Hielscher ультразвукова технологія

Глибокі еутектичні розчинники для високоефективного вилучення

Deep eutectic solvents (DESs) and natural deep eutectic solvents (NADES) offer advantages as extraction solvents on many levels and are thereby a promising alternative to conventional organic solvents. Deep eutectic solvent work excellent in combination with ultrasonic extraction and give high yields of premium quality extracts. Find out more about ultrasonic extraction using natural deep eutectic solvents.

What are Deep Eutectic Solvents (DES)?

Deep eutectic solvents (DESs) are mixtures of at least one hydrogen bond acceptor (HBA) and one hydrogen bond donor (HBD), including carboxylic acids and other renewable compounds. According to Cai et al. (2019), “the strong hydrogen bonding interaction between HBA and HBD is the most important factor for the formation of DESs.” [Cai et al. 2019] For hydrogen bond donors (HBDs), compounds such as sugars, amino acids, carboxylic acids (e.g., benzoic acid, citric acid, succinic acid) or amines (e.g., urea, benzamide) are often used. The chemical interaction potential of HBDs is the major factors contributing to formation and efficiency of deep eutectic solvents. Halide salts such as choline chloride or zinc chloride can be also used in conjunction with the HBDs. Other choline chloride-based DES are formed with malonic acid, phenol or glycerine. As result of the strong hydrogen-bonding interactions, the melting point of deep eutectic solvents is significantly reduced when compared to its individual components. In contrast to conventional solvents (e.g., ethanol, methanol, hexane, butane etc.) DES are non-volatile, which means they have a very low vapour pressure and are thereby hardly inflammable. The toxicity of deep eutectic solvents is low, their biodegradability is high, and the necessary precursors are inexpensive, easily and plentiful available as well as renewable. Natural deep eutectic solvents (NADESs) are even more eco-friendly as all precursors are sourced from natural sources. DESs also offer a tunable solvency based on the chemistry of the solute and the species used to create the DES. Some NADES exhibit a high viscosity and they are therefore not very suitable for batch extraction. However, NADES with higher viscosities can be successfully applied as solvents in ultrasonic flow-through extraction.

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Deep eutectic solvents (DES) are highly effective solvents for ultrasonic botanical extraction.

Ultrasonic extraction with (natural) deep eutectic solvents is a highly efficient method for superior botanical extracts. The picture shows the ultrasonic processor UP400St (400 Вт) with a 8L batch for botanical extraction.

Ultrasonic Botanical Extraction with the UP200Ht

How Does Ultrasonic Extraction with Deep Eutectic Solvents Work?

Ultrasonic extraction is based on the sonomechanical effects of high-intensity, low-frequency ultrasound. To promote and intensify the extraction of botanical compounds (i.e., bioactive substances) via ultrasonication, high-power ultrasound waves are coupled via an ultrasonic probe (also called ultrasonic horn or sonotrode) into the liquid medium, i.e. the slurry consisting in the botanical raw material and the (natural) deep eutectic solvent. The ultrasound waves travel through the liquid and create alternating low-pressure / high-pressure cycles. During low-pressure cycles, minute vacuum bubbles (so-called cavitation bubbles) are created, which grow over several pressure cycles. During those cycles of bubble growth, the dissolved gases in the liquid enter the vacuum bubble, so that the vacuum bubble transform into growing gas bubbles. After growing over several cycles, the vacuum bubbles reach a certain size at which they cannot absorb more energy, so that they implode violently during a high-pressure cycle. The bubble implosion is characterised by intense cavitational forces, including very high temperature and pressure reaching up to 4000K and 1000atm, respectively; as well as corresponding high temperature and pressure differentials. These ultrasonically generated turbulences and shear forces break plant cells up and release the intracellular bioactive compounds into the (natural) deep eutectic solvent. Ultrasonic extraction opens the cell structure of botanicals and intensifies mass transfer between plant material and solvent. Sonication promotes thereby the efficacy of natural deep eutectic solvents. Ultrasonic extraction with (natural) deep eutectic solvents results in exceptionally high yields within a very short processing time.

Ultrasonic extraction is works by  disrupting cell structures and promoting mass transfer

Power ultrasound waves disrupt the cell structure of botanicals, release the bioactive compounds and promote the mass transfer between the plant material and the solvent (e.g., deep eutectic solvents).

Advantages of Ultrasonic Extraction with Deep Eutectic Solvents

  • високоефективний
  • швидкий процес
  • Exactly tunable to the specific botanical
  • Mild processing conditions
  • Batch and flow mode
  • Легко і безпечно
  • Environmental-friendly / biodegradable
  • Recycable
  • недорогий
  • Easily accessible
  • Нетоксичний

The combination of ultrasonic extraction with (natural) deep eutectic solvents gives you the opportunity combine the process intensifying power of ultrasound with the remarkable solubilizing effects and outstanding designability of deep eutectic solvents.
Contact us now to learn more about the powerful ultrasonic extraction application using deep eutectic solvents!

Ultrasonic extraction can be combined with deep eutectic solvents for superior efficiency and eco-friendliness.

ультразвуковий екстрактор UIP2000hdT (2kW) for the production of botanical extracts

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Високопродуктивні ультразвукові Екстрактори

Ultrasonic inline extraction system UIP4000hdT for the use of deep eutectic solventsUltrasonic extraction is a reliable processing technology, which facilitates and accelerates the production of high-quality extracts from various botanical as well as any solvent. Ultrasonic extraction is highly compatible with (natural) deep eutectic solvents, which are favourable due to their excellent solubilizing power, designability to the extract, sustainability, biodegradability, and eco-friendliness. The combination of the process intensification of power ultrasound with the advantages of (natural) deep eutectic solvents gives this process technology superiority on many levels. Hielscher Ultrasonics portfolio covers the full range from compact lab ultrasonicators to industrial extraction systems. All of them are of course suitable for the extraction with deep eutectic solvents.
Our long-time experienced staff will assist you from feasibility tests and process optimisation to the installation of your ultrasonic system on final production level.

Hielscher Ultrasonics’ Extractors feature:

  • high efficiency power-ultrasound
  • висока надійність
  • дуже високі амплітуди
  • operation in batch and flow-mode
  • repeatable / reproducible results
  • Робота 24/7/365
  • надійність
  • smart software
  • Дистанційне керування браузером
  • user-friendliness
  • low maintenance requirements
  • безпека

У таблиці нижче наведено приблизну потужність обробки наших ультразвукових пристроїв:

пакетний Обсяг швидкість потоку Рекомендовані пристрої
Від 1 до 500мл Від 10 до 200мл / хв UP100H
Від 10 до 2000мл Від 20 до 400мл / хв UP200Ht, UP400St
0.1 до 20 л 0.2 до 4л / хв UIP2000hdT
Від 10 до 100 л Від 2 до 10 л / хв UIP4000hdT
застосовується Від 10 до 100 л / хв UIP16000
застосовується більший кластер UIP16000

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Ultrasonic high-shear homogenizers are used in lab, bench-top, pilot and industrial processing.

Hielscher Ultrasonics виробляє високоефотозні ультразвукові гомогенізатори для змішування застосувань, дисперсії, емульгування та екстракції в лабораторних, пілотних і промислових масштабах.


Hielscher Ultrasonics supplies high-performance ultrasonic homogenizers from lab to industrial size.

Висока продуктивність ультразвуку! Асортимент продукції Hielscher охоплює повний спектр від компактного лабораторного ультразвукового над лавковими агрегатами до повноіндативних ультразвукових систем.