I-Hielscher Ultrasound Technology

Ukukhishwa kwe-ultrasonic kwe-Piperine kusuka ku-Pepper

  • I-piperine ingumuthi ophilayo otholakala kuma-peppercorns futhi ulinganiswa nezakhiwo zawo zemithi.
  • I-Ultrasonic iyindlela ephumelelayo, elula, futhi esheshayo yokukhipha ukuhlukanisa i-piperine ephezulu.
  • Isizinda se-ultrasonic yindlela enokwethenjelwa futhi efakazelwe, esetshenzisiwe kakade embonini ye-pharma kanye nokudla.

Ukukhishwa kwe-Piperine yi-High-Performance Ultrasound

I-piperine i-compound ebizwa ngokuthi i-bioactive compound eyaziwa ngokusemandleni ayo okukhulisa ukunakekelwa kwe-curcumin, selenium, i-vitamin B12, i-beta-carotene nezinye izinhlanganisela. Ngakho-ke, imboni ye-pharma kanye nomsoco inesithakazelo esikhulu ekufakeni okusheshayo nokulula kwepiperine eliphezulu.
I-piperine evamile kanye ne-piperidine isizinda senziwa nge-extra-consuming solvent extraction usebenzisa i-DMC eyingozi (dichloromethane). I-Ultrasonic isizinda se-excels esivamile se-solvent isizinda sezitshalo eziphakeme, ukusetshenziswa kwe-solvents engeyona ene-toxic (isib. I-ethanol) kanye nenqubo yokukhipha ngokushesha. I-high-performance ultrasound idala cavitation ezitsheni. I-cavitation ye-Acoustic noma ye-ultrasonic idala izimo ezimbi kakhulu endaweni ezifana nokushisa okungaphezulu kokuphezulu nokucindezela okuhlukile, i-jets yamanzi kanye ne-shear force. Lezi zinsizwa ze-ultrasonic ziphula izindonga zamangqamuzana futhi zandisa ukudluliselwa kwamaphakathi phakathi kwezingaphakathi zamaseli kanye ne-solvent ezungezile ukuze kukhishwe izinto eziphilayo. Isizinda se-ultrasonic yindlela yokufakazela ukuthi ihlukanise ama-compounds ahlosiwe afana ne-piperine kusuka emhlabathini we-pepper (i-piper nigrum, i-piper longum).

Imibandela yokuqhafaza enhle

Enye yezinzuzo ezibaluleke kakhulu ukuhlukaniswa kwe-ultrasonic ukulawula okuqondile kwazo zonke izinqubo zemigomo. Ukuphakama kwe-Ultrasonic (i-amplitude, amandla, umjikelezo womsebenzi), isikhathi sokukhipha, i-solvent, eqinile kuya kwe-solvent ratio, nokushisa kungahle kulungiswe izimo ezifanele ukuze uthole isivuno esiphezulu se-piperine ephezulu.

I-ultrasonic extractors njenge-UIP1000hdT isetshenziselwa ukukhishwa kwepiperine.

I-UIP1000hdT nge-ultrasonic flow flower

Isicelo solwazi




Qaphela kwethu Inqubomgomo yobumfihlo.


Izinzuzo:

  • isivuno esiphezulu
  • izitshalo eziphezulu
  • non-thermal
  • Ukukhipha okusheshayo
  • inqubo Safe
  • ukuphathwa kwemvelo

I-Exemplary Protocol ye-Ultrasonic Piperine Extraction

Esikhathini esincane se-beaker setup, isivuno esiphezulu se-piperine (5.8 mg / g) kusuka emhlabathini i-piper longum itholakala ezimweni eziphakeme ze-ultrasonic izizinda, ezitholakale zilandelayo:
idivayisi ultrasonic UP200St noma UP200Ht (200W, 26kHz)
Imingcele ye-ultrasonic: 100% amplitude, umjikelezo womsebenzi wama-80%
isikhathi sonication: approx. 18 iminithi.
i-solvent: i-ethanol
eqinile kuya kwesilinganiso se-solvent: 1:10
lokushisa: 50 ° C

Imiphumela Ephakeme

I-UP200Ht - idivayisi enamandla ene-ultrasonic ephathekayo.Isizinda se-ultrasonic sinenzuzo ephawulekayo ngaphezu kwesimiso se-batch nesizinda se-solvent. I-Rathod (2014) ikhombisa ukuthi isikhathi sokukhipha sincishisiwe kusuka ku-8h batch solvent extraction kanye no-4h Soxhlet isizinda sincishiswe sibe ngu-18 min. isizinda se-ultrasonic. Ngaphezu kwalokho, isizinda se-ultrasonic sinika isivuno esiphezulu se-piperine. Izitshalo zokukhiqizwa kwe-piperine ezitholakala ku-Soxhlet extraction kanye ne-batch method extraction zitholakala zibe yi-1.67 mg / g no-0.98 mg / g, ngokulandelana, ezazingaphansi kakhulu kokuvunwa kwe-ultrasonically ka-5.8mg / g. I-Rathod (ngo-2014) iphetha ngokuthi isizinda esisizwa nge-ultrasound of phytoconstituents yemvelo efana ne-piperine sinciphisa inkinga ye-extractability ephansi kanye nezikhathi eside zokukhipha ngezindlela zendabuko.

