I-Hielscher Ultrasound Technology

I-Nantriposomes ye-Ultrasonic Yezindlela Zokuqina Ezihlanganisiwe

I-Allicin iyindawo esebenza kahle, engakhishwa kuma-clove wegalikhi amasha. I-Allicin ithambekele ekuwohlokeni ngakho-ke kufanele yenziwe ifomu lokwengezelelwa okuzinzile ukuze ithole ifomula elinamandla lesikhathi eside. Ukuvalelwa kwe-Ultrasonic kwe-allicin ku-nanoliposomes kuvikela i-allicin ekuwohlokeni futhi kuholele ekukhishweni kwezidakamizwa okuqhubekayo.

Ukuqina kwe-Allicin

Ukwenziwa kwemikhiqizo ye-allicin efana nezithasiselo kuwumsebenzi oyinselelo ngenxa yokuqina kwe-allicin. U-Allicin uzwela ku-oxidation kanye namazinga okushisa, okusho ukuthi okuqukethwe kwe-allicin kwehle isikhathi kanye lokushisa. Ukusebenza kokushisa nokulondolozwa ikakhulukazi yizici ezibucayi. Umsebenzi we-Allicin uzinze ku-4ºC uma uqhathaniswa ne-allicin egcinwe endaweni yokushisa yasekamelweni (cishe. 22ºC). Ukuphila kwayo okwenziwe ngamakhemikhali ku-4ºC kwakuzimisele ukuthi kuqondakale. Izinsuku ezingama-150, ngenkathi kumazinga okushisa esegumbini kwakufanele. Izinsuku ezingama-20.
Ukulungiswa kwangaphambili kwe-allicin sis enye into ebalulekile okufanele icatshangelwe. I-Allicin ibukeka izinzile kakhulu kugalikhi elisikiwe kunogalikhi womhlabathi.
Uma kukhulunywa ngokukhishwa kwe-ultrasonic, ngokuvamile i-sonication isebenza kangcono lapho indawo enkulu yendawo itholakala, okuwukuthi lapho ugarliki usemhlabathini kahle. Ngakho-ke, ukwelashwa kwangaphambili kwangaphambi kokugaya (ukugaya vs isilinganisi) sikagalikhi kufanele kusungulwe njengepharamitha eyengeziwe ngaphandle kwepharamitha yenqubo ejwayelekile ye-sonication. Funda kabanzi mayelana nokukhipha i-allicin ekhishwa ku-garlic!

I-Allicin Liposomes Yokuqina Kwesikhathi Eside

I-Allicin ithambekele ekuwohlokeni kwe-thermal futhi ibhujiswa ngaphansi kwezimo ze-acidic (pH 3.5 nangaphansi). Ukukhishwa kwe-Allicin kanye nezithasiselo kufanele kugcinwe endaweni ebizwa ngokuthi, okusho isiqandisi, cishe. I-4ºC yokuqinisekisa ukuqina kokuphila kwengxenye. Unyaka owodwa.
Ukwenziwa kwe-allicin ku-lipid nano carriers njenge-liposomes nama-nanoemulsion gels kwandisa impilo yeshalofu nokuqina kwemikhiqizo ye-allicin.

Ukwakhiwa Kwamandla Okuphelele kwe-Allicin-Loaded Liposomes

Lu et al. (2014) bika ukulungiswa okuphumelelayo kwe-allicin nanoliposomes isebenzisa ukuguquguquka kwesigaba kwe-allicin. Kwasetshenziswa amapharamitha alandelayo: isilinganiso se-lecithin-allicin se-3.70: 1, isilinganiso se-lecithin-cholesterol esingu-3.77: 1, isikhathi se-ultrasonic 3 min. I-40 sec., I-organic phase-aqueous phase ratio ye-3.02: 1.Ukuphumelela kokufakelwa kwe-allicin efakwe ngaphakathi kwe-75.20 ± 0.62% ngosayizi oqondile we-allicin nanoliposome ka-145.27 of 15.19 nm. I-allicin nanoliposomes elungiselelwe nge-ultrasonic ifaka ukukhishwa kwezidakamizwa okuqhubekayo, okunika amandla ukukhishwa okuqinile kwesithako esisebenzayo esikhathini esengeziwe. Lokhu kusiza ukuphathwa kwezidakamizwa nezithasiselo futhi kunciphisa imiphumela ye-cytotoxic.
Funda kabanzi mayelana ne-Ultrasonic Liposome Ukulungiselela!

