic process parameters such as amplitude, time, temperature, and pressure can be exactly set and monitored. An integrated SD-card automatically protocols the ultrasonic parameters and facilitates thereby reproducibility and quality control.
Read more about the use of ultrasonic processors for the preparation of liposomes!
Utrasonic topic: "supplements"
Dietary or nutritional supplements are products that help to provide nutrients in order to balance out the nutrient intake from the regular diet. Common dietary supplements include vitamins, minerals, proteins, amino acids, antioxidants, herbs or other nutritional substances.
There a two major applications for ultrasonic processors in dietary supplement production:
- the extraction or synthesis of nutrients, and
- the formulation of the final supplement product.
Ultrasonic Extraction of Nutrients
In first step, nutrients for the supplement must be prepared. This can happen either by extracting the compound from a natural product, e.g. a plant, or by synthesizing the compound chemically.
Ultrasonic extraction is a potent technique, which breaks cell walls and releases the bioactive compounds. The main advantage s of ultrasonic extraction are its exceptional high extraction rate, rapid extraction speed, the use of green solvents (e.g. water, ethanol, vegetable oils etc.), safety, and user-friendliness. Being a non-thermal extraction method, ultrasonic extraction prevents the thermal degradation of heat-sensitive materials and results in superior extract quality. Typical extracts produced by sonication include curcumin, algae lipids, antioxidants, cannabinoids (CBD, THC, CBG, terpenes etc.), vitamins and flavonoids.
For synthesis, sonochemical intensification of reactions can speed up the conversion rate and increase yields. Sonochemical preparation of amino acids in aqueous solutions is a good example, where ultrasonicators are successfully applied in nutrient production.
Ultrasonic Supplement Formulation
Ultrasonic is a powerful technique of mixing, dispersing and emulsification. To formulate dietary supplements, the actual nutrients must be processed a bioavailable form, e.g. nano-droplets. Ultrasonic mixers help to distribute the active ingredients uniformly throughout the formulation, which is subsequently processed into pills, capsules, powders, gel tabs, extracts, or liquids. Many bioactive ingredients such as curcumin, cannabidiol or resveratrol are not water-soluble and exhibit a low natural bioavailability. Liposomal formulations, where the active compound is encapsulated in a bilayer of phospholipids, increase the bioavailability of such compounds significantly. Ultrasonic processors are the preferred technique to formulate nutrients into stable, nano-sized liposomes, including liposomal vitamin C, CBD, or resveratrol to name just a few.
Ultrasonic mixing and dispersing is also used to create formulations such as nano-sized suspensions and dispersions, nano-emulsions, pickering emulsions and gels.
Ultrasonic processors are well established in the food and pharma industry. Hielscher Ultrasonics offers high-performance ultrasonic devices from lab and bench-top size up to full-commercial industrial scale with capacities of processing several tons per hour.
Read more about how ultrasonic processors can improve the manufacturing of nutritional supplements.
Utrasonic topic: "Ultrasonically Intensified Solvent Extraction"
Ultrasonication intensifies conventional solvent extraction and makes the process significantly more efficient. Ultrasonic extraction works with various types of solvents such as water, ethanol, methanol, isopropanol, vegetable oils, glycerin to name just a few. Ultrasonically generated cavitation improves mass transfer and disrupts cells so that the intracellular material and the targeted bioactive substances are released into the solvent. As a non-thermal extraction method, sonication prevents the thermal degradation of thermo-labil ingredients. Thereby, ultrasonic extraction increases the yield, improves extract quality and speeds-up the process.
Read more about the manifold ultrasonic extraction applications including case studies and ultrasonic extraction protocols!
Utrasonic topic: "What is Sonochemistry?"
Sonochemistry is the application of ultrasound to chemical reactions and processes. SOnication is used to intensify chemical reactions such as synthesis and catalysis. When intense ultrasound waves are couples into liquids, the phenomenon of acoustic cavitation occurs. Ultrasonic cavitation improves mass transfer between reactants, speeds up the reaction and/or allows to change the chemicals pathway.
Learn more about Hielscher ultrasonic laboratory and industrial devices and how they are used in manifold sonochemical processes!
Utrasonic topic: "extracts"
Extracts are substances, which have been released from a raw material via an extraction process. Ultrasonic extraction (also sono-extraction) is a highly efficient, rapid, safe, and user-friendly technique to extract bioactive compounds from botanicals such as herbs, seeds, fruits, vegetables, flowers, roots and bark. For the extraction process a solvent is required. One advantage of ultrasonic extraction is the broad selection of solvents to chose from: Ultrasonic extraction works with common solvents (e.g. ethanol, methanol, heptane, hexane etc.), but also very mild, green solvents such as water, vegetable oils, glycerine etc. are suitable for the ultrasonic extraction from many raw materials.
Extracts are available as tinctures, absolutes or in powder form. Extracts are often used in the food, pharma and nutraceutical industry, where extracts are used as flavour additives or as bioactive compounds with medicinal or nutritional effects.
