Utrasonic topic: "How to facilitate the Sample Preparation "
In daily laboratory work, sample preparation is a procedure in which a sample is treated prior to its analysis. Ultrasonic lab homogenizers are a reliable and powerful tool to prepare samples before common analysis steps such as chromatography (e.g. GC, LC, UPLC, IC), mass spectrometry (e.g. GC/MS, TD GC-MS, LC/MS), microscopy (e.g. SEM, TEM), surface analysis (e.g. SEM, TEM, EDX, XRD, FTIR), elemental analysis techniques etc.
Ultrasoniators fulfil common sample preparation tasks such as homogenising of solids and liquids, emulsifying of two or more immiscible liquids, dispersing powders, milling of nanoparticles, extracting of bioactive compounds or analytes, deaerating and degassing of samples etc. rapidly and reliable.
Since Hielscher ultrasonic devices can precisely controlled, all sonication results are reproducible. Furthermore, all ultrasonically obtained results can be linearly scaled to smaller or larger volumes. This facilitates the reproduction of sample preparation and analytical results significantly.
Hielscher Ultrasonics manufactures various ultrasonic lab homogenizers such as hand-held and stand-mounted devices, the VialTweeter for the simultaneous indirect sonication of up to 10 vials without cross-contamination or the SonoStep, a sample prep unit which combines sonication, stirring and pumping in one compact system. Digital touch-screen, integrated SD for automatic data protocoling and sample illumination ensure user-friendliness and comfort.
Read more about how ultrasonic sample preparation can facilitate your daily lab work!

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Chromatin Shearing: High-Throughput and Non-Contact Precision
Chromatin shearing is a critical step in many molecular biology workflows, enabling the fragmentation of chromatin into precise sizes for applications like ChIP and NGS. The UIP400MTP multi-well plate sonicator revolutionizes this process with its high-throughput, non-contact technology, offering unmatched…
https://www.hielscher.com/uip400mtp-chromatin.htmSonication Devices for your Lab Tasks
Sonication devices, particularly probe-type sonicators, are highly specialized tools widely employed in both laboratory and industrial settings. These instruments harness the power of ultrasound to efficiently process various materials. By transmitting ultrasonic energy through a probe (or horn) into a…
https://www.hielscher.com/sonication-devices-for-your-lab-tasks.htmVideo: Multi-Sample Sonicator
Effortless Chromatin, DNA, RNA, and Protein Shearing with Unmatched Consistency. The UIP400MTP multi-sample sonicator delivers superior sonication performance with short processing times, outstanding uniformity and at minimal operating costs. The Hielscher UIP400MTP multi-sample sonicator is a versatile, high-performance ultrasonic…
https://www.hielscher.com/video-multi-sample-sonicator.htmSterile Sonication of Falcon Tubes
The VialTweeter VT26dxx is an ultrasonic sample homogenizer designed specifically for Falcon tubes. The VialTweeter VT26dxx sonicates the sample in a Falcon tube indirectly, avoiding the insertion of an ultrasonic probe into the sample. This allows cross-contamination and sample loss…
https://www.hielscher.com/sterile-sonication-of-falcon-tubes.htmMastering Lab Tasks with an Ultrasonic Homogenizer
Sonicators are essential lab tools used for a wide range of applications, such as homogenization and mixing, extraction, dispersing, emulsifying, dissolution, cell disruption, DNA fragmentation, and sonochemical reactions. Typically, probe-type sonicators are used to fulfill these common tasks in daily…
https://www.hielscher.com/mastering-lab-tasks-with-an-ultrasonic-homogenizer.htmProteomic Research – Why a Sonicator is Indispensable for Sample Preparation
Proteomic research gives deep insights into cell biology and widens our understanding of biological systems by enabling the comprehensive analysis of proteins and their functions. Central to the success of proteomic studies is the preparation of high-quality samples, which often…
https://www.hielscher.com/proteomic-research-why-a-sonicator-is-indispensable-for-sample-preparation.htmUltrasonic Lysis: Step-by-Step Guide to Perfecting Cell Disruption
Do you want to master the science of cell lysis? Look no further! In this step-by-step guide, we will walk you through the process of ultrasonic cell disruption and ensure that your cell lysis technique gets you optimal results. Whether…
https://www.hielscher.com/ultrasonic-lysis-step-by-step-guide-to-perfecting-cell-disruption.htmSterile Homogenization using Sonification
For sterile homogenization, a sample is placed into a sterile container which then is agitated in order to obtain a homogeneous blend. Ultrasonification is a highly efficient and reliable technique to treat one or multiple samples under sterile conditions and…
https://www.hielscher.com/sterile-homogenization-using-sonification.htmUltrasonic Applications in MonkeyPox Virus
Ultrasonication is an important processing method for the isolation of the monkeypox virus (MPXV) from analytical samples, for virus DNA fragmentation as well as in monkeypox vaccine manufacturing. For sample preparation before diagnostics and analysis (PCR, ELISA etc.) ultrasonication is…
https://www.hielscher.com/ultrasonic-applications-in-monkeypox-virus.htmUltrasonically Agitated Syringe Filter for Higher Throughputs
Ultrasonically agitated syringe filters enable to work at higher flow rates and loading capacities. Samples with higher solid contents can be reliable and efficiently processed using an ultrasonically vibrated syringe filters. This allows for higher throughputs. Ultrasonically agitation of syringe…
https://www.hielscher.com/ultrasonically-agitated-syringe-filter-for-higher-throughputs.htmUltrasonic DNA Fragmentation for Next Gen Sequencing
Next Generation Sequencing (NGS) requires the reliable shearing and fragmentation of genomic DNA in order to sequence genomic DNA strands and to create genome libraries. The controlled fragmentation of DNA into DNA fragments is an essential sample preparation step required…
https://www.hielscher.com/ultrasonic-dna-fragmentation-for-next-gen-sequencing.htmFlow Cells and Inline Reactors for Lab Ultrasonicators
Ultrasonic lab homogenizers can be used for batch and inline processing of liquids and slurries. Typical applications include homogenization, dispersing, emulsification, dissolving as well as sonochemical reactions. For the continuous inline sonication, flow cells and in-line reactors in various sizes…
https://www.hielscher.com/flow-cells-and-inline-reactors-for-lab-ultrasonicators.htm