I-Ultrasonically Ihlelwe i-Famotidine Solid-Lipid Nanoparticles
I-Ultrasonically Famotidine-Loaded Solid Lipid Nanoparticles
I-Sonication isetshenziswa kabanzi ekwenziweni kwemithi, imigomo kanye nezithasiselo zokudla. Isicelo esibalulekile ukwakhiwa, ukugoqa kanye / noma ukufakwa kwamamolekyuli we-bioactive (okusho izidakamizwa zezidakamizwa) kumasistimu wokulethwa kwezidakamizwa we-nano ahlelwe njenge-nanoparticles eqinile-lipid, liposomes, niosomes, ukufakwa kwezihlanganisi noma ama-polymeric nanoparticles.
I-Famotidine
I-Famotidine yi-H2 receptor blocker kanye nenhlanganisela esebenzayo esetshenzisweni esetshenziswa kakhulu ngaphezulu kwesibambiso (i-OTC) i-heartburn drugPepcid. Ukuqunjelwa ngomlomo kushesha ngokwanele, kepha i-famotidine ingahle ihliswe i-acid esiswini ibangele ukuncipha kwamaphesenti kuze kube ngama-35,8% ngemuva kwemizuzu engama-50. Lesi sidakamizwa sibuye sifakwe i-metabolism yokuqala ephumela ekunciphiseni ukutholakala kwe-bio yayo kuphela kuze kube ngu-40-50%
Ekupheleni kuka-Ephreli 2020, i-famotidine nayo ifundelwa njengomuthi ongaba khona wokwelapha iziguli ezinesifo i-SARS-CoV-2 (coronavirus) esidale isifo i-COVID-19. Esivivinyweni somtholampilo, iziguli ezinesifo esibuhlungu se-coronavirus COVID-19 zithola i-Famotidine intrarally.
I-femotidine ejwayelekile equkethe izidakamizwa iyaziwa ngaphansi kwamagama ahlukahlukene omkhiqizo njenge-Pepcid AC, i-Acid Controller, i-Pepcid, i-Acid Reducer (i-Famotidine), i-Heartburn Prevention, ne-Heartburn Relief (i-Famotidine).
Ukulungiswa kwe-Ultrasonic kweSolid-Lipid Nanoparticles
Ukulungiswa kwe-Ultracot ye-Famotidine-egcwele i-lipid nanoparticles (SLNs) kuyindlela elula futhi ephumelelayo yokwenza uhlelo oluphezulu lokulethwa kwezidakamizwa olusezingeni eliphakeme nge-bioavailability ekhule kakhulu.
UZai et al. (I-2019) ilungiselele i-lipid nanoparticles (SLNs) eqinile isebenzisa indlela ye-hot emulsation esizwa nge-ultrasonic. Ingxubevange ye-Glyceryl monstearate ne-Span 20 (3: 1 w / w) yancibilika cishe. I-60 ° C futhi ingezwe i-Famotidine (2 mg / mL ye-vol vol.). Amanzi aqukethe i-poloxamer (4mg / mL) nawo ayephehlwa futhi. I-60 ° C futhi idluliselwe kwingxube ye-lipid encibilikisiwe. Isigaba se-lipid nesamanzi sixutshwe yi-homogenizer ephezulu ye-shear ngo-5,000 rpm ngemizuzu engu-5, sabe sesikhonjiswa nge-probe-Type ultrasonicator yemizuzu engu-5.
Imiphumela ikhombisile ukuthi i-Famotidine-egcwele umthwalo we-lipid nanoparticles yayinosayizi oyinhlayiyana oyisilinganiso wesilinganiso esingu-151,90 ± 26,05 nm nokusatshalaliswa kosayizi omncane (0,35 35 0,04). Ama-virotidine-alayishwe ngokuqinile ama-lipid nanoparticles aba nokusebenza okuphezulu kokufakwa kwe-82,30 ± 4,39% nokukhula kwe-bioavailability.

