I-Hielscher Ultrasound Technology

Ultrasonic Cucurmin Extraction

  • I-Curcumin iyi-phytochemical yezokwelapha nezomsoco okwamanje ema-rhizomes e-Curcuma longa.
  • Ukuze uthole ukukhiqizwa okuphezulu, i-sonication iyindlela ephumelelayo kakhulu.
  • Isizinda se-ultrasonic imiphumela ephezulu, isivuno esikhulu futhi sidinga isikhathi esifushane sokucubungula.

I-Ultrasonic Isolation ye-Curcumin

Isizinda se-ultrasonic yindlela ephumelelayo kakhulu ekusebenziseni amasu avamile okukhipha njenge-maceration, ishukela se-solvent noma i-Soxhlet isizinda.
Ukuhlukaniswa kwe-Ultrasonic ye-curcumin ne-curcuminoids esitshalweni se-curcuma (isb I-Curcuma longa, I-Curcuma amada) inqubo ephumelelayo, elula futhi elula. Uma kuqhathaniswa ne-Soxhlet isizinda kanye nesisindo esidala se-batch, i-ultrasonically yasiza i-excels ye-excels ne-curcumin ekhuphuka kakhulu isivuno ngesikhathi sokuphumula esifushane.
I-ultrasonic isizinda se-phytoconstituents, i-solvents ehlukahlukene ingasetshenziswa njengamanzi, i-solvents e-aqueous, i-ethanol, i-methanol, i-glycerin njll. Ngoba isisetshenziswa se-curcumin, amanzi, i-ethanol kanye ne-triacylglycerol yi-solvents esebenzayo futhi ephephile, okuholela ekuvuneni okuphezulu khipha.

Izinzuzo:I-powder ye-Turmeric ye-ultrasonic isizinda se-curcumin.

  • isivuno high
  • Ukukhipha okusheshayo
  • Ukuthola okuphelele okuphelele
  • Ukusebenza okuphephile
  • Ukuqaliswa okulula

Inkqubo ye-Ultrasonic Extraction

Imishini ye-Hielscher yombuso ka-Hielscher ivumela ukulawula okugcwele phezu kwemingcele yenqubo efana ne-amplitude, izinga lokushisa, ukucindezela kanye namandla okufaka amandla.
Ukuze kusetshenziswe i-ultrasonic isizinda, imingcele yezingcingo ezifana nobukhulu bezinhlayiya ezibonakalayo, uhlobo lwe-solvent, isilinganiso esiqinile-kuya-solvent, kanye nesikhathi sokukhipha kungenziwa kalula futhi kulungiselelwe imiphumela engcono kakhulu.
Njengoba isilawuli se-ultrasonic yisindlela esingeyona esishisayo yesikhumba, ukuchithwa okushisayo kwama-bioactive izithako kugwenywe.
Ngokuvamile, izinzuzo ezinjengokuvunwa okuphezulu, isikhathi esifushane sokukhipha, ukushisa okuphansi okukhipha, kanye nesilinganiso esincane se-solvent kwenza i-sonication ibe yindlela yokwenza ngcono kakhulu.

Izidakamizwa ze-ultrasonic ezifana ne-UIP1000hdT zisetshenziselwa ukukhishwa kwe-curcumin.

I-UIP1000hdT nge-ultrasonic flow flower

Isicelo solwazi




Qaphela kwethu Inqubomgomo yobumfihlo.


Isizinda se-ultrasonic se-curcumin esivela ku-turmeric sitholakale sisebenza ngokuphumelelayo uma i-sonication isetshenziselwa ukusetha okuhleliwe okuqhubekayo, besebenzisa i-ultrasonic flow cell. Ukushisa kwamazinga okushisa okuphakathi kwama-60 kuya kwangu-80 ° C kuyasiza ekuthuthukiseni isivuno sokukhipha.
Inqubo ephezulu yokusebenza: Isizinda se-Ultrasonic sihle kakhulu njengezinqubo eziqhubekayo ezidinga kuphela ukutshalwa kwemali okulinganiselwe kwemishini ye-ultrasound. Inqubo ye-ultrasonic ingahle ibe ne-linearly eyakhelwe ukukhiqizwa kwezimboni. Izindleko zokuxazulula i-solvent namandla ukuze inqubo ye-ultrasonic iphansi kakhulu. Izinzuzo ezibaluleke kakhulu ukuhlinzwa okulula futhi okuphephile, izindleko zokonga kanye nokukhiqiza kabusha, okubalulekile ekukhiqizeni okuqinisekisiwe.

