साइलोसिबिन की अल्ट्रासोनिक ठंडे पानी की निकासी

Ultrasonic Psilocybin Extraction

Ultrasonic extraction is used successfully in many industries such as food, pharmaceutical, cosmetic, and fine-chemical industry to extract and isolate bioactive compounds and other substances from raw materials. The ultrasonic technique is considered as highly efficient, rapid, reliable, safe and easy to operate as well as environmental-friendly extraction method. Due to these advantages, the ultrasonically-assisted extraction (UAE) outperforms alternative extraction methods. Compounds such as psilocybin, psilocin, baeocystin and norbaeocystin are already successfully extracted using Hielscher Ultrasonics equipment. The ultrasonic extraction of psychedelic compounds gives high yields of superior extract quality within a turbo-extraction procedure. Ultrasonic extraction is compatible with any solvent and allows for the production of full-spectrum extracts.

अल्ट्रासोनिक निष्कर्षण – A Cold Extraction Technique

Bioactive compounds are heat-sensitive, which means they degrade and decompose under high temperatures so that they loose their effect and potency. Therefore, most botanical extraction benefit from a non-thermal extraction method, which is not based on heat a basic working principle. Ultrasonic extraction is a purely mechanical extraction technique, which working principle is the generation of acoustic cavitation.
What is Ultrasonic Cavitation and How does it Impact Extraction?
For instance, when a liquid is sonicated with an ultrasound probe at 20kHz, 20,000 vibrations per second are transmitted into the medium. The ultrasonic waves travel through the liquid, where they create alternating high-pressure (compression) / low-pressure (rarefaction or expansion) cycles. During the low-pressure vacuum cycle, minute vacuum bubbles or cavities occur in the liquid, which grow over several pressure cycles. During the compression phase of the liquid and bubbles, the pressure is positive, while the rarefaction phase produces a vacuum (negative pressure.) During the compression-expansion cycles, the cavities in the liquid grow until they reach a size, at which they cannot absorb more energy. At this point, they implode violently. The implosion of those cavities results in various highly energetic sonomechanical effects, which are known as the phenomenon of acoustic / ultrasonic cavitation. During the implosion of ultrasonic cavitation bubbles, extreme energy dense forces such as high shear, liquid streaming and turbulences are created in the sonicated liquid. These cavitational forces disrupt cell walls of plant tissues and release the intracellular compounds, including bioactive substances such as the hallucinogenics psilocybin, psilocin, baeocystin and norbaeocystin from mushroom species. The alternating high-pressure/low-pressure cycles also promote intense mass transfer rates, which results in the superior extraction yield obtained by sonication. Ultrasonic extraction can release the complete active substance content from botanicals.

Ultrasonic Psilocybin Extraction: Step-by-Step

You can extract psilocybin and other bioactive substances from mushrooms using water, ethanol or 200 proof ethyl alcohol as solvents.
Chop the fresh or dried psilocybin mushrooms into small bits and pieces. You can use caps and stems. Both contain the psychoactive compounds, however the caps consistently are richer in psilocybin. The spores do not contain psilocybin.
Place the chopped mushrooms in a glass beaker and fill it with cold water.
Optionally, you might place the glass beaker in an ice bath to keep the process temperature as cold as possible.
The sonicated slurry turn blue with blue water containing extracted psilocybin from the mushroom fruits.
Separate the mushroom pieces and debris by straining or filtering. Optionally, keep the mushroom material from filtration for a second extraction run using either water or ethanol.
Use an evaporation system to remove the solvent. 1 to 2 grams of dried magic mushrooms should yield in approx. 1cc of final extract. As mushrooms are a natural product, the content of psychedelic substances can vary.
Fill the final extract into a dark glass container or vial and store in the freezer.
By an optional crystallization step, the shelf-life of the psilocybin extract can be prolonged further.

