I-Hielscher Ultrasound Technology

I-Nantriposomes ye-Ultrasonic Yezindlela Zokuqina Ezihlanganisiwe

I-Allicin iyindawo esebenza kahle, engakhishwa kuma-clove wegalikhi amasha. I-Allicin ithambekele ekuwohlokeni ngakho-ke kufanele yenziwe ifomu lokwengezelelwa okuzinzile ukuze ithole ifomula elinamandla lesikhathi eside. Ukuvalelwa kwe-Ultrasonic kwe-allicin ku-nanoliposomes kuvikela i-allicin ekuwohlokeni futhi kuholele ekukhishweni kwezidakamizwa okuqhubekayo.

Ukuqina kwe-Allicin

The formulation of allicin products such as supplements is a challenging task due to the instability of allicin. Allicin is sensitive to oxidation and temperature, meaning allicin content decreased with time and temperature. Especially processing and storage temperatures are critical factors. Allicin activity is relatively stable at 4ºC when compared to allicin stored at room temperature (at approx. 22ºC). Its chemical half life at 4ºC was determined to be approx. 150 days, while at room temperature it was approx. 20 days.
Ukulungiswa kwangaphambili kwe-allicin sis enye into ebalulekile okufanele icatshangelwe. I-Allicin ibukeka izinzile kakhulu kugalikhi elisikiwe kunogalikhi womhlabathi.
Uma kukhulunywa ngokukhishwa kwe-ultrasonic, ngokuvamile i-sonication isebenza kangcono lapho indawo enkulu yendawo itholakala, okuwukuthi lapho ugarliki usemhlabathini kahle. Ngakho-ke, ukwelashwa kwangaphambili kwangaphambi kokugaya (ukugaya vs isilinganisi) sikagalikhi kufanele kusungulwe njengepharamitha eyengeziwe ngaphandle kwepharamitha yenqubo ejwayelekile ye-sonication. Funda kabanzi mayelana nokukhipha i-allicin ekhishwa ku-garlic!

I-Allicin Liposomes Yokuqina Kwesikhathi Eside

I-Allicin ithambekele ekuwohlokeni kwe-thermal futhi ibhujiswa ngaphansi kwezimo ze-acidic (pH 3.5 nangaphansi). Ukukhishwa kwe-Allicin kanye nezithasiselo kufanele kugcinwe endaweni ebizwa ngokuthi, okusho isiqandisi, cishe. I-4ºC yokuqinisekisa ukuqina kokuphila kwengxenye. Unyaka owodwa.
Ukwenziwa kwe-allicin ku-lipid nano carriers njenge-liposomes nama-nanoemulsion gels kwandisa impilo yeshalofu nokuqina kwemikhiqizo ye-allicin.

Ukwakhiwa Kwamandla Okuphelele kwe-Allicin-Loaded Liposomes

Lu et al. (2014) bika ukulungiswa okuphumelelayo kwe-allicin nanoliposomes isebenzisa ukuguquguquka kwesigaba kwe-allicin. Kwasetshenziswa amapharamitha alandelayo: isilinganiso se-lecithin-allicin se-3.70: 1, isilinganiso se-lecithin-cholesterol esingu-3.77: 1, isikhathi se-ultrasonic 3 min. I-40 sec., I-organic phase-aqueous phase ratio ye-3.02: 1.Ukuphumelela kokufakelwa kwe-allicin efakwe ngaphakathi kwe-75.20 ± 0.62% ngosayizi oqondile we-allicin nanoliposome ka-145.27 of 15.19 nm. I-allicin nanoliposomes elungiselelwe nge-ultrasonic ifaka ukukhishwa kwezidakamizwa okuqhubekayo, okunika amandla ukukhishwa okuqinile kwesithako esisebenzayo esikhathini esengeziwe. Lokhu kusiza ukuphathwa kwezidakamizwa nezithasiselo futhi kunciphisa imiphumela ye-cytotoxic.
Funda kabanzi mayelana ne-Ultrasonic Liposome Ukulungiselela!

Isakhiwo se-liposome

Ukwakheka kwe-liposome: Umthombo wamanzi we-amoyo oyisisekelo kanye ne-phospholipid enamakhanda we-hydrophilic kanye nemisila ye-hydrophobic / lipophilic

Ama-Ultrasonically Nanomemulsion Gels ane-Allicin

Nanomemulsion gels using polyethylene glycol was tested successfully as allicin drug carrier in order to improve the water solubility and bioavailability of allicin. (cf. Ranjbar et al.)
Funda kabanzi nge-Ultrasonic Nano-Emulsification!

