Utrasonic topic: "flow cell"
A flow cell or flow reactor is an accessory, which makes it possible to process material, e.g. by sonication, in a continuous inline process. Ultrasonic processes can be run as batch process or in continuous flow mode using an ultrasonic flow cell. The advantages of an ultrasonic in-line process using a flow cell reactor are the more uniform processing of the medium, the application of pressure, which is an important parameter, and the convenient, efficient sonication of large volumes.
A pump feeds the raw material into the ultrasonic flow cell reactor, where ultrasonic power is highly can be focused and concentrated on a small volume. This results in a more uniform processing and higher product quality. A back pressure valve can be used to increase the pressure in the flow cell. This intensifies the acoustic cavitation, resulting in higher hydraulic shear and pressure and temperature differentials due to a more violent implosion of the cavitation bubbles.
Hielscher Ultrasonics offers manifold flow cell and reactor types with varying sizes and geometries. Used in combination with Hielscher high-performance ultrasonic processors, the right configuration of sonotrode and flow cell allow for optimal process conditions and superior sonication output.
Read more about ultrasonic flow cell reactors and their use in lab, pilot and industrial applications!
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Ultrasonic processes are widely used in manifold industries for mixing, dispersing, homogenisation and extraction. Whilst small volumes easily can be sonicated in batch mode, for larger volume processes a sophisticated inline setup is recommended. The SonoStation is a complete…https://www.hielscher.com/sonostation-hielschers-ultrasonic-pump-solution-setup.htm
Ultrasonic dismembrators are commonly used in the laboratory, bench-top and industry to prepare homogeneous colloidal suspensions such as emulsions and dispersions with droplet or particle sizes in the submicron- and nano-range. Furthermore, ultrasonic dismembrators are used for cell disruption,…https://www.hielscher.com/most-efficient-ultrasonic-dismembrators.htm
High shear mixers apply high shear forces into liquids and slurries in order to provide the uniform dispersing, blending, and emulsification of two or more liquid-solid or liquid-liquid phases. Ultrasonication generates high shear forces via acoustic cavitation, which occurs…https://www.hielscher.com/high-shear-mixing-with-ultrasonics.htm
Ultrasonic integrators are widely used to wet, disperse or dissolve particles and powders into liquids. High-performance ultrasonicators create intense shear forces, which break and shatter aggregates, agglomerates and primary particles to microscopic or nano size. The uniform particle processing…https://www.hielscher.com/disintegration-wetting-dissolving-dispersing.htm
Cell disintegration is a common task in biotechnology and in many applications that involve processing cells and intracellular material. Ultrasonic cell disintegrators are efficient and reliable, when it comes to breaking cell wall or membranes of plant cells, mammalian…https://www.hielscher.com/ultrasonic-disintegrators.htm
Famotidine is a common pharmaceutical molecule used in heartburn medications. In order to overcome the poor solubility and the resulting poor bioavailability, famotidine can be formulated into solid-lipid nanoparticles using sonication as encapsulation technique. Ultrasonically Famotidine-Loaded Solid Lipid Nanoparticles…https://www.hielscher.com/ultrasonically-formulated-famotidine-solid-lipid-nanoparticles.htm
Remdesivir (GS-5734) is an anti-viral drug, which is under research for treating the Ebola virus disease and COVID-19, which is caused by the Sars-CoV-2 coronavirus. Remdesivir is pharmaceutical solution, which is administered intravenously. Whilst short ultrasonic dissolving alone enhances…https://www.hielscher.com/improved-remdesivir-solubility-by-sonication.htm
Chitosan is a chitin-derived biopolymer which has many applications in pharma, food, agriculture and industry. Ultrasonic deacetylation of chitin to chitosan intensifies the treatment significantly - leading to an efficient and fast process with a high chitosan yield of…https://www.hielscher.com/ultrasonic-deacetylation-of-chitin-to-chitosan.htm
Jellyfish collagen is a high-quality collagen, which is unique but exhibits similar properties to type I, II, III and type V collagen. Ultrasonic extraction is a purely mechanical technique, that increases yield, accelerates the process and produces high molecular…https://www.hielscher.com/ultrasonic-collagen-extraction-from-jellyfish.htm
In order to microencapsulate active ingredients via spray-drying, a fine-sized stable micro- or nanoemulsion must be prepared. Ultrasonic emulsification is a facile and reliable technique to produce stable micro- and nano-emulsions As alternative surfactant, biopolymers such gum arabi or…https://www.hielscher.com/ultrasonic-nano-emulsification-for-microencapsulation-before-spray-drying.htm
Research has shown that ultrasonic milling can be successfully used for fabrication of thermoelectric nanoparticles and has the potential to manipulate the surfaces of the particles. Ultrasonically milled particles (e.g. Bi2Te3-based alloy) showed a significant size reduction and fabricated…https://www.hielscher.com/ultrasonic-milling-of-thermoelectrical-nano-powders.htm
Ultrasonic extraction has been proven to be highly efficient for the isolation of superior quality extracts of microalgae. Spirulina pigments such as phycocyanin are known as superfood, which contribute to health benefits due to their high content of antioxidants,…https://www.hielscher.com/ultrasonic-extraction-of-spirulina-pigments.htm