I-Hielscher Ultrasound Technology

Ama-Nootropics kanye nama-Smart Drug formulations ane-Ultrasonics

Izidakamizwa ezi-Smart nezithasiselo ze-nootropic zidliwa "njengezithuthukisi eziqondayo" ukuze zikhulise ukusebenza kwengqondo, umthamo wobuchopho, ukugxilisa ingqondo, inkumbulo nobuqambi, ukuqinisa ugqozi namandla engqondo kanye nokusekela impilo yobuchopho. Ukuphakamisa ukuthuthwa kwamakhemikhali we-bioactive anjenge-nootropics, izidakamizwa ezihlakaniphile nezinto ezinika amandla kulo lonke igazi-brain-barriers (BBB), ama-molecule kufanele abe kwifomu elithuthukisiwe le-nano. Ama-nano-liposomes alungiselelwe ngokwe-ultrasonically, ama-micoples, ama-nanoparticles aqinile we-Ultrasonic, ama-nanano ahlelekile we-nano kanye ne-nano-emulsions ukukhulisa i-bioavailability yama-molecule we-bioactive, amavithamini nama-phytochemicals.

AmaNootropics noma izidakamizwa eziwusizo zingama-molecule obuchopho bomzimba nomzimba – okubizwa ngokuthi abathuthukisi bokuqonda – , engahlukaniswa ngezigaba ezilandelayo ama-racetams, izishukumisi, ama-adaptogens, ama-cholinergics, ama-serotonergics, ama-dopaminergics, izidakamizwa ezi-metabolic function nezigaba eziningi.
Unentshisekelo kulezo zigaba ezihlukene ze-nootropics? Chofoza lapha ukuze ufunde kabanzi mayelana ne-nootropics kanye nokuhlukaniswa kwabo!

Yini amaLiposomes kanye neLipid-based Nanocarriers?

Ama-liposomes kanye ne-lipid-based nano carriers ezifana ne-nano-emulsions, i-nano-suspensions, i-lipid nanoparticles (SLNs) eqinile ne-nanostructured lipid carriers (NLCs) zaziwa njengezinhlelo zokuthwala izidakamizwa ezinamandla, ezilethela ama-molecule we-bioactive nezakhi ezakhiweni zeseli eziqondisiwe kanye Umphumela walokho ngamanani aphakeme we-bioavailability kanye namazinga wokufaka.

Liposomes

I-Ultrasonication iyindlela ekhethekayo yokwenza ama-liposomes anomthwalo omkhulu wezinto ezihlanganayo.AmaLiposomes angahlukaniswa njengefomu elithile le-nanostructured lipid nanocarriers. AmaLiposomes ama-vesicles ayindilinga anomgogodla omanzi obiyelwe umjikelezo wamabhange owodwa noma amaningi we-lipid. Njengoba ama-liposomes anikeza amandla okubamba ama-molecule we-lipophilic ne-hydrophilic, athola ukwamukelwa okukhulu njengohlelo olunamandla lokulethwa kwezidakamizwa. Esakhiweni sayo esiziqoqele, esizivalile, i-liposome ingakwazi ukufaka imakhompiyutha amaningi (okusho izakhi zomzimba noma ama-molecule okwelapha) ngasikhathi sinye. I-phospholipidic bilayer yayo ivikela ama-molecule we-bioactive afakiwe ukungahambisani ne-hydrolysis kanye nokuwohloka kwe-oxidative. Njengoba ukwakheka kwengqimba ye-liposome kubonisa ukufana okubalulekile kweseli yezilwane ezincelisayo, ama-liposomes ayakwazi ukudlulisa izingxube ze-bioactive zibe amaseli neziza ezingaphansi. Izinzuzo ezaziwayo zezinhlelo zokulethwa kwe-liposomal zifaka phakathi ukuvikela kwazo ekuwohlokeni kwe-enzymatic, ubuthi bawo obuphansi, ukuphakama okuningana kwezinto eziphakeme, i-biodegradability kanye ne-non-immunogenicity.

Ultrasonication is a fast and reliable technique to produce superior liposomes, nanoliposomes and nano-structured lipid carriers.

UP400St, i-400 watts enamandla homogeniser enamandla e-400, yokwenziwa kwe-nano-liposomes.

Isicelo solwazi




Qaphela kwethu Inqubomgomo yobumfihlo.


Liposomes, niosomes, nanoemulsions, solid-lipid nanoparticles, and nanostructured lipid carriers can be produced by ultrasonic emulsification.

