Extraction ultrasonique du sureau

Elderberry extracts are well-known for their antiviral properties and thereby heavily used as natural remedy to relieve flu symptoms such as fever, cough, and sore throat. To produce elderberry extracts with a high polyphenol and antioxidant content, a mild yet efficient extraction method is required. Ultrasonic extraction as a non-thermal, mild technique is used widely in the production of high-quality botanical extracts. Sonication increases extraction rate, yield and quality of elderberry extracts.

Elderberry Extract

Polyphenols, flavonoids and vitamins are efficiently extracted from elderberry fruits and flowers by ultrasonicationElderberries are the fruit of the Black Elder (Sambucus nigra L.) tree. Elderberry fruits and flowers are well-known for their richness in flavonoids and vitamins. The berries contain high amounts of certain anthocyanins, and both berries and flowers contain high amounts of certain flavonols. Flavonoids such as anthocyanins, proanthocyanidins, flavonols, flavanones, and flavones are polyphenolic antioxidants, which support the immune system and show various benefits on overall health. Additionally, elderberry has antiviral, anti-bacterial and anti-cancer properties and has shown to improve cardiovascular health. Especially the flavonoids give elderberry products their exceptional antiviral properties.
To get the highest benefit from elderberry’s health-promoting properties, the bioactive compounds such as polyphenols, flavonoids, anthocyanins, and vitamins are extracted from elderberry fruits and flowers and formulated into a concentrated, highly potent health product.
Commercial elderberry preparations for the treatment of the common cold and flu are available in various forms, including liquids, syrups, capsules, tablets, lozenges and gummies.

extraction par ultrasons – A Turbo Extraction Technique

To produce large amounts of high-quality elderberry extract, an efficient, yet mild extraction technique is required. The mildness of the extraction process is important to avoid the degradation of the bioactive compounds. For instance, many phytonutrients are thermo-labil, which means they are decomposed by heat. The ultrasonic extraction is a non-thermal technique, whose mechanism is purely mechanical. Ultrasonic extraction is based on the generation of acoustic cavitation, which produces shear forces and turbulences in the extraction liquid. These cavitational shear forces disrupt the cell matrix of plant and releases the bioactive compounds, such as polyphenols, anthocyanins, flavonoids and vitamins, into the surrounding extraction liquid / solvent. Due to the effectiveness of ultrasonic cavitation, ultrasonic extraction can release the complete amount of bioactive phyto-nutrients from the botanical raw material. Ultrasonic extraction gives exceptionally high yields in a very short processing time.

Ultrasonic extractor UP400St + sonotrode S24d22L2D with 8L extraction batch for botanical extraction

Le UP400ST is a 400 watts powerful ultrasonic extractor to release and isolate phyto-nutrients from botanicals

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Ultrasonic Homogenizer UP400St for the agitated batch extraction of botanicals

Ultrasonic Extraction of Botanicals - 8 Liter Batch - UP400St

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Another benefit is the compatibility of ultrasonics with any kind of solvents. Whilst conventional extraction techniques such as soaking, maceration or Soxhlet extraction often require harsh and toxic solvents, ultrasonic extraction allows you to select the solvent of your choice. Ultrasonic extraction can be performed using water, water/alcohol mixtures, ethanol, vegetable oils and other mild solvents. Especially (aqueous) ethanol has been established as a potent and reliable solvent, which can be easily evaporated after extraction and residual trace amounts in the extract would be non-toxic.
Ultrasonication is a well-established method to produce high-quality extracts from botanicals, e.g., elderberry fruits and flowers. High-performance ultrasonics is a process intensifying technique: It makes the extraction more efficient by giving higher yields and accelerates the process. Therefore, sonication is also known as a turbo extraction technique.

