Focused Sonicators for Mid-Throughput Sample Prep
Process multiple samples quickly, consistently, and without direct probe contact. The Hielscher UIP400MTP and UIP550MTP are focused, non-contact sonicators designed for efficient sample preparation in microplates, Petri dishes, and tube racks – sample preparation from mid-throughput to high-throughput.
Unlike probe sonicators, these focused non-contact sonicators transmit ultrasonic energy through the walls of the sample vessel. Not only are workflows streamlines – the samples remain safely contained, reducing the risk of cross-contamination, sample loss, and probe-related carryover.
Who Benefits from Mid-Throughput Focused Non-Contact Sonication?
- Laboratories processing multiple samples in parallel
- Genomics and proteomics teams performing lysis, extraction, or nucleic-acid fragmentation
- Pharmaceutical and biotechnology R&D laboratories
- Clinical and diagnostic research facilities
- Researchers requiring reproducible processing with minimal cross-contamination
- Laboratories using microplates, Petri dishes, or tube racks
Streamline your sample preparation with mid- to high-throughput focused non-contact ultrasonication!
UIP400MTP focused non-contact ultrasonicator for mid-throughput sample prep
One Sonicator for Different Sample Formats
The UIP400MTP and UIP550MTP work with standard laboratory consumables – no proprietary plates or specialized vessels are required. Both models accommodate a wide range of formats, including:
- 6-, 12-, 24-, 48-, 96-, and 384-well plates
- PCR and ELISA plates
- Petri dishes
- Sample tubes in tube racks
- Other compatible laboratory vessels
This flexibility makes it easy to integrate focused sonication into existing protocols without changing established consumables or workflows.
Focused non-contact sonicator UIP400MTP delivers focused ultrasound for mid-to high-throughput sample prep
Focused Non-Contact Ultrasonicators
UIP400MTP – Versatile 400-Watt Focused Non-Contact Sonication
The UIP400MTP provides 400 watts of ultrasonic power for reliable mid-throughput sample preparation. It delivers focused, uniform sonication across the sample vessel and is well suited to routine laboratory applications such as cell lysis, homogenization, protein extraction, DNA and RNA fragmentation, particle dispersion, emulsification, and degassing.
UIP550MTP – More Focused Ultrasound Power for Demanding Samples
With 550 watts of ultrasonic power, the UIP550MTP is designed for difficult samples, higher processing intensities, and time-sensitive protocols. Its additional power supports fast, reproducible processing while advanced parameter and temperature control helps protect sensitive samples from excessive heat.
German Quality – Built for Robustness and Durability
Built for durability, both the UIP400MTP and UIP550MTP feature a robust stainless-steel housing and industrial-grade construction suitable for continuous 24/7 operation.
Choose the Right Focused Non-Contact Sonicator Model
| Focused Non-Contact Sonicator Model |
Plate format | Ultrasound Power/Samples | FactSheet |
|---|---|---|---|
| UIP400MTP | Microplates, multiwells, tube racks, Petri dish | 400W focused ultrasound energy for sample prep in microplates (e.g. lysis, DNA fragmentation, cell detachment) | Download the FactSheet of the UIP400MTP Multi-well Plate Sonicator – 400W Focused Non-Contact Sonicator! |
| UIP550MTP | Microplates, multiwells, tube racks, Petri dish | 550W focused ultrasound energy for more demanding applications (e.g. lysis of even sturdy cells such as yeast, DNA fragmentation, ) | Download the FactSheet of the UIP550MTP Multi-well Plate Sonicator – 550W Focused Non-Contact Sonicator! |
Efficient, Reproducible Sample Preparation from Mid- to High-Throughput
Both Hielscher microplate sonicators offer key advantages for laboratories handling multiple samples allowing to streamline mid- to high-throughput lab tasks:
- Non-contact processing with no probe immersed in the sample
- Simultaneous sonication of multiple wells or vessels
- Uniform treatment for consistent, reproducible results
- Reduced risk of cross-contamination and sample loss
- Compatibility with common laboratory plates and vessels
- Precise control of sonication parameters
- Easy integration into existing and automated workflows
Find the Right Sonicator for Your Workflow
Choose the UIP400MTP for versatile routine processing or the more powerful UIP550MTP for demanding samples and higher-intensity applications. Both systems combine focused ultrasonic performance with flexible vessel compatibility, helping laboratories streamline mid-throughput sample preparation while maintaining control, consistency, and sample integrity.
