Special topics and frequent searches on our website
Ultrasonic extraction or sono-extraction is a process intensifying technology, which works by the coupling of high power ultrasonics into a slurry of plant or cell tissue. Hielscher Ultrasonics supplies reliable ultrasonicators for cell disruption and extraction from small lab samples up to high volumes in industrial processing. The appeal of the ultrasonically assisted extraction lies in the non-thermal treatment of the material, its easy application and the scaleability from test to production scale. Hielscher’s ultrasonic devices generate high intense ultrasound that can be exactely controlled to your process requirements.
Process intensification makes the reactions and the production of materials more efficient. Ultrasonic processing is well known to speed-up processes and to improve the output (e.g. superior quality, higher yields). Hielscher Ultrasonics manufactures superior ultrasonic equipment for homogenization, dispersion & wet-milling, emulsification, extraction, lysis, and sonochemical reactions. Learn more about how ultrasonication can intensify your process and make it more efficient!
Extraction describes the release and isolation of intracellular material from plant cells, tissue, cell cultures and microorganisms. Conventional extraction processes such as solvent extraction, maceration, Soxhlet etc. are often slow and inefficient. Ultrasonic extraction promotes mass transfer and increases the efficiency of extraction significantly. Ultrasonic extraction is known for its rapid processing, higher yields and superior extract quality!
Power ultrasonics is a highly efficient and reliable tool for the production of vaccines, nano-formulated drugs and drug carriers (e.g. liposomes). Hielscher Ultrasonics’ lab, pilot and industrial systems produce pharma-grade micron- and nano-emulsions / -dispersions, liposomes as well as vaccines. Hielscher’s ultrasonic systems are equipped with CIP (clean-in-place) and SIP (sterilize-in-place) and guarantee thereby safe and efficient production according to pharmaceutical standards. All specific ultrasonic processes can be easily tested in lab or bench-top scale and then be linearly scaled up to industrial production.
The UIP2000hdT is a powerful 2kW ultrasonic processor used for heavy duty applications such as homogenization, dispersion & wet-milling, emulsification, extraction and chemical reactions. With its digital control, automatic data recording and user-friendly operation, the UIP2000hdT allows for intensifying processes and to produce medium-sized volumes on industrial scale. The UIP2000hdT can be operated in batch mode as well as in combination with a flow cell reactor for continuous inline sonication. Since ultrasonic processes can be linearly scaled-up by adding several ultrasonic units in parallel or by installing a larger ultrasonic unit such as Hielscher’s UP16000 (16kW).
Read more about the features of the UIP2000hdT and the multiple applications!
Ultrasonication intensifies conventional solvent extraction and makes the process significantly more efficient. Ultrasonic extraction works with various types of solvents such as water, ethanol, methanol, isopropanol, vegetable oils, glycerin to name just a few. Ultrasonically generated cavitation improves mass transfer and disrupts cells so that the intracellular material and the targeted bioactive substances are released into the solvent. As a non-thermal extraction method, sonication prevents the thermal degradation of thermo-labil ingredients. Thereby, ultrasonic extraction increases the yield, improves extract quality and speeds-up the process.
Read more about the manifold ultrasonic extraction applications including case studies and ultrasonic extraction protocols!
Sonication (also termed ultrasonication) is the application of low frequency, high intensity ultrasound waves into a liquid or pastes medium. Acoustic cavitation generated by intense sonication creates energy-dense conditions such as high pressure and temperature differentials as well as high shear forces and turbulences. Those ultrasonically generated forces break particles and droplets, disrupt cells and initiate chemical reaction. Due to these effects, sonication is used for homogenisation, wet-milling & dispersing, emulsification, extraction and sonochemistry. Read more about the manifold advantages of sonication and learn how your process can benefit from the application of power ultrasound!
The application of powerful ultrasound waves to liquid food products is used to homogenise and disperse them evenly, to extract aromatic and bioactive compounds (e.g. flavours, vitamins, natural colorants) and to improve microbial stability. As a non-thermal treatment, ultrasonication avoids the thermal decomposition of temperature-sensitive substances and is thereby a mild processing method. Hielscher Ultrasonics offers a wide product range of high-performance ultrasonic food processing systems, which can be operated in batch mode or continuous inline setup using an ultrasonic flow-through reactor.
Learn more about powerful ultrasonic food processing and its benefits!
Ultrasonic extractors are the superior tool when it comes to the intensification of ultrasonic extraction processes. As a non-thermal method, sonication prevents the degradation of temperature-sensitive substances (e.g. vitamins, flavours, antioxidants, CBD etc.). The application of high-power ultrasound waves causes the perforation and disruption of cells and tissues and promotes mass transfer. This means the intracellular material (i.e. the targeted substances) is released from the inner cell and transferred into the solvent. Ultrasonic extraction intensifies the extraction process resulting in higher yields, superior extract quality and rapid processing. At the same time, ultrasonic extraction is an environmental-friendly, green method.
Read more about how sonication can improve your extraction process!
Ultrasonication is the application of intense ultrasound waves into liquids and slurries. The acoustic cavitation generated by intense sonication creates energy-dense conditions such as high pressure and temperature differentials as well as high shear forces and turbulences. Those forces agitate particles, break droplets and disrupt cells causing homogenisation, dispersion, emulsification and extraction effects. Read more about ultrasonication and its multiple applications!