Psilocybin-Containing Mushrooms

Psilocybin can be found in more than 200 species of mushrooms of the four fungus genera Conocybe. Panaeolus, Psilocybe, Stropharia, which are all suitable for extracting the the active compound psilocybin ultrasonically. In general, mushrooms that contain psilocybin exhibit the following characteristics: They have dark spores, are lamella / gills fungi, grow mostly in humus-rich soil in meadows and woods of tropical and sub-tropical regions and exhibit blue bruises which occurs due to an oxidative reaction, when the mushroom is handled or damaged.
The most well-known species of psilocybin-containing mushroom is Psilocybe cubensis, which contains two psycho-active compounds, psilocybin and psilocin. Commonly known as shrooms, magic mushrooms, golden tops, cubes, or gold caps, Psilocybe cubensis belongs to the fungus family Hymenogastraceae, and was formerly known as Stropharia cubensis. As it is widely distributed and easy to cultivate, Psilocybe cubensis is the best-known pscilocybin-containing mushroom species.
Psilocybe cubensis is probably the most famous for its hallugcinogenic effects, which are caused mainly by the active compounds triggering psychedelic experiences after ingestion. Its major psychoactive compounds are:

• Psilocybin (4-phosphoryloxy-N,N-dimethyltryptamine)
• Psilocin (4-hydroxy-N,N-dimethyltryptamine)
• Baeocystin (4-phosphoryloxy-N-methyltryptamine)
• Norbaeocystin (4-phosphoryloxytryptamine)

अल्ट्रासोनिक एक्सट्रैकेशन सिस्टम के फायदे

The advantages of ultrasonic extraction are the high extraction yield of psychedelic compounds (i.e. psilocybin, psilocin, baeocystin, norbaeocystin), the free choice of solvent (e.g. water, ethanol, water-alcohol mixture etc.), as well as the simple and safe operation. Due to the intensive mechanical forces of sonication, ecological and mild solvents such as water, ethanol etc. are usually sufficient to achieve an extraordinary extraction rate and yield. As a result, ultrasonic extraction shortens the extraction time and enables a reduced use of solvents or the use of milder, gentler solvents. This means that ultrasonic extraction allows for both, higher extraction rates and healthier extracts (e.g. cold water extracts). Since the process temperature can be precisely controlled during the sonication, thermal decomposition of the extracts due to excessively high temperatures as well as evaporation of the substances are avoided.

Sophisticated Ultrasonicators for Mushroom Extraction

Hielscher Ultrasonics product portfolio covers the full range of high-performance ultrasonic extractors from small to large scale. Additional accessories allow for the easy assembly of the most suitable ultrasonic extractor configuration for your process. The optimal sonication setup depends on the envisaged capacity, volume, raw material, batch or inline process and timeline. Our long-experiences, well-trained staff will recommend you the most suitable ultrasonic extractor and will assist you during the establishing phase of your mushroom extraction process.

अल्ट्रासोनिक निष्कर्षण – बैच और इनलाइन

Hielscher ultrasonicators can be used for batch and continuous flow-through processing. Depending on your process volume and hourly throughput, inline processing might be recommended for higher processing volumes. Whilst batching of large violumes is time- and labour-intensive, a continuous inline mixing process comes handy as it is more efficient, faster and requires significantly less labour. Hielscher Ultrasonics has the most suitable extraction setup for your extraction volume and process goals.

हर उत्पाद क्षमता के लिए अल्ट्रासोनिक चिमटा

Hielscher Ultrasonics उत्पाद रेंज प्रति घंटे ट्रक लोड प्रक्रिया करने की क्षमता के साथ पूरी तरह से औद्योगिक अल्ट्रासोनिक प्रोसेसर के लिए बेंच-टॉप और पायलट सिस्टम पर कॉम्पैक्ट लैब अल्ट्रासोनिक से अल्ट्रासोनिक प्रोसेसर का पूरा स्पेक्ट्रम शामिल है । पूर्ण उत्पाद रेंज हमें आपको अपने कच्चे माल, प्रक्रिया क्षमता और उत्पादन लक्ष्यों के लिए सबसे उपयुक्त अल्ट्रासोनिक चिमटा प्रदान करने की अनुमति देता है।
अल्ट्रासोनिक बेंचटॉप सिस्टम व्यवहार्यता परीक्षणों और प्रक्रिया अनुकूलन के लिए आदर्श हैं। स्थापित प्रक्रिया मापदंडों के आधार पर रैखिक स्केल-अप से प्रसंस्करण क्षमताओं को छोटे लॉट से पूरी तरह से वाणिज्यिक उत्पादन तक बढ़ाना बहुत आसान हो जाता है। अप-स्केलिंग या तो अधिक शक्तिशाली अल्ट्रासोनिक चिमटा इकाई स्थापित करके या समानांतर में कई अल्ट्रासोनिकेटर को क्लस्टर करके किया जा सकता है। UIP16000 के साथ, Hielscher दुनिया भर में सबसे शक्तिशाली अल्ट्रासोनिक चिमटा प्रदान करता है।

