I-Hielscher Ultrasound Technology

I-Ultrasonic Crystallization ne-Precipitation

  • I-Ultrasound iqalisa futhi ikhuthaza i-nucleation ne-crystallization yama-molecule aphilayo.
  • Ukulawula phezu kwe-crystallization nezinqubo zokuncipha kubalulekile ukuqinisekisa izinga eliphezulu lomkhiqizo.
  • Izinzuzo eziyinhloko ze-crystallization ye-ultrasonic kanye nokusalela eceleni kokulawula okugcwele kwenqubo yilapho yisikhathi sokungeniswa okusheshayo ngokushesha, izinga lokungaphezulu kwe-oversaturation, nokulawulwa kwe-crystal ukukhula.
  • I-Hielscher inikeza imishini esebenzayo yokusebenzisa i-ultrasonic ye-sonocrystallization ephumelelayo ne-sonoprecipitation njenge-batch, ukusabela okuqhubekayo noma oku-in-situ.

Sono-Crystallization & Sono-Isikhuphu

Ukusetshenziswa kwamagagasi e-ultrasonic ngesikhatsi i-crystallization nemvula inemiphumela emihle ehlukahlukene kule nqubo.
I-Power ultrasound iyasiza

  • fometha izixazululo ezingaphezu kwe-saturated / supersaturated
  • qalisa i-nucleation esheshayo
  • lawula izinga lokukhula kwe-crystal
  • lawula imvula
  • lawula ama-polymorphs
  • ukunciphisa ukungcola
  • thola ukusabalalisa usayizi we-crystal usayizi
  • thola ngisho ne-morphology
  • ukuvimbela ukufaka imali engadingeki ezindaweni
  • qalisa i-nucleation yesibili
  • ukuqinisa ukuhlukaniswa okuqinile-uketshezi

Umehluko phakathi kweCrystallization ne-Precipitation

Kokubili, i-crystallization kanye nezulu kunqunywa njengenqubo ehlobene nokuhlangana kwamanzi okusho ukuthi iqinile – kungaba i-crystal noma i-precipitate – isakhiwe isisombululo esiphezulu. Umehluko phakathi kwe-crystallization nesimo sezulu kunomsebenzi wokubunjwa kanye nomkhiqizo wokugcina owenziwe.
Ngesikhathi Crystallization, inethiwekhi ye-crystal ngokukhetha futhi kancane kancane eyakhiwe kusuka emangqamuzaneni ephilayo okwenza a i-cristalline ehlanzekile, i-polymorph isakhi. A Ukwehliswa inqubo ibonakala ngokubunjwa okusheshayo kokuqina okuvela kwisisombululo esiphezulu sokudala i-an crystalline noma amorphous eqinile. I-Crystallization ne-precipitation ngezinye izikhathi akunakunqotshwa ngoba eziningi zezinto eziphilayo zitholakala kuqala njengama-solids ama-amorphus noncrystalline kamuva aphendule ngekristalline ngempela. Kulezi zimo i-nucleation inzima ukuhlukanisa nemvula ye-amorphous eqinile.
I-crystallization nenqubo yokudonsa inqunywa izinyathelo ezimbili ezinkulu, i i-nucleation futhi i crystal ukukhula. Ukuqala i-nucleation, ukuxazululwa kwesisombululo esiphezulu kuqoqa amaqoqo. Lezo ziqoqo zakha i-nuclei okuvela kuyo lapho izinhlabathi zikhula khona.

Izinkinga

I-Crystallization ne-precipitation zivame ukukhetha izinqubo ezikhethiwe kakhulu futhi zikwazi ukulawula kalula. Umphumela wukuthi ngokuvamile, i-nucleation ivela ngezikhathi ezithile, ukuze ikhwalithi yamakhemikhali afanelekile (okusabalalisa) angalawulwa. Ngakho-ke, amakristalu akhona anesayizi esingavunyelwe i-crystal, asatshalaliswa ngendlela engafanele futhi engafani ngendlela efanayo. Amakristalu anjalo anqamukile angabangela kakhulu izinkinga zekhwalithi kusukela ubukhulu be-crystal, ukusabalalisa i-crystal nokuziphatha kwe-morphology yizinga elibaluleke kakhulu lezinhlayiya ezibandayo. I-crystallization engalawulwayo kanye nokusalela kusho umkhiqizo ompofu.

Isixazululo

An ultrasonically basiza crystallization (sonocrystallization) kanye nesimo sezulu (sonoprecipitation) ivumela i-the ukulawula okuqondile phezu kwezimo zenqubo. Yonke imingcele ebalulekile ye-crystallization ye-ultrasonic ingathonywa ngqo – okwenza kube khona i-nucleation elawulwayo ne-crystallization. I-ultrasonically precipitated crystals feature has more umfaniswano usayizi nokuningi i-cubic i-morphology. Izimo ezilawulwayo ze-sonocrystallization zivumela Reproducibility. Yonke imiphumela efinyeleleka ngezinga elincane, ingaba phezulu-ukukhishwa ngokuphelele okukodwa. I-ultrasonic crystallization kanye nezulu kunika amandla ekukhiqizeni okunamandla kwe-crystalline nano-izinhlayiya – kokubili, I-Lab futhi Izimboni isikali.