I-Ultrasonication iyindlela esheshayo nethembekile yokukhiqiza i-nano-liposomes ephakeme.

UP400St, i-400 Watts enamandla homogeniser enamandla, yokwenza ama-liposomes nama-SLN

Isicelo solwazi




Qaphela kwethu Inqubomgomo yobumfihlo.


I-High-Performance Ultrasonicators ye-Liposomal Encapsulation

Izinhlelo ze-Hielscher Ultrasonics 'zingamadivayisi athembekile asetshenziswa ekhemisi nasekwenziweni kokungezelela ukwakha ama-liposomes asezingeni eliphakeme alayishwe ngama-antioxidants, polyphenols, acid acid, amavithamini, ama-peptides nezinye izinto ezihlanganisiwe. Ukuhlangabezana nezidingo zamakhasimende ayo, abakwaHielscher bahlinzeka ngama-ultrasonicators avela kuma-compact hand-hand lab homogeniser nama-bench-top ultarsonicators ezinhlelweni ze-ultrasonic zezimboni ngokugcwele zokukhiqizwa kwamanani aphezulu we-liposomal form form. Ukwakheka kwe-liposome ye-Ultrasonic kungaqhutshwa njenge-batch noma njengenqubo eqhubekayo yolayini. Uhla olubanzi lwe-sonotrodes ye-ultrasonic (eyaziwa nangokuthi ama-probes noma izimpondo) nemikhumbi ye-reactor iyatholakala ukuqinisekisa ukusethwa okuphezulu komkhiqizo wakho we-liposome. Ukuba namandla kwemishini yokusebenza kwe-Hielscher sika-Hielscher kuvumela ukusebenza kwe-24/7 emsebenzini osindayo nasezindaweni ezifunwayo.
Ithebula elingezansi linikeza isibonakaliso somthamo wokucubungula we-ultrasonicators wethu:

Iqoqwana Ivolumu flow Rate Amadivayisi ezinconyiwe
1 kuya ku-500mL 10 kuya ku-200mL / min UP100H
10 kuya ku-2000mL 20 kuya ku-400mL / min UP200Ht, UP400St
0.1 kuya ku-20L 0.2 kuya ku-4L / min I-UIP2000hdT
10 kuya ku-100L 2 kuya ku-10L / iminithi I-UIP4000hdT
na 10 kuya ku-100L / iminithi UIP16000
na sikhulu yinhlanganisela UIP16000

Xhumana nathi! / Cela Us!

Cela ulwazi oluthe xaxa

Uyacelwa ukuthi usebenzise ifomu elingezansi ukucela ulwazi olungeziwe mayelana nezinhlelo zokusebenza ze-ultrasonic, izinhlelo zokusebenza nentengo. Sizokujabulela ukuxoxa ngenqubo yakho nawe futhi sikunikeze uhlelo lwe-ultrasonic oluhlangabezana nezidingo zakho!









Sicela uqaphele wethu Inqubomgomo yobumfihlo.


I-Hielscher Ultrasonics yenza ama-homogenizer aphezulu we-ultrasonic wokuhlakazeka, i-emulsation kanye nokukhishwa kweseli.

Amandla aphezulu we-homogenizer ephezulu I-Lab kuya umshayeli futhi Izimboni isikali.



Amaqiniso Okufanele Ukwazi

Allicin

I-Allicin iyikhemikhali ekhiqizwa lapho ugalikhi echobozekile noma emisiwe. Kutholakala kwifomu lokungezelela ekudleni, kutholakele ukunciphisa ukuvuvukala futhi kunikeze nezinzuzo ze-antioxidant.
Ugalikhi omusha uqukethe i-amino acid ebizwa nge-alliin. Lapho i-clove ichotshozwa noma inqunywe, kukhululwa i-enzyme, i-alliinase. U-Alliin ne-alliinase bayasebenzisana ukwakha i-allicin, ethathwa njengesakhi esikhulu segalikhi esisebenzayo.
Izakhi ze-organosulfur zika-Garlic ezifana ne-allicin ziyaziwa ngemiphumela yazo ekhemisi kufaka phakathi i-antioxidative, anti-protozoal, anti-inflammatory, antimicrobial, anticancer, kanye nemiphumela ye-cardioprotective.