I-Hielscher Ultrasound Technology

Ultrasonic Psilocybin Extraction kusuka Amakhomikhali

  • I-Psilocybin yiyona into esebenzayo ekhishwe kuma-mushroom e-hallucinogenic.
  • Isizinda se-ultrasonic ngokuvamile sisetshenziselwa ukukhipha i-psilocybin ngokuphumelelayo kusuka kumakhowe.
  • Isizinda se-Ultrasonic sinikeza isivuno esiphakeme se-psilocybin ngesikhathi sokutshala ngokushesha kakhulu.

 

I-Ultrasonic Isolation ye-Psilocybin

Isizinda se-Ultrasonic se-magic omisiwe samakhowe wensimbi sisebenza kakhulu nge-ethanol noma i-methanol njenge-solvent. Ukuze uthole imiphumela engcono kakhulu, kunconywa ukuba usebenzise amakhowe omisiwe. Ngaphambi kwe-ultrasonication, okumele kusetshenziswe amakhowe omisiwe kufanele kube khona ukuhlinzekela indawo enkulu yokudlulisa okuningi phakathi kwe-mushroom ne-solvent. Ukwelashwa kwe-ultrasonic kuphula izindonga zamaseli we-mushroom ukuze i-psilocybin ne-psilocin i-molecules ikhishwe ku-solvent.
Indlela yokuhlukanisa i-ultrasonic yezinto ezisebenzayo ezifana ne-psilocybin isetshenziselwa ukukhipha izinhlanganisela zokwelashwa kanye nezinhloso zokuhlaziya.

Isizinda se-Ultrasonic se-Psilocybin kusuka kuma-Mushrooms

Isizinda se-Ultrasonic

I-Ultrasound yaziwa njengendlela elula kunazo zonke futhi ehlukahlukene kakhulu yokuphazanyiswa kwamaseli nokukhiqizwa kokukhipha. Amagagasi amakhulu ase-ultrasound asetshenziswe ngempumelelo embonini yokudla, i-pharma kanye ne-nutraceutical ukuze ahlukanise izimboni ezihlosiwe ezifetheni zezitshalo nezilwane. Izicelo ezijwayelekile zihlanganisa ukukhipha izithako ezivuthayo kusuka ekudleni (isib. Utamatisi, amakhambi, ikhofi, izithelo, i-shellfish njll) kanye nokwehlukaniswa kwemithi eyenziwa ngamakhemikhali kanye ne-nutraceutically (isib. I-CBD kusuka ku-cannabis, i-polysaccharides ephakeme yamangqamuzana yamamithi, amavithamini kusuka emifino njll). Enye inzuzo eyinhloko ye-cell lysis eyisizwa nge-ultrasound kanye nokwehlukanisa ukusebenza okuvelele kwenqubo yokukhipha, okuholela ekuvuneni okuphezulu kakhulu kanye namazinga okuphuma okusheshayo. Eminye inzuzo, edlalwa ukudla kanye nezinto zokwelashwa, yilolo sonication inqubo engezona ezishisayo. Lokhu kusho ukuthi ama-compounds asebenzayo awaphilwanga emazingeni okushisa aphezulu ukuze kusetshenziswe ukuchithwa okushisayo kwama-extracts – ukuvikela izikhwama’ Ukuphila okuphilayo.

Izinsimbi zokusebenza zokususa i-Ultrasonic

I-Ultrasonicator UP400St yesikhumba. (Chofoza ukuze ukhulise!)I-Hielscher Ultrasonics inikeza amadivaysi e-ultrasonic ngokuphazanyiswa kweseli kanye nokukhipha I-Lab futhi Izimboni isikali. Ukukhishwa kwama-sampuli webhu kanye nama-batches amancane kuze kufike ku-4L (noma kufika ku-50L / hr nge-flow cell), i-homogenizer ye-lab ye-ultrasonic efana ne- UP200St (200W) noma UP400St (400W) inamandla futhi iphumelele ngokwanele ukufeza ukwelashwa.
Ngaphandle kwesizinda, idivaysi efanayo ye-ultrasonic ingasetshenziselwa ukulungiselela ama-emulsions noma ama-tincture, isib. Ukuthuthukisa ukutholakala kwegazi nokugaya.

I-Psilocybin ingakhishwa kahle kumakhowe nge-ultrasonics.

Isizinda se-Psilocybin

Isicelo solwazi




Qaphela kwethu Inqubomgomo yobumfihlo.


Xhumana nathi! / Cela Us!

Sicela usebenzise ifomu elingezansi, uma ufisa ukucela ulwazi oluthe xaxa mayelana ne-homogenization yama-ultrasonic. Sizojabula ukukunikeza uhlelo lwe-ultrasonic ukuhlangabezana nezidingo zakho.









Sicela uqaphele wethu Inqubomgomo yobumfihlo.


Izincwadi / Izinkomba

  • I-Mason, i-NL; I-Mischler, E .; Uthaug, MV; I-Kuypers, i-KPC (2019) Imiphumela emincane emibi ye-Psilocybin ku-Uzwela, ukuCabangela okuCabanga, nokuPhepha okuPhezulu, i-Journal of Psychoactive Drugs 2019.
  • U-Pedersen-Bjergaard, uS .; I-Sannes, E .; I-Rasmussen, KE; T√łnnesen, F. (1997): Ukunqunywa kwe-psilocybin ePsilocybe semilanceata nge-capillary zone electrophoresis. I-Journal ye-Chromatography B, 694; 1997. 375-381.
  • Stamet, P. (1996): Ama-mushroom e-Psilocybin wezwe. 1996


