Utrasonic topic: "How to use ultrasonicators"
Ultrasonicators are ultrasonic probe-type devices, which are used for manifold applications including homogenization, dispersing, wet-milling, emulsification, extraction, lysis, disintegration, and chemical reactions.
The working principle of an ultrasonicator is based on the phenomenon of acoustic cavitation. When intense ultrasound waves are coupled into a liquid, alternating high-pressure / low-pressure cycles travel through the liquid. During the low-pressure cycles, the ultrasonic waves create minuscule vacuum bubbles, which grow over several pressure cycles. When the vacuum bubbles reach a volume at which they cannot absorb further energy, they implode violently during a high-pressure cycle. Briefly, cavitation is the growth and collapse of vacuum bubbles or cavities. During the bubble implosion, an exceptionally energy-dense field is created. In an acoustic cavitation field, extreme conditions – including very high temperature and pressure differentials, turbulences, shear forces and liquid jets – can be measured. These intense cavitational forces are used to fulfil the manifold applications mentioned above.
Ultrasonicators create cavitation to apply it purposefully to liquids, slurries and gas in order to achieve particle size reduction, mixing of oil/water phases, cell disruption or to induce chemical reactions.
Sonication (also ultrasonication) describes the process of applying ultrasound energy to a liquid or slurry. Hielscher Ultrasonics designs, manufactures and distributes high-intensity, low-frequency ultrasonicators from lab & bench-top to fully industrial scale.
Read more about ultrasonicators and their applications!
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Drosophila melanogaster is widely used in laboratories as model organism. Therefore, pre-analytical preparation steps such as lysis, cell disruption, protein extraction and DNA shearing of Drosophila melanogaster samples must be frequently carried out. Ultrasonic dismembrators are reliable and efficient…https://www.hielscher.com/lysis-of-drosophila-melanogaster-samples.htm
BL21 cells are a strain of E. coli that is widely used in research laboratories, biotechnology and industrial production due to their capability to express proteins highly efficient. Ultrasonic cell disruption, lysis and protein extraction is the common method…https://www.hielscher.com/cell-lysis-of-bl21-cells-by-ultrasonication.htm
Prussian Blue or iron hexacyanoferrate is a nano-structured metal organic framework (MOF), that is used in sodium‐ion battery manufacturing, biomedicine, inks and electronics. Ultrasonic wet-chemical synthesis is efficient, reliable and rapid pathway to produce Prussian Blue nanocubes and Prussian…https://www.hielscher.com/ultrasonic-wet-precipitation-of-prussian-blue-nanocubes.htm
Olive leaf extracts are a potent dietary supplement and therapeutic as it contains strong antioxidants such as the polyphenols oleuropein, hydroxytyrosol and verbascoside. Ultrasonic extraction is highly efficient technique to release and isolate bioactive compounds such as polyphenols, flavones…https://www.hielscher.com/ultrasonic-extraction-of-olive-leaf-extract.htm
Ultrasonic dismembrators are commonly used in the laboratory, bench-top and industry to prepare homogeneous colloidal suspensions such as emulsions and dispersions with droplet or particle sizes in the submicron- and nano-range. Furthermore, ultrasonic dismembrators are used for cell disruption,…https://www.hielscher.com/most-efficient-ultrasonic-dismembrators.htm
High shear mixers apply high shear forces into liquids and slurries in order to provide the uniform dispersing, blending, and emulsification of two or more liquid-solid or liquid-liquid phases. Ultrasonication generates high shear forces via acoustic cavitation, which occurs…https://www.hielscher.com/high-shear-mixing-with-ultrasonics.htm
Ultrasonic integrators are widely used to wet, disperse or dissolve particles and powders into liquids. High-performance ultrasonicators create intense shear forces, which break and shatter aggregates, agglomerates and primary particles to microscopic or nano size. The uniform particle processing…https://www.hielscher.com/disintegration-wetting-dissolving-dispersing.htm
Garlic (Allium sativum) is rich in organosulfur compounds (e.g. allicin, glutathione), which promote many health benefits. Ultrasonic extraction is a reliable and efficient technique to produce highly concentrated garlic extracts. Ultrasonication results in high yields of high quality, full…https://www.hielscher.com/ultrasonic-solvent-free-garlic-extraction.htm
Ultrasonic extraction is the superior method to disrupt algae cells effectively and rapidly. Sonication can release the complete amount of the bioactive compounds, which makes the ultrasonic technique highly efficient. How To Extract Proteins, Lipids and Phenolics from Algae…https://www.hielscher.com/ultrasonic-algae-extraction-for-nutritional-supplements.htm
Ultrasonication is a powerful tool used in biology, molecular chemistry and biochemistry as well as in the production of pharmaceuticals. Bio-sciences use ultrasonic homogenizers to lyse cells and extract proteins and other intracellular materials, the pharma industry applied ultrasonics…https://www.hielscher.com/coronavirus-covid-19-sars-cov-2-and-ultrasonics.htm
Nano-size drug carriers are widely used to deliver pharmaceutically active compounds into the targeted cells. In order to encapsulate the active substances into a drug carrier with a high bioavailability, solid lipid nanoparticles are used. Ultrasonic nano-emulsification and encapsulation…https://www.hielscher.com/pharmaceuticals-encapsulated-in-lipid-nanoparticles-with-ultrasonics.htm
Liposomal vitamin formulations are known for their higher bioavailability and absorption rate. Vitamin C, an antioxidant, is a common supplement used in nutritional and medical drugs to support the human body's own immune system. Ultrasonication is a reliable and…https://www.hielscher.com/liposomal-vitamin-c-production-with-ultrasonics.htm