Ukubunjwa kwe-Lipsonomal Ultrasonic

I-Curcumin iyi-molecule yamakhemikhali e-hydrophobic. Lokhu kusho ukuthi i-curcumin kumele ihlelwe ohlelweni lokuthwala izidakamizwa ezifana nama-liposomes, ama-nanoemulsions, ama-nanospheres, ama-nanoparticles e-polymeric, noma i-phyto-phospholipid complex. Izixazululo ezinama-curcumin ezinamandla zingahle zenziwe ngokufaka ama-surfactants, lipids, albins, i-cyclodextrins, i-biopolymers njll. Ukulungiswa kwe-ultrasonic ye-nanoemulsions kanye nokumisa okwesikhashana kuyindlela ephumelelayo kakhulu yokwenza i-curcumin ibe yinkimbinkimbi yezimboni. Abathwala izidakamizwa bathuthukisa ukuxazululwa kwemithi, ukumuncwa, i-pharmacokinetics, nokutholakala kwe-curcumin. Ngokwenza i-curcumin ibe yi-nano-complexes, ukuxazululwa kwamanzi kuthuthukiswa cishe. I-98000-ihlombe (kuqhathaniswa ne-curcumin yamahhala emanzini). I-nanopleplexation kakhulu ithuthukise ukutholakala kwezinto eziphilayo kanye nokugcinwa kokugcina kwe-curcumin.
Chofoza lapha ukuze ufunde kabanzi mayelana ne-ultrasonic encapsulation kuma-liposomes!

Ultrasonic Isizinda of Ginger omisiwe

Izinsimbi zokusebenza zokususa i-Ultrasonic

I-Hielscher Ultrasonics ingumlingani wakho wezinqubo zesikhumba kusuka ku-botanicals. Kungakhathaliseki ukuthi ufuna ukukhipha imali encane yokucwaninga nokuhlaziywa noma ukucubungula imiqulu emikhulu yokukhiqiza ukuhweba, sinombonisi ofanelekayo we-ultrasonic. Wethu i-ultrasonic lab homogenizers kanye nathi bench-top kanye nezimboni ze-industrial ultrasonicators ziqinile, zisebenziseka kalula futhi zakhiwe ukusebenza kwe-24/7 ngaphansi komthwalo ogcwele. Ububanzi obubanzi Izesekeli ezifana ne-sonotrodes (i-proxy ultrasonic / izimpondo) ezinobukhulu obuhlukene nobubunjwa, amaseli okugeleza nezigameko kanye nezikhuni zivumela ukusetha okuhle kuwe inqubo ethile yokukhipha.
Zonke imishini ye-ultrasonic yedijithali ifakwe isibonisi sokuthinta imibala, i-SD Card edidiyelwe ye-othomathikhi yedatha yokulandelela, kanye nesilawuli esilawuliwe esikude sokuqapha inqubo ephelele. Ngezinhlelo ze-ultrasonic zikaHielscher eziyinkimbinkimbi, ukuhlelwa kwenqubo ephezulu nokulawulwa kwekhwalithi kwenziwa lula.
Xhumana nathi namhlanje ukuxoxa ngezidingo zenqubo yakho yokukhipha! Sizokujabulela ukukusiza ngokuhlangenwe nakho kwethu okuhlala isikhathi eside emithini ye-botanical extractions!

Amandla we-ultrasound yindlela ekhethwayo uma kuziwa ezitokisini zekhwalithi eziphezulu kusuka ku-botanicals. (Chofoza ukuze ukhulise!)

Amaphrosesa ase Industrial industrial with flow cells

Xhumana nathi! / Cela Us!