Imiphumela Ye-Ultrasonic Cavitation

Lapho amagagasi amakhulu e-ultrasonic enamandla ehlanganiswa abe yiziqu, ukushintsha ukucindezela okukhulu / ukucindezelwa okuphansi kwenza ama-bubbles noma ama-voids ku-liquid. Lezi zibhulabhaka zikhula ngaphezu kwemijikelezo eminingana kuze kube yilapho zingenakuthola amandla amaningi ukuze ziwe phansi ngokucindezela ngesikhathi sokujikeleza okucindezelayo. I-phenomenon ye-bubble implosions enjalo enobudlova iyaziwa ngokuthi cavitation futhi libhekene nezimo ezimbi kakhulu zendawo ezifana nokushisa okuphakeme kakhulu, amazinga aphezulu okupholisa, izingcindezi eziphakeme eziphezulu, amagagasi ashaqisayo kanye namajethi e-liquid.
Imiphumela ye-ultrasonic cavitation ukugqugquzela i-crystallization kanye nesimo sezulu ukuhlinzeka ngokuxuba okuhambisana kakhulu kwama-precursors. I-Ultrasonic ukuqedwa iyindlela eqinisekisiwe yokukhiqiza izixazululo ezingaphezu kwe-saturated / supersaturated. Ukuxuba okukhulu futhi ngaleyo ndlela kuthuthukise ukudluliselwa kwamandla kuthuthukisa ukuhluma kwe-nuclei. Ama-shockwaves ama-ultrasonic asiza ukwakheka kwe-nuclei. I-nuclei eningi iyabalwa, i-finer futhi iyashesha kuyokwenzeka ukwanda kwe-crystal. Njengoba i-ultrasonic cavitation ingalawulwa ngokuqondile, kungenzeka ukulawula inqubo ye-crystallization. Izithiyo ezikhona ngokwemvelo ze-nucleation zinqotshwa kalula ngenxa yamandla ase-ultrasonic.
I-Sonication isiza ngesikhathi sokuthiwa yi-nucleation yesibili futhi kusukela ku-cavitation ene-ultrasonic enamandla ukuphumula futhi ama-deggomerom amakristalu amakhulu noma ama-agglomerate.
Nge-ultrasound, ukwelashwa kwangaphambi kwe-precurse ngokuvamile akudingekile ngoba i-sonication ithuthukisa i-reaction kinetics.

I-cavitation ye-Ultrasonic idala amabutho amakhulu kakhulu akhuthaza izinqubo zokukhipha i-crystallization (Chofoza ukuze ukhulise!)

Ultrasonic bubble ukwakheka kanye implosion yayo enobudlova

Ukuthinta i-Crystal Size ngu-Sonication

I-Ultrasound yenza ukwenziwa kwama-crystals afane nezidingo. Izinketho ezintathu zokuxhumana nge-sonication zinemiphumela ebalulekile ekuphumeni:

    1. Sonication yokuqala:

Ukusetshenziswa okusheshayo kwamagagasi e-ultrasound kwisisombululo se-supersaturated kungaqala ukuhluma nokubunjwa kwe-nuclei. Njengoba i-sonication isetshenziswa kuphela ngesikhathi sesigaba sokuqala, ukukhula kristall okulandelayo kulandela ukungafihli sikhulu amakristalu.

    1. Sonication okuqhubekayo:

I-irradiation eqhubekayo yesisombululo se-supersaturated iveza amakristalu amancane kusukela i-ultrasonication engasetshenzisiwe idala iningi le-nuclei eliholela ekukhuleni kwabaningi encane amakristalu.

    1. I-Sonication ene-Pulsed

I-ultrasound ekhishwe ngamapulisi isho ukusetshenziswa kwe-ultrasound ngezikhathi ezimisiwe. Okufakwayo okulawulwa kahle kwamandla e-ultrasonic kuvumela ukuthonya i-crystal ukukhula ukuze uthole ifanelwe usayizi we-crystal.

