Utrasonic topic: "Ultrasonic liposome production and its advantages"
A liposome is a spherical vesicle with at least one lipid bilayer. Liposomes are widely used as vehicles for drug and nutrient delivery. Due to its composition and size, liposomes offer a great bioavailability and absorption rate in the body. Sonication is the preferred technique to prepare loaded liposomes, such as small, unilamellar vesicles (SUV) with diameters in the range of 15-50nm or large, multilamellar vesicles (LMV) with a size of with a mean diameter of 120-140nm. The majority of liposomes is composed of phospholipids, e.g. phosphatidylcholine, but other lipids, such as egg phosphatidylethanolamine, are successfully used too, if compatible with lipid bilayer structure.
Hielscher ultrasonicators are reliable tools to produce nano-sized liposomes and to formulate liposomal products. To ensure reproducibility and highest quality standards of the liposomal products, Hielscher ultrasonicators can be precisely controlled. The most important ultrasonic process parameters such as amplitude, time, temperature, and pressure can be exactly set and monitored. An integrated SD-card automatically protocols the ultrasonic parameters and facilitates thereby reproducibility and quality control.
Read more about the use of ultrasonic processors for the preparation of liposomes!
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The fatty acid amide palmitoylethanolamide (PEA) is used as oral drug administered for its anti-inflammatory and neuroprotective effects. However, being a lipid and expressing a large particle size, the bioavailability and bioaccessibility of palmitoylethanolamide (PEA) is limited due its poor…https://www.hielscher.com/ultramicronization-and-nano-formulation-of-palmitoylethanolamide-pea.htm
Extracts of the Baggibuti (Stachys parviflora L.) plant are valued as herbal medicine used as treatment of cramps, arthralgia, epilepsy, falling sickness, and dracunculiasis. Ultrasonic extractors are successfully applied for the isolation of polyphenols and other phytochemicals from Stachys parviflora.…https://www.hielscher.com/ultrasonic-extraction-of-polyphenols-from-baggibuti-stachys-parviflora.htm
Ultrasonication is a well-established process intensifying technique, which is used in many kinds of liquid applications such as homogenization, mixing, dispersing, wet-milling, emulsification as well as improving heterogeneous chemical reactions. If your production process is underperforming and does not achieve…https://www.hielscher.com/ramp-up-slow-and-insufficient-manufacturing-processes.htm
An emulsion is a two-phase system of two immiscible liquids, where one phase, the so-called internal or dispersed phase, is distributed as small droplets into the other, so-called external or continuous, phase. To prepare an emulsion, generally energy input into…https://www.hielscher.com/ultrasonic-emulsifiers.htm
Ultrasonically-assisted production of antibiotics can increase their effectiveness, eben against drug-resistant bacteria: The increasing number of antibiotic-resistant bacteria strains is a still unsolved problem making bacterial infections, which have been successfully treated with antibiotics within the last decades, a worldwide…https://www.hielscher.com/ultrasonic-nanostructuring-of-antibiotics.htm
Elderberry extracts are well-known for their antiviral properties and thereby heavily used as natural remedy to relieve flu symptoms such as fever, cough, and sore throat. To produce elderberry extracts with a high polyphenol and antioxidant content, a mild yet…https://www.hielscher.com/ultrasonic-elderberry-extraction.htm
Pet food manufacturing requires reliable high-shear mixing equipment to prepare homogeneous mixtures of various ingredients. Ultrasonic mixers provide ultras-high shear forces that can process highly viscous slurries and doughs. Furthermore, ultrasonic mixers are used to produce stable nano-emulsions and to…https://www.hielscher.com/high-shear-mixers-for-pet-food-manufacturing.htm
Are you looking for a powerful and reliable extraction setup to produce high-quality botanical extracts? Here you can find a comparison of common extraction techniques including ultrasonic extraction, supercritical CO2 extraction, ethanol extraction, maceration amongst others and their advantages as…https://www.hielscher.com/most-efficient-botanical-extracts.htm
Smart drugs and nootropic supplements are consumed as “cognitive enhancers” in order to increase cognitive function, brain capacity, concentration, memory and creativity, to boost motivation and mental energy as well as to support brain health. To promote the transport of…https://www.hielscher.com/nootropics-and-smart-drug-formulations-with-ultrasonics.htm
Ultrasonication is well known to be highly efficient in the preparation of liposomal formulations. Typical liposome formulations encapsulate vitamin C, CBD, curcumin, quercitin, astaxanthin, peptides and manifiold other bioactive compounds using ultrasonication. Ultrasonic liposome encapsulation is a simple, fast and…https://www.hielscher.com/liposomal-encapsulated-bioactive-molecules-with-ultrasonics.htm
The formulation of THC-enhanced beverages is challenging. - THC-infused drinks must be nano-emulsified in order to provide a high bioavailability and thereby potency, long-term stability and clear appearance. Ultrasonic nano-emulsification of THC into beverage is highly efficient and efficacious resulting…https://www.hielscher.com/water-soluble-nano-thc-formulations-with-sonication.htm
Skin care products such as cremes, lotions, moisturizers, balms and ointments are generally based on stable submicron- and nano-sized emulsions. Ultrasonic emulsification creates high-shear forces and is well-established as a potent and reliable blending technique for skin care and cosmetic…https://www.hielscher.com/ultrasonically-emulsified-cremes-and-cosmetic-products.htm