Cela ulwazi oluthe xaxa

Sicela usebenzise ifomu elingezansi, uma ufisa ukucela ulwazi oluthe xaxa mayelana ne-homogenization yama-ultrasonic. Sizojabula ukukunikeza uhlelo lwe-ultrasonic ukuhlangabezana nezidingo zakho.









Sicela uqaphele wethu Inqubomgomo yobumfihlo.



I-Protocol: Ultrasonic Nano-Encapsulation ye-Curcumin

Ukulungiselela ama-Nanoparticles ayenziwe nge-Curcumin

I-curcumin elayishiwe i-nanoparticles ihlanganiswa ngokusetshenziswa kwezinqubo ze-miniemulsification-evaporation. Inqubo iyahlukahluka kuye ngokuthi i-encapsulant esetshenzisiwe njengoba ichazwe ngezansi. Ukubunjwa okusetshenzisiwe kwakungamanzi angu-22.400g, i-leculin engu-0.180g, i-11.500g dichloromethane, ne-0.390g encapsulant (Poly (L-lactic acid) PLLA, 4,000g / gmol noma poly (methacylic acid-co-methyl methacrylate Eudragit S100, 125,000 g / i-gmol noma ingxube yayo isetshenziswe njenge-encapsulant). Akukho-stabilizer edingekayo ngoba yaziwa ukuthi ama-polymers asengaphambili asebenza kahle ekuvimbeleni ukuchithwa kwe-emulsion ngokusabalalisa.
I-homogenizer Ultrasonic UP100H yokulungiselela ama-nanoparticles ane-curcumin alayishiwe (Chofoza ukuze ukhulise!)Ngesikhathi i-PLLA isetshenzisiwe njenge-encapsulant, i-PLLA ne-lecithin zachithwa ku-dichloromethane imizuzu engu-10, futhi, emva kwalokhu, i-curcumin yengezwe futhi ixubene ngamaminithi angu-5 (1, 3, 6, 18,% wt% we-mass encapsulant mass). Lesi sinkinga sangeziwe emanzini ase-distilled ngaphansi kokugqugquzela okuncane. I-macroemulsion eyakhiwe yenziwa i-sonicated ne-homogenizer ye-ultrasonic efana UP100H imizuzwana engu-180 kumjikelezo we-pulse (30sec sonication, i-10sec break). Emva kwalokho, i-solvent iyashintshwa amahora angu-18 ku-40 ° C. Lapho i-PLLA ne-Eudragit S100 ndawonye isetshenziselwa njenge-encapsulant, i-Eudragit S100 ichitheka ku-dichloromethane ku-60 ° C imizuzu engu-20. Emva kwalokhu, ingxube yayilahliwe futhi i-solvent evaporated yanezelwa futhi.

Izincwadi / Izinkomba



Amaqiniso Okufanele Ukwazi

I-Ultrasound nemiphumela yayo yokukhipha

Ultrasonically kusiza isizinda isekelwe isimiso i-acoustic cavitation. Uma amandla amakhulu e-ultrasound (imvamisa ephansi, i-high intensity US) ihlanganiswa ibe yikhulumi lesikhumba noma esinamathisela, amagagasi adala ukushintsha okuphezulu okucindezelayo (ukucindezela) nokujikeleza okuphansi (okungajwayelekile). Phakathi nale mijikelezo ephezulu yokucindezela / engaphansi kokucindezela, ama-bubbles avumayo akhule futhi akhule phezu kwemijikelezo ehlukahlukene. Ngesikhathi lapho ama-bubbles abengeke athole amandla angaphezulu, athandaza ngokufutheka. Le-bubble implosion nemiphumela yayo yaziwa ngokuthi i-acoustic cavitation. I-cavitation ikhiqiza ama-microjets, amabutho we-shear, ama-shockwaves / ukucindezela okukhulu, ukubunjwa okukhulu, amazinga okushisa okwedlulele nokusakaza kwe-acoustic. Lezi zimo ezimbi ziphula izindonga zamaseli kanye nokudluliswa kwamandla amaningi ukuze i-intracellular impahla idluliselwe ku-solvent.

