Sonication bilan suvda eriydigan nano-THC formulalari
THC bilan mustahkamlangan ichimliklarni shakllantirish juda qiyin. – THC bilan to'ldirilgan ichimliklar yuqori bioavailability va shu bilan kuch, uzoq muddatli barqarorlik va aniq ko'rinishni ta'minlash uchun nano-emulsiyalangan bo'lishi kerak. THC ning ichimlikka ultratovushli nano-emulsifikatsiyasi yuqori samarali va samarali bo'lib, natijada THC-ichimligi yuqori bo'ladi.
Ultrasonik nano-emulsifikatsiyalangan THC
THC uchun yangi iste'mol usullarini ochish uchun THC bilan boyitilgan ichimliklar va ovqatlar kabi alternativalar ko'paymoqda. Ultrasonik emulsifikatsiya qiluvchi qurilmalar oziq-ovqat sifatli, toza yorliq va uzoq muddatli barqaror nano-emulsiyalarni ishlab chiqarish uchun ishlatiladi. Ultrasonik emulsifikatsiya oziq-ovqat stabilizatorlari bilan mos keladi (masalan Stuf nano-emulsifikatori), bu juda yuqori bioavailability bilan yuqori sifatli, uzoq muddatli barqaror shaffof nano-emulsiyalarni tayyorlashga yordam beradi. Ultrasonik nano-emulsiyalar THC ni suvda eruvchan, nano-mukammallashtirilgan aralashmaga aylantiradi, uni oziq-ovqat va ichimliklarga qo'shish mumkin. Ultrasonik emulsifikatsiya sizning formulangizning asl ta'miga xalaqit bermaydi.
Zond tipidagi ultrasonikatorlar nano-kengaytirilgan, suvda eruvchan THC nano-emulsiyalarini ichimliklar va yuqori bioavailability bilan qutulish mumkin bo'lgan retseptlar uchun ishlab chiqaradi!
Nima uchun THC nanoemulsiyalari?
THC-nano-emulsiyalari nano o'lchamdagi suvdagi moy (O/W) emulsiyalari bo'lib, ular aniq/shaffof ko'rinishga va uzoq vaqt barqarorlikka ega. THC yog'li birikma bo'lib, tabiiy sharoitda uni suvga aralashtirib bo'lmaydi, chunki neft va suv bir-birini rad etadi. Ultrasonikatsiya mexanik kesishni ta'minlaydi, bu yog 'va suv tomchilarini nano-o'lchamga buzadi. Nano-miqyosdagi tomchilar o'lchamlari tufayli nano-emulsiyalar shaffof, tiniq ko'rinishga ega va kinetik jihatdan barqarordir, ya'ni neft va suv fazalari ajralmaydi. Yog'li bioaktiv birikmaning mayda tomchilari, ya'ni THC, juda kichik suv tomchilari bilan yutib yuboriladi. Emulsifikator / sirt faol moddasi nano-emulsiyani uzoq muddatli barqaror qilishga yordam beradi.
Ultrasonik nano-emulsiyalar CBD, THC, vitaminlar, polifenollar kabi bioaktiv birikmalar uchun to'liq so'rilishi va ularning sog'liq uchun foydali xususiyatlarini qamrab olishi uchun muhim bo'lgan yuqori bioavailability taklif qiladi. Shunday qilib, ultratovushli tayyorlangan nano-emulsiyalar oziq-ovqat, ichimliklar va kosmetika sanoatida formulalar uchun idealdir. Katta bioavailability bilan nano-emulsiyalarni ishlab chiqarish, ultratovushli nano-emulsifikatsiya - bu yuqori bio-mavjud THC o'z ichiga olgan ichimliklar, oziq-ovqat, xun takviyeleri va kosmetika mahsulotlarini shakllantirishning oson va ishonchli usuli.
UP400St, nano-emulsiyalangan THC ichimliklar ishlab chiqarish uchun 400 vattli kuchli ultratovushli gomogenizator.