Izinsiza ze-Ultrasonic

I-Sono-crystallization ne-sono-precipitation izinqubo zingenziwa amabhethri noma ama-reactors avaliwe, njenge eqhubekayo inqubo esebenzayo noma njenge in-situ ukusabela. I-Hielscher Ultrasonics ikunikezela kahle kakhulu idivayisi ultrasonic for sono-crystallization yakho ethize & inqubo-sempiphisa – kungakhathaliseki ukuthi inhloso yocwaningo I-Lab futhi ibhentshi-phezulu isikali noma Izimboni ukukhiqizwa. Ibanga lethu lomkhiqizo obanzi lihlanganisa izidingo zakho. Wonke ama-ultrasonicators angasethwa ku-ultrasonic pulsation imijikelezo – isici esivumela ukuthi sithonye i i-crystal efanelwe usayizi.
Ukwenza ngcono izinzuzo ze-crystallization ultrasonic nakakhulu, ukusetshenziswa kwe-Hielscher's flow flow cell MultiPhaseCavitator Kunconywa. Lokhu kufaka okhethekile kunikeza umjovo we-precursor ngokusebenzisa ama-cannulas ama-48 amahle okuthuthukisa ukuhlwanyela kokuqala kwe-nuclei. Ama-precursors angaba ncamashi i-dosed iholela ekuphakeme ukulawula phezu kwenqubo ye-crystallization.

Idivaysi ye-Ultrasonic ene-reactionor ye-crystallization kanye nokuhanjiswa kwezulu

I-Ultrasonicator I-UIP1500hd

Faka i-InsertMPC48 enama-cannulas ama-48 amahle kakhulu afanele ukukhipha i-sono-crystallization kanye ne-sono-precipitation

Faka i-InsertMPC48 – for sono-crystallization eliphezulu

Ultrasonic Crystallization

 

  • Okusheshayo
  • ephumelelayo
  • ncamashi i-reproducible
  • ukukhishwa kwekhwalithi ephezulu
  • izithelo eziphakeme
  • ukulawula
  • ethembekile
  • izinketho ezahlukene zokusetha
  • ephephile
  • umsebenzi olula
  • kulula ukuhlanza (CIP / SIP)
  • Ukugcinwa okuphansi

 

I-homogenizers ye-ultrasonic yokulungiselela izixazululo ze-supersaturated kanye ne-crystallization esilandelayo kanye nokwephuza kwama-solids

idivayisi ultrasonic UP200S

Isicelo solwazi




Qaphela kwethu Inqubomgomo yobumfihlo.


I-ultrasonication eqhubekayo ne-glass flow cell (Chofoza ukuze ukhulise!)

Sonication kwikhompiyutha ye-reactor

Izincwadi / Izinkomba

  • Deora, NS; Misra, NN; U-Deswal, A .; Mishra, HN; Cullen, PJ; I-Tiwari BK (2013): i-Ultrasound for Crystal Improved ku-Processing Processing. Ukubuyekezwa Kwama-Engineering Engineering, 5/1, 2013. 36-44.
  • Jagtap, Vaibhavkumar A .; I-Vidyasagar, i-G .; Dvivedi, SC (2014): Ukuthuthukiswa kwesisombululo se-rosiglitazone ngokusebenzisa inqubo ye-sonocrystallization encibilikisiwe. I-Journal ye-Ultrasound 17/1., 2014. 27-32.
  • Jiang, Siyi (2012): Ukuhlolwa kwe-Sonocrystallization Kinetics ye-L-Glutamic Acid. I-Doctoral Thesis e-University of Leeds 2012.
  • Luque de Castro, MD; Priego-Capote, F. (2007): I-crystallization eyayisizwa nge-Ultrasound (sonocrystallization). Ultrasonics Sonochemistry 14/6, 2007. 717-724.
  • URuecroft, uGraham; U-Hipkiss, uDavid; Ly, iTuan; Okuthunyelwe, Neil; I-Cains, uPeter W. (2005): I-Sonocrystallization: Ukusetshenziswa kwe-Ultrasound ye-Crystallization Ethuthukisiwe Yezimboni. Process Organic Research and Development 9/6, 2005. 923-932.
  • USander, uJohn RG; Zeiger, uBrad W .; Suslick, Kenneth S. (2014): I-Sonocrystallization kanye ne-sonofragmentation. Ultrasonics Sonochemistry 21/6, 2014. 1908-1915.

Xhumana Nathi / Cela Ukwaziswa Olwengeziwe

Khuluma nathi mayelana nezidingo zakho zokucubungula. Sizosikisela ukusetha nokulungiswa kwemingcele efanele yephrojekthi yakho.





Sicela uqaphele wethu Inqubomgomo yobumfihlo.




Amaqiniso Okufanele Ukwazi

Ukusetshenziswa kwamagagasi amakhulu e-ultrasound kulesosizi, izingxube ezimanzi-eziqinile neziketshezi zamagesi zenza izinqubo eziningi ezakhiweni zesayensi, amakhemikhali, i-biology kanye ne-biotechnology. Ngokufanayo nezinhlelo zayo eziningi, ukuhlanganiswa kwamagagasi e-ultrasonic abe ngamanzi noma ama-slurries kuthiwa ngamagama ahlukahlukene achaza inqubo yomsindo. Amagama avamile yi: sonication, ultrasonication, sonification, irradiation ultrasonic, insonation, sonorisation, kanye insonification.