I-Hielscher Ultrasound Technology

Ultrasonic Kratom Extraction

  • I-Ultrasonication iphumelela kakhulu ukukhiqiza iziqhumane ezivela e-alkaloid ezivela emaqabungeni e-kratom (Mitragyna speciosa).
  • I-Sonication ikhulula ama-bioactive njenge-mitragynine ne-7-hydroxymitragynine evela kumaseli esitshalo ukuze ahlukaniswe.
  • Isizinda se-Ultrasonic sinikeza isivuno esiphezulu esimweni sokunciphisa kwesilinganiso.

I-Kratom ne-Mitragynine

Isizinda se-ultrasonic se-mitragynine ne-7-hydroxymitragynine kusuka emaqabungeni e-kratom.I-Mitragynine ne-7-hydroxymitragynine yi-alkaloids ye-indole ye-Mitragyna speciosa, eyaziwa nangokuthi i-Kratom. Zombili izinhlanganisela zisebenza njenge-opioid-receptor ophikisanayo futhi ziyaziwa ngemiphumela yazo yokunciphisa ubuhlungu. I-7-hydroxymitragynine iyisisindo esihle kakhulu se-painkilling. Ngokungafani ne-mitragynine, ekhona kakhulu emaqabunga e-Kratom, i-7-hydroxymitragynine itholakala kuphela ngamanani amancane. Nokho, ngenxa yobungako obuphezulu, i-7-hydroxymitragynine ikhulula ubuhlungu obukhulu nakakhulu futhi iyaziwa nokunciphisa izimpawu zokuhoxiswa kwe-opiate.
Amahlamvu kratom abomile aqukethe cishe. 1-6% i-mitragynine ne-approx. 0.01 – 0.04% we-7-hydroxymitragynine. I-Kratom isithako semvelo se-botanical esingasetshenziselwa izithako zokudla noma njengemithi yokwelapha ngendlela yama-powders, ama-capsules noma ama-tinctures ukuze kunciphise ubuhlungu, ukugqugquzela noma ukwenza njengesizo semvelo sokuhoxisa i-opioid.

Isizinda se-Ultrasonic

Isizinda se-Ultrasonic yindlela ephumelelayo kakhulu yokukhulula ama-keyactive compounds mitragynine ne-7-hydroxymitragynine (i-7-HMG) kanye nezinye izidakamizwa ezingaphezu kuka-40, ezihlanganisa ama-alkaloids angaba ngu-25 (isib. Ajmalicine, mitraphylline, mitragynine pseudoindoxyl, rhynchophylline) ukusuka kratom . Amanye amakhemikhali asebenzayo e-bioactive amaqabunga e-M. speciosa afaka i-raubasine ne-Pausinystalia johimbe alkaloids njenge-corynantheidine.
Amakhemikhali asetshenziswa kakhulu kunawo wonke ama-Mitragyna speciosa (kratom) angama-mitragynine (MG), i-7-hydroxymitragynine, eyaziwa ngokuthi yizinto ezinamandla ezithinta i-painkilling. I-7-hydroxymitragynine i-opioid-antagonist, esiza iziguli ukuba zihoxise kuma-opioid. Zombili lezi zinto zingakhululwa ngempumelelo emtholampilo wesitembu nge-sonication. Izitshalo ze-Kratom zingenziwa nge-ultrasonically noma zisebenzisa utshwala noma amanzi njengesixazululo. Ukukhethwa kwe-solvent kuthonya imiphumela yekratom. Ukukhipha ngaphandle kwe-ethanol ukubonisa okunciphisa izakhiwo ezivuselela, kuyilapho imiphumela ephumuzayo, ekwehliseni ukukhathazeka yanda. Isizinda se-ultrasonic singasetshenziswa ngezinhlobonhlobo ze-solvent futhi sikunikeza ithuba lokukhiqiza izitshalo ze-kratom ngezakhiwo ezahlukene.