Isakhiwo se-liposome

Ukwakheka kwe-liposome: Umthombo wamanzi we-amoyo oyisisekelo kanye ne-phospholipid enamakhanda we-hydrophilic kanye nemisila ye-hydrophobic / lipophilic

Ama-Ultrasonically Nanomemulsion Gels ane-Allicin

Ama-gels aseNanomemulsion asebenzisa i-polyethylene glycol yahlolwa ngempumelelo njenge-Allicin drug carriers ukuze kuthuthukiswe ukuguquguquka kwamanzi ne-bioavailability ye-allicin. (cf. Ranjbar et al.)
Funda kabanzi nge-Ultrasonic Nano-Emulsification!

I-Ultrasonication iyindlela esheshayo nethembekile yokukhiqiza i-nano-liposomes ephakeme.

UP400St, i-400 Watts enamandla homogeniser enamandla, yokwenza ama-liposomes nama-SLN

Isicelo solwazi




Qaphela kwethu Inqubomgomo yobumfihlo.


I-High-Performance Ultrasonicators ye-Liposomal Encapsulation

Izinhlelo ze-Hielscher Ultrasonics 'zingamadivayisi athembekile asetshenziswa ekhemisi nasekwenziweni kokungezelela ukwakha ama-liposomes asezingeni eliphakeme alayishwe ngama-antioxidants, polyphenols, acid acid, amavithamini, ama-peptides nezinye izinto ezihlanganisiwe. Ukuhlangabezana nezidingo zamakhasimende ayo, abakwaHielscher bahlinzeka ngama-ultrasonicators avela kuma-compact hand-hand lab homogeniser nama-bench-top ultarsonicators ezinhlelweni ze-ultrasonic zezimboni ngokugcwele zokukhiqizwa kwamanani aphezulu we-liposomal form form. Ukwakheka kwe-liposome ye-Ultrasonic kungaqhutshwa njenge-batch noma njengenqubo eqhubekayo yolayini. Uhla olubanzi lwe-sonotrodes ye-ultrasonic (eyaziwa nangokuthi ama-probes noma izimpondo) nemikhumbi ye-reactor iyatholakala ukuqinisekisa ukusethwa okuphezulu komkhiqizo wakho we-liposome. Ukuba namandla kwemishini yokusebenza kwe-Hielscher sika-Hielscher kuvumela ukusebenza kwe-24/7 emsebenzini osindayo nasezindaweni ezifunwayo.
Ithebula elingezansi linikeza isibonakaliso somthamo wokucubungula we-ultrasonicators wethu:

Iqoqwana Ivolumu flow Rate Amadivayisi ezinconyiwe
1 kuya ku-500mL 10 kuya ku-200mL / min UP100H
10 kuya ku-2000mL 20 kuya ku-400mL / min UP200Ht, UP400St
0.1 kuya ku-20L 0.2 kuya ku-4L / min I-UIP2000hdT
10 kuya ku-100L 2 kuya ku-10L / iminithi I-UIP4000hdT
na 10 kuya ku-100L / iminithi UIP16000
na sikhulu yinhlanganisela UIP16000

Xhumana nathi! / Cela Us!

Cela ulwazi oluthe xaxa

Uyacelwa ukuthi usebenzise ifomu elingezansi ukucela ulwazi olungeziwe mayelana nezinhlelo zokusebenza ze-ultrasonic, izinhlelo zokusebenza nentengo. Sizokujabulela ukuxoxa ngenqubo yakho nawe futhi sikunikeze uhlelo lwe-ultrasonic oluhlangabezana nezidingo zakho!









Sicela uqaphele wethu Inqubomgomo yobumfihlo.


I-Hielscher Ultrasonics yenza ama-homogenizer aphezulu we-ultrasonic wokuhlakazeka, i-emulsation kanye nokukhishwa kweseli.

Amandla aphezulu we-homogenizer ephezulu I-Lab kuya umshayeli futhi Izimboni isikali.



Amaqiniso Okufanele Ukwazi

Allicin

I-Allicin iyikhemikhali ekhiqizwa lapho ugalikhi echobozekile noma emisiwe. Kutholakala kwifomu lokungezelela ekudleni, kutholakele ukunciphisa ukuvuvukala futhi kunikeze nezinzuzo ze-antioxidant.
Ugalikhi omusha uqukethe i-amino acid ebizwa nge-alliin. Lapho i-clove ichotshozwa noma inqunywe, kukhululwa i-enzyme, i-alliinase. U-Alliin ne-alliinase bayasebenzisana ukwakha i-allicin, ethathwa njengesakhi esikhulu segalikhi esisebenzayo.
Izakhi ze-organosulfur zika-Garlic ezifana ne-allicin ziyaziwa ngemiphumela yazo ekhemisi kufaka phakathi i-antioxidative, anti-protozoal, anti-inflammatory, antimicrobial, anticancer, kanye nemiphumela ye-cardioprotective.