Utrasonic topic: "polyphenols"
Polyphenols or polyhydroxyphenols are chemical compounds that occur in nature, but can be also synthesized chemically. As polyphenols act as antioxidants, they are known as health-beneficial bio-compound and the consumption of polyphenol-rich foods such as fruits, vegetables, cereals, tea and coffee is linked to a reduced risk of chronic diseases.
Fruits like berries, grapes, apples, pears, and cherries show a high polyphenol content containing up to 200–300mg polyphenols per 100 grams fresh weight. Subsequently, products manufactured from these fruits, also contain significant amounts of polyphenols.
The class of polyphenols includes tannins, catechins, epicatechins, flavanones, isoflavones, phloridzin, quercitin etc. In foods, polyphenols contribute to the bitterness, astringency, color, flavor, smell and oxidative stability. Therefore, polyphenol extracts, e.g. from grape skin, grape seeds, olive pulp, citrus peel, or maritime pine bark, are sold as ingredients for functional foods, dietary supplements, and cosmetics.
As secondary metabolites of plants, polyphenols are located within the cell matrix. In order to produce polyphenol-rich foods such as olive oil, wine, juices, purees or extracts, the polyphenols must be released from the plant cells. Ultrasonic extraction is a powerful method to break cell structures of botanicals and to release them into the surrounding liquid. As a non-thermal technique, ultrasonic extraction prevents the thermal decomposition of the heat-labil polyphenols. At the same time, sonication is a process-intensifying method, which increases the extraction yield and accelerates the process speed. Ultrasonic extraction is used to produce superior polyphenol extracts. Available from lab to industrial scale, ultrasonic processors can be easily implemented into your production line to improve your extraction process.
Read more about the benefits of ultrasonic extraction of polyphenols from botanical raw materials!
Utrasonic topic: "antioxidants"
Antioxidants are naturally occuring compounds that inhibit oxidation. During oxidation free radicals are produced, which may damage cells and thereby negatively influence health and vitality.
Antioxidants act as free-radical scavengers. This means they can prevent or slow damage to cells caused by free radicals, unstable molecules that the body produces as a reaction to environmental and other stressors.
Main source of antioxidants are plants. Herbs, fruits and vegetables are rich in antioxidants and are therfore used as raw material to extract antioxidants. Plant nutrients and phyto-chemicals like vitamin A, C and E, the minerals copper, zinc and selenium, flavonoids, phenols, polyphenols, and phytoestrogens are known potent antioxidants.
Ultrasonic extraction is used to isolate antioxidative phyto-chemicals from botanicals in order to manufacture antioxidants, which are used in health foods, pharmaceuticals, supplements and as cosmetic additives. Being a non-thermal method, ultrasonic extraction prevents the thermal degradation of temperature-sensitive antioxidants. Furthermore, sonication gives high antioxidant yields in a very rapid process. Read more about the extraction of antioxidants and other bioactive substances below!
Utrasonic topic: "Ultrasonic Cell Disruption"
Cell disruption is a technique or process used to release and isolate biological molecules from inside a cell. Ultrasonication is a highly efficient method to perforate and disrupt cell walls and membranes so that the intracellular material and the targeted biomolecules are released into the solvent. As a non-thermal, mild , yet highly efficient technique, ultrasonic disruptors are used in lab and industry to lyse cells and to produce superior extracts. Ultrasonic cell disruptors are used to prepare DNA and RNA as well as to extract bioactive compounds such as vitamins, polyphenols or natural pigments.
Read more about the manifold applications of ultrasonic cell disruption and extraction!
Utrasonic topic: "ultrasonicator"
Ultrasonicators are ultrasonic probe-type devices, which are used for manifold applications including homogenization, dispersing, wet-milling, emulsification, extraction, lysis, disintegration, and chemical reactions.
The working principle of an ultrasonicator is based on the phenomenon of acoustic cavitation. When intense ultrasound waves are coupled into a liquid, alternating high-pressure / low-pressure cycles travel through the liquid. During the low-pressure cycles, the ultrasonic waves create minuscule vacuum bubbles, which grow over several pressure cycles. When the vacuum bubbles reach a volume at which they cannot absorb further energy, they implode violently during a high-pressure cycle. Briefly, cavitation is the growth and collapse of vacuum bubbles or cavities. During the bubble implosion, an exceptionally energy-dense field is created. In an acoustic cavitation field, extreme conditions – including very high temperature and pressure differentials, turbulences, shear forces and liquid jets – can be measured. These intense cavitational forces are used to fulfil the manifold applications mentioned above.
Ultrasonicators create cavitation to apply it purposefully to liquids, slurries and gas in order to achieve particle size reduction, mixing of oil/water phases, cell disruption or to induce chemical reactions.
Sonication (also ultrasonication) describes the process of applying ultrasound energy to a liquid or slurry. Hielscher Ultrasonics designs, manufactures and distributes high-intensity, low-frequency ultrasonicators from lab & bench-top to fully industrial scale.
Read more about ultrasonicators and their applications!
Utrasonic topic: "Ultrasonic Reactors"
Ultrasonic reactors are used for manifold applications to homogenise and disperse nano materials, to extract bioactive substances and to initiate chemical reactions (sonochemistry). Since sonication is a highly efficient process intensifying technology, ultrasonic reactors are used in chemistry and material science, the production of biodiesel and aqua-fuels, and in the food, pharma and cosmetic industry.