Frequently Asked Questions about Focused Sonication in Mid-Throughput Sample Preparation
What is focused sonication?
Focused sonication concentrates ultrasonic energy within the sample vessel to produce efficient cavitation and controlled mechanical forces. This enables rapid and reproducible sample processing without inserting an ultrasonic probe into the sample.
What makes focused sonication suitable for mid-throughput sample preparation?
Focused sonicators can process multiple wells or vessels simultaneously, reducing manual handling and shortening preparation times. They bridge the gap between single-sample probe sonication and large-scale automated systems.
Which sample vessels can be used with the UIP400MTP and UIP550MTP?
Both models accommodate standard microplates, including 6-, 12-, 24-, 48-, 96-, and 384-well formats. They can also process PCR and ELISA plates, Petri dishes, and sample tubes held in suitable racks.
How robust are the UIP400MTP and UIP550MTP?
The UIP400MTP and UIP550MTP are industrial-grade sonicators built for demanding laboratory environments. Their robust stainless-steel construction and German engineering ensure reliable performance, long service life, and dependable 24/7 operation.
Are proprietary microplates or consumables required?
No. The UIP400MTP and UIP550MTP work with common laboratory plates and vessels, allowing users to retain their preferred consumables and established protocols.
How does non-contact sonication reduce contamination risks?
Are proprietary microplates or consumables required?
No. The UIP400MTP and UIP550MTP work with common laboratory plates and vessels, allowing users to retain their preferred consumables and established protocols.
How does non-contact sonication reduce contamination risks?
How does non-contact sonication reduce contamination risks?
The ultrasonic probe does not come into direct contact with the sample. Samples remain inside their plates, tubes, or dishes, helping to minimize cross-contamination, carryover, and sample loss.
What applications are suitable for focused sonication?
Typical applications include cell and tissue lysis, protein extraction, DNA and RNA fragmentation, sample homogenization, particle dispersion, emulsification, extraction, and degassing.
What is the difference between the UIP400MTP and UIP550MTP?
The UIP400MTP delivers 400 watts of ultrasonic power and is suitable for versatile routine sample preparation. The UIP550MTP provides 550 watts for more demanding samples, higher processing intensities, and time-sensitive workflows.
How is sample temperature controlled during sonication?
The systems support temperature monitoring and controlled processing parameters. Temperature limits, pulsed operation, and appropriate cooling can help prevent excessive heating and protect sensitive biological samples.
Can sonication protocols be reproduced?
Yes. Precisely adjustable operating parameters allow users to standardize their protocols for consistent treatment across samples, plates, and processing runs.
Can the sonicators be integrated into automated workflows?
Yes. Their compatibility with standard plate formats makes the UIP400MTP and UIP550MTP suitable for integration with plate-handling systems and other automated laboratory workflows.
Discover how the UIP400MTP and UIP550MTP can be easily integrated into lab automation systems!
Which model should I choose?
Choose the UIP400MTP for routine, flexible mid-throughput processing. Select the UIP550MTP when greater ultrasonic power, continuous operation, or more intensive processing is required. Hielscher can assist with model selection and recommend suitable parameters for a specific application.
Do the UIP400MTP and UIP550MTP require proprietary software installation?
No, both microplate sonicator models – UIP400MTP and UIP550MTP – can be controlled through any common web browser via LAN. This means no additional software is required for its LAN interface. Depending on the network configuration, users can operate the microplate sonicators from a PC or Mac connected directly or through a router or switch. It can also be controlled from a tablet or smartphone over a suitable network connection.
