Ultrasonic topic: "Farmatsevtika sanoatida ultratovushli ishlov berish"
Quvvatli ultratovushlar vaktsinalar, nano-formulali dorilar va dori tashuvchilar (masalan, lipozomalar) ishlab chiqarish uchun yuqori samarali va ishonchli vositadir. Hielscher ultratovush’ Laboratoriya, pilot va sanoat tizimlari farmatsevtika darajasidagi mikron va nano-emulsiyalar/dispersiyalar, lipozomalar hamda vaktsinalar ishlab chiqaradi. Hielscher ultratovush tizimlari CIP (toza joyida) va SIP (sterilizatsiya joyida) bilan jihozlangan va shu bilan farmatsevtika standartlariga muvofiq xavfsiz va samarali ishlab chiqarishni kafolatlaydi. Barcha maxsus ultratovush jarayonlari laboratoriya yoki dastgoh miqyosida osongina sinovdan o'tkazilishi mumkin va keyin sanoat ishlab chiqarishiga chiziqli ravishda kengaytirilishi mumkin.
Found 63 hits. Showing results 1 - 12.
Liposomal Semaglutid GLP-1 dori vositalarini yetkazib berishda keyingi katta sakrash bo'lishi mumkin
, Katrin XilsherSemaglutide and other GLP-1 peptides are among the most important modern therapeutics, but formulation scientists still face a fundamental barrier: peptide drugs are difficult to protect and deliver, especially by the oral route. Even approved oral semaglutide products show bioavailability below 1%, requiring high doses and complex formulation strategies.
A growing technical focus in pharmaceutical development is liposomal encapsulation combined with high-intensity ultrasonic processing. Liposomes can stabilize GLP-1 peptides and enable nano-scale carrier systems, while ultrasound provides reproducible nano-sizing and a scalable manufacturing pathway. Semaglutide is particularly compatible with lipid carriers because studies indicate it can associate with vesicle membranes via its lipid tail, supporting efficient loading into lipid bilayers.
Dori vositalarini ishlab chiqarish: sonikatsiya biogen dorilarning kelajagini shakllantirmoqda
, Katrin XilsherThis news article presents how sonication is transforming biogenic drug manufacturing: Ultrasonic processing is rapidly emerging as a key technology in the manufacturing of biogenic drugs, enabling greener, more efficient production of bioactive compounds and nanomedicines. New research demonstrates that ultrasound-assisted synthesis, using plant extracts such as broccoli, can produce highly stable, biologically active gold nanoparticles with antioxidant, wound-healing, and selective anticancer properties. High-performance probe-type sonicators, including industrial systems from Hielscher Ultrasonics, play a critical role by enhancing extraction efficiency, accelerating green nanoparticle synthesis, and ensuring precise process control. As demand grows for sustainable pharmaceutical manufacturing, sonication is positioning itself as a scalable, GMP-compatible platform for next-generation biogenic drugs.
https://www.hielscher.com/sonication-shapes-biogenic-medicines.htm
Sonication orqali yig'ilgan supramolekulyar tuzilmalar
Sonication supramolekulyar kimyoda kuchli va ko'p qirrali vosita bo'lib, ko'pincha kinetik va termodinamik parametrlarga sezgir bo'lmagan kovalent yig'ish jarayonlarini aniq nazorat qilish imkonini beradi. Quvvatli ultratovushni suyuq muhitga qo'llash molekulyar o'zaro ta'sirga ta'sir qiladi, o'z-o'zini yig'ishni tezlashtiradi,…
https://www.hielscher.com/supramolecular-structures-assembled-via-sonication.htm
Sonikatsiya orqali heterojen kimyoviy reaksiya kinetikasini yaxshilang
Sonication suyuqlik-suyuqlik va suyuq-qattiq jarayonlarda heterojen kimyoviy reaksiya kinetikasini yaxshilashning innovatsion usullarini taklif etadi. Oddiy aralashtirishdan farqli o'laroq, ultratovush to'lqinlari portlashi va intensiv aralashtirish zonalarini yaratadigan mikroskopik pufakchalarni hosil qiladi. Bu zonalar qattiq moddalar va tomchilarni bir tekis taqsimlashga yordam beradi, kuchaytiradi…
