Utrasonic topic: "liposomes"
A liposome is a spherical vesicle with at least one lipid bilayer. Liposomes are widely used as vehicles for drug and nutrient delivery. Due to its composition and size, liposomes offer a great bioavailability and absorption rate in the body. Sonication is the preferred technique to prepare loaded liposomes, such as small, unilamellar vesicles (SUV) with diameters in the range of 15-50nm or large, multilamellar vesicles (LMV) with a size of with a mean diameter of 120-140nm. The majority of liposomes is composed of phospholipids, e.g. phosphatidylcholine, but other lipids, such as egg phosphatidylethanolamine, are successfully used too, if compatible with lipid bilayer structure.
Hielscher ultrasonicators are reliable tools to produce nano-sized liposomes and to formulate liposomal products. To ensure reproducibility and highest quality standards of the liposomal products, Hielscher ultrasonicators can be precisely controlled. The most important ultrasonic process parameters such as amplitude, time, temperature, and pressure can be exactly set and monitored. An integrated SD-card automatically protocols the ultrasonic parameters and facilitates thereby reproducibility and quality control.
Read more about the use of ultrasonic processors for the preparation of liposomes!
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Skin care products such as cremes, lotions, moisturizers, balms and ointments are generally based on stable submicron- and nano-sized emulsions. Ultrasonic emulsification creates high-shear forces and is well-established as a potent and reliable blending technique for skin care and…https://www.hielscher.com/ultrasonically-emulsified-cremes-and-cosmetic-products.htm
Lipstick manufacturing involves the grinding and mixing of waxes and colour pigments on a precisely controllable level to ensure a certain colour and texture profile of the lipstick. Ultrasonic grinding and mixing is a reliable, efficient, and exactly controllable…https://www.hielscher.com/ultrasonic-milling-for-lipstick-manufacturing.htm
Famotidine is a common pharmaceutical molecule used in heartburn medications. In order to overcome the poor solubility and the resulting poor bioavailability, famotidine can be formulated into solid-lipid nanoparticles using sonication as encapsulation technique. Ultrasonically Famotidine-Loaded Solid Lipid Nanoparticles…https://www.hielscher.com/ultrasonically-formulated-famotidine-solid-lipid-nanoparticles.htm
Nanostructure lipid carriers (NLCs) are an advanced form of nano-sized drug delivery systems featuring a lipid core and a water-soluble shell. NLCs have a high stability, protect the active bio-molecules against degradation and offer sustained drug release. Ultrasonication is…https://www.hielscher.com/ultrasonic-formulation-of-nanostructured-lipid-drug-carriers.htm
Allicin is a bioactive compound, which can be extracted from fresh garlic cloves. Allicin is prone to degradation and must be therefore formulated into a stabilised supplement form in order to obtain a long-term potent formula. Ultrasonic encapsulation of…https://www.hielscher.com/ultrasonic-nanoliposomes-for-stabilised-allicin-formulations.htm
Garlic (Allium sativum) is rich in organosulfur compounds (e.g. allicin, glutathione), which promote many health benefits. Ultrasonic extraction is a reliable and efficient technique to produce highly concentrated garlic extracts. Ultrasonication results in high yields of high quality, full…https://www.hielscher.com/ultrasonic-solvent-free-garlic-extraction.htm
Nanoliposomes are highly effective drug carriers used to enhance the bioavailability of bioactive compounds such as omega-2 fatty acids, vitamins, and other substances. Ultrasonic encapsulation of bioactive compounds is a fast and simple technique to prepare nanoliposomes with high…https://www.hielscher.com/ultrasonic-production-of-liposomal-omega-3-fatty-acids.htm
Remdesivir (GS-5734) is an anti-viral drug, which is under research for treating the Ebola virus disease and COVID-19, which is caused by the Sars-CoV-2 coronavirus. Remdesivir is pharmaceutical solution, which is administered intravenously. Whilst short ultrasonic dissolving alone enhances…https://www.hielscher.com/improved-remdesivir-solubility-by-sonication.htm
Drugs such avermectin and ivermectin are often encapsulated into nano-structured drug carriers to improve absorption rate and bioavailability as well to obtain a sustained‑release effect. Ultrasonic nano-emulsification is an efficacious and reliable technique to entrap bioactive medicinal compounds into…https://www.hielscher.com/ultrasonic-nano-encapsulation-of-ivermectin.htm
Nanoparticle-based drug carrier are an evolving technology, which allows to formulate vaccine delivery systems with a high protection rate against various diseases. Ultrasonic emulsification and encapsulation is a highly efficient method to prepare loaded nano-structured drug carriers such as…https://www.hielscher.com/nano-encasulated-intranasal-vaccine-against-s-pneumoniae-with-ultrasonics.htm
Ultrasonication is a powerful tool used in biology, molecular chemistry and biochemistry as well as in the production of pharmaceuticals. Bio-sciences use ultrasonic homogenizers to lyse cells and extract proteins and other intracellular materials, the pharma industry applied ultrasonics…https://www.hielscher.com/coronavirus-covid-19-sars-cov-2-and-ultrasonics.htm
Chloroquine seem to be a promising drug in the fight against the COVID-19 pandemic. Whilst chloroquine is a long-known, cheap drug, the supply must be significantly ramped up to fulfil the current need. Ultrasonic synthesis is a simple, safe…https://www.hielscher.com/ultrasonic-synthesis-of-pharma-grade-chloroquine.htm