Ultrasonic Lactose Crystallization

  • Ezinkambisweni eziningi zobisi, i-whey (ubisi permeate) iyenzeka emigqumeni enkulu njengomkhiqizo. I-Whey inokuqukethwe okuphezulu kwe-lactose futhi kufanele ilahlwe, okuyinto ebiza futhi inemithelela yemvelo.
  • Ngokuphulukisa i-lactose nge-ultrasound, i-whey effluent ingancishiswa kakhulu, kanti i-lactose etholakalayo ingumkhiqizo odayiswayo.
  • I-ultrasonication ikhuthaza i-crystallization esheshayo futhi ephumelelayo eholela ekuvuneni okuphezulu kwama-crystals afanayo.

Ukukhiqizwa kwe-Lactose

I-Lactose ikhiqizwa kwisisombululo esicacile se-lactose (esitholakalayo kusuka ku-whey). I-lactose slurry egxile kakhulu kumele ikhuphuke ekushiseni okuphansi ukuze kukhishwe amakristalu. Ngemuva kwesinyathelo sokungena, ama-crystals lactose ahlukaniswa yi-centrifugation. Emva kwalokho, amakristalu asomile abe yi-powder.
Izinyathelo ze-Lactose Crystallization:

  • Ukugxila
  • i-nucleation
  • crystal ukukhula
  • Ukuvuna / ukugeza

Ukwenza ngcono i-Lactose Crystallization nge-Sonication

I-Ultrasound yaziwa kakhulu ngomthelela wayo omuhle ekwakheni i-crystallization kanye ne-precipitation processes (sono-crystallization). I-Sonication ithuthukisa ukubunjwa nokukhula kwama-crystalline lactose, futhi.
I-Sono-crystallization ye-lactose isiza ukuthola isivuno esiphezulu se-lactose crystals ngesikhathi esincane.
Ukukhula okuhle kwe-crystal kubalulekile ukuqinisekisa ukuvunwa nokuhlanza kahle kwe-lactose (ukukhipha & ukuhlanzwa). I-Sonication ibangela i-supersaturation ye-lactose futhi iqala i-nucleation eyinhloko yama-crystall lactose. Ngaphezu kwalokho, i-sonication eqhubekayo inikeza insimu yesibili, eqinisekisa ukuthi i-crystal distibution encane (CSD) isincane.

Izinzuzo ze-Ultrasound:

  • isivuno esiphezulu
  • isikhathi esifushane kakhulu senqubo
  • isayizi ye-crystal isayizi
  • ubukhulu bekristall obukhululekile
  • ukufaniswa kwe-crystal shape

Kusukela kumfucuza we-lactose

Ngenxa yokukhiqizwa kwezimbuzi ezinkulu, i-whey ivame ukuba ngumkhiqizo ophathwa njenge-waste effluent. Ukulahlwa kwamagesi oketshezi kuyabiza kakhulu ngenxa yokufunwa kwe-oxygen ephezulu ye-oksijini (BOD) nokuqukethwe kwamanzi. Uma i-lactose ibuye itholakale kum whey, umkhiqizo usetshenziselwa isinyathelo sokulandela ukukhiqiza i-lactose powder. Ukutholakala kwe-lactose kunciphisa i-BOD ye-whey ngamaphesenti angu-80% okwenza lo mkhiqizo usebenziseke futhi unobungozi obunemvelo. Inqubo ye-crystallization esebenza nge-ultrasonically ithuthukisa ukukhula kwe-crystal, isivuno kanye nekhwalithi.
I-Lactose isetshenziselwa kabanzi njengesithako embonini yokudla kanye ne-pharma, njengento eluhlaza ekukhiqizeni i-lactitol noma njengezinto eziyisisekelo zokukhiqizwa kwezinhlamvu ezincane ze-polyester engakhiwe.

Izinsiza ze-Ultrasonic

Hielscher Ultrasonics ikunikeza imishini ultrasonic for sonocrystallization izinqubo – kungaba nge-sonication ye-batch noma ngokucubungula kwe-inline ku-reactor ye-ultrasonic. Wonke amadivaysi ethu e-ultrasonic aklanyelwe ukuqhubeka ngokuqhubekayo (24hrs / 7d / 365d) ukuqinisekisa ukusetshenziswa kwemishini esiphezulu. Amadivaysi e-industrial ultrasonic avela ku-0.5kW kuya ku-16kW ngeyunithi ngayinye afanele ukucutshungulwa kwezebhizinisi kokumiswa kwamagesi amakhulu.

