Utrasonic topic: "liposomes"
A liposome is a spherical vesicle with at least one lipid bilayer. Liposomes are widely used as vehicles for drug and nutrient delivery. Due to its composition and size, liposomes offer a great bioavailability and absorption rate in the body. Sonication is the preferred technique to prepare loaded liposomes, such as small, unilamellar vesicles (SUV) with diameters in the range of 15-50nm or large, multilamellar vesicles (LMV) with a size of with a mean diameter of 120-140nm. The majority of liposomes is composed of phospholipids, e.g. phosphatidylcholine, but other lipids, such as egg phosphatidylethanolamine, are successfully used too, if compatible with lipid bilayer structure.
Hielscher ultrasonicators are reliable tools to produce nano-sized liposomes and to formulate liposomal products. To ensure reproducibility and highest quality standards of the liposomal products, Hielscher ultrasonicators can be precisely controlled. The most important ultrasonic process parameters such as amplitude, time, temperature, and pressure can be exactly set and monitored. An integrated SD-card automatically protocols the ultrasonic parameters and facilitates thereby reproducibility and quality control.
Read more about the use of ultrasonic processors for the preparation of liposomes!
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In order to microencapsulate active ingredients via spray-drying, a fine-sized stable micro- or nanoemulsion must be prepared. Ultrasonic emulsification is a facile and reliable technique to produce stable micro- and nano-emulsions As alternative surfactant, biopolymers such gum arabi or…https://www.hielscher.com/ultrasonic-nano-emulsification-for-microencapsulation-before-spray-drying.htm
Ultrasonic terpene extraction has been proven to give high yields of terpene caryophyllene oxide, e.g. from cannabis and hops. Caryophyllene oxide is a terpene found in cannabis, hops, pepper, basil and rosemary. As an active compound, extracted terpene caryophyllene…https://www.hielscher.com/ultrasonic-terpene-extraction.htm
Resveratrol is a polyphenol, which promises many health benefits, e.g. prolonging life span, and to treat heart disease, diabetes, cancer, Alzheimer's as well as other chronic conditions. However, resveratrol has a low bioavailability and shows a rapid clearance from…https://www.hielscher.com/ultrasonic-resveratrol-inclusion-complex.htm
Ultrasonic nanoemulsions excel as drug carrier due to a significantly higher solubilization capacity than simple micelle solutions. Their thermodynamic stability offers advantages over unstable systems such as macro-sized emulsions, dispersions and suspensions. Hielscher's ultrasonicators are used to prepare nanoemulsions…https://www.hielscher.com/why-nanoformulated-medicines.htm
Hielscher ultrasonic extractors are the state-of-art technique when it comes to the reliable and efficient extraction of hemp and CBD oils. Ultrasonication is well-known as a highly potent extraction technique to release valuable compounds from botanicals. In comparison to…https://www.hielscher.com/highly-efficient-ultrasonic-cannabidiol-cbd-extraction-from-cannabis.htm
Piperine is a bioactive substance that is found in peppercorns and valued for its pharmacological properties. Ultrasonic is an efficient, simple, and rapid extraction technique to isolate high-quality piperine. Ultrasonic extraction is a reliable and proven method, already widely…https://www.hielscher.com/ultrasonic-extraction-of-piperine-from-pepper.htm
Since turmeric contains only 2-9 wt% of curcuminoids, a efficient extraction or synthesis technique is necessary to obtain a medically potent powder. Ultrasonically assisted antisolvent precipitation is a highly efficient method to synthesise curcumin particles. The ultrasonic antisolvent precipitation…https://www.hielscher.com/ultrasonic-precipitation-of-curcumin-superparticles.htm
Herbs, spices and other plant materials are rich in phytochemicals, which are valued components for medicinal and nutritional products. Sonication breaks the cell structure and releases the bioactive compounds - resulting in higher yields and faster extraction rates. As…https://www.hielscher.com/ultrasonic-extraction-of-medicinal-herbs.htm
Curcumin is a pharmacological and nutritional phytochemical present in the rhizomes of Curcuma longa. For high extraction yield, sonication is the most efficient technique. Ultrasonic extraction results in high quality, high yield and requires only short processing time. Ultrasonic…https://www.hielscher.com/ultrasonic-cucurmin-extraction.htm
Henna extracts are widely used in cosmetic, nutritional and medical products. The ultrasonic extraction method increases the yield of the active compounds such as antioxidants, phenolics, and colorants. Ultrasonic processing is a mild non-thermal technique to intensify the Henna…https://www.hielscher.com/ultrasonic-henna-extraction.htm
Ultrasonic dispersion is the superior method to blend C60 homogeneously into a stable oil-based supplement. The mild, precisely controllable ultrasonic treatment ensures that the C60 molecules are kept intact for best results. The ultrasonically blended nano-structured formulation results in…https://www.hielscher.com/ultrasonic-dispersion-of-c60-into-supplements.htm
During DNA and RNA shearing, DNA molecules are broken into smaller pieces. DNA / RNA fragmentation is one of the important sample prep steps required create libraries for next generation sequencing (NGS). Ultrasonic DNA shearing uses the forces of…https://www.hielscher.com/ultrasonic-dna-shearing.htm