Ukukhishwa kwe-ultrasonic yezinto eziphilayo ezivela emahlathini

Izifundo ze-Case of Ultrasonic Kratom Extraction

Ucwaningo seluvele luphenywe futhi lubonakaliswe isizinda se-ultrasonically esizisizwa njengenqubo, okwandisa ukusebenza kahle kokukhipha kanye nokukhiqizwa kwe-mitragynine ekhishwe.
Orio et al. U-2011 waqhathanisa amasu ahlukahlukene okukhipha njenge-extraction-assisted extraction, i-microwave-eyasizwa isizinda kanye ne-carbon dioxide extraction, usebenzisa i-methanol, i-ethanol, amanzi kanye nezingxube zebhanana. I-probe-type ultrasonicator yanikeza isivuno esiphezulu kunama-mitragynine. Njengoba izinqubo ze-ultrasonic zesikhukhula zingahle zihlukaniswe ngokuhambisana nokukhiqizwa kwezimboni, kuyindlela ephumelela kunazo zonke ukukhiqiza ubuningi obukhulu be-alkaloid.

Isiqalo sokuqala sokushisa esihlanganisiwe nesizinda se-ultrasonic sitholakale siphumelele kakhulu uma inhlanganisela ye-CHCl3 : MeOH 1: 4 (v / v) ku-pH 9.5 isetshenzisiwe. Ukushisa okuphansi okukhipha phakathi kuka-25 no-45 ° C kusiza ukugwema ukuchithwa kwamakhemikhali abizayo.
Ukuze uthole isizinda se-ultrasonic, ama-5 g weqabunga lama-Kratom afakwe amafriji afakwe ama-pulverized afakwe ku-beaker equkethe 200 ml we-CHCl3: CH3OH, 1: 4 (v / v), efakwa ebhodini lokugezela ukuze kugcinwe izinga lokushisa ngesikhathi sokuqeda ingane. Isampula ihanjiswa nge-homogenizer ye-ultrasonic efana ne- UP200Ht (200W, 26kHz). I UP200Ht isethelwe ku-100% amplitude ne-50% imodi yomjikelezo futhi isampula ihanjiswa nge-approx. 4 iminithi. Emva kwalokho, i-leaf extract ihlungwa ngephepha lokuhlunga futhi i-filtrate yavunyelwa ukuba yome phezu kwesidlo sokuphuma esikhwameni sokugeza amanzi.
Isizinda se-ultrasonic siphumelele ekukhishwe kwekhwalithi ephezulu futhi kuqinisekiswe yizivuno eziphezulu, isikhathi sokucubungula okusheshayo, ukusebenza okuphephile nokulula, izindleko ezitshaliwe zokutshalwa kwemali kanye nokuhlelwa kwemvelo.

I-UIP2000hdT - i-2000W high performance ultrasonicator yezizinda zezimboni

I-UIP2000hdT nge-flow cell reactor for extractions ze-botanical

Isicelo solwazi




Qaphela kwethu Inqubomgomo yobumfihlo.


Ultrasonic Obumba Systems

I-Hielscher Ultrasonics ngumhlinzeki wakho owaziwa isikhathi eside we-high-performance ultrasound extractors. Ukunikeza uhla olugcwele kusuka kuma-ultrasonicators amancane abamba ngesandla ukuthi asebenzise ama-extractors e-industrial ultrasonic ngokugcwele okusetshenziselwa ukuqhutshwa kwe-inline, sizokuncoma uhlelo lwe-ultrasonic oluhambisana nenqubo yakho yemfuneko.
Wonke ama-ultrasonicators ethu angasebenza ku-24/7 ukusebenza. Izinhlelo zethu zokushayela kanye nezimboni (isib UIP500hdT (0.5kW), I-UIP1000hdT (1kW), I-UIP1500hdT (1.5kW), I-UIP2000hdT (2kW), I-UIP4000hdT (4kW), I-UIP10000 (10kW), I-UIP16000hdT (16kW)) zikhulu kakhulu futhi zingakwazi ukuletha ama-amplitudes aphakeme kakhulu. Kuye ngevolumu yakho ye-raw materials kanye neyesikhumba, unganquma phakathi kwe-batch sonication kanye ne-sonication encane usebenzisa i-ultrasonic flow-through reactor.
Iphothifoliyo yama-ultrasonicators kanye Izesekeli (njenge-sonotrodes, i-Cascatrodes, i-booster horns, i-flow cells, i-reactors njll) ikuvumela ukuba uhlanganise ukusetha okulungiselelwe imigomo yakho yenqubo.
Thintana nathi namuhla! Siyajabula ukuxoxa ngenqubo yakho yokukhipha nawe!

