I-Hielscher Ultrasound Technology

I-Ultrasonic Synthesis ye-Pharma-grade Chloroquine

IChloroquine ibukeka njengesidakamizwa esithembisayo ekulweni nobhubhane lwe-COVID-19. Ngenkathi i-chloroquine iyisidakamizwa esidumile, eshibhile, ukulethwa kumele kuklanywe kakhulu ukuze kufezekiswe isidingo samanje. I-Ultrasonic synthesis inqubo elula, ephephile nethembekile yokukhiqizwa okusheshayo kwe-pharma-grade chloroquine. Ngokukalwa ngokomugqa, kuvumela ukukhiqiza amanani amakhulu enqubekweni enkulukazi yokulinganisa.

I-Chloroquine

I-Chloroquine ne-quinoline analogues zingahunyushwa ngokwenziwe nge-ultrasonical.I-Chloroquine, chloroquine phosphate ne-hydroxychloroquine yomibili imishanguzo esetshenzisiwe njengokwelapha umalaleveva kanye nomalaleveva womalaleveva. Izinto zivimbela i-glycosylation ye-ACE2, inqubo lapho amaphrotheni emvilophini yegciwane aguqulwa ngokuthile. I-Glycosylation isinyathelo esibalulekile ngesikhathi sokutheleleka ngegciwane esitokisini. I-chloroquine induction inhibition ye-glycosylation ibonakala ivimbela noma inciphisa izinga lokutheleleka ngabakwa-SARS-CoV-2 kakhulu.
Okushiwo ucwaningo lwamanje:
“I-Chloroquine ibuye ibe yi-immunomodulatory, ekwazi ukucindezela ukukhiqizwa nokukhipha izinto ezixhumanisa ubunzima bezinkinga zezifo ezibangelwa amagciwane (i-tumor necrosis factor ne-interleukin 6). Kuthunyelwe ukuthi i-chloroquine isebenza ngokushintsha i-ACE2 glycosylation ne-endosomal pH. Izici zalo zokulwa nokuvuvukala zingaba usizo ekwelapheni kwa-SARS. ” [Pang et al. 2020]
USolwazi Didier Raoult wase-Institut Hospitalo-Universitaire (IHU) eMarseille uthi ngecala lakhe lokuqala le-chloroquine: "Sikwazile ukuthola ukuthi iziguli ezazingayitholanga iPlaquenil (umuthi oqukethe i-hydroxychloroquine) zisatheleleka ngemuva kwezinsuku eziyisithupha, kepha labo abathole iPlaquenil, ngemuva kwezinsuku eziyisithupha, babengama-25% kuphela ababesathathelanayo. ”

Ngenkathi i-chloroquine yemithi yokwelapha engakavunyelwa (okwamanje) ivunyelwe ukwelapha iziguli ezinesifo i-COVID-19, ucwaningo luyaqhubeka kanti nezifundo ezisetshenziswayo sezivele zikhombisile ukuthembisa.

Izinzuzo ze-Ultrasonic Synthesis yama-Molecule Wemithi:

  • Izinga eliphakeme, ubumsulwa obuphakeme
  • Izinga lokuguqula eliphakeme
  • inqubo esheshayo
  • ukusabalalisa okulinganayo
  • kuqiza kahle
  • Luhlaza okotshani, okwezemvelo
Iprosesa iprosesa ye-UIP2000hdT (2kW) enogwebu lwe-pharma batch reactor

I-homogenizer ye-ultrasonic I-UIP2000hdT (2kW) ngesivinini sokushukumisa se-batch

Isicelo solwazi




Qaphela kwethu Inqubomgomo yobumfihlo.