इष्टतम परिणामों के लिए ठीक नियंत्रणीय आयाम

All Hielscher ultrasonicators are precisely controllable and thereby reliable work horses in production. The amplitude is one of the crucial process parameters that influence the efficiency and effectiveness of ultrasonic extraction of bioactive phyto-nutrients and hallucinogenic compounds from botanicals. Raw material such as soft fresh mushrooms require milder sonication and lower amplitude settings, whilst dried mushrooms might require sonication at higher amplitudes to release the intracellular content. All Hielscher Ultrasonics’ प्रोसेसर आयाम की सटीक सेटिंग के लिए अनुमति देते हैं। सोनोटरोड और बूस्टर सींग सहायक उपकरण हैं जो एक भी व्यापक रेंज में आयाम को संशोधित करने की अनुमति देते हैं। Hielscher के औद्योगिक अल्ट्रासोनिक प्रोसेसर बहुत उच्च आयाम प्रदान कर सकते हैं और आवेदनों की मांग के लिए आवश्यक अल्ट्रासोनिक तीव्रता प्रदान कर सकते हैं। 200μm तक के आयामों को 24/7 ऑपरेशन में आसानी से लगातार चलाया जा सकता है।
सटीक आयाम सेटिंग्स और स्मार्ट सॉफ्टवेयर के माध्यम से अल्ट्रासोनिक प्रक्रिया मापदंडों की स्थायी निगरानी आपको सबसे प्रभावी अल्ट्रासोनिक स्थितियों के साथ अपने बीजों का इलाज करने की संभावना देती है। सर्वश्रेष्ठ निष्कर्षण परिणामों के लिए इष्टतम सोनीशन!
Hielscher अल्ट्रासोनिक उपकरण की मजबूती भारी शुल्क पर 24/7 आपरेशन के लिए और मांग वातावरण में अनुमति देता है । यह Hielscher के अल्ट्रासोनिक उपकरण एक विश्वसनीय काम उपकरण है कि अपनी निष्कर्षण आवश्यकताओं को पूरा करता है ।

आसान, जोखिम मुक्त परीक्षण

अल्ट्रासोनिक प्रक्रियाओं को पूरी तरह से रैखिक पहुंचाया जा सकता है। इसका मतलब यह है कि हर परिणाम है कि आप एक प्रयोगशाला या बेंच शीर्ष अल्ट्रासोनिकेटर का उपयोग कर हासिल किया है, बिल्कुल एक ही प्रक्रिया मापदंडों का उपयोग कर वास्तव में एक ही उत्पादन के लिए पहुंचा जा सकता है । यह वाणिज्यिक विनिर्माण में जोखिम मुक्त व्यवहार्यता परीक्षण, प्रक्रिया अनुकूलन और बाद में कार्यान्वयन के लिए अल्ट्रासोनिकेशन आदर्श बनाता है। यह जानने के लिए हमसे संपर्क करें कि कैसे सोनीशन आपकी अंकुरित उपज और गुणवत्ता को बढ़ा सकता है।

उच्चतम गुणवत्ता – जर्मनी में डिजाइन और निर्मित

एक परिवार के स्वामित्व वाले और परिवार द्वारा संचालित व्यवसाय के रूप में, Hielscher अपने अल्ट्रासोनिक प्रोसेसर के लिए उच्चतम गुणवत्ता मानकों को प्राथमिकता देता है । जर्मनी के बर्लिन के पास टेल्टो में हमारे मुख्यालय में सभी अल्ट्रासोनिकेटर डिजाइन, निर्मित और अच्छी तरह से परीक्षण किए जाते हैं। Hielscher के अल्ट्रासोनिक उपकरणों की मजबूती और विश्वसनीयता इसे आपके उत्पादन में एक काम का घोड़ा बनाती है। 24/7 पूर्ण भार के तहत ऑपरेशन और मांग वातावरण में Hielscher उच्च प्रदर्शन मिक्सर की एक प्राकृतिक विशेषता है ।

You can buy Hielscher ultrasonic processor in any different size and exactly configured to your process requirements of mushroom extraction. From treating fungi in a small lab beaker to the continuous flow-through mixing of mushroom slurries on industrial level, Hielscher Ultrasonics offers a suitable ultrasonicator for you! Please contact us – हम आपको आदर्श अल्ट्रासोनिक सेटअप की सिफारिश करने के लिए खुश हैं!
नीचे दी गई तालिका आपको हमारे अल्ट्रासोनिकटर की अनुमानित प्रसंस्करण क्षमता का संकेत देती है: