I-Hielscher Ultrasound Technology

Ukusabalalisa kwe-Ultrasonic kwe-C60 ibe yi-Supplements

  • Ukusabalalisa kwe-Ultrasonic yindlela ephakeme yokuhlanganisa i-C60 homogeneously ibe isisindo esisezinzile samafutha-based.
  • Ukwelashwa kwe-ultrasonic emnene, okulawulwa kahle kuqinisekisa ukuthi ama-molecule a-C60 agcinwa ahambelana nemiphumela emihle.
  • Ukuhlanganiswa kwe-ultrasonically blended nano-structured imiphumela ye-bioavailability ye-C60.

Ukuqina okuqinile, okuphezulu okusebenzayo kwe-C60 ne-Ultrasonics

Amafutha e-C60 akhonjisiwe ukuba aphule amagundane’ isikhathi sokuphila nge-approx. 90%. Umphumela wokulondoloza impilo ka-C60 uwukwazi ukucima ama-radicals ahlukene mahhala, okwenza njengesihluku esikhulu samahhala.
Ukuze kusetshenziswe ngomlomo, i-C60 powder kufanele ichitheke emafutheni aphezulu okudla okunjengomnqumo, i-linseed, i-avocado noma amafutha kakhukhunathi. Ukuze uthole ukutholakala okuphezulu, ukufakwa kwe-liposomes (nano-size lipid carrier) kuyadingeka.
Ama-molecule angu-C60 ayaziwa ngenxa yokungabi namanzi aphansi kakhulu, kepha ngisho nalapho i-C60 ixubene namafutha yemifino ayinayo i-bioavailability enhle. Lokhu kwenza kube umsebenzi obalulekile ukudala isengezo nemiphumela efunwa ukuphila-yokwandisa. Ukuze unqobe inkinga yokungabi nalutho, ama-molecule C60 kufanele afakwe ngaphakathi kuma-liposomes.
I-ultrasonic emulsification iyindlela yokwenza kahle eyenziwe kahle yokwakha ama-nano-gxobhothi nama-liposomes. I-C60 efomini ye-liposomal ine-bioavailability ephakeme. I-liposomes elayishiwe i-C60 nayo ingencibilika kwamanzi ukuze ichungechunge lwe-C60-liposome lucubungulwe ngokuqhubekayo emisekelweni yokugcina yamanzi.
Chofoza lapha ukuze ufunde kabanzi mayelana nokulungiselela i-ultrasonic liposome!

Nge-ultrasonics, i-Carbon 60 (C60) ingafakwa kahle kahle kuma-liposomes - okuholela ekutheni kube nokutholakala okuphezulu kakhulu!

I-buckyball ye-C60

Isicelo solwazi




Qaphela kwethu Inqubomgomo yobumfihlo.


Izinzuzo ze-Ultrasonics

  • Ukwelapha okuncane
  • Ama-molecule e-Intact C60
  • I-Liposomal encapsulation
  • Ukutholakala kwe-bioavailability
  • Ukulungiselela okusheshayo
  • Ukwakhiwa okuqinile

Kungani I-C60 Supplement?

Amafutha e-C60 asekutholile ukunakekelwa okwedlule kusukela ukwengezwa kwe-C60 kumagundane kwandise ama-rats’ ukuphila isikhathi eside ngokumangalisa 90%. Umphumela ovelele weCarbon 60 (C60) ngokuphila isikhathi eside kubangelwa kakhulu isenzo saso esiphezulu se-antioxidant. Ama-C60 asebenza njengesiponji esikhululekile – ukuhlambalaza izinhlobo ze-oksijini ezisebenzayo (ROS) ukuze zingalimazi ngokulimaza amangqamuzana anempilo. Ngaleyo ndlela, ukuvuvukala, ukuguga nokuthuthukiswa kwe-desease kungavinjelwa.
Enye incazelo ye-C60 fullerenes’ Impumelelo yokuphila okuqhubekayo yindlela yokusebenza njenge-mitochondria protonophore kanye nokulinganisa okuhlukahlukene kokuthuthwa kwe-C60 kanye ne-hydroxylated yayo nezinye izidakamizwa ngokusebenzisa i-lipid bilayer membranes, okungabangela ukukhwabanisa kwama-fullerenes ezinhlobonhlobo ze-oksijeni esebenzayo futhi abasebenza njengomoya wokuphefumula komzimba we-mitochondrial i-uncouplers.[2]

Izinzuzo ze-C60

  • Ukuphila isikhathi eside
  • Ukukhishwa kwamahhala okukhululekile
  • Ukuvimbela ukuvuvukala
  • Ukuvikela izinzwa
  • Ukuvikelwa emisebeni ye-UVA
  • Ukuqedwa kwamabhaktheriya namagciwane

Amadivayisi we-Ultrasonic

I-Ultrasonicator UP400St ye-liposome ukulungiselela. (Chofoza ukuze ukhulise!)Hielscher Ultrasonics ngumhlinzeki wakho ophezulu wezinqubo ezinamandla nezinokwethenjelwa ze-ultrasonic. Kungakhathaliseki ukuthi udinga i-compact idivayisi ukukhiqiza ama-batches amancane noma ufuna ukukhiqiza amanani amaningi ama-C60, uhla lwemikhiqizo ye-Hielscher lunikeza i-ultrasonicator efanelekayo ngezidingo zakho.

Cela ulwazi oluthe xaxa

Sicela usebenzise ifomu elingezansi, uma ufisa ukucela ulwazi oluthe xaxa mayelana ne-homogenization yama-ultrasonic. Sizojabula ukukunikeza uhlelo lwe-ultrasonic ukuhlangabezana nezidingo zakho.









Sicela uqaphele wethu Inqubomgomo yobumfihlo.


Izincwadi / Izinkomba

  1. I-Baati T.; I-Bourasset F .; I-Gharbi N .; I-Njim L.; Abderrabba M .; I-Kerkeni A .; I-Szwarc H .; UMoussa F. (2012): Ukwandiswa kwenkathi yokuphila yamagundane ngokuphathwa ngokuphindaphindiwe komlomo we-fullerene. Ama-Biomaterials 2012. 1-11.
  2. I-Galvan YP; I-Alperovich I .; I-Zolotukhin P .; I-Prazdnova E .; Mazanko M .; I-Belanova A .; I-Chistyakov V. (2017): Ama-Fullerenes njenge-Anti-Aging Antioxidants. I-Curr Aging Sci. 10 (1); 2017. 56-67.
  3. UMarkovic, Z .; I-Trajkovic, V. (2008): Amandla wezinto eziphilayo ezakhiwe yizifo ze-oksijeni esebenzayo futhi aqedwa yi-fullerenes (C60). Ama-Biomaterials 29/26; 2008. 3561-3573.
  4. Nichita, C .; I-Stamatin, I. I. (2013): Umsebenzi we-antioxidant we-biohybrides ngokusekelwe kwe-carboxylated / hydroxylated carbon nanotubes-flavonoid compounds. I-Digest Journal ye-Nanomaterials kanye neZakhiwo Zomhlaba Vol. 8, No. 1; 2013. 445-455.
  5. I-Prylutska SV; Burlaka AP; I-Yu.I-Prylutskyy. I-Ritter U .; Scharff P. (2011): UKUPHILA C60 FULLERENES KUHLELA UMTHETHO WOKUKHULUMA KWEZINDAWO KANYE NE-METASTASIS. I-oncology yokuhlola 33, 3; 2011. 162-164.


Amaqiniso Okufanele Ukwazi

C60

I-Carbon 60 noma i-C60 i-nano-size fullerene, eyaziwa nangokuthi i-buckminster fullerene, i-buckyballs, i-fullerene, i-carboxyl C60 noma i-fullerene-C60. I-C60 iyi-powder yama-cristall kanye nama-crystals elilodwa anombala omnyama nesimo esifana nesinaliti. I-C60 fullerenes i-hydrophobic kakhulu. Zisuke zingenasifo emanzini, i-acetone, i-ethers, ne-alcohols, kodwa zingancibilika emafutheni (isib. I-avocado, umnqumo, ukhukhunathi, i-linseed, i-MCT oil njll)
Ucwaningo lwe-Pharmacokinetic kumagundane lubonise ukuthi iCarbon 60 encibilikile igxila nge-gastro-intestinal tract futhi iqedwe emahoreni ambalwa ambalwa.
I-C60 yinye indlela yeqoqo le-buckyball. Ilungu elincinci kunazo zonke lamackyballs yi-C20, okuyiyona inguqulo engaxhunyiwe ye-dodecahedrane, kanti uhlobo oluvamile kakhulu lwe-buckyball ngu-C60. I-fullerene C70 yinye uhlobo olujwayelekile kakhulu lwe-buckyball enkulu futhi ngisho no-72, 76, 84 kanye ngisho nama-athomu angu-100 e-carbon atholakala njenge-buckminster fullerenes.
Isakhiwo seC60 sivame ukuhambisana nesakhiwo sebhola lebhola. I-C60 iyi-icosahedron esinezintathu, eyenziwe ngamahektare angu-20 namapentagon ayishumi nambili, ne-athomu ye-carbon ku-vertices ngayinye ye-polygon kanye nesibopho ngakwesokunene ngasinye se-polygon. I-van der Waals ububanzi be-molecule ye-C60 inamaphesenti ayi-1.1 nanometers (nm). I-nucleus kuya nucleus ububanzi be-molecule ye-C60 cishe i-0.71 nm. I-molecule ye-C60 inezinhlangothi ezimbili zokubopha. Izibopho ze-6: 6 (phakathi kwamahektha amabili) zingacatshangwa “izibopho ezimbili” futhi zifushane kunezibopho ezingu-6: 5 (phakathi kwehektaregi ne-pentagon). Ubude bayo obude bokubopha yi-1.4 angstroms.

