I-Hielscher Ultrasound Technology

I-Ultrasonication ivuselela ukuphendulela kwe-Suzuki

I-Suzuki Cross-Coupling (eyaziwa nangokuthi i-Suzuki-Miyaura Coupling) iyisenzo esithinta umzimba ngenhloso yokwenza izinsimbi ezivela ku-biphenyl, ama-vinyl aromates (isib. Ama-styrenes), ama-poly-olefini, kanye nama-alkyl bromide. Izinto zokwenza izinto ezisabelayo yi-aryl noma i-vinyl-boronic acid ene-aryl noma i-vinyl-halide etholakala yi-palladium (0) eyinkimbinkimbi, engase ibe ngesimo se-catalyst esisekelwe nanomaterial.
Ngenxa yokusabela kwe-Suzuki Coupling, i-ultrasound itholakale ukusheshisa ukusabela konke. Lesi sihloko sinikeza umbono wokubukeza mayelana nemiphumela yezifundo ezihlukahlukene mayelana nokuthuthukiswa kwe-ultrasonic kwe-Suzuki Coupling reaction.

Ucwaningo lukaZhang et al. (2008) kwafakazela ukuthi i-ultrasound ihlinzeka ngokuphendula okungafaniyo kwe-Suzuki okuhlanganiswa kwe-phenylboronic acid ne-arylhalides phambi kwe-TBAB ngokusebenzisa i-ferrocenylimines yama-cyclopalladated yama-cycpalladated kalula emanzini afanele. Ukuhlanganiswa kwe-arylchlorides, ukufezwa kokulinganisela kuya kwezivuno ezinhle kuye kwabikwa. Uma kuqhathaniswa nokushisa okwejwayelekile, i-ultrasonically-basizwa ekuhlanganyeleni kwe-coupling yayishesha kakhulu. Ngaphezu kwalokho, le ndlela yokwenza ngcono yokusabela inenzuzo enkulu yokusebenzisa i-solvent engenakuqothulwa, engenakuvuthayo okusiza futhi ilondoloze ukulungiswa.
Rajagopal et al. uhlola umsebenzi wabo wokuthi i-palladium yathinteka ukusabela kokubambisana kwe-Suzuki kwama-halobenzenes kufaka phakathi ama-chlorobenzenes ne-phenylboronic acid efinyelelekile ekushiseni okungaka (30 ° C) ngokungabikho kwe-phosphine ligand besebenzisa i-ionic liquid 1,3-di–i-butylimidazolium tetrafluoroborate [bbim] [BF4] nge-methanol njenge-solvent ngaphansi kwe-ultrasonic irradiation. [Rajagopal et al. 2002, k. 616]

Imizila eminingi yamakhemikhali efana nokuphendula kwe-Suzuki yokuxhuma ingakwazi ukuzuza kusuka ku-ultrasonication.

I-Equ.1: Ukuxhunyaniswa kwe-Suzuki okuxhaswe nge-Ultrasound [Rajagopal et al. 2002, k. 616]

I-Hielscher Ultrasonics I-UIP1500hd iyi-homogeniser enamandla e-ultrasonic esetshenziselwa i-batch ne-sonication inline.

Hielscher's I-UIP1500hd nge flow cell - 1.5kW enamandla ultrasonic processor for izinqubo zamakhemikhali in flow-ngokusebenzisa mode

I-Sonogashira ekuhambeni kwe-cross-coupling

I-Ultrasound iphinde ithole ukugqugquzela ukusabela kwe-Sonogashira ngokuhlanganyela ngokuphumelelayo. I-Sonogashira-cross-coupling i-palladium-isetshenziselwa futhi isetshenziselwa ukuhlanganiswa kwesibhakabhaka se-carbon-carbon (CC) ngaphansi kwezimo ezibucayi, njengendawo yokushisa kwamahhala, emithonjeni yama-aqueous and base base. Liyasetshenziswa kakhulu embonini yezokwelapha namakhemikhali ukuze kuhlanganiswe ama-molecule eyinkimbinkimbi.
I-palanddium e-ligand-, i-copper-, ne-amine-free catalyzed-pot pot benzo [B] i-furans / i-nitro benzo [B] ama-furans nge-Sonogashira yokuhlanganisa-5-endo-dig-cyclization esebenzisa i-ultrasonication ngesikhathi sokushisa okukhulu. Ukusabela kuye kwathonywa kakhulu kakhulu ngemiphumela ye-sonochemical. [cf. I-Palimkar et al. 2008]

Xhumana Nathi / Cela Ukwaziswa Olwengeziwe

Khuluma nathi mayelana nezidingo zakho zokucubungula. Sizosikisela ukusetha nokulungiswa kwemingcele efanele yephrojekthi yakho.





Sicela uqaphele wethu Inqubomgomo yobumfihlo.


Izincwadi / Izinkomba

  • Oxley, JD; I-Prozorov, T .; Suslick, KS (2003): i-Sonochemistry ne-Sonoluminescence ye-Room-Temperature Ionic Liquids. Ku: Journal of American Chemical Society 125/2003. pp. 11138-11139.
  • I-Palimkar, i-SS; Okuningi, i-VS; I-Srinivasan, i-KV (2008): I-Ultrasound ikhuthazwa ngethusi-, i-ligand- ne-amine-free of benzo [b] furans / nitro benzo [b] furans nge-Sonogashira yokuhlanganisa-5-endo-dig-cyclization. Ku: Ultrasonics Sonochemistry 15/2008. k. 853-862.
  • I-Rajagopal, R .; I-Jarikote, i-DV; I-Srinivasan, i-KV (2002): I-ultrasound ikhuthaze ukuphendula kwe-Suzuki ukuxhunyaniswa kwe-ioniki ezimweni ezimbi. Ku: Ukuxhumana kweMikhiqizo yezokuThutha 6/2002. iphe. 616-617.
  • I-Zhang, J .; I-Yang, F ,; Ren, G .; Mak, Th. I-CW; Ingoma, M .; I-Wu, Y. (2008): I-ultrasonic irradiation yasheshisa i-ferrocenylimines ye-cyclopalladated eyenziwe yi-Suzuki yokusabela emanzini afanele. Ku: Ultrasonics Sonochemistry 15/2008. k. 115-118.