Ukwakheka okuhlelekile kwama-liposomes, ama-niosomes, ama-nanoemulsions, ama-nanoparticles aqinile-we-lipid, abathwali be-lipid be-nanostructured
umfanekiso: Poonia et al. 2016

Ezinye Izithwali zeLipidic Nano-Carriers

I-Famotidine-egcwele-lipid nanoparticles (SLNs) eyenziwe nge-FamotidineI-Lipidic nano-carriers noma i-lipid-based nano-carriers ichazwa njengezinhlelo zokulethwa kwezidakamizwa / zama-molecule, ezisebenzisa ukwakheka kwe-lipid ukufaka ama-molecule we-biiovail ukuze kutholakale ukuphuculwa kwe-bioavailability, amazinga aphezulu okufaka, ukuqina okuhlala isikhathi eside nokuvikelwa ngokumelene izinto zokonakaliswa kwangaphandle (isb. i-oxidation, hydrolysis). Izithwali ze-lipid ze-Nanostructured zifaka i-lipid nanoparticles eqinile (i-SLN), i-nanostipured lipid carriers (NLC), nanoliposomes, micelles, nanoemulsions, nanosuspensions kanye ne-lipid nanotubes. Ukwakheka kwamakhemikhali athize kanye nezimpawu zawo ezihambisanayo ze-physicochemical kunika ifomu ngalinye le-nano-carriers izinzuzo ezihlukile, ezizenza zifanele amafomu athile okuphatha (isib. Ngomlomo, ngaphakathi, ngaphakathi, phakathi kwe-transdermal njll), inhlanganisela yamamolekyuli, ukulayisha umthamo noma ukwakheka kwesikhathi.
Ama-solidi e-lipid nanoparticles (SLN) nama-lipid carriers (NLC) achazwa njengezinhlayiya eziqinile eziqukethe i-matrix ye-lipid esigabeni esinamanzi esizinzile ngabasizi bokusebenza.
I-Liposomal namanye ama-nano-encapsated (isb. Ama-SLNs, ama-NLC) anikela nge-bioavailability ephakeme, okusho ukuthi iphesenti eliphakeme kakhulu lezinto eziphilayo (isib. I-vithamini, i-antioxidant, i-flavonoid njll) iyangenwa futhi isungulwe amaseli womzimba. Ingxenyenamba encane kakhulu kuphela edotiwe ngoba ayigwenywa kepha idlulwa ngumzimba. Lokhu kwenza ukwakheka kwe-nano-liposomal kube namandla amakhulu, kusebenze futhi kuthembeke ngoba cishe wonke ama-mocule we-bioactive ahanjiswa kumaseli wokuya.

Ukwakheka kwe-Ultrasonic kweMolekyuli Eyishukumisa nge-Bioavailability ephezulu kakhulu

I-Ultrasonic nano-emulsation ne-nano-encapsulation yenza ama-molecule we-nootropic kanye ne-psychoactive amanzi-ancibilikayo futhi ngaleyo ndlela ancengeke kakhulu futhi abe yi-bioavava. Izinga lokumunca eliphakeme kanye nokukhula kwe-bioavailability kanye nokusebenza ngokweqile kwezinto eziphilayo kwenza into ephilayo ibe namandla amakhulu futhi kungakuvumela ukuwela umgoqo wegazi-ubuchopho.

Ukubethelwa kwe-Ultrasonic kwezinto zokwelapha kuma-nanoparticles e-lipid (SLNs)

Ukulungiswa kwe-Ultrasonic kweSolid-Lipid Nanoparticles
(Kumar et al. 2019)

Ukwenziwa kwe-Ultrasonic kwe-Nootropics

  • Liposomes
  • I-Nano-Emulsions
  • Imicibisholo
  • I-Solid-Lipid Nanoparticles (SLN)
  • Izithwali ze-Nanostructured Lipid Carriers (NLC)
  • I-inclusive Complex (isib. Cyclodextrin)
  • Niosomes
Iprosesa le-Ultrasonic UIP2000hdT (2kW) elinamandla ashukumisayo we-batch

I-homogenizer ye-ultrasonic I-UIP2000hdT (2kW) ene-batch reactionor eqhubekayo

Kunezimpilo zobuchopho eziphindaphindwe kaningi namandla okulekelela ama-molecule, izakhi zomzimba nama-phytochemicals, angakhishwa futhi / noma ahlanganiswe kokungezelelwa okuthuthukisiwe kwe-nano, njengamanzi uketshezi, ama-tincture, amaphaphu, izifutho zamakhala, imikhiqizo yokudla eqinile njll.

Ama-nootropics aziwa kakhulu yizinto zesigaba se-racetam, njenge-piracetam, i-aniracetam, i-oxiracetam, i-pramiracetam ne-phenylpiracetam. Ama-Racetams amaningi angama-lipophilic (= amafutha-anyibilikayo). Kusetshenziswa ukwelashwa kwe-ultrasonic, i-fat-soluble racetam ifakwe ifomu elithuthukisiwe le-nano elifana ne-nano-emulsions, liposomes, solid-lipid nanoparticles (SLNs), kanye ne-nanostructured lipid carriers (NLCs). Lezi zinqubo ezithuthukisiwe ze-nano ziguqula i-repetant enamanzi, i-solar-soluble racetam ibe ngumkhiqizo oncibilikiswa ngamanzi. Njengoba ukugeleza kwegazi emzimbeni womuntu kungokwakhiwa kwamanzi okuncibilikisa okwenziwa ngamanzi okusebenzisa i-nano kunikeze amandla we-bioavailability aphezulu kakhulu.