Advantages of Ultrasonic Elderberry Extraction

  • Des rendements plus élevés
  • extraction rapide
  • High-quality extract
  • Non-thermal treatment
  • Free choice of solvent
  • Facile et sûr à utiliser

Turbo Extraction of Botanical Compounds with Ultrasonics

As a turbo extraction process, ultrasonication extracts significantly more intensiv than other conventional extraction methods (e.g. cold soaking, infusion, maceration, percolation etc.). This is due to the ultrasonically induced mixing, size reduction of particles, and the thereby enhanced mass transfer. With an increased mass transfer, the concentration equilibrium between botanical material (biomass) and the surrounding solvent is significantly faster achieved. As soon as this concentration equilibrium has been reached, the extraction step is completed since the solvent cannot absorb more bioactive molecules. The ultrasonic mixing, dispersing and reducing of botanical solids flushes the targeted molecules from the cellular matrix of the plant out into the solvent. Whilst other extraction methods require often several hours or days, the ultrasonic extraction is achieved within a few minutes. The short, non-thermal ultrasonic treatment prevents the active molecules against temperature-induced degradation.

Ultrasonic probe-type extractor for the isolation of phytoconstituents from elderberries, elderflower and leaves (Sambucus nigra)Ultrasonic probe-type extraction has proven to be a highly efficient method of obtaining extracts from various plant materials, including elderberries, elder flowers, and leaves. The process involves exposing the plant material to high-frequency sound waves, which creates cavitation bubbles that disrupt the cell walls and release the desired bioactive compounds.
A scientific study by Sánchez-Hernández et al (2023), published in the International Journal of Molecular Sciences, looked at the phytochemical profiling and antimicrobial potential of Sambucus nigra L. flower and leaf extracts obtained through ultrasonic extraction using the Hielscher ultrasonicator UIP1000hdT. Results showed that this method was highly effective in extracting bioactive compounds from both the flowers and leaves of elderberry plants.

Advantages of Ultrasonic Elderberry and Elderflower Extraction

Some advantages of ultrasonic probe-type extraction for elderberry products include:

  • Greater yields: Ultrasonic extraction has been shown to produce higher yields of bioactive compounds compared to traditional methods such as maceration or Soxhlet extraction.
  • Accelerated processing, shortened duration: Ultrasonic extraction can be completed within minutes rather than hours or days, making it a much more time-efficient option.
  • Improved quality: The gentle nature of ultrasonic extraction helps preserve the integrity and potency of plant compounds, leading to higher quality extracts.
  • Mild Solvents:Designing extraction processes that efficiently extract the desired compounds while minimizing the extraction of unwanted substances requires careful optimization and selection of suitable solvents. Ultrasonic extractors have the advantage that they can be operated with any solvent. This means that you should chose a solvent that is most suitable regarding its dissolving capacity of your target compounds. Commonly used solvents for ultrasonic extraction include aqueous ethanol, water, ethanol, methanol, isopropyl alcohol, hexane, glycerine, vegetable oils, deep eutectic solvents as well as any other usual solvent.
  • Full Spectrum: Ultrasonication is a great extraction technique to obtain a full spectrum extract that contains the complete array of phytochemical constituents present in a plant. Full spectrum extracts are known for their entourage effect. The entourage effect describes the synergistic effects of different compounds working together to enhance the overall therapeutic benefits of the extract.

Overall, ultrasonic probe-type extraction using sophisticated ultrasonicators such as the UIP1000hdT is an efficient method for obtaining high-quality extracts from elderflowers and leaves. Its efficiency and effectiveness make it an attractive option for researchers and manufacturers alike looking to harness the health benefits of these natural ingredients.
 

Dans cette présentation, nous vous introduisons à la fabrication d'extraits botaniques. Nous expliquons les défis que pose la production d'extraits botaniques de haute qualité et comment un sonicateur peut vous aider à surmonter ces défis. Cette présentation vous montrera comment fonctionne l'extraction par ultrasons. Vous apprendrez quels avantages vous pouvez attendre d'un sonicateur pour l'extraction et comment vous pouvez mettre en œuvre un extracteur à ultrasons dans votre production d'extraits.

