Utrasonic topic: "How to use ultrasonicators"
Ultrasonicators are ultrasonic probe-type devices, which are used for manifold applications including homogenization, dispersing, wet-milling, emulsification, extraction, lysis, disintegration, and chemical reactions.
The working principle of an ultrasonicator is based on the phenomenon of acoustic cavitation. When intense ultrasound waves are coupled into a liquid, alternating high-pressure / low-pressure cycles travel through the liquid. During the low-pressure cycles, the ultrasonic waves create minuscule vacuum bubbles, which grow over several pressure cycles. When the vacuum bubbles reach a volume at which they cannot absorb further energy, they implode violently during a high-pressure cycle. Briefly, cavitation is the growth and collapse of vacuum bubbles or cavities. During the bubble implosion, an exceptionally energy-dense field is created. In an acoustic cavitation field, extreme conditions – including very high temperature and pressure differentials, turbulences, shear forces and liquid jets – can be measured. These intense cavitational forces are used to fulfil the manifold applications mentioned above.
Ultrasonicators create cavitation to apply it purposefully to liquids, slurries and gas in order to achieve particle size reduction, mixing of oil/water phases, cell disruption or to induce chemical reactions.
Sonication (also ultrasonication) describes the process of applying ultrasound energy to a liquid or slurry. Hielscher Ultrasonics designs, manufactures and distributes high-intensity, low-frequency ultrasonicators from lab & bench-top to fully industrial scale.
Read more about ultrasonicators and their applications!
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Click Chemistry – How to Enhance Click Reactions with Sonication
Click chemistry reactions such as copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions can greatly benefit from the application of power ultrasound. Sonochemical effects increase yield and conversion rate. Additionally, the overall efficiency of click chemistry reactions is improved. As a technique of…https://www.hielscher.com/click-chemistry-how-to-enhance-click-reactions-with-sonication.htm
Lubricants with Nanoparticle-Improved Functionalities
Lubricating oils can greatly benefit from nano-additives, which help to reduce friction and wear. It is however crucial, that nano-additives such as nanoparticles, graphene monolayers or core-shell nanospheres are uniformly and single-dispersed in the lubricant. Ultrasonic dispersion has been proven…https://www.hielscher.com/lubricants-with-nanoparticle-improved-functionalities.htm
Nanodiamonds Dispersed in Aqueous Suspension with Sonication
Nanodiamond dispersions are efficient and quickly produced using ultrasonic dispersers. Ultrasonic deaggregation and dispersion of nanodiamonds can be reliably performed in an aqueous suspension. The ultrasonic dispersion technique uses salt for pH modification and is thereby a facile, inexpensive, and…https://www.hielscher.com/nanodiamonds-dispersed-in-aqueous-suspension-with-sonication.htm
Dissolving: High-Performance Dissolvers
Dissolvers by Hielscher Ultrasonics use the mechanical forces of acoustic cavitation in order to disperse and deagglomerate powders into a colloidal suspension. Ultrasonic dissolvers are widely used in the paint and pigment industry, where pigment powder is dispersed in a…https://www.hielscher.com/dissolving-high-performance-dissolvers.htm
Ultrasonic Extraction of Active Compounds from Grape and Wine By-Products
Grapes (Vitis vinifera), vine and wine by-products are rich in polyphenols and other bioactive substances, which are valuable compounds for the production of medicinal and nutritional supplements. Ultrasonic extraction allows for the simple and highly efficient isolation of grape- and…https://www.hielscher.com/ultrasonic-extraction-of-active-compounds-from-grape-and-wine-by-products.htm
Polyol Synthesis via Ultrasonic Transesterification
Polyols are synthetic esters produced mainly via a transesterification of triglycerides from vegetable oils or animal fats. These polyols are raw material for the production of polyurethans, biolubricants and other cemicals. Ultrasonication is used to enhance transesterification reactions by applying…https://www.hielscher.com/polyol-synthesis-via-ultrasonic-transesterification.htm
Homogenizers – Working Principle, Use and Scale-Up
Homogenizers are a type of mixers, which apply mechanical forces to blend, emulsify, disperse, and dissolve liquid-liquid and solid-liquid systems. Depending on the homogenizer model rotational shear, nozzles or high-power ultrasound are used to create the required forces to disintegrate…https://www.hielscher.com/homogenizers-working-principle-use-and-scale-up.htm
Ultrasonication Outcompetes Other Extraction Methods by Speed
The rapid procedure of ultrasonic extraction and the therefrom resulting time savings in extract production are one of many advantages of ultrasonic extraction of bioactive compounds from plants. Ultrasonic extraction has been scientifically compared to alternative extraction techniques such as…https://www.hielscher.com/ultrasonication-outcompetes-other-extraction-methods-by-speed.htm
Ultrasonically Improved Kombucha Fermentation
Kombucha is a fermented beverage containing tea, sugar, bacteria, yeast and often a little amount of juice, fruit or spices as flavouring. Kombucha as well as fermented juice and vegetable juices are known for having positive effects on health, strengthening…https://www.hielscher.com/ultrasonically-improved-kombucha-fermentation.htm
Nasal Spray Formulations Emulsified with Ultrasound
Nasal sprays and mouth sprays are widely used drug administering solutions to apply active ingredients to the respiratory mucosa. Ultrasonic emulsification is a highly efficient and reliable technique to produce highly efficacious nasal and mouth spays with very high bioavailability,…https://www.hielscher.com/nasal-spray-formulations-emulsified-with-ultrasound.htm
Ultrasonic Production of Highly Purified Schizophyllan β-Glucans
Schizophyallan is a fungal β-glucan with immunomodulating properties. For highly active medicinal effects, schizophyllan must have a low molecular weight in order to show improved bioavailability. Ultrasonication has been proven to reduce the molecular weight of schizophyllan. As reliable and…https://www.hielscher.com/ultrasonic-production-of-highly-purified-schizophyllan-%ce%b2-glucans.htm
Efficient and Controlled Synthesis of Gold Nanoparticles
Gold nanoparticles of uniform shape and morphology can be efficiently synthesized via sonochemical route. The ultrasonically promoted chemical reaction of gold nanoparticle synthesis can be precisely controlled for particle size, shape (e.g., nanospheres, nanorods, nanobelts etc.) and morphology. The efficacious,…https://www.hielscher.com/efficient-and-controlled-synthesis-of-gold-nanoparticles.htm