I-Ultrasound isebenzise ngempumelelo ukukhishwa kwamafutha abalulekile avela kumnyama omnyama, futhi. Chofoza lapha ukuze ufunde kabanzi mayelana ne-ultrasonic hydrodistillation yamafutha abalulekile!

Ultrasonic Extractors

Hielscher Ultrasonics ngumkhiqizi omdala owaziwayo we-high-performance ultrasonic isizinda izinhlelo. Imikhiqizo yethu yamaphothifoliyo kusuka ezincane, ezinamandla lab ultrasonicators ukuze ube namandla amabhentshi-phezulu nezinhlelo zezimboni, okuletha ukuphakama okukhulu kwe-ultrasound ukuze kusetshenziswe i-extraction kanye nokuhlukanisa izinto eziphilayo (isib. ipiperine, i-curcumin njll).
Wonke amadivaysi e-ultrasonic avela ku-200W kuya ku-16,000W afaka isibonakaliso semibala ngokulawula kwe-digital, ikhadi elihlanganisiwe le-SD lokuqopha okuzenzakalelayo kwedatha, isilawuli esikude sesiphequluli kanye nezinye izici eziningi zomsebenzisi. I-sonotrodes namaseli okugeleza (izingxenye, ezithintana nephakathi) zingenziwa nge-autoclaved futhi kulula ukuzihlanza.
Wonke ama-ultrasonicators ethu akhiwe ngomsebenzi we-24/7, adinga ukugcinwa okuphansi futhi kulula futhi ephephile ukusebenza.

Ithebula elingezansi linikeza isibonakaliso somthamo wokucubungula we-ultrasonicators wethu:

Iqoqwana Ivolumu flow Rate Amadivayisi ezinconyiwe
0.5 kuya ku-1.5mL na I-VialTweeter
1 kuya ku-500mL 10 kuya ku-200mL / min UP100H
10 kuya ku-2000mL 20 kuya ku-400mL / min UP200Ht, UP400St
0.1 kuya ku-20L 0.2 kuya ku-4L / min I-UIP2000hdT
10 kuya ku-100L 2 kuya ku-10L / iminithi UIP4000
na 10 kuya ku-100L / iminithi UIP16000
na sikhulu yinhlanganisela UIP16000

Xhumana nathi! / Cela Us!

Sicela usebenzise ifomu elingezansi, uma ufisa ukucela ulwazi oluthe xaxa mayelana ne-homogenization yama-ultrasonic. Sizojabula ukukunikeza uhlelo lwe-ultrasonic ukuhlangabezana nezidingo zakho.









Sicela uqaphele wethu Inqubomgomo yobumfihlo.


Izincwadi / Izinkomba

  • I-Cao X .; Ye X .; Lu Y .; Mo W. (2009): Ionic liquid based based ultrasonic isisetshenziswa kusiza of piperine kusuka pepper omhlophe. I-Analytica Chimica Acta 640, 2009. 47-51.
  • I-Rathod SS; I-Rathod VK (2014): Ukukhishwa kwe-piperine kusuka ku-Piper longum usebenzisa i-ultrasound. Izitshalo Zomsebenzi Nemikhiqizo Vol. 58, 2014. 259-264.


Amaqiniso Okufanele Ukwazi

Isizinda se-Ultrasonic

Isizinda se-Ultrasonic sezinto eziphilayo ezivela ku-botanicals sisekelwe esimisweni i-acoustic cavitation. I-cavitation yama-acoustic ivela lapho amaza aphezulu kakhulu e-ultrasound (isib. Ama-amplitudes aphezulu ka-100μm, akhiqizwa ngu-20-26kHz ultrasound) ahlanganiswa abe yi-liquid. Amandla okugcoba amakhanda aphihliza futhi aphule izindonga zeseli zesibhakabhaka, futhi asunduze futhi adonse i-solvent ezungezile ngaphakathi nangaphandle kweseli elingaphakathi. Emva kwenqubo yokukhipha, i-solvent ithwala ama-molecule ahlosiwe, okungahlukaniswa (isib. Nge-centrifugation). Isizinda se-ultrasonic siyaziwa ngokunikeza izithelo eziphezulu ze-phyto eziqhamukayo.