Extraction botanique par ultrasons - Comment utiliser des sonicateurs pour extraire des composés botaniques ?

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High-Performance Ultrasonic Extractors for Elderberry Extraction

All extraction results achieved on small scale, can be linearly scaled to larger production capacities. Hielscher Ultrasonics large product portfolio from lab to industrial extraction systems has the most suitable ultrasonicator for your envisaged process capacity. Our long-time experienced staff will assist you from feasibility tests and process optimisation to the installation of your ultrasonic system on final production level.

Hielscher Ultrasonics – Sophisticated Extraction Equipment

Hielscher Ultrasonics product portfolio covers the full range of high-performance ultrasonic extractors from small to large scale. Additional accessories allow for the easy assembly of the most suitable ultrasonic device configuration for your process. The optimal ultrasonic setup depends on the envisaged capacity, volume, raw material, batch or inline process and timeline.

par lots et en ligne

Hielscher ultrasonicators can be used for batch and continuous flow-through processing. Depending on your process volume and hourly throughput, inline processing might be recommended. Whilst batching is more time- and labour-intensive, a continuous inline mixing process is more efficient, faster and requires significantly less labour. Hielscher Ultrasonics has the most suitable extraction setup for your extraction volume and process goals.

Ultrasonic Extractors for Every Product Capacity

Cellule d'écoulement UIP4000hdT pour la sonication en ligne à l'échelle industrielleHielscher Ultrasonics product range covers the full spectrum of ultrasonic processors from compact lab ultrasonicators over bench-top and pilot systems to fully-industrial ultrasonic processors with the capacity to process truckloads per hour. The full product range allows us to offer you the most suitable ultrasonic extractor for your raw material, process capacity and production targets.
Ultrasonic benchtop systems are ideal for feasibility tests and process optimization. Linear scale-up based on established process parameters makes it very easy to increase the processing capacities from smaller lots to fully commercial production. Up-scaling can be done by either installing a more powerful ultrasonic extractor unit or clustering several ultrasonicators in parallel. With the UIP16000, Hielscher offers the most powerful ultrasonic extractor worldwide.

Amplitudes contrôlables avec précision pour des résultats optimaux

All Hielscher ultrasonicators are precisely controllable and thereby reliable work horses in production. The amplitude is one of the crucial process parameters that influence the efficiency and effectiveness of ultrasonic extraction of bioactive photo-nutrients from botanicals.
Hielscher's industrial processors of the hdT series can be comfortable and user-friendly operated via browser remote control.Raw material such as soft berries require milder sonication and lower amplitude settings, whilst thick leaves or seeds with a robust and hard shell require sonication at higher amplitudes to release the intracellular compounds. All Hielscher Ultrasonics’ permettent un réglage précis de l'amplitude. Les sonotrodes et les cornes d'amplification sont des accessoires qui permettent de modifier l'amplitude dans une plage encore plus large. Les processeurs ultrasoniques industriels de Hielscher peuvent délivrer des amplitudes très élevées et fournir l'intensité ultrasonique requise pour des applications exigeantes. Des amplitudes allant jusqu'à 200µm peuvent être facilement exploitées en continu, 24 heures sur 24 et 7 jours sur 7.
Precise amplitude settings and the permanent monitoring of the ultrasonic process parameters via smart software give you the possibility to treat your seeds with the most effective ultrasonic conditions. Optimal sonication for best extraction results!
The robustness of Hielscher’s ultrasonic equipment allows for 24/7 operation at heavy duty and in demanding environments. This makes Hielscher’s ultrasonic equipment a reliable work tool that fulfils your extraction requirements.

Des tests faciles et sans risque

Ultrasonic processes can be completely linear scaled. This means every result that you have achieved using a lab or bench-top ultrasonicator, can be scaled to exactly the same output using the exactly same process parameters. This makes ultrasonication ideal for risk-free feasibility testing, process optimization and subsequent implementation into commercial manufacturing. Contact us to learn how sonication can increase your sprout yield and quality.