Ukucubungula kwebanga lokudla

Ama-Hielscher ultrasonic systems atholakala ngokufaka izinto zangasese. I-sonotrodes ye-ultrasonic (probes / izimpondo) nama-reactors afaka i-geometry elula yokuhlanza kalula. I-cavitation ye-ultrasonic isebenza njengokuhlanza-in-place (CIP). Ama-sonotrode ethu kanye nama-reactor athuthukile.
Ngenxa yezinyathelo ezincane, izinhlelo ze-ultrasonic zikaHielscher zingahlanganiswa kalula noma zifakwa kabusha endaweni yakho ekhona.
Xhumana nathi namuhla ukuthola ulwazi oluthe xaxa! I-Hielscher Ultrasonics inikeza izixazululo ezihlukahlukene nezindlela ezenziwe ngezifiso ze-ultrasonic yobisi nezinqubo zokudla!

I-Ultrasound yindlela yokwethenjelwa yokulungisa amamululsi okudla okulinganiselwe (Chofoza ukuze ukhulise!)

I-Ultrasonic flow reactor at I-UIP1000hdT

Isicelo solwazi




Qaphela kwethu Inqubomgomo yobumfihlo.


I-Lactose crystallization nge-ultrasonication

I-lactose i-molecule

Izincwadi / Izinkomba

  • Deora, NS; Misra, NN; U-Deswal, A .; Mishra, HN; Cullen, PJ; Tiwari, BK (2013): i-Ultrasound for Crystal Improved ekuHlangeni Ukudla. Ukubuyekezwa kobuNjini bezokudla 5/1, 2013. 36-44.
  • I-Dincer, i-TD; I-Zisu, B .; I-vallet, i-CGMR; UJayasena, uV .; I-Palmer, i-M.; Amasonto, M. (2014): Ukuqothulwa kwe-lactose nge-system equeous. I-International Dairy Journal 35. 2014. 43-48.
  • Kougoulos E, Marziano I, Miller PR. (2010): i-Lactose izinhlayiya zobunjiniyela: ithonya le-ultrasound ne-anti-solvent emkhatsini wemikhuba ye-crystal kanye nosayizi wezinhlayiyana. J Cryst Growth 312 (23): 3509-20.
  • Martini, Silvana (2013): Sonocrystallization yamafutha. Izimpendulo Zama-Springer ku-Ukudla, Impilo, Nokudla. 2013.
  • UMcSweeney, i-PLH; I-Fox PF (2009): I-Advanced Chemistry Chemistry. I-Vol. 3. I-Lactose, amanzi, usawoti namavithamini. I-New York: I-Springer Science + Ibhizinisi Lemidiya. 759p.
  • I-Patel, i-SR; Murthy, ZVP (2011): Umphumela wezinqubo zemigomo eklasini nosayizi we-morphologie we-lactose e-crystallization eyayisizwa nge-ultrasound. I-Crystal Research Technology 46/3. 2011. 243-248.
  • I-Wong, SY; I-Hartel, i-RW (2014): I-Crystallization ku-Lactose Yokuhlanza – Ukubuyekezwa. Journal of Food Science 79/3, 2014. 257-272.

Xhumana Nathi / Cela Ukwaziswa Olwengeziwe

Khuluma nathi mayelana nezidingo zakho zokucubungula. Sizosikisela ukusetha nokulungiswa kwemingcele efanele yephrojekthi yakho.





Sicela uqaphele wethu Inqubomgomo yobumfihlo.




Mayelana ne-Sonocrystallization

Uma amandla ultrasound asetshenziselwa ukugqugquzela nokuthuthukisa izinqubo ze-crystallization, yaziwa ngokuthi i-sonocrystallization. I-Sonocrystallization isekelwe ekusebenziseni “amagagasi acoustic ukudala izinguquko physicochemical kule material. Ezinye izicelo ezivamile zamandla we-ultrasound zihlanganisa ukusetshenziswa kwayo ukudala ukuphendula kwamakhemikhali (sonochemistry) nokukhuthaza ukukhipha i-crystallization (sonocrystallization). Lezi zindlela ziye zathola izimboni eziningana ezihlanganisa izimboni zezokwelapha, amakhemikhali nezokudla ezanikeza inzuzo abayinikezayo. Amasu e-ultrasound asebenza kahle ngokwezomnotho futhi kulula ukuba afake ekusebenzeni kwezimboni. Lezi zindlela zingasetshenziswa ukuthuthukisa kokubili ukukhiqiza nokukhiqiza; azihlanzekile futhi azihlanzekile ngokwemvelo”. [Martini 2013, 4]