Ultrasonic chemical reactors are available for laboratory and industrial. Learn more about the applications of ultrasonic reactors and their easy integration!
Utrasonic topic: "Ultrasonic Cavitation and its Applications"
When high-power ultrasound is coupled into liquid, acoustic cavitation occurs. Acoustic cavitation creates extreme conditions, including very high temperature and pressure differentials, turbulences, shear forces and liquid jets. These intense forces of ultrasonic cavitation are used for various applications such as homogenization, emulsification, dispersing & wet-milling, extraction, disintegration and sonochemical reactions.
Read more about ultrasonic cavitation and its applications!
Utrasonic topic: "lysis"
Lysis is the term which describes the disruption of cell walls or membranes. Ultrasonic disruptors are a reliable tool to break cells in order to release intracellular compounds such as DNA, proteins, organelles, and phytochemicals. For ultrasonic lysis (aka cell disruption), high-intensity / low-frequency ultrasound waves are applied to disrupt the cell membranes. Since ultrasonication promotes mass transfer, the intracellular material is released into the surrounding solvent. The fluid containing the contents of lysed cells is called a lysate.
Cell lysis is the first step in cell fractionation, organelle isolation and protein extraction and purification.
Read more about ultrasonic cell disruptors and ultrasonic lysis!
Frequent search phrases:
Search results for: "cannabis"
Sonication applies intense shear forces and stress to the medium and releases thereby high extract yields in a very short extraction time. This means that the extraction process of active substances such as cannabinoids and terpenes from the cannabis plant can be substantially increased. Hielscher Ultrasonics offers a broad portfolio of ultrasonic extractors and accessories for the efficient isolation of active compounds (e.g., CBD, THC, CBG, terpenes) from the cannabis plant. Contact us today! We are glad to recommend you the most suitable ultrasonic extraction setup for your requirements!
Search results for: "cbd"
Ultrasonic extraction is used for the extraction and isolation of active compounds such as CBD, THC, CBG terpenes from cannabis. Ultrasonically-assisted extraction (UAE) is successfully used for the extraction of cannabinoids from hemp and marijuana. Hielscher Ultrasonics offers various systems for the extraction in batch and continuous flow mode for volumes from small and mid-scale up to full-commercial level of several tons per hour.
Search results for: "hemp"
Ultrasonication is a proven technique to release active compounds such as cannabinoids (such as CBD, CBG, etc.) and terpenes from hemp. Ultrasonic hemp treatment achieves an (almost) complete extraction of the targeted phytochemicals in a rapid process. Further advantages of ultrasonic extraction are the broad selection of solvents (e.g. water, ethanol, water:ethanol mix, glycerine, vegetable oils etc.), that can be used, its safe and easy operation, as well as its low investment and operational costs. This makes ultrasonic extraction the preferred extraction process in order to produce superior hemp extracts such as CBD oils. Hielscher Ultrasonics supplies high-performance ultrasonic extractors for small, mid-size and industrial scale. Contact us today! We will offer you the optimal ultrasonic system for your extraction requirements.
Search results for: "honey"
Ultrasonication is a non-thermal processing methods for honey. Ultrasonic honey processing is successfully used to inactivate microbes, to reduce particles, to break existing crystals and to inhibit further crystallization in honey. Since sonication is a mild, non-thermal treatment, the formation of undesirable components like 5-Hydroxymethylfurfural (5-HMF), which occurs when honey is thermally treated, is prevented. Hielscher Ultrasonics supplies various high-performance ultrasound systems and flow cells for the production of high-quality honey.
Search results for: "stem cell"
Adipose-derived stem cells (ASCs) are mesenchymal stem cells (MSCs) that are obtained from human adipose tissue. The stem cells in the eviscerated adipose tissue (the so-called stromal vascular fraction (SVF)) must be isolated to use them subsequently for medical or cosmetic treatments. Ultrasonication is a highly effective and reliable treatment to isolate stem cells from adipose tissue. The advantage of ultrasonic stem cell isolation lies in the fact that the ultrasonic treatment is based on the working principle of ultrasonic-derived cavitation, which is mechanical shear. Not chemical or enzymatic additives are required. The ultrasonic stem cell isolation allows for a repeatable protocol, high stem cell yield as well as superior stem cell quality. Hielscher Ultrasonics offers various ultrasonic systems for the direct and indirect sonication of SVF and the release of highly functional stem cells.
Search results for: "wire"
Hielscher Ultrasonics manufactures high-performance ultrasonic processors for the efficient inline cleaning of wires, rods, cables, tapes, tubes and other endless materials. Ultrasonic cavitation removes lubricants, soaps, stearates, grease, dust and other dirt effectively from endless materials. By applying powerful ultrasonic waves, Hielscher’s ultrasonic wire cleaning systems can be operated using water only or in combination with mild cleaning agents. Ultrasonic wire cleaning is not only highly efficient, but environmental-friendly, too. Hielscher’s portfolio of various wire cleaning systems with different throughput speeds and footprints offers the ideal cleaning setup for your wire processing line.