La plus haute qualité – Conçu et fabriqué en Allemagne

En tant qu'entreprise familiale, Hielscher accorde la priorité aux normes de qualité les plus élevées pour ses processeurs à ultrasons. Tous les appareils à ultrasons sont conçus, fabriqués et testés minutieusement dans notre siège social de Teltow, près de Berlin, en Allemagne. La robustesse et la fiabilité des équipements à ultrasons de Hielscher en font des outils de travail pour votre production. Le fonctionnement 24 heures sur 24, 7 jours sur 7, à pleine charge et dans des environnements exigeants est une caractéristique naturelle des mélangeurs haute performance de Hielscher.

Le tableau ci-dessous vous donne une indication de la capacité de traitement approximative de nos ultrasons :

Volume du lotdébitDispositifs recommandés
1 à 500mL10 à 200mL/minUP100H
10 à 2000mL20 à 400mL/minUP200Ht, UP400ST
0.1 à 20L0.2 à 4L/minUIP2000hdT
10 à 100L2 à 10L/minUIP4000hdt
n.d.10 à 100L/minUIP16000
n.d.plus grandegroupe de UIP16000

You can buy Hielscher ultrasonic processor in any different size and exactly configured to your process requirements. From treating seeds in a small lab beaker to the continuous flow-through mixing of seed slurries on industrial level, Hielscher Ultrasonics offers a suitable ultrasonicator for you! Please contact uswe are glad to recommend you the ideal ultrasonic setup!

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Veuillez utiliser le formulaire ci-dessous pour demander des informations supplémentaires sur les processeurs à ultrasons, les applications et les prix. Nous nous ferons un plaisir de discuter avec vous de votre processus et de vous proposer un système à ultrasons répondant à vos exigences !









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Hielscher Ultrasonics fabrique des homogénéisateurs à ultrasons de haute performance pour la dispersion, l'émulsification et l'extraction cellulaire.

Homogénéisateurs ultrasoniques haute puissance de laboratoires à pilote et Industriel échelle.



Littérature / Références

Qu'il faut savoir

Elderberry-containing Pharmaceuticals and Supplements

Black elder and elderberry extracts are formulated either into single extracts or black elder-containing multi-herb products. Pure elderberry extracts are products such as Sambucol® (Sambucol, Pharmacare US Inc., San Diego), Rubini® (Rubini, Iprona AG Via Industria LANA, Italy) and other S. nigra extracts or syrups , and black elder-containing multi-herb products such as Sinupret® (Sinupret, Bioforce USA). Elderberry extracts and elderberry containing products are especially administered to strengthen the immune system and to treat symptoms of the common cold and influenza.

effet d'entourage

The entourage effect in botanical extracts refers to the synergistic and interactive effects of different compounds working together to enhance the overall therapeutic benefits of the extract. It is based on the idea that individual compounds found in plants may have limited therapeutic effects on their own, but when combined with other compounds found in the same plant, they can enhance each other’s effects and create a more potent and effective therapeutic outcome.
For example, in cannabis extracts, THC and CBD are two well-known compounds that have been shown to have individual therapeutic benefits. However, studies suggest that when combined with other cannabinoids, terpenes, and flavonoids also present in cannabis, their therapeutic effects are enhanced due to their interaction with one another.
Similarly, many botanical extracts contain multiple bioactive compounds such as polyphenols, flavonoids, terpenes, and alkaloids that work together synergistically to provide a range of health benefits. The entourage effect suggests that these compounds are more effective when used together rather than in isolation.
In summary, the entourage effect is an important consideration in the use of botanical extracts for therapeutic purposes as it highlights the importance of using whole-plant extracts rather than isolated compounds. By harnessing this phenomenon through careful formulation and extraction methods, it may be possible to optimize the effectiveness of botanical medicine for various health conditions.

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