Amaqiniso Okufanele Ukwazi

Amakhomikhali Omlingo

Amakhowe, aqukethe izinto ezinengqondo / izimo ze-psychedelic ezifana ne-psilocybin, i-psilocin, ne-baeocystin, aziwa ngokuthi amakhowe angama-psychedelic, amakhowe omlingo, ama-shrooms, ama-truffles omlingo nama-mush. Izinhlobo ezingaphezu kwezingu-180 zamakhowe eziqukethe i-psilocybin noma i-psilocin yayo etholakala.
Amakhowe e-Psilocybin ayimthetho emazweni amaningi, isib. I-USA, Canada, Europe, India. EU.SA, zihlukaniswa njengezinto ezilawulwa yiSheduli I, kodwa maduzane, i-FDA ne-DEA ziye zavumela ezinye izifundo ezincane ezilawulwa kakhulu ekusebenziseni kwabo ekulawuleni izidakamizwa zezokwelapha nezengqondo. Imiphumela ye-psilocybin namanye ama-psychedelics iye yacwaningwa ngemiphumela yabo kanye nokwelashwa okungenzeka kube khona ukukhathazeka okunjengokuhlukunyezwa kwamakhanda, ukukhathazeka kwemizwelo nokulutha.

Izinhlobo

I-Psilocybe cubensis ingenye yamakhowe omlingo athandwa kakhulu enikeza ukuhlunga okuphakathi kwe-psilocybin ye-approx. 0.63% i-psilocybin ne-0.60% i-psilocin kumakhowe asendle omisiwe. Amakhowe asetshalwe ngaphakathi angenawo amakhemikhali awo asebenzayo.

Izinhlobo zePsilocibe % PSILOCYBIN % PSILOCIN % BAEOCYSTIN
P. azurenscens 1.78 0.38 0.35
P. bohemica 1.34 0.11 0.02
P. semilanceata 0.98 0.02 0.36
P. baeocystis 0.85 0.59 0.10
P. cyanescens 0.85 0.36 0.03
P. tampanensis 0.68 0.32 na
P. cubensis 0.63 0.60 0.025
P. weilii 0.61 0.27 0.05
P. hoogshagenii 0.60 0.10 na
P. stuntzii 0.36 0.12 0.02
P. cyanofibrillosa 0.21 0.04 na
P. liniformans 0.16 na 0.005

Psilocybin

I-Psilocybin iyisisindo sokusebenza kwengqondo, i-hallucinogenic esitholakala kumakhowe wesigodi sasePsilocybe, iPanaeolina, iPanaeolus, Copelandia, Conocybe, iGymnopilus, iStropharia noPluteus futhi kubhekwa njengesidakamizwa esingumlutha.
Ngaphandle kwe-psilocybin, i-psilocin ne-baeocystin kukhona izinto ezimbili ezisebenzayo ezitholakala kumakhowe omlingo.
I-potency yama-mushroom ingahluka kakhulu kusukela amakhowe engumkhiqizo wemvelo, oqala ukuphendula imvelo yawo. Izingxenye ezihlukahlukene zamakhowe ziyahlukahluka, futhi (isib. Isikhumba kanye nesitshalo singase sibe nezithako ezahlukene zezinhlanganisela ezingokwengqondo). Ngenxa yokuhlukahluka kwemvelo, i-maceration, i-homogenization kanye ne-ultrasonic isizinda kungasiza ukunciphisa ingozi yokungalindelekile (noma obuthakathaka) amanani we-psilocybin.
Ukusetshenziswa kanye nemiphumela: Emva kokuphathwa kwe-psilocybin, kunemiphumela eminingi ehlukahlukene yokuziphendulela kuye kwabikwa ukuthi yikuphi okuvela emizweni yokukhathazeka, ukungahambi kahle, ukugcoba, ukuthokoza, injabulo nokucindezeleka. Okungenani. ingxenye yesithathu yabasebenzisi izwa imizwa yokukhathazeka noma i-paranoia. Ukulinganisa okuphansi kwezidakamizwa kungadala imiphumela ye-hallucinatory, i-hallucination eye-closed-eye, kanye / noma i-synesthesia (okuhlangenwe nakho kwemizwelo ebuhlungu uma ubheka imibala). Emanzini aphezulu, i-psilocybin ingabangela ukwandiswa kwezimpendulo eziphathekayo, ikhono elikhuthaziwe lokufaka ingeniso, ukuguqula ekucabangeni kokuqala nokufana nengane, nokusebenza kokulandelana kwememori ecacile. Ama-hallucinations ebonakalayo evulekile-amehlo ajwayelekile futhi angachazwa kabanzi nakuba kungavamile ukudideka nento engokoqobo.
Imibiko ye-Anecdotal kanye nocwaningo lwakamuva lubonisa ukuthi ukuphathwa okukodwa kwe-psilocybin kungakhulisa ukucabanga okunokuzwela nokuzwela ngakho-ke kungaba ukwelashwa okungahle kwenzeke ekuziphatheni kokuqonda nakwezenhlalo. Imiphumela yocwaningo “Ukucabanga okubalulekile nozwela” (Mason et al. 2019) kubonisa ukuthi i-psilocybin ithuthukisa ukucabanga okuphambene nokuzwelana ngokomzwelo ekuseni emva kokusetshenziswa. Ukuthuthukiswa ekucabangeni okuguquguqukayo, ukuzwelana ngokomzwelo kwe-valence, nenhlalakahle kwaqhubeka izinsuku eziyisikhombisa ngemuva kokusetshenziswa. Izinguquko ezincane ezithinta uzwela ezihambisana nezinguquko enhlalakahleni. Ucwaningo lubonisa ukuthi ukuphathwa okulodwa kwe-psilocybin endaweni yokuhlalisana kungase kuhlotshaniswe nokuthuthukiswa okuncane kokucabanga kokudala, ukuzwela, nokuphila kahle.