Utrasonic topic: "How to use ultrasonicators"
Ultrasonicators are ultrasonic probe-type devices, which are used for manifold applications including homogenization, dispersing, wet-milling, emulsification, extraction, lysis, disintegration, and chemical reactions.
The working principle of an ultrasonicator is based on the phenomenon of acoustic cavitation. When intense ultrasound waves are coupled into a liquid, alternating high-pressure / low-pressure cycles travel through the liquid. During the low-pressure cycles, the ultrasonic waves create minuscule vacuum bubbles, which grow over several pressure cycles. When the vacuum bubbles reach a volume at which they cannot absorb further energy, they implode violently during a high-pressure cycle. Briefly, cavitation is the growth and collapse of vacuum bubbles or cavities. During the bubble implosion, an exceptionally energy-dense field is created. In an acoustic cavitation field, extreme conditions – including very high temperature and pressure differentials, turbulences, shear forces and liquid jets – can be measured. These intense cavitational forces are used to fulfil the manifold applications mentioned above.
Ultrasonicators create cavitation to apply it purposefully to liquids, slurries and gas in order to achieve particle size reduction, mixing of oil/water phases, cell disruption or to induce chemical reactions.
Sonication (also ultrasonication) describes the process of applying ultrasound energy to a liquid or slurry. Hielscher Ultrasonics designs, manufactures and distributes high-intensity, low-frequency ultrasonicators from lab & bench-top to fully industrial scale.
Read more about ultrasonicators and their applications!
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Nasal sprays and mouth sprays are widely used drug administering solutions to apply active ingredients to the respiratory mucosa. Ultrasonic emulsification is a highly efficient and reliable technique to produce highly efficacious nasal and mouth spays with very high…https://www.hielscher.com/nasal-spray-formulations-emulsified-with-ultrasound.htm
Schizophyallan is a fungal β-glucan with immunomodulating properties. For highly active medicinal effects, schizophyllan must have a low molecular weight in order to show improved bioavailability. Ultrasonication has been proven to reduce the molecular weight of schizophyllan. As reliable…https://www.hielscher.com/ultrasonic-production-of-highly-purified-schizophyllan-%ce%b2-glucans.htm
Gold nanoparticles of uniform shape and morphology can be efficiently synthesized via sonochemical route. The ultrasonically promoted chemical reaction of gold nanoparticle synthesis can be precisely controlled for particle size, shape (e.g., nanospheres, nanorods, nanobelts etc.) and morphology. The…https://www.hielscher.com/efficient-and-controlled-synthesis-of-gold-nanoparticles.htm
High power ultrasonication can efficient and reliably break-up particle agglomerates and even disintegrate primary particles. Due to its high-performance dispersion performance, probe-type ultrasonicators are used as preferred method to create homogeneous nanoparticle suspensions. Reliable Nanoparticle Dispersion by Ultrasonication Many…https://www.hielscher.com/reliable-nanoparticle-dispersion-for-industrial-applications.htm
The ASTM D5621 standard test method describes the sonic shear stability testing of hydraulic fluids and their viscosities at 40°C and 100°C, respectively. In order to test and determine the viscosity stability of hydraulic fluids under shear, a reliable…https://www.hielscher.com/ultrasonicators-for-astm-d5621-sonic-shear-stability-of-hydraulic-fluids.htm
The ASTM D2603 standard describes the sonic shear stability testing of hydraulic fluids under ultra-sonically induced shear stress. Hielscher ultra-sonicators are used as reliable shear creating devices used for shear stability testing of hydraulic fluids in accordance to ASTM…https://www.hielscher.com/ultra-sonicators-for-astm-d2603.htm
Thickening sauces, juices, jams and other foods by gelation is a common process in the production of liquid foods. Ultrasonic extraction of pectins and natural intracellular sugars from fruits and vegetables is a highly efficient method to promote the…https://www.hielscher.com/improved-fruit-and-vegetable-gelation-by-ultrasonics.htm
Drosophila melanogaster is widely used in laboratories as model organism. Therefore, pre-analytical preparation steps such as lysis, cell disruption, protein extraction and DNA shearing of Drosophila melanogaster samples must be frequently carried out. Ultrasonic dismembrators are reliable and efficient…https://www.hielscher.com/lysis-of-drosophila-melanogaster-samples.htm
BL21 cells are a strain of E. coli that is widely used in research laboratories, biotechnology and industrial production due to their capability to express proteins highly efficient. Ultrasonic cell disruption, lysis and protein extraction is the common method…https://www.hielscher.com/cell-lysis-of-bl21-cells-by-ultrasonication.htm
Prussian Blue or iron hexacyanoferrate is a nano-structured metal organic framework (MOF), that is used in sodium‐ion battery manufacturing, biomedicine, inks and electronics. Ultrasonic wet-chemical synthesis is efficient, reliable and rapid pathway to produce Prussian Blue nanocubes and Prussian…https://www.hielscher.com/ultrasonic-wet-precipitation-of-prussian-blue-nanocubes.htm
Olive leaf extracts are a potent dietary supplement and therapeutic as it contains strong antioxidants such as the polyphenols oleuropein, hydroxytyrosol and verbascoside. Ultrasonic extraction is highly efficient technique to release and isolate bioactive compounds such as polyphenols, flavones…https://www.hielscher.com/ultrasonic-extraction-of-olive-leaf-extract.htm
Ultrasonic dismembrators are commonly used in the laboratory, bench-top and industry to prepare homogeneous colloidal suspensions such as emulsions and dispersions with droplet or particle sizes in the submicron- and nano-range. Furthermore, ultrasonic dismembrators are used for cell disruption,…https://www.hielscher.com/most-efficient-ultrasonic-dismembrators.htm