Shaffof, suvda eriydigan THC nanoemulsiyalarini sonication orqali qanday tayyorlash mumkin
Ultrasonik emulsifikatorlar foydalanish uchun qulay qurilmalar bo'lib, ular sizga THC moyining suvdagi nanoemulsiyasini shakllantirish imkonini beradi. Ultrasonikatorlar aralashmangizga faqat mexanik kesishni qo'llaganligi sababli, masalan, suvdagi THC, natijada olingan formulalar oziq-ovqat uchun mo'ljallangan. Sonication deyarli har qanday emulsifikator bilan mos keladi (shuningdek, stabilizator / sirt faol moddasi sifatida ham tanilgan). Oziq-ovqat uchun mo'ljallangan emulsifikatsiya qiluvchi vositalarni tanlash (masalan Stuf nano-emulsifikatori) yuqori darajada bio-mavjud shaklda THC o'z ichiga olgan oqlangan toza yorliqli, oziq-ovqatga mo'ljallangan nano-kengaytirilgan formulani tayyorlashga yordam beradi.
THC moyini o'z ichiga olgan nano-emulsiyani tayyorlashda THC yog'i komponentini tashuvchi yog'ga, masalan, kenevir urug'i yog'i yoki MCT moyiga suyultirish mumkin. Keyinchalik, yog 'fazasi UP400St kabi ultrasonikator yordamida suv (suvli) fazaga emulsiyalanadi. Sonication tez va samarali nano-emulsifikatsiya jarayonini ta'minlaydi. Bir necha daqiqadan so'ng shaffof, uzoq muddatli barqaror suvda yog'li nanoemulsiya tayyor bo'ladi.
Ultrasonikatsiya yordamida nanoemulsiyalarni ishlab chiqarish juda oson bo'ladi!
- Yuqori bioavailability bilan toza nanoemulsiyalar
- Tez & Samarali
- Uzoq muddatli barqarorlik
- Oziq-ovqat va farmatsevtika uchun
- xavfsiz & Foydalanish oson
THC-NanoEmulsiyalari uchun yuqori samarali ultratovush apparatlari
Hielscher Ultrasonics’ systems are reliable machines used in the pharmaceutical and supplement production to formulate high-quality supplement formulations, which range from nano-emulsions to liposomes, nanostructured lipid carriers, solid-lipid nanoparticles, and inclusions complexes that are loaded with vitamins, antioxidants, flavonoids, peptides, polyphenols and other bioactive compounds and provide highest bioavailability, great stability and functionality. For the nano-emulsification of THC into drinks, beverages, tinctures and supplements, Hielscher offers you powerful and reliable ultrasonicators at the size of your production requirements. To meet its customers’ demands, Hielscher supplies ultrasonicators from the compact hand-held lab homogenizer and bench-top ultrasonicators to fully industrial ultrasonic systems for the production of high-volumes of nootropics and smart drug formulations. Ultrasonic formulating processes can be run as batch or as continuous inline process using an ultrasonic flow-through reactor. A broad range of ultrasonic sonotrodes (probes) and reactor vessels are available to ensure an optimal setup for your liposome production. The robustness of Hielscher’s ultrasonic equipment allows for 24/7 operation at heavy duty and in demanding environments.
Quyidagi jadvalda ultrasonikatorlarimizning taxminiy qayta ishlash quvvati ko'rsatilgan:
| To'plam hajmi | Oqim darajasi | Tavsiya etilgan qurilmalar |
|---|---|---|
| 1 dan 500 ml gacha | 10 dan 200 ml / min | UP100H |
| 10 dan 2000 ml gacha | 20 dan 400 ml / min | UP200Ht, UP400St |
| 0.1 dan 20 L gacha | 0.2 dan 4L/min gacha | UIP2000hdT |
| 10 dan 100 l gacha | 2 dan 10 l / min | UIP4000hdT |
| na | 10 dan 100 l / min | UIP16000 |
| na | kattaroq | ning klasteri UIP16000 |
Biz bilan bog'lanish! / Bizdan so'rang!