Xhumana nathi! / Cela Us!

Cela ulwazi oluthe xaxa

Sicela usebenzise ifomu elingezansi, uma ufisa ukucela ulwazi oluthe xaxa mayelana ne-homogenization yama-ultrasonic. Sizojabula ukukunikeza uhlelo lwe-ultrasonic ukuhlangabezana nezidingo zakho.









Sicela uqaphele wethu Inqubomgomo yobumfihlo.


Izincwadi / Izinkomba

  • U-Orio, uLaura; I-Alexandru, i-Lavinia; I-Cravotto, i-Giancarlo; Mantegna, uStefano; I-Barge, i-Alessandro (2012): UAE, MAE, SFE-CO2 kanye nezindlela zakudala zokufakelwa kwamashibi ama-Mitragyna speciosa. Ultrasonics Sonochemistry 19 (2012) 591-595.
  • Hakim Mas Haris et al. (2013): Ukubuyiswa Kokuvuselelwa Kwe-Mitragynine kusuka ku-Mitrgyna Speciosa Ukusebenzisa i-Freeze Drying kanye ne-Ultrasonic-Assisted Extraction Method. Umthamo Wokuhlola. 15 (3), 2013. 1077-1083.


Amaqiniso Okufanele Ukwazi

I-Kratom

I-Kratom iyaziwa kakhulu ngezinsimbi zayo eziyinhloko ze-psychora-mitragynine (MG) ne-7-hydroxymitragynine (i-7-HMG), etholakala emaqabini kaMitragyna speciosa.
I-Kratom yigama le-Thai futhi ichaza kokubili, isihlahla kanye namasu okulungiselela ukuqeda amaqabunga. Mitragyna speciosa Korth. Isihlahla esihlale sihlaza emkhayeni wekhofi (Rubiaceae umndeni) ohlala eNingizimu-mpumalanga ye-Asia.

Ama-opioid Antagonists

I-agonist iyisidakamizwa esenza i-receptors ethile ingene ebuchosheni. Ama-opioid agonist agcwele ama-receptor ama-opioid ebuchosheni ngokugcwele okuholela ekusebenzeni okugcwele kwe-opioid. Izibonelo zama-agonists agcwele yi-heroin, i-oxycodone, i-methadone, i-hydrocodone, i-morphine, i-opium nezinye.
Umphikisi ngumuthi ovimbela ama-opioid ngokuhlanganisa ama-receptor opioid ngaphandle kokuwasebenzisa. I-antagonists ingabangela umphumela we-opioid futhi ivimbele i-opioids egcwele ye-agonist. Izibonelo zine-naltrexone ne-naloxone. Ngezinye izikhathi i-Naloxone isetshenziselwa ukuguqula ukudlula ngokweqile kwe-heroin.

Terpenes vs Terpinoids

I-Terpenes yi-hydrocarboni ehlanzekile esekelwe ekuhlanganisweni kweyunithi ye-isoprene, kuyilapho i-terpenoids iguqulwa yi-oxidation. Lokhu kusho ukuthi, i-terpenoids yizinhlanganisela ezihlobene ne-terpenes, ezahlukaniswa ukusebenza komoya noma ukulungiswa kabusha kwamangqamuzana. Nakuba i-terpenes ne-terpenoids yizinhlobonhlobo zamakhemikhali, lezi zombi zombili zivame ukusetshenziselwa ngokuzenzekelayo njengendlela eguquguqukayo.