Sterile Sonication of Falcon Tubes
The VialTweeter VT26dxx is an ultrasonic sample homogenizer designed specifically for Falcon tubes. The VialTweeter VT26dxx sonicates the sample in a Falcon tube indirectly, avoiding the insertion of an ultrasonic probe into the sample. This allows cross-contamination and sample loss completely marking a significant advancement in biological sample processing. By offering precise control over processing parameters such as amplitude, temperature and duration, the VT26dxx enhances quality and reliability in sample preparation
Sonication of Samples in Falcon Tubes
The Hielscher VT26dxx is an indispensable tool for laboratories that frequently work with Falcon tubes. The VT26dxx is a highly reliable, consistent, and contamination-free method for sonication of samples in Falcon tubes. By offering precise energy control, reducing contamination risks, and improving sample homogeneity, the Hielscher VialTweeter VT26dxx for Falcon tubes outperforms traditional ultrasonic baths in virtually every aspect.
As research demands grow and evolve, this homogenizer exemplifies the forward-thinking design needed to meet the challenges of modern biological research. Researchers can look forward to achieving faster, more accurate results while preserving the quality and integrity of their valuable biological samples.
VT26dxx – Applications and Advantages
The VialTweeter model VT26dxx for ultrasonic sample homogenization in Falcon tubes is particularly advantageous in a variety of biological research applications, including:
- Tissue Homogenization: For extracting RNA, DNA, or proteins from tissues, uniform and effective homogenization is essential. The ability of this homogenizer to break down tough tissues – such as muscle, liver, or plant material – within Falcon tubes makes it a valuable tool for genomics and proteomics studies.
- Cell Suspensions and Microbial Cultures: Researchers working with microbial cultures or cell suspensions will appreciate the ability to quickly and uniformly resuspend cells after centrifugation. The gentle agitation settings also make it suitable for fragile cells that need to be kept intact.
- Enzyme Reactions and Drug Studies: Homogenizing biological samples in drug discovery or enzymatic reaction studies ensures that the entire sample is consistently exposed to treatment, enhancing the accuracy and reproducibility of results.
- Stem Cell Isolation: The indirect, yet intense sonication is ideal to isolate stem cells from adipose tissue under clinical conditions.
- Protein Purification: Indirect sonication provides the energy necessary to lyse cells while maintaining protein integrity, ensuring more efficient purification processes.
- Nanoparticle Dispersion: Uniform sonication energy is essential for the even dispersion of nanoparticles, and the Hielscher device delivers this consistency without the risk of contamination from probe contact.
- Emulsification: Indirect sonication with the Hielscher device facilitates the creation of stable emulsions, useful in pharmaceutical and cosmetic research.
VialTweeter Sonicator for Sterile Sample Preparation
The VialTweeter offers a distinctive approach to single vial sonication, delivering powerful and reliable results that are essential for both research and clinical analysis. Its engineering, rooted in German quality, ensures durability and precision, setting it apart from other sonicators in the market. The ultrasonic sterile homogenizer is designed with customization in mind, allowing users to tailor it to their specific needs, which enhances usability and effectiveness. Additionally, Hielscher Ultrasonics is committed to exceptional customer service, ensuring that users receive the support they need for optimal performance. This combination of robust functionality, reproducible results, and dedicated service makes the VialTweeter a top choice for those requiring effective sonication solutions.
Design, Manufacturing and Consulting – Quality Made in Germany
Hielscher ultrasonicators are well-known for their highest quality and design standards. Robustness and easy operation allow the smooth integration of our ultrasonicators into industrial facilities. Rough conditions and demanding environments are easily handled by Hielscher ultrasonicators.
Hielscher Ultrasonics is an ISO certified company and put special emphasis on high-performance ultrasonicators featuring state-of-the-art technology and user-friendliness. Of course, Hielscher ultrasonicators are CE compliant and meet the requirements of UL, CSA and RoHs.
Literature / References
- FactSheet VialTweeter VT26dxx – Customized VialTweeter Sonicator for Single Test Tubes or Vials
- FactSheet VialTweeter – Sonicator for Simultaneous Sample Preparation
- Michaela Wenzel, Alina Iulia Chiriac, Andreas Otto, Dagmar Zweytick, Caroline May, Catherine Schumacher, Ronald Gust, H. Bauke Albada, Maya Penkova, Ute Krämer, Ralf Erdmann, Nils Metzler-Nolte, Suzana K. Straus, Erhard Bremer, Dörte Becher, Heike Brötz-Oesterhelt, Hans-Georg Sahl, Julia E. Bandow (2014): Small Cationic Antimicrobial Peptides Delocalize Peripheral Membrane Proteins. PNAS April 8, 2014.
- Tim Krischuns; Franziska Günl; Lea Henschel; Marco Binder; Joschka Willemsen; Sebastian Schloer; Ursula Rescher; Vanessa Gerlt; Gert Zimmer; Carolin Nordhoff; Stephan Ludwig; Linda Brunotte (2018): Phosphorylation of TRIM28 Enhances the Expression of IFN-β and Proinflammatory Cytokines During HPAIV Infection of Human Lung Epithelial Cells. Frontiers in immunology Vol. 9, September 2018.
- Müller A., Eller J., Albrecht F., Prochnow P., Kuhlmann K., Bandow J. E., Slusarenko A. J., Leichert L.I.O. (2016): Allicin Induces Thiol Stress in Bacteria through S-Allylmercapto Modification of Protein Cysteines. Journal of Biological Chemistry, Vol. 291, No. 22, 2016. 11477-11490.
- Sabine Amon, Fabienne Meier-Abt, Ludovic C. Gillet, Slavica Dimitrieva, Alexandre P. A. Theocharides, Markus G. Manz, Ruedi Aebersold (2019): Sensitive Quantitative Proteomics of Human Hematopoietic Stem and Progenitor Cells by Data-independent Acquisition Mass Spectrometry. Molecular & Cellular Proteomics 18, 2019. 1454–1467.
- Stephanie Laughton; Adam Laycock; Frank von der Kammer;Thilo Hofmann; Elizabeth A. Casman; Sónia M. Rodrigues; Gregory V. Lowry (2019): Persistence of copper-based nanoparticle-containing foliar sprays in Lactuca sativa (lettuce) characterized by spICP-MS. Journal of Nanoparticle Research 21:174, 2019.
Frequently Asked Questions
What is a Falcon Tube?
A Falcon tube is a type of conical centrifuge tube commonly used in laboratories for the storage and centrifugation of biological samples, such as cells, tissues, and fluids. Typically made from plastic, these tubes are available in various sizes, often ranging from 15 to 50 milliliters, and feature a screw-cap lid to prevent leakage. They are designed to withstand the forces generated during centrifugation and are often used in molecular biology, microbiology, and biochemistry applications for sample preparation and processing.
Where does the Name “Falcon Tube” come from?
The name “Falcon Tube” comes from the brand name of the product manufactured by Becton, Dickinson and Company (BD). The term originated in the 1960s when BD introduced these conical centrifuge tubes, and they became widely recognized in scientific and laboratory settings. The brand name “Falcon” is now often used generically to refer to similar types of centrifuge tubes, regardless of the manufacturer.

Hielscher Ultrasonics manufactures high-performance ultrasonic homogenizers from lab to industrial size.