Izixazululo ezincane, ezingekho ezinobuthi

Izitshalo zamagciwane ezisetshenziselwa ukufaka imithi yokwelapha kanye nezomzimba zithola intshisekelo ekhula ngokushesha njengendlela yokwelashwa kwemithi kanye nezithako zokudla okunomsoco (nutraceuticals). Ukuze ukhulule ama-compounds oyifunayo avela ku-rhe impahla, kufanele ihlakazwe ngaphakathi kwe-solvent. Lapho izitshalo ezihlosiwe zikhishwa kusukela enqwaba yezinto ezitshaliwe futhi zihanjiswe ku-solvent, ukukhishwa kungagxila. Isizinda se-Ultrasonic singasetshenziswa njengendlela yokuxazululwa kwe-solvent-free ngokusebenzisa amanzi njengenxazululwazi. Ukuphuza utshwala ne-glycerin kokubili akuyona into enobuthi futhi ephumelelayo futhi, evame ukusetshenziselwa ukukhipha izithako zokudla, i-pharma kanye nezokuzithokozisa.
Ngokuqondene nokukhiqizwa kwamakhemikhali anamandla kakhulu, anempilo, angenayo i-toxic, kubalulekile ukusebenzisa indlela ephumelelayo yokukhipha, evumela ukusetshenziswa kwamakhemikhali amancane, angenobuthi njengamanzi, ama-triacylglycerol noma utshwala.
Chofoza lapha ukuze ufunde kabanzi mayelana nezixazululo ezisetshenziselwa izinqubo ze-ultrasonic extraction!

i-curcumin

I-Curcumin i-oleoresine e-turmeric ne-pigment yemvelo etholakala kuma-rhizomes wesitshalo se-tumeric. Ezinye izinhlanganisela ezibalulekile ze-curcuminoid yi-demethoxycurcumin (i-DMC) ne-bisdemethoxycurcumin (i-BDMC).
I-Curcumin (ifomula yamakhemikhali C21H20O6) ingasuswa I-Curcuma longa, I-Curcuma amada, I-Curcuma ochrorhiza I-Val. noma okwenziwa ngamakhemikhali.
I-Curcumin ithathwe kwinethiwekhi ye-polysaccharide-lignin ku-turmeric. Ngakho-ke, inqubo enamandla yokuhlanganisa njenge-sonication iyadingeka ukuba iphule izindonga zeseli ukuze kukhishwe i-bioactive phytochemical.
Ucwaningo luye lwabonisa ukuthi i-piperine esebenzayo esebenzayo, etholakala emgqonyeni omnyama, yandisa ukutholakala kwe-curcumin engaphezu kuka-2,000%.

I-Turmeric

turmeric (I-Curcuma longa) isitshalo se-herbaceous esetshenziswa njalo somndeni we-tge ginger I-Zingiberaceae. Ivela eNdiya naseningizimu-mpumalanga ye-Asia. Ama-rhizomes esitshalo se-turmeric avunwa ukuze asetshenziswe njengezinsizi nemithi.
I-Turmeric yi-spice eyenza i-curry umbala wayo ophuzi obomvu futhi isetshenziswe eNdiya iminyaka eyizinkulungwane njenge-spice culinary kanye nemithi ye-ayurvedic. I-powder ye-Turmeric ibhekwe ngendlavane efudumele, enomunyu, efana ne-pepper-like kanye nephunga elimhlaba.
I-powder ye-turmeric noma unamathisele isetshenziselwa ukulungisa isiphuzo esithandwayo esishisayo – okubizwa kanjalo “i-turmeric latte” noma “ubisi lwegolide” – okulungiselelwe ubisi noma ezinye izindlela zokubisi zobisi, njenge-soy, i-almond noma ubisi lwekakhukhunathi.
I-Turmeric inenani lemiphumela yayo yokulwa ne-antioxidative, anti-inflammatory and analgesic.
Ngaphandle kokusebenzisa ukwelashwa nokwelapha, i-turmeric isebenzisa idayi yemvelo.