Utrasonic topic: "supplements"
Dietary or nutritional supplements are products that help to provide nutrients in order to balance out the nutrient intake from the regular diet. Common dietary supplements include vitamins, minerals, proteins, amino acids, antioxidants, herbs or other nutritional substances.
There a two major applications for ultrasonic processors in dietary supplement production:
- the extraction or synthesis of nutrients, and
- the formulation of the final supplement product.
Ultrasonic Extraction of Nutrients
In first step, nutrients for the supplement must be prepared. This can happen either by extracting the compound from a natural product, e.g. a plant, or by synthesizing the compound chemically.
Ultrasonic extraction is a potent technique, which breaks cell walls and releases the bioactive compounds. The main advantage s of ultrasonic extraction are its exceptional high extraction rate, rapid extraction speed, the use of green solvents (e.g. water, ethanol, vegetable oils etc.), safety, and user-friendliness. Being a non-thermal extraction method, ultrasonic extraction prevents the thermal degradation of heat-sensitive materials and results in superior extract quality. Typical extracts produced by sonication include curcumin, algae lipids, antioxidants, cannabinoids (CBD, THC, CBG, terpenes etc.), vitamins and flavonoids.
For synthesis, sonochemical intensification of reactions can speed up the conversion rate and increase yields. Sonochemical preparation of amino acids in aqueous solutions is a good example, where ultrasonicators are successfully applied in nutrient production.
Ultrasonic Supplement Formulation
Ultrasonic is a powerful technique of mixing, dispersing and emulsification. To formulate dietary supplements, the actual nutrients must be processed a bioavailable form, e.g. nano-droplets. Ultrasonic mixers help to distribute the active ingredients uniformly throughout the formulation, which is subsequently processed into pills, capsules, powders, gel tabs, extracts, or liquids. Many bioactive ingredients such as curcumin, cannabidiol or resveratrol are not water-soluble and exhibit a low natural bioavailability. Liposomal formulations, where the active compound is encapsulated in a bilayer of phospholipids, increase the bioavailability of such compounds significantly. Ultrasonic processors are the preferred technique to formulate nutrients into stable, nano-sized liposomes, including liposomal vitamin C, CBD, or resveratrol to name just a few.
Ultrasonic mixing and dispersing is also used to create formulations such as nano-sized suspensions and dispersions, nano-emulsions, pickering emulsions and gels.
Ultrasonic processors are well established in the food and pharma industry. Hielscher Ultrasonics offers high-performance ultrasonic devices from lab and bench-top size up to full-commercial industrial scale with capacities of processing several tons per hour.
Read more about how ultrasonic processors can improve the manufacturing of nutritional supplements.
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Olive leaf extracts are a potent dietary supplement and therapeutic as it contains strong antioxidants such as the polyphenols oleuropein, hydroxytyrosol and verbascoside. Ultrasonic extraction is highly efficient technique to release and isolate bioactive compounds such as polyphenols, flavones…https://www.hielscher.com/ultrasonic-extraction-of-olive-leaf-extract.htm
Pet food manufacturing requires reliable high-shear mixing equipment to prepare homogeneous mixtures of various ingredients. Ultrasonic mixers provide ultras-high shear forces that can process highly viscous slurries and doughs. Furthermore, ultrasonic mixers are used to produce stable nano-emulsions and…https://www.hielscher.com/high-shear-mixers-for-pet-food-manufacturing.htm
The biosynthesis of human milk oligosaccharides (HMOs) via fermentation or enzymatic reactions is a complex, consuming and often low-yielding process. Ultrasonication increases the mass transfer between substrate and cell factories ans stimulates cell growth and metabolism. Thereby, sonication intensifies…https://www.hielscher.com/human-milk-oligosaccharides.htm
Are you looking for a powerful and reliable extraction setup to produce high-quality botanical extracts? Here you can find a comparison of common extraction techniques including ultrasonic extraction, supercritical CO2 extraction, ethanol extraction, maceration amongst others and their advantages…https://www.hielscher.com/most-efficient-botanical-extracts.htm
Smart drugs and nootropic supplements are consumed as “cognitive enhancers” in order to increase cognitive function, brain capacity, concentration, memory and creativity, to boost motivation and mental energy as well as to support brain health. To promote the transport…https://www.hielscher.com/nootropics-and-smart-drug-formulations-with-ultrasonics.htm
Ultrasonication is well known to be highly efficient in the preparation of liposomal formulations. Typical liposome formulations encapsulate vitamin C, CBD, curcumin, quercitin, astaxanthin, peptides and manifiold other bioactive compounds using ultrasonication. Ultrasonic liposome encapsulation is a simple, fast…https://www.hielscher.com/liposomal-encapsulated-bioactive-molecules-with-ultrasonics.htm
The formulation of THC-enhanced beverages is challenging. - THC-infused drinks must be nano-emulsified in order to provide a high bioavailability and thereby potency, long-term stability and clear appearance. Ultrasonic nano-emulsification of THC into beverage is highly efficient and efficacious…https://www.hielscher.com/water-soluble-nano-thc-formulations-with-sonication.htm
Edible oils are used for manifold applications in cooking and food production. Mechanical extraction of edible oils prevents the oils from degradation. Ultrasonic extraction of edible oils is a superior method to release oils from seeds, kernels and fruits.…https://www.hielscher.com/ultrasonic-extraction-of-edible-oils.htm
Mycoprotein are fungus-derived protein produced for human consumption, which are mainly used to prepare meat substitutes or “fake meat”. Ultrasonic extraction and homogenization is a highly efficient method to release mycoprotein from the fungus achieving very high protein yields…https://www.hielscher.com/ultrasonic-extraction-of-mycoprotein.htm
Famotidine is a common pharmaceutical molecule used in heartburn medications. In order to overcome the poor solubility and the resulting poor bioavailability, famotidine can be formulated into solid-lipid nanoparticles using sonication as encapsulation technique. Ultrasonically Famotidine-Loaded Solid Lipid Nanoparticles…https://www.hielscher.com/ultrasonically-formulated-famotidine-solid-lipid-nanoparticles.htm
Nanostructure lipid carriers (NLCs) are an advanced form of nano-sized drug delivery systems featuring a lipid core and a water-soluble shell. NLCs have a high stability, protect the active bio-molecules against degradation and offer sustained drug release. Ultrasonication is…https://www.hielscher.com/ultrasonic-formulation-of-nanostructured-lipid-drug-carriers.htm
Allicin is a bioactive compound, which can be extracted from fresh garlic cloves. Allicin is prone to degradation and must be therefore formulated into a stabilised supplement form in order to obtain a long-term potent formula. Ultrasonic encapsulation of…https://www.hielscher.com/ultrasonic-nanoliposomes-for-stabilised-allicin-formulations.htm