Utrasonic topic: "supplements"
Dietary or nutritional supplements are products that help to provide nutrients in order to balance out the nutrient intake from the regular diet. Common dietary supplements include vitamins, minerals, proteins, amino acids, antioxidants, herbs or other nutritional substances.
There a two major applications for ultrasonic processors in dietary supplement production:
- the extraction or synthesis of nutrients, and
- the formulation of the final supplement product.
Ultrasonic Extraction of Nutrients
In first step, nutrients for the supplement must be prepared. This can happen either by extracting the compound from a natural product, e.g. a plant, or by synthesizing the compound chemically.
Ultrasonic extraction is a potent technique, which breaks cell walls and releases the bioactive compounds. The main advantage s of ultrasonic extraction are its exceptional high extraction rate, rapid extraction speed, the use of green solvents (e.g. water, ethanol, vegetable oils etc.), safety, and user-friendliness. Being a non-thermal extraction method, ultrasonic extraction prevents the thermal degradation of heat-sensitive materials and results in superior extract quality. Typical extracts produced by sonication include curcumin, algae lipids, antioxidants, cannabinoids (CBD, THC, CBG, terpenes etc.), vitamins and flavonoids.
For synthesis, sonochemical intensification of reactions can speed up the conversion rate and increase yields. Sonochemical preparation of amino acids in aqueous solutions is a good example, where ultrasonicators are successfully applied in nutrient production.
Ultrasonic Supplement Formulation
Ultrasonic is a powerful technique of mixing, dispersing and emulsification. To formulate dietary supplements, the actual nutrients must be processed a bioavailable form, e.g. nano-droplets. Ultrasonic mixers help to distribute the active ingredients uniformly throughout the formulation, which is subsequently processed into pills, capsules, powders, gel tabs, extracts, or liquids. Many bioactive ingredients such as curcumin, cannabidiol or resveratrol are not water-soluble and exhibit a low natural bioavailability. Liposomal formulations, where the active compound is encapsulated in a bilayer of phospholipids, increase the bioavailability of such compounds significantly. Ultrasonic processors are the preferred technique to formulate nutrients into stable, nano-sized liposomes, including liposomal vitamin C, CBD, or resveratrol to name just a few.
Ultrasonic mixing and dispersing is also used to create formulations such as nano-sized suspensions and dispersions, nano-emulsions, pickering emulsions and gels.
Ultrasonic processors are well established in the food and pharma industry. Hielscher Ultrasonics offers high-performance ultrasonic devices from lab and bench-top size up to full-commercial industrial scale with capacities of processing several tons per hour.
Read more about how ultrasonic processors can improve the manufacturing of nutritional supplements.
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Nanoparticle-based drug carrier are an evolving technology, which allows to formulate vaccine delivery systems with a high protection rate against various diseases. Ultrasonic emulsification and encapsulation is a highly efficient method to prepare loaded nano-structured drug carriers such as…https://www.hielscher.com/nano-encasulated-intranasal-vaccine-against-s-pneumoniae-with-ultrasonics.htm
Catechin such as epigallocatechin gallate (EGCG), epigallocatechin (EGC), epicatechin gallate (ECG), and epicatechin (EC) are polyphenols, which show significant health benefits. Whilst catechin are found in smaller amounts in green tea, cocoa, fruits and some other foods, for high…https://www.hielscher.com/superior-catechin-extracts-with-ultrasonics.htm
Ultrasonication is a powerful tool used in biology, molecular chemistry and biochemistry as well as in the production of pharmaceuticals. Bio-sciences use ultrasonic homogenizers to lyse cells and extract proteins and other intracellular materials, the pharma industry applied ultrasonics…https://www.hielscher.com/coronavirus-covid-19-sars-cov-2-and-ultrasonics.htm
Chloroquine seem to be a promising drug in the fight against the COVID-19 pandemic. Whilst chloroquine is a long-known, cheap drug, the supply must be significantly ramped up to fulfil the current need. Ultrasonic synthesis is a simple, safe…https://www.hielscher.com/ultrasonic-synthesis-of-pharma-grade-chloroquine.htm
Liposomal vitamin formulations are known for their higher bioavailability and absorption rate. Vitamin C, an antioxidant, is a common supplement used in nutritional and medical drugs to support the human body's own immune system. Ultrasonication is a reliable and…https://www.hielscher.com/liposomal-vitamin-c-production-with-ultrasonics.htm
Hops and hop extracts are essential ingredients for the production of beer. The alpha-acids a-caryophyllene (humulone) and beta-caryophyllene (humulene) are important flavour compounds, which give beer its bitterness and contribute to its aroma, foam structure, and microbiological stability. Ultrasonic extraction…https://www.hielscher.com/efficient-production-of-hops-extracts-by-sonication.htm
Conventional tobacco extraction is a slow, time-consuming process, which involves the use of toxic solvents at high temperatures, which makes the process hazardous. Ultrasonically-assisted extraction of alkaloids from tobacco can be run using water or mild solvents in a…https://www.hielscher.com/ultrasonic-tobacco-extraction.htm
Chitosan is a chitin-derived biopolymer which has many applications in pharma, food, agriculture and industry. Ultrasonic deacetylation of chitin to chitosan intensifies the treatment significantly - leading to an efficient and fast process with a high chitosan yield of…https://www.hielscher.com/ultrasonic-deacetylation-of-chitin-to-chitosan.htm
Water-soluble polyhydroxylated C60 fullerene, called fullerenol or fullerol, is a strong free radical scavenger and is therefore used as an antioxidant in supplements and pharmaceuticals. Ultrasonic hydroxylation is a rapid and simple one-step reaction, which is used to produce…https://www.hielscher.com/ultrasonic-polyhydroxylated-c60-fullerenol.htm
Jellyfish collagen is a high-quality collagen, which is unique but exhibits similar properties to type I, II, III and type V collagen. Ultrasonic extraction is a purely mechanical technique, that increases yield, accelerates the process and produces high molecular…https://www.hielscher.com/ultrasonic-collagen-extraction-from-jellyfish.htm
Ellagitannins are a precursor for the age-defying compound urolithin A, which is converted from ellagitannins by the gut microbiome. Ultrasonic extraction promotes the release of ellagitannins from fruit and vegetal cells to produce supplements and pharmaceuticals with a highly…https://www.hielscher.com/ellagitannin-extraction-from-pomegranate.htm
Capsaicin is the main flavour and spice compound in hot peppers, also known as chilies. To produce high-quality capsaicin as aromatic flavour and medicinal ingredient, an efficient, yet mild extraction technique is required to prevent degradation. Ultrasonic extraction is…https://www.hielscher.com/ultrasonic-capsaicin-extraction-from-hot-chili-peppers.htm