https://www.hielscher.com/improve-heterogeneous-chemical-reaction-kinetics-by-sonication.htm
Sonifikatsiya yordamida steril homogenlash
Steril homogenlashtirish uchun namuna steril idishga solinadi, keyin bir hil aralashmani olish uchun aralashtiriladi. Ultrasonifikatsiya steril sharoitlarda bir yoki bir nechta namunalarni davolash uchun yuqori samarali va ishonchli texnikadir…
https://www.hielscher.com/sterile-homogenization-using-sonification.htm
Bioavailability yaxshilangan farmatsevtik nanosuspenziyalar
Sonikatsiya yordamida tayyorlangan nanosuspenziyalar farmakologik bioavailability sezilarli darajada yaxshilanganligini ko'rsatadi. Ayniqsa, suvda eruvchanligi past bo'lgan, uning bioavailability va ta'sir boshlanishini kamaytiradigan dori molekulalari ultratovushning nanozizatsiya texnikasidan foyda ko'radi. Ultrasonikatsiya dori zarralari va kristallarini nanometrgacha kamaytirish uchun ishlatiladi…
https://www.hielscher.com/pharmaceutical-nanosuspensions-with-improved-bioavailability.htm
Ultratovush bilan emulsiyalangan burun spreyi formulalari
Burun spreyi va og'iz spreyi nafas olish shilliq qavatiga faol moddalarni qo'llash uchun keng tarqalgan bo'lib foydalaniladigan dori vositalaridir. Ultrasonik emulsifikatsiya - bu juda yuqori bio-mavjudlikka ega bo'lgan yuqori samarali burun va og'iz bo'shlig'ini ishlab chiqarish uchun yuqori samarali va ishonchli usul,…
https://www.hielscher.com/nasal-spray-formulations-emulsified-with-ultrasound.htm
Yuqori darajada tozalangan shizofillan beta-glyukanlarining ultratovushli ishlab chiqarilishi
Shizofiallan immunomodulyatsion xususiyatlarga ega qo'ziqorin b-glyukandir. Yuqori faol dorivor ta'sirlar uchun shizofillan yaxshilangan bioavailability ko'rsatish uchun past molekulyar og'irlikka ega bo'lishi kerak. Ultrasonikatsiya shizofillanning molekulyar og'irligini kamaytirishi isbotlangan. Ishonchli va…
https://www.hielscher.com/ultrasonic-production-of-highly-purified-schizophyllan-beta-glucans.htm
Baggibuti (Stachys parviflora) dan polifenollarning ultratovushli ekstraktsiyasi
Baggibuti (Stachys parviflora L.) o'simligining ekstrakti kramplar, artralgiya, epilepsiya, yiqilish va drakunkulozni davolashda ishlatiladigan o'simlik dori sifatida baholanadi. Ultrasonik ekstraktorlar Stachys parviflora dan polifenollar va boshqa fitokimyoviy moddalarni izolyatsiya qilish uchun muvaffaqiyatli qo'llaniladi.…
https://www.hielscher.com/ultrasonic-extraction-of-polyphenols-from-baggibuti-stachys-parviflora.htm
Sonikatsiya bilan yuqori samarali artemisinin ekstraktsiyasi
Artemisinin yuqori samarali sonikatsiya yordamida samarali ravishda olinishi mumkin. Ultrasonik ekstraksiya yumshoq erituvchilar yordamida artemisinin juda yuqori hosilini beradi. Ultratovushni qo'llash orqali ekstraktsiya jarayoni keskin tezlashadi. Ultrasonik ekstraktorlarda ishlov berish shartlari aniq nazorat qilinadi, bu esa imkon beradi…
https://www.hielscher.com/highly-efficient-artemisinin-extraction-with-sonication.htm
Yuqori samarali ekstraksiya uchun chuqur evtektik erituvchilar
Chuqur evtektik erituvchilar (DESs) va tabiiy chuqur evtektik erituvchilar (NADES) ko'p darajalarda ekstraksiya erituvchilari sifatida afzalliklarga ega va shuning uchun an'anaviy organik erituvchilarga istiqbolli alternativ hisoblanadi. Chuqur eutektik hal qiluvchi ultratovushli ekstraktsiya va berish bilan birgalikda juda yaxshi ishlaydi…
https://www.hielscher.com/extraction-with-deep-eutectic-solvents.htm
Superkritik suyuqlik ekstraktsiyasi Power Ultrasonics tomonidan yaxshilangan
Ultrasonik ekstraksiya yakka o'zi yoki muqobil ekstraksiya usullari bilan, masalan, hal qiluvchi ekstraktsiyasi yoki superkritik CO2 ekstraktorlari bilan birgalikda nasha o'simligidan (kenevir va marixuana) kannabinoidlarning to'liq spektrini olish uchun muvaffaqiyatli qo'llaniladi. Marixuanada asosiy kannabinoid…
https://www.hielscher.com/supercritical-fluid-extraction-improved-by-power-ultrasonics.htm