C60 Imiphumela Yempilo

Uphenyo lwemiphumela eqondile yeC60 emangqamuzaneni nomzimba womuntu kusekuqaleni kwezinyathelo zawo. Kuze kube manje, abacwaningi basikisela ukuthi i-C60 ithinta kakhulu i-mitochondria kumaseli. I-Mitochondria yaziwa ngokuthi izitshalo zamandla eselula, okwenza amandla ngendlela ye-adenosine triphosphate (ATP) ngokusebenzisa inqubo yokuphefumula. Njengoba uneminyaka ekhulayo, ukusebenza kwamaseli kanye ne-mitochondria kuvame ukunciphisa nokusebenza kancane kancane. Ngokwemetabolism ye-cell eyancipha, ama-radicals mahhala kanye nobuthe buthelela kumaseli. Lokhu kwakhiwa kwezinto ezixubile cishe okungenye yezimbangela eziyinhloko zokuguga. Ucwaningo lwezocwaningo lucabanga ukuthi ama-molecule a-C60 akwazi ukungena embranini ye-mitochondria kanye nesibopho nama-radicals amahhala, okuwenza kube lula ukuthi kube yimfucuza yeselula. Lokhu kwandisa ukusebenza kahle kwenqubo yokwenza umzimba futhi kunika amandla amaseli ukufeza imisebenzi yakhe ngokufanele. Ngaphezu kwalokho, kuphakanyiswa ukuthi i-C60 Fullerenes, ehlakazekile ngamafutha omnqumo, isenzo njengokuthi i-adaptogen. Izinto ze-Adagtogenic zenza i-homeostasis, okwenza amangqamuzana angaphansi kokucindezeleka.

Liposomes

I-liposomes i-vesicles eyindilinga encane, engayilungisa, isib. Ngo-sonication. Lezi zinhlayiya ziyindlela ebalulekile yokuhlinzekwa kwezidakamizwa kusukela lapho impahla yabo yokukhulisa iminyango ibenza bahlobise kuzo zombili izimo eziphuthumayo nezama-polar. Lesi sakhiwo esiphambanisayo sibangelwa umsila we-hydrophobic kanye nenhloko yama-hydrophilic noma i-polar ama-liposomes akhiwe kuwo. Ngenxa yalolu hlobo, ama-liposomes asetshenziswa kakhulu njengendlela yokuphatha izakhi nemithi yokwelapha. I-liposomes ingalungiswa ngokuphazamisa izimbungulu eziphilayo. Indlela evamile futhi ephumelelayo ye- Ukulungiselela ama-liposomes yi-ultrasonication.
I-liposomes iqukethe izinto eziphathekayo eziphilayo futhi eziphilayo, okwenza kube yisiphathimandla sezidakamizwa esiphephile.

Ama-Synonyms engeziwe kanye neChimikhali kuma-Buckyballs angu-C60

I-Fullerene C60, i-carboxyl C60, i-99685-96-8, i-fullerene, i- Fullerene 60, i-Footballene, i-Fullerene-C60, i- 5,6] i-fullerene-C60-Ih, i-C60-Ih) [5,6] i-fullerene, i-131159 -39-2, (5,6) i-Fullerene-C60-Ih, i-C60 Compound, i-MFCD00151408, (C_ {60} -I_ {h}) [5,6] fullerene, i-soccerballene, UNII-NP9U26B839, i-CCRIS 9349, [60 -Ih] fullerene, AC1L3WXP, DTXSID4031772, i-CHEBI: 33128, i-Fullerenes – Inhlanganisela ye-C60 / C70, i-XMWRBQBLMFGWIX-UHFFFAOYSA-N, NP9U26B839, i-ZINC85548520