Ultrasonic devices couple intense ultrasound waves into liquids and slurries in order to homogenize, disperse, emulsify, extractor to initiate chemical reactions. The vibration of low-frequency, high intensity ultrasound is transmitted via a sonotrode (also known as ultrasonic probe, horn, or tip) into the medium so that acoustic cavitation occurs. In the energy-dense cavitation field high pressure and temperature differentials, high shear forces and turbulences are the responsible forces, which promote homogenisation, particle fragmentation, the breakage of droplets, cell disruption and mass transfer.
Hielscher Ultrasonics manufactures powerful ultrasonic systems for lab, bench-top and industry. Read more about the applications of our high-performance ultrasonic devices!
Cell disruption is a technique or process used to release and isolate biological molecules from inside a cell. Ultrasonication is a highly efficient method to perforate and disrupt cell walls and membranes so that the intracellular material and the targeted biomolecules are released into the solvent. As a non-thermal, mild , yet highly efficient technique, ultrasonic disruptors are used in lab and industry to lyse cells and to produce superior extracts. Ultrasonic cell disruptors are used to prepare DNA and RNA as well as to extract bioactive compounds such as vitamins, polyphenols or natural pigments.
Read more about the manifold applications of ultrasonic cell disruption and extraction!
Sonochemistry is the application of ultrasound to chemical reactions and processes. SOnication is used to intensify chemical reactions such as synthesis and catalysis. When intense ultrasound waves are couples into liquids, the phenomenon of acoustic cavitation occurs. Ultrasonic cavitation improves mass transfer between reactants, speeds up the reaction and/or allows to change the chemicals pathway.
Learn more about Hielscher ultrasonic laboratory and industrial devices and how they are used in manifold sonochemical processes!
Ultrasonic dispersers are a common tool used to distribute particles of one phase (dispersed phase) in a continuous phase of a different material assisted by ultrasonic waves. Due to the intense dispersion forces of high-performance ultrasound, sonication is the superior method for the preparation of nanoparticle suspensions (e.g. CNTs in an aqueous medium). The energy input and intensity of sonication can be precisely controlled. Due to the exact control of the ultrasonic process parameters, sonication results are reproducible and can be linearly scaled to larger volumes. Ultrasonic dispersion achieves narrow particle distribution curves and the high quality dispersions.
Learn more about ultrasonic dispersing!
Ultrasonic reactors are used for manifold applications to homogenise and disperse nano materials, to extract bioactive substances and to initiate chemical reactions (sonochemistry). Since sonication is a highly efficient process intensifying technology, ultrasonic reactors are used in chemistry and material science, the production of biodiesel and aqua-fuels, and in the food, pharma and cosmetic industry.
Ultrasonic chemical reactors are available for laboratory and industrial. Learn more about the applications of ultrasonic reactors and their easy integration!
High-performance sonication is a well-established technique for particle size reduction in nano-sized dispersions and emulsions. Besides the fine-size distribution of particles, ultrasonic processors are used to synthesise nano-structured materials such as nanodiamonds or to precipitate nanoparticles (e.g. magnetite (Fe3O4)).
Hielscher’s ultrasonic processors are available from lab to industrial size and can be used for batch and continuous inline sonication. Learn how sonication can improve your nano-material processing!
Powerful ultrasonication is a proven technique to prepare stable macro- and nano-emulsion, double emulsions and pickering emulsions. Nano-emulsions are emulsions with a nano-sized dispersed phase and their preparation requires intense energy input to disperse the droplets to nano-size. Emulsions have manifolds applications ranging from food, dairy, pharmaceutics to paint and oil industries. Hielscher’s ultrasonic processors and reactors provide high-performance ultrasound to obtain high-quality emulsions. Learn more about our ultrasonic systems and ultrasonically-assisted emulsification!
The UP200St is a 200W powerful ultrasonic processor for homogenising, dispersing, emulsification, extraction and sonochemistry. Equipped with a digital touch-display, browser remote control and automatic data recording, the UP200St ensures highest user-friendliness. Supplying 200W ultrasound energy, the UP200St is well suited for all ultrasonic liquid processes in small and medium scale. It can be operated continuously 24h/7d under full load and is good for processing up to 200L/h.
Read more about the features and applications of the UP200St!
The UP400St is a 400W powerful ultrasonic processor for homogenising, dispersing, emulsification, extraction and sonochemistry. Equipped with a digital touch-display, browser remote control and automatic data recording, the UP400St ensures highest user-friendliness. Supplying 400W ultrasound energy, the UP400St is the ideal device for volumes from 5.0 to 4000mL. It can be operated continuously 24h/7d under full load and is good for processing up to 400L/h.
Read more about the features and applications of the UP400St!
Lysis is the term which describes the disruption of cell walls or membranes. Ultrasonic disruptors are a reliable tool to break cells in order to release intracellular compounds such as DNA, proteins, organelles, and phytochemicals. For ultrasonic lysis (aka cell disruption), high-intensity / low-frequency ultrasound waves are applied to disrupt the cell membranes. Since ultrasonication promotes mass transfer, the intracellular material is released into the surrounding solvent. The fluid containing the contents of lysed cells is called a lysate.
Cell lysis is the first step in cell fractionation, organelle isolation and protein extraction and purification.
Read more about ultrasonic cell disruptors and ultrasonic lysis!
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