I-Nucleation ne-Crystal Growth

I-crystallization inqunywa njengenqubo yokwakheka, lapho amakristalu aqinile ephuma khona esisombululo esiphezulu, esikhwameni noma egazini.
Inqubo ye-crystallization inezinyathelo ezimbili ezinkulu: i-nucleation ne-crystal ukukhula.
Ngesikhathi se-nucleation, ama-molecule ahlanganisiwe esisombululo aqala ukwakha amaqoqo, okumele kube mkhulu ngokwanele ukuze azinze ngaphansi kwezimo zokusebenza. Iqoqo elinjalo eliqinile lakha i-nucleus. Ngemuva kokufinyelela ubukhulu obukhulu ukudala i-nucleus ezinzile, isigaba sokukhula kwe-crystal siqala.
Esikhathini sesigaba sokukhula kwe-crystal, i-nuclei eyakhiwe iyaba mkhulu njengoba ama-molecule amaningi aphethwe kwi-cluster. Inqubo yokukhula ixhomeke ebangeni le-saturation kanye neminye imingcele efana nokuxuba, ukushisa njll.
I-classical crystallization theory isekelwe ekutheni i-thermodynamic conception ukuthi uhlelo olulodwa lwalodwa luqinile lapho i-entropy yayo ingenakwenzeka.

Amaqiniso nge-Lactose

I-Lactose (ishukela lobisi) i-disaccharide eyakhiwe kusuka ku-glucose ne-galactose exhunywe yisibopho se-β (1 → 4) se-glycosidic.
Ngenxa yokuthi kukhona i-chiral carbon, i-lactose ingavela ngendlela elandelayo: 2 izinhlobo ze-isomer: α- noma β-lactose. I-Lactose itholakala kakhulu njengama-hydrated α-lactose monohydrate crystal. Elinye i-polymorph, i-β-lactose anhydrous, ayitholakali kakhulu futhi ihlanganisa crystallizes ngaphezu 93.5 ° C. I-α- ne-β-anomers inezakhiwo ezahluke kakhulu. I-polymorphs ingahlukaniswa ngokushintshaniswa okuqondile (+ 89 ° C no + 35 ° C ye-α- ne-β-lactose, ngokulandelana) kanye nokwehlisa amandla (70 no-500g / L (ku-20 ° C) ye-α- ne-lac-lactose , ngokulandelana). [McSweeney et al. 2009]
I-carbohydrate ebalulekile yobisi futhi itholakala ekugxilweni kwe-2-8 wt%. I-Lactose ayinambitheka futhi inobumnandi obuphansi. I-Lactose yenza njengoshukela onciphisa futhi ikhuthaza ukuphendula kwe-Maillard kanye ne-Stecker. Ngaleyo ndlela, i-lactose isetshenziselwa ukuthuthukisa umbala nokuvutha kwemikhiqizo yokudla njengemikhiqizo yokubhaka, ama-pastries kanye ne-confectionery.
I-Lactose iyinhlanganisela yokudla okusetshenziselwa kabanzi esebenza njenge-carrier, filler, stabilizer, ne-tablet diluent kokudla nemikhiqizo yezokwelapha.
I-α-lactose yindlela ehlanzekile, esetshenziselwa imikhiqizo yezokwelapha.
I-Lactose iyisithako esibalulekile uma kuziwa kokunambitheka, iphunga kanye nokusabela okubomvu.
Ifomu: C12H22O11
IUPAC ID: β-D-galactopyranosyl- (1 → 4) -D-glucose
Inqwaba ye-Molar: 342.3 g / mol
Iphuzu lokuxuba: 202.8 ° C
Ubuningi: 1.53 g / cm3
Ukuhlukaniswa: FODMAP
I-soluble ku: amanzi, i-ethanol


Ukukhipha Ukudla nano i-pharma Ama-Phytochemicals inqubo yokuqinisa i-solvent isizinda Sonication Sonochemistry I-UIP2000hdT I-UIP4000hdT ultrasonication Isizinda se-Ultrasonic umshini we-ultrasonic UP400St