Yuqori quvvatli ultratovushli gomogenizatorlardan laboratoriya uchun uchuvchi va sanoat masshtab.
Adabiyot / Adabiyotlar
- Daniel G. Barrus, Kristen L. Capogrossi, Sheryl C. Cates, Camille K. Gourdet, Nicholas C. Peiper, Scott P. Novak, Timothy W. Lefever, Jenny L. Wiley (2016): Tasty THC: Promises and Challenges of Cannabis Edibles. Methods Rep RTI Press. Nov. 2016.
- Kentish, S.; Wooster, T.; Ashokkumar, M.; Simons, L. (2008): The use of ultrasonics for nanoemulsion preparation. Innovative Food Science Emerging Technologies 9(2):170-175.
- Campelo, Pedro Henrique; Junqueira, Luciana Affonso; de Resende, Jaime Vilela; Domingues Zacarias, Rosana; de Barros Fernandes, Regiane Victória; Alvarenga Botrel, Diego; Vilela Borges, Soraia (2017): Stability of lime essential oil emulsion prepared using biopolymers and ultrasound treatment. International Journal of Food Properties Vol.20, No.S1, 2017. 564-579.
- Maphosa, Yvonne; Jideani, Victoria A. (2018): Factors Affecting the Stability of Emulsions Stabilised by Biopolymers. In: Science and Technology Behind Nanoemulsions (Edited by Selcan Karakuş). 2018.
Bilishga arziydigan faktlar
CBD va THC
Cannabis o'simlik jinsini kanop va marixuana o'simliklariga ajratish mumkin.
Cannabidiol (CBD) is found in hemp and marijuana plants, whilst the compounds tetrahydrocannabinol (THC) is exclusively present in marijuana plants. Tetrahydrocannabinol (THC) and cannabidiol (CBD) are the two most important cannabinoids of at least 113 cannabinoids identified in cannabis. THC is the principal psychoactive constituent of cannabis, chemically known as (−)-trans-Δ9-tetrahydrocannabinol. Per definition, hemp plants are cannabis plants that contain less than 0.3 percent THC, while marijuana plants are cannabis plants that contain higher concentrations of THC. Hemp is also grown as crop to produce industrial fibre. CBD, the main bioactive compound in hemp, is a non-psychoactive substance, which means CBD does not make you “yuqori”. CBD is commercially available in various forms such as tinctures, gels, gummies, oils, tablets, capsules, full spectrum extracts, topicals (creams, lotions, balms, oils and ointments) etc..
THC is the main psychoactive bioactive substance in marijuana which is responsible for the “yuqori” feeling of euphoria. THC can be ingested via smoking a “begona o'tlar” joint or by consuming THC-enriched edibles, e.g. brownies. It’s also available in oils, tinctures, capsules, and other forms of administration.
Ikkala nasha birikmalari, CBD va THC insonning endokannabinoid tizimiga bog'lanadi, ammo har bir birikma juda boshqacha ta'sirga ega (masalan, psixoaktiv bo'lmagan va psixoaktiv).
CBD va THC ikkalasi ham terapevtik vositalar sifatida tanilgan, ular bir nechta kasalliklarni va tibbiy sharoitlarni davolash yoki engillashtirish uchun dori yoki dorivor qo'shimcha sifatida ishlatiladi. CBD o'zining yallig'lanishga qarshi va tinchlantiruvchi ta'siri bilan mashhur. Shuning uchun u tutilishlar, yallig'lanish, og'riq, psixoz yoki ruhiy kasalliklar (masalan, OKB), yallig'lanishli ichak sindromi (IBS), ko'ngil aynishi, bosh og'rig'i va migren, depressiya va tashvish kabi turli xil sharoitlarda yordam berish uchun qo'shimcha davolash sifatida ishlatiladi.
THC og'riq, mushaklarning spazmlari, glaukoma, uyqusizlik, ishtahaning pastligi, ko'ngil aynishi va tashvish kabi tibbiy sharoitlarni bartaraf etish uchun qo'llaniladi.