Sonication orqali yaxshilangan Remdesivir eruvchanligi
Remdesivir (GS-5734) virusga qarshi dori boʻlib, u Ebola virusi kasalligi va Sars-CoV-2 koronavirusi sabab boʻlgan COVID-19 ni davolash uchun tadqiqot qilinmoqda. Remdesivir - bu vena ichiga yuboriladigan farmatsevtik eritma. Qisqa ultratovushli eritishning o'zi remdesivirning eruvchanligini oshiradi va uning formulasini yaxshilaydi, remdesivirning siklodekstrin komplekslari ichida ultratovushli kompleksi remdesivirning eruvchanlik muammolarini bartaraf etishning istiqbolli usuli bo'lib, bu preparatni bioavailable qiladi.
Remdesivirning siklodekstrin dori tashuvchilarga ultratovushli murakkablashishi
Sulfobutil-eter beta-siklodekstrin (SBE-b-CD) yomon eriydigan moddalarning eruvchanligini oshirish uchun yordamchi yoki shakllantirish agenti sifatida ishlatiladi. Tadqiqotlar shuni ko'rsatadiki, remdesivirning SBE-b-CD komplekslariga kompleksi remdesivirning eruvchanligini yaxshilaydi va shu bilan uning so'rilish tezligi va bio-mavjudligini sezilarli darajada yaxshilaydi.
Formulations for “in vitro” research:
- H2O: 250 mg/ml – eritish uchun ultratovush talab qiladi
- Dimetil sulfoksid (DMSO): 5,625 mg/ml – eritish uchun ultratovush + isitish talab qiladi
Formulations for “in vivo” research:
- Har bir erituvchini birma-bir qo'shing: 10% DMSO, 40% PEG300, 5% Tween 80, 45% sho'r + sonikasyon
Eruvchanligi: ≥ 2,17 mg/ml (3,60 mM); Aniq yechim - Har bir erituvchini birma-bir qo'shing: 10% DMSO, 90% (20% sulfobutil-eter beta-siklodekstrin (SBE-b-CD) sho'r suvda) + sonikatsiya
Eruvchanligi: ≥ 2,17 mg/ml (3,60 mM); Aniq yechim - Har bir erituvchini birma-bir qo'shing: 10% DMSO, 90% makkajo'xori yog'i + sonication
Eruvchanligi: ≥ 2,17 mg/ml (3,60 mM); Aniq yechim
Ultrasonikatsiya remdesivirning tarqalishi va eritilishiga yordam beradi, bu esa yanada samarali formulalar va yuqori bioavailabilityga olib keladi.
Siklodekstrin komplekslarining afzalliklari
Siklodekstrinlar (CD) dori samaradorligini va kuchini oshirish uchun keng qo'llaniladi, ya'ni preparatni optimal terapevtik faollikka erishish bilan birga eng past dozada yuborish mumkin.
Drugs formulated into cyclodextrin complexes offer a significantly increased drug solubility, which lowers cytotoxicity by making the drug effective at lower doses. For instance, β-cyclodextrin complexation of ganciclovir improved the drug’s antiviral activity of on human cytomegalovirus clinical strains. Subsequently, the increased drug potency resulted in a reduced the drug toxicity. Overall, cyclodextrins show a very good absorption rate and reduce drug-induced irritancies. Cyclodextrin inclusion complexes lower the local concentration of the free drug, so that the concentration is below the irritancy threshold. Cyclodextrin inclusion improves drug stability and prevents against incompatibilities. Finally, CD complexes mask drug odour and off-flavours.
UIP2000hdT zanglamaydigan po'latdan yasalgan farmatsevtika reaktorida farmatsevtika uchun ultrasonikator
Dori-darmonlarni inkapsulyatsiya qilish uchun yuqori samarali ultrasonikatorlar
Hielscher Ultrasonics farmatsevtika, oziq-ovqat va kosmetika sanoati uchun yuqori samarali ultratovushli homogenizatorlarni loyihalash, ishlab chiqarish va tarqatishda uzoq vaqt tajribaga ega. Hielscher nafaqat apparat yetkazib beruvchisi bo'lishdan faxrlanadi, balki ultratovushli ilovalar uchun murakkab maslahat va treninglar, shuningdek, ultratovush tizimlarini o'rnatish va ishlatish uchun taklif qiladi.
Yuqori sifatli siklodekstrin komplekslari va niosomalar, lipozomalar, qattiq lipid nanopartikullar yoki polimerik nanozarralar kabi boshqa nanostrukturali dori tashuvchilarni tayyorlash Hielscher ultratovush tizimlari yuqori ishonchliligi, izchil quvvat chiqishi va aniq nazorat qilinishi tufayli ustun bo'lgan jarayonlardir. Hielscher ultrasonikatorlari amplituda, harorat, bosim va sonikatsiya energiyasi kabi barcha jarayon parametrlarini aniq nazorat qilish imkonini beradi. Intellektual dasturiy ta'minot o'rnatilgan SD-kartadagi barcha sonikatsiya parametrlarini (vaqt, sana, amplituda, aniq energiya, umumiy energiya, harorat, bosim) avtomatik ravishda protokollaydi.
The robustness of Hielscher’s ultrasonic equipment allows for 24/7 operation at heavy duty and in demanding environments.
Quyidagi jadvalda ultrasonikatorlarimizning taxminiy qayta ishlash quvvati ko'rsatilgan:
| To'plam hajmi | Oqim darajasi | Tavsiya etilgan qurilmalar |
|---|---|---|
| 1 dan 500 ml gacha | 10 dan 200 ml? min | UP100H |
| 10 dan 2000 ml gacha | 20 dan 400 ml? min | UP200Ht, UP400St |
| 0.1 dan 20 L gacha | 0.2 dan 4L/min gacha | UIP2000hdT |
| 10 dan 100 l gacha | 2 dan 10 l? min | UIP4000hdT |
| na | 10 dan 100 l? min | UIP16000 |
| na | kattaroq | ning klasteri UIP16000 |
Biz bilan bog'lanish!? Bizdan so'rang!
Yuqori quvvatli ultratovushli gomogenizatorlardan laboratoriya uchun uchuvchi va sanoat masshtab.
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remdesivir
Remdesivir is drug, which has been developed by Gilead Science to treat viral infections such as Ebola virus disease and Marburg virus disease. As of state April 2020, it is in the phase of clinical trail studies in order to get possibly approved as treatment for the Ebola virus disease. In the 2020 COVID-19 pandemic, remdesivir’s antiviral effects on the SARS-CoV-2 coronavirus is investigates. As a nucleotide analogue, specifically an adenosine analogue, remdesivir inserts into the RNA chain of the virus, interfering with the virus’ replication mechanism.