Literature / References
- FactSheet UIP550MTP Multi-well Plate Sonicator – 550W Focused Non-Contact Sonicator – Hielscher Ultrasonics
- FactSheet UIP400MTP – 400W Focused Non-Contact Sonicator – Hielscher Ultrasonics
- Lauren E. Cruchley-Fuge, Martin R. Jones, Ossama Edbali, Gavin R. Lloyd, Ralf J. M. Weber, Andrew D. Southam, Mark R. Viant (2024): Automated extraction of adherent cell lines from 24-well and 96-well plates for multi-omics analysis using the Hielscher UIP400MTP sonicator and Beckman Coulter i7 liquid handling workstation. Metabomeeting 2024, University of Liverpool, 26-28th November 2024.
- Dreyer J., Ricci G., van den Berg J., Bhardwaj V., Funk J., Armstrong C., van Batenburg V., Sine C., VanInsberghe M.A., Marsman R., Mandemaker I.K., di Sanzo S., Costantini J., Manzo S.G., Biran A., Burny C., Völker-Albert M., Groth A., Spencer S.L., van Oudenaarden A., Mattiroli F. (2024): Acute multi-level response to defective de novo chromatin assembly in S-phase. Molecular Cell 2024.
- Mochizuki, Chika; Taketomi, Yoshitaka; Irie, Atsushi; Kano, Kuniyuki; Nagasaki, Yuki; Miki, Yoshimi; Ono, Takashi; Nishito, Yasumasa; Nakajima, Takahiro; Tomabechi, Yuri; Hanada, Kazuharu; Shirouzu, Mikako; Watanabe, Takashi; Hata, Kousuke; Izumi, Yoshihiro; Bamba, Takeshi; Chun, Jerold; Kudo, Kai; Kotani, Ai; Murakami, Makoto (2024): Secreted phospholipase PLA2G12A-driven lysophospholipid signaling via lipolytic modification of extracellular vesicles facilitates pathogenic Th17 differentiation. BioRxiv 2024.
- Cosenza-Contreras M, Seredynska A, Vogele D, Pinter N, Brombacher E, Cueto RF, Dinh TJ, Bernhard P, Rogg M, Liu J, Willems P, Stael S, Huesgen PF, Kuehn EW, Kreutz C, Schell C, Schilling O. (2024): TermineR: Extracting information on endogenous proteolytic processing from shotgun proteomics data. Proteomics. 2024.
- De Oliveira A, Cataneli Pereira V, Pinheiro L, Moraes Riboli DF, Benini Martins K, Ribeiro de Souza da Cunha MDL (2016): Antimicrobial Resistance Profile of Planktonic and Biofilm Cells of Staphylococcus aureus and Coagulase-Negative Staphylococci. International Journal of Molecular Sciences 17(9):1423; 2016.
- Martins KB, Ferreira AM, Pereira VC, Pinheiro L, Oliveira A, Cunha MLRS (2019): In vitro Effects of Antimicrobial Agents on Planktonic and Biofilm Forms of Staphylococcus saprophyticus Isolated From Patients With Urinary Tract Infections. Frontiers in Microbiology 2019.
- Wang Y., Joshu C.E., Curtis S.D., Douville C., Burk V.A., Ru M., Popoli M., Ptak J., Dobbyn L., Silliman N., Coresh J., Boerwinkle E., Prizment A., Bettegowda C., Kinzler K.W., Papadopoulos N., Platz E.A., Vogelstein B. (2025): Detection of cancers three years prior to diagnosis using plasma cell-free DNA. Cancer Discovery 2025 May.
- Galsky, Matt; Izadmehr, Sudeh; Yu, Menggang; Curtis, Samuel; Douville, Christopher; Popoli, Maria; Ptak, Janine; Dobbyn, Lisa; Silliman, Natalie; Chan, Kevin; Dorff, Tanya; Cetnar, Jeremy; O’Neil, Brock; D’Souza, Anishka; Mamtani, Ronac; Kyriakopoulos, Christos; Brody, Rachel; Sadimin, Evita; Mehrazin, Reza; Wang, Yuxuan (2026): Monitoring of plasma and urine tumor-derived DNA to inform bladder-sparing approaches for patients with muscle-invasive bladder cancer. Preprint Jan. 2026.
Multi-well Plate Sonicator UIP400MTP
Hielscher Ultrasonics manufactures high-performance ultrasonic homogenizers from lab to industrial size.