Utrasonic topic: "Ultrasonic Processing in the Pharma Industry"
Power ultrasonics is a highly efficient and reliable tool for the production of vaccines, nano-formulated drugs and drug carriers (e.g. liposomes). Hielscher Ultrasonics’ lab, pilot and industrial systems produce pharma-grade micron- and nano-emulsions / -dispersions, liposomes as well as vaccines. Hielscher’s ultrasonic systems are equipped with CIP (clean-in-place) and SIP (sterilize-in-place) and guarantee thereby safe and efficient production according to pharmaceutical standards. All specific ultrasonic processes can be easily tested in lab or bench-top scale and then be linearly scaled up to industrial production.
12 pages about this topic are being shown:
To produce hand sanitizers and disinfecting solutions, a powerful mixing technology is required to obtain a consistent mixture. Ultrasonic mixers and agitators are the most reliable and efficient mixing technology for blending and emulsifying two or more phases in…https://www.hielscher.com/production-of-hand-sanitizers-with-industrial-ultrasonic-mixers.htm
Famotidine is a common pharmaceutical molecule used in heartburn medications. In order to overcome the poor solubility and the resulting poor bioavailability, famotidine can be formulated into solid-lipid nanoparticles using sonication as encapsulation technique. Ultrasonically Famotidine-Loaded Solid Lipid Nanoparticles…https://www.hielscher.com/ultrasonically-formulated-famotidine-solid-lipid-nanoparticles.htm
Nanostructure lipid carriers (NLCs) are an advanced form of nano-sized drug delivery systems featuring a lipid core and a water-soluble shell. NLCs have a high stability, protect the active bio-molecules against degradation and offer sustained drug release. Ultrasonication is…https://www.hielscher.com/ultrasonic-formulation-of-nanostructured-lipid-drug-carriers.htm
Allicin is a bioactive compound, which can be extracted from fresh garlic cloves. Allicin is prone to degradation and must be therefore formulated into a stabilised supplement form in order to obtain a long-term potent formula. Ultrasonic encapsulation of…https://www.hielscher.com/ultrasonic-nanoliposomes-for-stabilised-allicin-formulations.htm
Garlic (Allium sativum) is rich in organosulfur compounds (e.g. allicin, glutathione), which promote many health benefits. Ultrasonic extraction is a reliable and efficient technique to produce highly concentrated garlic extracts. Ultrasonication results in high yields of high quality, full…https://www.hielscher.com/ultrasonic-solvent-free-garlic-extraction.htm
Nanoliposomes are highly effective drug carriers used to enhance the bioavailability of bioactive compounds such as omega-2 fatty acids, vitamins, and other substances. Ultrasonic encapsulation of bioactive compounds is a fast and simple technique to prepare nanoliposomes with high…https://www.hielscher.com/ultrasonic-production-of-liposomal-omega-3-fatty-acids.htm
Remdesivir (GS-5734) is an anti-viral drug, which is under research for treating the Ebola virus disease and COVID-19, which is caused by the Sars-CoV-2 coronavirus. Remdesivir is pharmaceutical solution, which is administered intravenously. Whilst short ultrasonic dissolving alone enhances…https://www.hielscher.com/improved-remdesivir-solubility-by-sonication.htm
Niosomes are nano-sized vesicles, which can be used as carrier for drugs (e.g. cancer drugs) and other bioactive substances. Ultrasonic emulsification is a simple and rapid method to formulate small niosomes with a high drug load. Niosome Preparation A…https://www.hielscher.com/ultrasonic-formulation-of-niosomes.htm
Drugs such avermectin and ivermectin are often encapsulated into nano-structured drug carriers to improve absorption rate and bioavailability as well to obtain a sustained‑release effect. Ultrasonic nano-emulsification is an efficacious and reliable technique to entrap bioactive medicinal compounds into…https://www.hielscher.com/ultrasonic-nano-encapsulation-of-ivermectin.htm
Nanoparticle-based drug carrier are an evolving technology, which allows to formulate vaccine delivery systems with a high protection rate against various diseases. Ultrasonic emulsification and encapsulation is a highly efficient method to prepare loaded nano-structured drug carriers such as…https://www.hielscher.com/nano-encasulated-intranasal-vaccine-against-s-pneumoniae-with-ultrasonics.htm
Catechin such as epigallocatechin gallate (EGCG), epigallocatechin (EGC), epicatechin gallate (ECG), and epicatechin (EC) are polyphenols, which show significant health benefits. Whilst catechin are found in smaller amounts in green tea, cocoa, fruits and some other foods, for high…https://www.hielscher.com/superior-catechin-extracts-with-ultrasonics.htm
Ultrasonication is a powerful tool used in biology, molecular chemistry and biochemistry as well as in the production of pharmaceuticals. Bio-sciences use ultrasonic homogenizers to lyse cells and extract proteins and other intracellular materials, the pharma industry applied ultrasonics…https://www.hielscher.com/coronavirus-covid-19-sars-cov-2-and-ultrasonics.htm