I-Ultrasonic Synthesis yeChloroquine

I-Ultrasonic Synthesis ye-Chloroquine Derivatives

Njengoba i-chloroquine yaziwa ngokudlela kwayo emgomeni we-Zika, uBarbosa-Lima et al. (2017) bacwaninge ukuhlanganiswa kokuphuma kwe-chloroquine ukuthola ama-molecule e-chloroquine asebenza ngempumelelo ngokwedlulele kuZika. I-N- (2- (arylmethylimino) ethyl) -7-chloroquinolin-4-imine ekhombisa imiphumela ethembisayo.
UBarbosa-Lima et al. (2017) ithole ukuthi ukuhlanganiswa kwe-ultrasonic kokukhiqiza okufanisiwe kuqhathaniswa nendlela ye-Reflux yokushisa kepha ngezikhathi ezimfushane kakhulu ze-30-180 sec sonication kuqhathaniswa nesikhathi sokuphendula se-30-180 min.
I-quinoline derivative, i-N- (2 - ((5-nitrofuran-2-yl) methylimino) ethyl) -7-chloroquinolin-4-amine, 40, iyisizinda esinamandla kakhulu kulolu chungechunge, sinciphisa ukuphindaphinda kwe-ZIKV ngama-72% e- I-10 μM. Imisebenzi emihle yabuye yatholakala kwezinye izinhlanganisela, kufaka phakathi lezo ezinamaqembu e-aryl = phenyl, 4-fluorophenyl, 4-nitrophenyl, 2,6-dimethoxyphenyl, 3-pyridinyl ne-5-nitrothien-2-yl. Onke lama molekyuli adalwe ngempumelelo nge-ultrasonication.

I-Ultrasonic Synthesis ye-Quinolones

UKowsari et al. (2011) yaklanywa ama-quinolones athile ngokusabela i-isatin ene-aryl methyl ketones lapho kukhona iziphuzo eziyisisekelo ze-ionic emanzini. Ukusabela kwaqhutshwa ngaphansi kwezimo zokwenziwa okuluhlaza ze-ultrasound. Izinzuzo eziphambili zale nqubo ziyindlela eluhlaza, isikhathi sokuphendula esimfushane nesifushane, kanye nezithelo eziphakeme kanye nokukhetha ngaphandle kwesivivinyo sensimbi sokuguqula.

Phakathi kwalesi sifo esiwubhubhane se-COVID-19 i-Hielscher Ultrasonics ibeka yonke imiyalo yomkhakha wezemithi. Sicela ubuze ukucutshungulwa kwe-oda elibekwe phambili kanye nokuhanjiswa okusheshayo!

Ama-Ultrasonicators aphezulu enza umsebenzi we-Pharmaceutical Synthesis

Ukulawulwa okuqondile kwamapharamitha wenqubo we-ultrasonic yi-software ekhaliphile ye-Hielscher UltrasonicsIzinhlelo ze-Hielscher Ultrasonics 'zisetshenziselwa kabanzi ekwenziweni kwemithi ukuhlanganisa ama-molecule asezingeni eliphakeme futhi kwakhiwe ama-nanoparticles e-lipid aqinile kanye nama-liposomes athwala izinto zemithi, amavithamini, ama-antioxidants, ama-peptides nezinye izinto ezixubile. Ukuhlangabezana nezidingo zamakhasimende ayo, ama-Hielscher anikezela ngama-ultrasonicators avela ku-compact, nokho ama-hand homogenizer aphethwe ngesandla anamandla aphezulu okubeka ezinhlelweni ze-ultrasonic zezimboni ngokugcwele zokukhiqiza izimfanelo eziphakeme zezinto zokwenziwa kwemithi nokwakhiwa. Uhla olubanzi lwama-sonotrodes we-ultrasonic kanye nama-reactors atholakalayo ukuqinisekisa ukusethwa okuphezulu komkhiqizo wakho wemithi. Ukuba namandla kwemishini yokusebenza kwe-Hielscher sika-Hielscher kuvumela ukusebenza kwe-24/7 emsebenzini osindayo nasezindaweni ezifunwayo.
Ukuze uvumele amakhasimende ethu ukuthi afeze i-Good yokukhiqiza imisebenzi (i-GMP) futhi asungule izinqubo ezihleliwe, wonke ama-ultrasonicators edijithali afakwe isoftware ehlakaniphile yokusetha ngokunembile ipharamitha ye-sonication, ukulawulwa kwenqubo okuqhubekayo nokuqoshwa okuzenzakalelayo kwawo wonke amapharamitha wenqubo abalulekile esakhiweni -Kukhadi le-SD. Ikhwalithi ephezulu yomkhiqizo incike ekulawulweni kwenqubo nakumazinga wokuphakama aphezulu ngokuqhubekayo. Ama-ultrasonicators we-Hielscher akusiza ukuthi uqaphele futhi wenze inqubo yakho ibe ng linye!