I-UIP1000hdT nge-reaction flow yeglasi yokukhiqiza okuqinile-lipid nanoparticle (SLN)
- Ukusebenza kahle okuphezulu
- Ukuguquguquka okulula, okusebenzayo
- Ukulayisha okuphezulu kwama-molecule we-bioactive
- Ukulawulwa okuqondile kwamapharamitha wenqubo
- Inqubo Esheshayo
- Ukulawulwa kwe-temp-non-Thermal okuqondile
- ukusabalalisa okulinganayo
- Reproducibility
- Ukumiswa kwenqubo / GMP
- Izinduna ezihlaselayo nezisebenzayo
- I-CIP / SIP
Ama-Ultrasonicators aphezulu enza umsebenzi weP Pharma
I-Hielscher Ultrasonics yesikhathi eside isipiliyoni kumklamo, ukukhiqiza, ukusabalalisa kanye nensizakalo ye-homogenisers ephezulu esebenza kahle yomkhakha wezemithi nowokudla.
Ukulungiswa kwezinga eliphakeme eliqinile le-lipid nanoparticles, i-nanostructured lipid carriers, ama-liposomes, ama-niosomes, kanye ne-cyclodextrin ukufakwa kwezinqubo eziyinkambiso, okuyizinhlelo ze-Hielscher ultrasonic ezisetshenziselwa ukuthembeka okuphezulu nekhwalithi ephezulu yokuphuma. Ama-ultrasonicators ama-Hielscher avumela ukulawula okuqondile kuwo wonke amapharamitha enqubo, njenge-amplitude, izinga lokushisa, ingcindezi namandla we-sonication. Isoftware ehlakaniphile ithela ngokuzenzakalelayo yonke imingcele ye-sonication (isikhathi, usuku, amplitude, amandla net, amandla aphelele, izinga lokushisa, ingcindezi) ekhadini le-SD-khadi elakhelwe ngaphakathi.
Ithebula elingezansi linikeza isibonakaliso somthamo wokucubungula we-ultrasonicators wethu:
Iqoqwana Ivolumu | flow Rate | Amadivayisi ezinconyiwe |
---|---|---|
1 kuya ku-500mL | 10 kuya ku-200mL / min | UP100H |
10 kuya ku-2000mL | 20 kuya ku-400mL / min | UP200Ht, UP400St |
0.1 kuya ku-20L | 0.2 kuya ku-4L / min | I-UIP2000hdT |
10 kuya ku-100L | 2 kuya ku-10L / iminithi | I-UIP4000hdT |
na | 10 kuya ku-100L / iminithi | UIP16000 |
na | sikhulu | yinhlanganisela UIP16000 |
Xhumana nathi! / Cela Us!
Izincwadi / Izikhombo
- Khadijah Zai, Rachmat Mauludin, Diky Mudhakir (2019): Solid Lipid Nanoparticle Improves Oral Bioavailability of Famotidine. J. Pharm. Sci. & Res. Vol. 11(6), 2019. 2437-2439.
- Rachmat Mauludin, Nurmazidah (2014): Formulation of Famotidine Solid Lipid Nanoparticles (SLN): Preparation, Evaluation and Release Study. International Conference on Pharmacy and Pharmacology, Bangkok, Thailand. December 18-19, 2014.
- Eszter L. Kiss, Szilvia Berkó, Attila Gácsi, Anita Kovács, Gábor Katona, Judit Soós, Erzsébet Csányi, Ilona Gróf, András Harazin, Mária A. Deli, Mária Budai-Szűcs (2019): Design and Optimization of Nanostructured Lipid Carrier Containing Dexamethasone for Ophthalmic Use. Pharmaceutics. 2019 Dec; 11(12): 679.
Amaqiniso Okufanele Ukwazi
Ama-Nanocarriers okulethwa kwezidakamizwa
I-nanocarrier yi-nanomaterial esetshenziswa njengemodyuli yokuhamba kwenye into, njengomuthi. Ama-nanocarriers asetshenziswa ngokujwayelekile afaka ama-micelles, ama-polymers, ama-nanoparticles ama-core-shell, ama-liposomes, ama-dendrimers, ama-nanoparticles aqinile-ne-lipid nama-nanostructured lipid carriers. Enye yezinzuzo eziphambili ze-nanocarriers usayizi wabo wemizuzu obenza bakwazi ukungena ngamaseli futhi bahambise into elayishwe ku-izicubu eziqondisiwe. Ukwazi ukuguqula izakhiwo ezingokomzimba zama-nanocarriers, isb. Ukwakheka, ukwakheka nosayizi, ama-nanocarriers angahle asebenze ngokuqondile kumanxusa athile wezokwelapha namaphethini wokukhishwa kwezidakamizwa.