Utrasonic topic: "Topic: Ultrasonic Cell Disruptor"
An ultrasonic cell disruptor breaks open biological cells and releases critical intracellular materials for downstream applications. For most processes, ultrasonic cell disruptors produce better and more scalable results than a french press cell disruptor or a high pressure cell disruptor.
Many also refer to ultrasonic cell disruptors as a cell disruptor homogenizer, or sonicator cell disruptor because they thoroughly lyse cells and homogenize samples. Each technique performs an essential task in research and production settings, providing efficient access to proteins, nucleic acids, and other valuable biomolecules.
Hielscher ultrasonic cell disruptors outperforms traditional options by delivering a faster, more controlled, and scalable process. The french press cell disruptor and the high pressure cell disruptor typically operate in batch mode, which restricts throughput and requires extra cleanup time. In contrast, a Hielscher ultrasonic disruptor continuously processes samples, allowing researchers to adjust amplitude and intensity for a gentle or forceful cell disruption. This high level of control minimizes heat generation, reduces cell debris, and preserves sensitive proteins or enzymes while maximizing yield.
In addition to superior performance, Hielscher ultrasonic cell disruptors boast robust construction and user-friendly interfaces, ensuring minimal downtime and maintenance. Researchers can easily scale up from small test samples to industrial-scale batches without sacrificing efficiency. Whether you work in biotechnology, pharmaceuticals, or academic research, Hielscher ultrasonic cell disruptors deliver consistent, reproducible results that surpass traditional methods. With this reliable approach, scientists can streamline their workflows and achieve higher productivity, making it an indispensable tool in modern laboratories and production facilities.
Below, you find more technical articles about ultrasonic cell disruptors.

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Probe-Type Sonication for Sample Preparation: A Comprehensive Guide
Probe-type sonication is a powerful tool for disrupting cells, shearing DNA, and dispersing particles in liquid samples. Like all techniques in life science, microbiology and clinical analysis, sonication requires careful optimization to avoid sample damage, particularly when working with heat-sensitive…
https://www.hielscher.com/probe-type-sonication-for-sample-preparation-a-comprehensive-guide.htmBuffer Solutions Prepared with Ultrasonication
Lysis buffers can be efficiently and quick prepared using ultrasonic tissue homogenizers. Since ultrasonicators are a dream tool for mixing, dissolving and dispersing, they allow for a reliable and user-friendly preparation of lysis buffers. Ultrasonic Preparation of Lysis Buffers Ultrasonic…
https://www.hielscher.com/buffer-solutions-prepared-with-ultrasonication.htmGenetic Transformation in Plant Cells using Ultrasonics
Sonication-Assisted Agrobacterium-Mediated Transformation (SAAT) is an efficient method to infect plant cells with foreign genes using Agrobacterium as transporter. Ultrasonic cavitation causes sonoporation, which can be described as targeted micro-wounding of plant tissue. Via these ultrasonically creates micro-wounds, DNA and…
https://www.hielscher.com/genetic-transformation-in-plant-cells-using-ultrasonics.htmUltrasonication Outcompetes Other Extraction Methods by Speed
The rapid procedure of ultrasonic extraction and the therefrom resulting time savings in extract production are one of many advantages of ultrasonic extraction of bioactive compounds from plants. Ultrasonic extraction has been scientifically compared to alternative extraction techniques such as…
https://www.hielscher.com/ultrasonication-outcompetes-other-extraction-methods-by-speed.htmUltrasonic Lysis of Bioengineered Cells in Industrial Production
Bioengineered bacteria species such E. coli as well as genetically modified mammalian and plant cell types are used widely in biotech to express molecules. In order to release these synthesized bio-molecules, a reliable cell disruption technique is required. High-performance ultrasonication…
https://www.hielscher.com/ultrasonic-lysis-of-bioengineered-cells-in-industrial-production.htmUltrasonic DNA Fragmentation for Next Gen Sequencing
Next Generation Sequencing (NGS) requires the reliable shearing and fragmentation of genomic DNA in order to sequence genomic DNA strands and to create genome libraries. The controlled fragmentation of DNA into DNA fragments is an essential sample preparation step required…
https://www.hielscher.com/ultrasonic-dna-fragmentation-for-next-gen-sequencing.htm96-Well Plate Sonicator UIP400MTP for High-Throughput Sample Prep
96-well plates, microplates, multi-well plates, microtiter plates or ELISA plates are used for the mass sample cultivation and processing of biological samples. With the microtiter plate ultrasonicator UIP400MTP, Hielscher offers a unique ultrasonic solution of the uniform and reliable sample…
https://www.hielscher.com/microtiter-plate-mass-sample-preparation-by-ultrasonication.htmUltrasonic Sample Prep for ELISA Assays
Assays such as ELISA are widely used for in-vitro diagnostics, disease-related protein detection and quality control (e.g. monitoring food allergens). Ultrasonic sample preparation is a rapid, reliable and reproducible technique to lyse cell and isolate intracellular proteins, DNA, RNA and…
https://www.hielscher.com/ultrasonic-sample-prep-for-elisa-assays.htmProtocol for SARS-CoV-2 Coronavirus Inactivation with Sonication
The Hielscher VialTweeter is a unique ultrasonic multi-sample preparation unit, which is used to inactivate the coronavirus SARS-COV-2. The VialTweeter allow to prepare up to 10 sample vials simultaneously and is thereby the ideal unit for mass sample processing. Inactivation…
https://www.hielscher.com/protocol-for-sars-cov-2-coronavirus-inactivation-with-sonication.htmSample Preparation with the Ultrasonic VialTweeter
Sample preparation before analysis can require various pre-analytical processes such as tissue homogenization, lysis, extraction of proteins, DNA, RNA, organelles and other intracellular substances, dissolving and degassing. The VialTweeter is a unique ultrasonic device that prepares multiple sample tubes simultaneously…
https://www.hielscher.com/sample-preparation-with-the-ultrasonic-vialtweeter.htmMost Efficient Ultrasonic Dismembrators
Ultrasonic dismembrators are commonly used in the laboratory, bench-top and industry to prepare homogeneous colloidal suspensions such as emulsions and dispersions with droplet or particle sizes in the submicron- and nano-range. Furthermore, ultrasonic dismembrators are used for cell disruption, lysis,…
https://www.hielscher.com/most-efficient-ultrasonic-dismembrators.htmUltrasonic Extraction of Mycoprotein
Fulfilling the demands for sustainable and nutritious food alternatives, mycoprotein has emerged as a revolutionary ingredient, derived from fungi and primarily used in the creation of meat substitutes, often referred to as "fake meat." This protein source offers a promising…
https://www.hielscher.com/ultrasonic-extraction-of-mycoprotein.htm