Ukulinganisa

Inani eliphakeme lamacala e-COVID-19 ayinselelo enkulu ohlelweni lwezempilo kubandakanya nokucwaninga nokukhiqizwa kwezemithi. Ngenkathi okwamanje kunezinto eziningi zemithi ezingaphansi kophenyo (in vitro and vivo), kusukela manje sekutholakele ukwelashwa kweziguli ze-COVID-19, inani elikhulu lezidakamizwa kumele likhiqizwe esikhathini esifushane.
Ukuhlanganiswa kwe-ultrasonic kwe-chloroquine ne-chloroquine kuyinqubo esheshayo, elula nephephile, engalinganiswa ngokuqondile kusuka kwelebhu nesitshalo somshayeli kuya ekukhiqizeni okugcwele okuthengiswayo. Abasebenzi bethu abaqeqeshiwe nabanesipiliyoni eside bazokusiza ngobuchwepheshe kusuka ekuvivinyweni komshayeli kuya ekukhiqizweni kwenani elikhulu.

Ithebula elingezansi linikeza isibonakaliso somthamo wokucubungula we-ultrasonicators wethu:

Iqoqwana Ivolumu flow Rate Amadivayisi ezinconyiwe
1 kuya ku-500mL 10 kuya ku-200mL / min UP100H
10 kuya ku-2000mL 20 kuya ku-400mL / min UP200Ht, UP400St
0.1 kuya ku-20L 0.2 kuya ku-4L / min I-UIP2000hdT
10 kuya ku-100L 2 kuya ku-10L / iminithi I-UIP4000hdT
na 10 kuya ku-100L / iminithi UIP16000
na sikhulu yinhlanganisela UIP16000

Xhumana nathi! / Cela Us!

Cela ulwazi oluthe xaxa

Uyacelwa ukuthi usebenzise ifomu elingezansi ukucela ulwazi olungeziwe mayelana nezinhlelo zokusebenza ze-ultrasonic, izinhlelo zokusebenza nentengo. Sizokujabulela ukuxoxa ngenqubo yakho nawe futhi sikunikeze uhlelo lwe-ultrasonic oluhlangabezana nezidingo zakho!









Sicela uqaphele wethu Inqubomgomo yobumfihlo.


I-Hielscher Ultrasonics yenza ama-homogenizer aphezulu we-ultrasonic wokuhlakazeka, i-emulsation kanye nokukhishwa kweseli.

Amandla aphezulu we-homogenizer ephezulu I-Lab kuya umshayeli futhi Izimboni isikali.

Izincwadi / Izinkomba



Amaqiniso Okufanele Ukwazi

I-Chloroquine

UChloroquine uyilungu lesigaba sezidakamizwa 4-aminoquinoline. Njengomenzeli owaziwayo we-antimalarial, chloroquine, ukhombisa imiphumela elwa namagciwane ngokumelana namagciwane amaningi kufaka phakathi uhlobo lwe-HIV 1, i-hepatitis B ne-HCoV-229E.
I-Chloroquine iyisidakamizwa esijwayelekile eshibhile futhi esitholakala kalula. Ine-bioavailability ephezulu yomlomo futhi ikhemisi layo laziwa kakhulu.