Ultrasonic topic: "Ultrasonic Processing in the Pharma Industry"
Power ultrasonics is a highly efficient and reliable tool for the production of vaccines, nano-formulated drugs and drug carriers (e.g. liposomes). Hielscher Ultrasonics’ lab, pilot and industrial systems produce pharma-grade micron- and nano-emulsions / -dispersions, liposomes as well as vaccines. Hielscher’s ultrasonic systems are equipped with CIP (clean-in-place) and SIP (sterilize-in-place) and guarantee thereby safe and efficient production according to pharmaceutical standards. All specific ultrasonic processes can be easily tested in lab or bench-top scale and then be linearly scaled up to industrial production.
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Ultrasonic Preparation of Platelet Rich Serum
Platelet-rich plasma (PRP) is blood plasma that has been enriched with platelets, which is used for medical and estethic treatments. Ultrasonic lysis and conditioning is an very effective method to prepare platelet-rich plasma. Hielscher Ultrasonics offers various ultrasonic systems matching…
https://www.hielscher.com/ultrasonic-preparation-of-platelet-rich-serum.htmSurfactant-Free Cosmetic Emulsions by Power Ultrasonics
Due to the increasing demand for eco-friendly cosmetics, the cosmetic industry is focussing on the formulation of surfactant-free emulsions. Pickering emulsions are surfactant-/emulsifier-free w/o- or o/w-mixtures stabilized by particles. Ultrasonic mixing and emulsification is an excellent technique to formulate highly…
https://www.hielscher.com/surfactant-free-cosmetic-emulsions-by-power-ultrasonics.htmUltrasonic-Enzymatic Diacylglycerol Production
Diacylglycerol (DAG) rich oils have shown a high nutritional value since they are digested and metabolized in a way, which significantly reduces body weight. Diacylglycerol can be produced by the hydrolysis of palm oil using a commercial lipase as a…
https://www.hielscher.com/ultrasonic-enzymatic-diacylglycerol-production.htmUltrasonic High-Shear Batch Mixers for Lab & Production Scale
Wetting, hydration, homogenization, grinding, dispersion, emulsification and dissolving are common applications for Hielscher's ultrasonic high-shear batch mixers. Ultrasonic batch mixing is carried out at high speed with reliable, reproducible results for outstanding process results at lab, bench-top and full commercial…
https://www.hielscher.com/ultrasonic-high-speed-batch-mixers.htmClosed Ultrasonic Reactor for Pharmaceutical Batch Processing
Transform your batch processes with controlled, scalable, and safe ultrasonic processing. From nanomaterial or API synthesis to chemical reactions, Hielscher closed batch reactors for sonication processes deliver unmatched consistency, efficiency, and process control - engineered for modern R&D and production…
https://www.hielscher.com/closed-ultrasonic-reactor-for-pharmaceutical-batch-processing.htmSonofragmentation – The Effect of Power Ultrasound on Particle Breakage
Sonofragmentation describes the breakage of particles into nano-sized fragments by high power ultrasound. In contrast to the common ultrasonic deagglomeration and milling - where particles are mainly grinded and separated by inter-particle collision - , sono-fragementation is distinguished by the…
https://www.hielscher.com/sonofragmentation-the-effect-of-power-ultrasound-on-particle-breakage.htmUltrasonic Treatment of Nanoparticles for Pharmaceuticals
Probe-type sonicators play a crucial role in pharmaceutical research and manufacturing by providing a powerful and controlled means of achieving particle size reduction, cell disruption, and homogenization. Sonicators utilize ultrasonic waves to generate cavitation, resulting in the formation and collapse…
https://www.hielscher.com/ultrasonic-treatment-of-nanoparticles-for-pharmaceuticals.htmUltrasonication Accelerates the Suzuki Coupling Reaction
The Suzuki Cross-Coupling (also known as Suzuki-Miyaura Coupling) is an organic reaction with the aim to synthesize biphenyl derivatives, vinyl aromates (e.g. styrenes), poly-olefins, as well as alkyl bromides. The reaction base materials are an aryl- or vinyl-boronic acid with…
https://www.hielscher.com/ultrasonication-accelerates-the-suzuki-coupling-reaction.htmUltrasonically Assisted Fermentation for Bioethanol Production
Ultrasonically-assisted fermentation can enhance bioethanol production by promoting the breakdown of complex carbohydrates into simpler sugars, making them more readily available for yeast to convert into ethanol. Simultaneously, sonication also improves the efficiency of yeast cell wall permeability, allowing for…
https://www.hielscher.com/ultrasonically-assisted-fermentation-for-bioethanol-production.htmUltrasonically Induced and Enhanced Phase Transfer Catalysis
High power ultrasound is well-known for its contribution to various chemical reactions. This is the so-called sonochemistry. Heterogeneous reactions – and especially phase transfer reactions – are highly potential application fields for power ultrasound. Due to the mechanical and sonochemical…
https://www.hielscher.com/ultrasonically-induced-and-enhanced-phase-transfer-catalysis.htmUltrasonicators and Probes for Liquid Processing
Hielscher Ultrasonics offers a complete range of high-performance sonicators - from compact lab devices to robust industrial systems. Engineered for precision and reliability, our ultrasonic processors deliver reproducible results for sample preparation, particle size reduction, extraction, and chemical processing. Hielscher…
https://www.hielscher.com/products.htmSonicator UIP1500hdT – High Ultrasonic Processing Power
The probe-type sonicator UIP1500hdT (20kHz, 1500W) combines high processing power with flexibility and user-comfort. This 1.5kW powerful ultrasonic homogenizer is suitable for process development, optimization and for production processes. This includes emulsifying, dispersing and sono-chemistry, lysis and extraction or homogenizing.…
https://www.hielscher.com/i1500_p.htm