Ama-ultrasonic ama-disruptors asetshenziselwa ukuchithwa kwempahla yezitshalo

Isizinda se-Ultrasonic esivela kumaseli: isigaba esincane esithintekayo (TS) se-apical stem of mint (Mentha piperita) sibonisa indlela yezenzo phakathi kwesikhumba se-ultrasonic kusuka kumangqamuzana (ukukhulisa 2000x) [isisetshenziswa: Vilkhu et al. 2011]

Ipiperine

I-piperine (i-1-piperyol-piperidine) iyinhlanganisela eyinhloko ye-pepper (i-piper nigrum / i-piper longum, I-Piperaceae). I-pepper flavour, i-pungency yayo, ngakho-ke ikhwalithi yayo, ihambisana nomthamo we-piperine. Lesi simfanelo sekhwalithi singashintshwa ngokukhipha i-hydrolysing piperine, ukuze indandatho ye-piperidine ihlulwe.
I-piperine yaziwa ngemiphumela ehlukahlukene yemithi, isib. I-antifungal, antidiarrhoeal, anti-inflammatory, ne-5-lipoxygenase nemisebenzi ye-cyclooxygenase-1 yokuvimbela. Ngaphezu kwalokho, i-piperine ikwandisa ukutholakala kwemvelo i-curcumin ngo-2000%. Ngakho-ke, i-piperine iyisidakamizwa esithandwayo esisetshenziselwa ukwakheka (isib. BioPerine®).
I-piperine ingasuswa i-piper nigrum futhi i-piper longum.
I-Piperidine iyi-amine yesibili ye-cyclic, okuyinto isakhiwo samangqamuzana esitholakala kuma-alkaloids amaningi. Imiphumela ye-Piperidine evela ku-hydrolysis of piperine. I-Piperidine kanye neziqalo zayo ziyizivimbela ezakhiwe ngokugcwele ekuqalisweni kwemithi kanye namakhemikhali amahle.

Upelepele

i-piper nigrum, pepper omnyama, ngumvini wezimbali emndenini I-Piperaceae. Iyalinywa ngenxa yezithelo zayo ze-peppercorn ngokuvamile ezomile futhi zisetshenziswe njenge-spice kanye nokuvuna. Zonke izinhlobo ze-peppercorns ezimnyama, eziluhlaza kanye ezimhlophe zitholakala esitshalweni somnyama omnyama. Imibala ehlukahlukene yimbangela yokwelashwa nokulungiselela ama-peppercorns. Ama-peppercorns amnyama atholakala ngokubilisa izidakamizwa ezingavuthiwe emanzini ashisayo bese uyomisa ngemva kwalokho. I-pepper elimhlophe livunwa njengamajikijolo avuthiwe okutshalwe yi-pepper; khona-ke isikhumba esimnyama sezithelo ezivuthiwe sisusiwe (retting). Ama-peppercorns ahlaza ayenziwa ngama drupes angavuthiwe ngokuwaphatha nge-sulfur dioxide, ukugaya noma ukugcoba ukuze ugcine imibala yayo eluhlaza.

I-Piper Longum Linn, owaziwa nangokuthi i-pepper ende yamaNdiya (ipipli), isondelene kakhulu i-piper nigrum futhi unenambatho efanayo, kodwa ukunambitheka okushisayo kune i-piper nigrum.
Izithelo i-piper longum iqukethe i-approx. Amaphesenti angu-1 angama-volatile, i-resin, i-alkaloids ipiperine ne-piperlonguminine, i-waxy alkaloid Nisobutyldeca-trans-2-trans-4-dienamide kanye ne-terpenoid. I-piperidine alkaloid piperine inesibopho esiphunga, ukunambitheka okunamathelayo amajikijolo ka-pepper. I-Piperlongumine yinto esebenzayo yezokwelapha ekhombisa umsebenzi olwa nomdlavuza omkhulu, isifuba, amaphaphu, i-colon, i-lymphoma, i-leukemia, i-tumorous primary tumor kanye nomdlavuza wesisu.
Ngaphezu kwalokho, lezi zimali zamaminerali zingatholakala emajikijolo ka-pepper: 1230mg / 100g calcium, 190mg / 100g phosphorous, no-62.1mg / 100g iron. Izimpande ziqukethe i-piperine, i-piperlongumine noma i-piplartine ne-dihydrostigmasterol.