Utrasonic topic: "liposomes"
A liposome is a spherical vesicle with at least one lipid bilayer. Liposomes are widely used as vehicles for drug and nutrient delivery. Due to its composition and size, liposomes offer a great bioavailability and absorption rate in the body. Sonication is the preferred technique to prepare loaded liposomes, such as small, unilamellar vesicles (SUV) with diameters in the range of 15-50nm or large, multilamellar vesicles (LMV) with a size of with a mean diameter of 120-140nm. The majority of liposomes is composed of phospholipids, e.g. phosphatidylcholine, but other lipids, such as egg phosphatidylethanolamine, are successfully used too, if compatible with lipid bilayer structure.
Hielscher ultrasonicators are reliable tools to produce nano-sized liposomes and to formulate liposomal products. To ensure reproducibility and highest quality standards of the liposomal products, Hielscher ultrasonicators can be precisely controlled. The most important ultrasonic process parameters such as amplitude, time, temperature, and pressure can be exactly set and monitored. An integrated SD-card automatically protocols the ultrasonic parameters and facilitates thereby reproducibility and quality control.
Read more about the use of ultrasonic processors for the preparation of liposomes!
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Nanoparticle-based drug carrier are an evolving technology, which allows to formulate vaccine delivery systems with a high protection rate against various diseases. Ultrasonic emulsification and encapsulation is a highly efficient method to prepare loaded nano-structured drug carriers such as…https://www.hielscher.com/nano-encasulated-intranasal-vaccine-against-s-pneumoniae-with-ultrasonics.htm
Ultrasonication is a powerful tool used in biology, molecular chemistry and biochemistry as well as in the production of pharmaceuticals. Bio-sciences use ultrasonic homogenizers to lyse cells and extract proteins and other intracellular materials, the pharma industry applied ultrasonics…https://www.hielscher.com/coronavirus-covid-19-sars-cov-2-and-ultrasonics.htm
Chloroquine seem to be a promising drug in the fight against the COVID-19 pandemic. Whilst chloroquine is a long-known, cheap drug, the supply must be significantly ramped up to fulfil the current need. Ultrasonic synthesis is a simple, safe…https://www.hielscher.com/ultrasonic-synthesis-of-pharma-grade-chloroquine.htm
Nano-size drug carriers are widely used to deliver pharmaceutically active compounds into the targeted cells. In order to encapsulate the active substances into a drug carrier with a high bioavailability, solid lipid nanoparticles are used. Ultrasonic nano-emulsification and encapsulation…https://www.hielscher.com/pharmaceuticals-encapsulated-in-lipid-nanoparticles-with-ultrasonics.htm
Liposomal vitamin formulations are known for their higher bioavailability and absorption rate. Vitamin C, an antioxidant, is a common supplement used in nutritional and medical drugs to support the human body's own immune system. Ultrasonication is a reliable and…https://www.hielscher.com/liposomal-vitamin-c-production-with-ultrasonics.htm
Clear nano-emulsions have a wide range of applications in food, beverage and cosmetic formulations. Stuph Corp supplies is various food-grade, high-quality emulsifiers for the preparation of clear nano-emulsions for the use in food, drinks, tinctures, concentrates as well as…https://www.hielscher.com/clear-nano-emulsions-with-stuph-and-ultrasonics.htm
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Ultrasonic terpene extraction has been proven to give high yields of terpene caryophyllene oxide, e.g. from cannabis and hops. Caryophyllene oxide is a terpene found in cannabis, hops, pepper, basil and rosemary. As an active compound, extracted terpene caryophyllene…https://www.hielscher.com/ultrasonic-terpene-extraction.htm
Resveratrol is a polyphenol, which promises many health benefits, e.g. prolonging life span, and to treat heart disease, diabetes, cancer, Alzheimer's as well as other chronic conditions. However, resveratrol has a low bioavailability and shows a rapid clearance from…https://www.hielscher.com/ultrasonic-resveratrol-inclusion-complex.htm
Ultrasonic nanoemulsions excel as drug carrier due to a significantly higher solubilization capacity than simple micelle solutions. Their thermodynamic stability offers advantages over unstable systems such as macro-sized emulsions, dispersions and suspensions. Hielscher's ultrasonicators are used to prepare nanoemulsions…https://www.hielscher.com/why-nanoformulated-medicines.htm
Hielscher ultrasonic extractors are the state-of-art technique when it comes to the reliable and efficient extraction of hemp and CBD oils. Ultrasonication is well-known as a highly potent extraction technique to release valuable compounds from botanicals. In comparison to…https://www.hielscher.com/highly-efficient-ultrasonic-cannabidiol-cbd-extraction-from-cannabis.htm
Piperine is a bioactive substance that is found in peppercorns and valued for its pharmacological properties. Ultrasonic is an efficient, simple, and rapid extraction technique to isolate high-quality piperine. Ultrasonic extraction is a reliable and proven method, already widely…https://www.hielscher.com/ultrasonic-extraction-of-piperine-from-pepper.htm