Ultrasonic topic: "Ultrasonic Processing in the Pharma Industry"
Power ultrasonics is a highly efficient and reliable tool for the production of vaccines, nano-formulated drugs and drug carriers (e.g. liposomes). Hielscher Ultrasonics’ lab, pilot and industrial systems produce pharma-grade micron- and nano-emulsions / -dispersions, liposomes as well as vaccines. Hielscher’s ultrasonic systems are equipped with CIP (clean-in-place) and SIP (sterilize-in-place) and guarantee thereby safe and efficient production according to pharmaceutical standards. All specific ultrasonic processes can be easily tested in lab or bench-top scale and then be linearly scaled up to industrial production.
Found 63 hits. Showing results 1 - 12.
Liposomal Semaglutide Could Be the Next Big Leap in GLP-1 Drug Delivery
, Kathrin HielscherSemaglutide and other GLP-1 peptides are among the most important modern therapeutics, but formulation scientists still face a fundamental barrier: peptide drugs are difficult to protect and deliver, especially by the oral route. Even approved oral semaglutide products show bioavailability below 1%, requiring high doses and complex formulation strategies.
A growing technical focus in pharmaceutical development is liposomal encapsulation combined with high-intensity ultrasonic processing. Liposomes can stabilize GLP-1 peptides and enable nano-scale carrier systems, while ultrasound provides reproducible nano-sizing and a scalable manufacturing pathway. Semaglutide is particularly compatible with lipid carriers because studies indicate it can associate with vesicle membranes via its lipid tail, supporting efficient loading into lipid bilayers.
Drug Manufacturing: Sonication Is Shaping the Future of Biogenic Medicines
, Kathrin HielscherThis news article presents how sonication is transforming biogenic drug manufacturing: Ultrasonic processing is rapidly emerging as a key technology in the manufacturing of biogenic drugs, enabling greener, more efficient production of bioactive compounds and nanomedicines. New research demonstrates that ultrasound-assisted synthesis, using plant extracts such as broccoli, can produce highly stable, biologically active gold nanoparticles with antioxidant, wound-healing, and selective anticancer properties. High-performance probe-type sonicators, including industrial systems from Hielscher Ultrasonics, play a critical role by enhancing extraction efficiency, accelerating green nanoparticle synthesis, and ensuring precise process control. As demand grows for sustainable pharmaceutical manufacturing, sonication is positioning itself as a scalable, GMP-compatible platform for next-generation biogenic drugs.
https://www.hielscher.com/sonication-shapes-biogenic-medicines.htm
Supramolecular Structures Assembled via Sonication
Sonication is a powerful and versatile tool in supramolecular chemistry, enabling precise control over noncovalent assembly processes that are often sensitive to kinetic and thermodynamic parameters. The application of power ultrasound to a liquid medium affects molecular interactions, accelerating self-assembly,…
https://www.hielscher.com/supramolecular-structures-assembled-via-sonication.htm
Improve Heterogeneous Chemical Reaction Kinetics by Sonication
Sonication offers innovative ways to improve heterogeneous chemical reaction kinetics in liquid‐liquid and liquid‐solid processes. Unlike ordinary stirring, ultrasonic waves generate microscopic bubbles that implode and create intense mixing zones. These zones help disperse solids and droplets more evenly, boost…
https://www.hielscher.com/improve-heterogeneous-chemical-reaction-kinetics-by-sonication.htm
Sterile Homogenization using Sonification
For sterile homogenization, a sample is placed into a sterile container which then is agitated in order to obtain a homogeneous blend. Ultrasonification is a highly efficient and reliable technique to treat one or multiple samples under sterile conditions and…
https://www.hielscher.com/sterile-homogenization-using-sonification.htm
Pharmaceutical Nanosuspensions with Improved Bioavailability
Nanosuspensions prepared by sonication show a significant improved pharmacological bioavailability. Especially drug molecules with poor water-solubility, which reduces its bioavailability and effect onset, benefit from the nanosizing technique of ultrasonication. Ultrasonication is used reduce drug particles and crystals to nanometer…
https://www.hielscher.com/pharmaceutical-nanosuspensions-with-improved-bioavailability.htm
Nasal Spray Formulations Emulsified with Ultrasound
Nasal sprays and mouth sprays are widely used drug administering solutions to apply active ingredients to the respiratory mucosa. Ultrasonic emulsification is a highly efficient and reliable technique to produce highly efficacious nasal and mouth spays with very high bioavailability,…
https://www.hielscher.com/nasal-spray-formulations-emulsified-with-ultrasound.htm
Ultrasonic Production of Highly Purified Schizophyllan Beta-Glucans
Schizophyallan is a fungal β-glucan with immunomodulating properties. For highly active medicinal effects, schizophyllan must have a low molecular weight in order to show improved bioavailability. Ultrasonication has been proven to reduce the molecular weight of schizophyllan. As reliable and…
https://www.hielscher.com/ultrasonic-production-of-highly-purified-schizophyllan-beta-glucans.htm
Ultrasonic Extraction of Polyphenols from Baggibuti (Stachys parviflora)
Extracts of the Baggibuti (Stachys parviflora L.) plant are valued as herbal medicine used as treatment of cramps, arthralgia, epilepsy, falling sickness, and dracunculiasis. Ultrasonic extractors are successfully applied for the isolation of polyphenols and other phytochemicals from Stachys parviflora.…
https://www.hielscher.com/ultrasonic-extraction-of-polyphenols-from-baggibuti-stachys-parviflora.htm
Highly Efficient Artemisinin Extraction with Sonication
Artemisinin can be efficiently extracted using high-performance sonication. Ultrasonic extraction gives very high yields of artemisinin using mild solvents. The process of extraction applying ultrasound is accelerated drastically. The processing conditions in ultrasonic extractors are precisely controllable, which allows to…
https://www.hielscher.com/highly-efficient-artemisinin-extraction-with-sonication.htm
Deep Eutectic Solvents for Highly Efficient Extraction
Deep eutectic solvents (DESs) and natural deep eutectic solvents (NADES) offer advantages as extraction solvents on many levels and are thereby a promising alternative to conventional organic solvents. Deep eutectic solvent work excellent in combination with ultrasonic extraction and give…
https://www.hielscher.com/extraction-with-deep-eutectic-solvents.htm
Supercritical Fluid Extraction Improved by Power Ultrasonics
Ultrasonic extraction alone or in combination with alternative extraction methods such as solvent extraction or supercritical CO2 extractors is successfully used to extract the full spectrum of cannabinoids from the cannabis plant (hemp and marijuana). In marijuana, the main cannabinoid…
https://www.hielscher.com/supercritical-fluid-extraction-improved-by-power-ultrasonics.htm