Ultrasonically Nano-Thuthukisiwe Izidakamizwa ze-Smart

Ubuchwepheshe bokufakelwa kwe-ultrasonic nobuchwepheshe be-nano-formula bunika amandla ukulungiselela ukulungiswa kwezithasiselo ezinamandla kakhulu kanye nemithi yokwelapha. Ama-molecule we-bioactive azuza ekwakhekeni kwe-liposomal noma kolunye uhlelo lwenethiwekhi ethwala i-lipid afaka amavithamini, ama-antioxidants, ama-flavonoid, akhipha i-botanical, amaminerali, ama-amino acid kanye nama-peptides.

  • Amavithamini kanye nama-antioxidants, angahle akhishwe emthonjeni wemvelo noma ahlanganiswe, afaka amavithamini C, amavithamini B, i-glutathione, i-resveratrol, i-CoQ10 (ubiquinone), njll.
  • Ama-molecule we-herbal kanye ne-botanical anjenge-CBD, THC, CBG (cannabis), ikhekhe eliluhlaza okotshani (isib. EGCG), i-nicotine, ikhafeine, i-ashwagandha, i-Berberine, i-kratom njll.
  • Izikhunta / amakhowe akhishwa njenge-astragalus, i-mane's lion, umsila we-turkey, i-chaga, i-psilocybin (amakhowe omlingo), njll.
  • Ama-amino acid anjenge-creatine, glycine, 5-HTP (5-hydroxytryptophan), phenylalanine, L-theanine (i-aninoue analogue etholakala etiyeni), i-GABA (gamma-aminobutyric acid), taurine, N-acetylcysteine (NAC), L -tyrosine, njll.
  • Amaminerali afana ne-magnesium chelates (isb. Magnesium threonate, magnesium orotate) angakwazi ukufakwa ngembobo ephezulu njenge-nano-elementumates in liposomes.
  • Ama-nati, ama-peptides, namanye ama-molecule afana ne-alpha-GPC, i-melatonin, i-choline (choline bitartrate, i-choline chloride), (ubuhlanga) i-ketamine, i-omega-3 fatty acids (EPA, DHA), α-lipoic acid (ALA), selegiline ( I-L-deprenyl), i-centrophenoxine, i-oxytocin, i-methylene eluhlaza okwesibhakabhaka, njll.

Ukwakheka kwe-liposomal okwenziwe ngcono kwama-molecule we-bioactive nezakhi zomzimba kunika i-bioavailability ephakeme futhi kungavumela izinto eziqondisiwe ukuthi zeqe umgoqo wobuchopho begazi. Ukugoqeka kuvimbela ama-molecule we-bioactive ngokumelene ne-hydrolysis eyenziwe nge-acid esiswini nokuwohloka kwe-enzymatic kulo lonke lelo pheshana lesisu, ukuze kuthi inani elikhulu lezakhi lihanjiswe lingonakaliswa endaweni eqondiwe yamangqamuzana.

I-Excursus: Isizinda se-Ultrasonic se-Phyto-Chemicals

I-Sonication ubuchwepheshe obukhulu bokukhipha ama-molecule we-bioactive ezitshalweni, isikhunta namagciwane. Ukukhishwa kwe-Ultrasonic kuyindlela engashisi, yomgomo wayo osebenzayo usekwe ku-acoustic cavitation. I-acoustic / i-ultrasonic cavitation yakha i-shear yemishini kanye neziphithiphithi, eziphelisa futhi ziphazamise izindonga zeseli nolwelwesi futhi zikhuthaza ukudluliselwa ngobuningi. Ngaleyo ndlela, i-sonication ikhipha izinto ezi-bioactive kusuka ezingaphakathi kweseli bese ziyidlulisela endaweni eyi-solvent (isib. Amanzi, i-ethanol, i-glycerine, i-oyela yemifino njll).
Funda kabanzi mayelana nokukhishwa kwe-ultrasonic kwama-molecule we-biioactive kusuka ku-botanicals!

Ama-Ultrasonicators aphezulu enza umsebenzi we-Nootropic

Izinhlelo ze-Hielscher Ultrasonics 'ziyimishini ethembekile esetshenziselwa ukwakhiwa kwezemithi nokwengeza amakhambi ukwakha ama-nootropics asezingeni eliphakeme nezidakamizwa ezihle, ezisukela kuma-nano-emulsions kuya kuma-liposomes, abathwali be-lipid be-nanostructured, i-nanoparticles eqinile, ne-inclusions complexes elayishwe ngamavithamini , ama-antioxidants, ama-flavonoid, ama-peptides, ama-polyphenols nezinye izinto ezihlanganisiwe futhi anikezela nge-bioavailability ephezulu kakhulu, ukuzinza okukhulu nokusebenza. Ukuhlangabezana nezidingo zamakhasimende ayo, ama-Hielscher anikeza ama-ultrasonicators avela ku-compact hand-hand lab homogenizer ehlanganisiwe kanye ne-bench-top ultrasonicators to the yakazara ultrasonicators system for ukwenziwa kwama-high-volumes of nootropics and smart drug formuction. Izinqubo zokuqamba ze-Ultrasonic zingaqhutshwa njenge-batch noma njengenqubo eqhubekayo emugqeni kusetshenziswa i-ultrasonic flow-ngokusebenzisa reactionor. Uhla olubanzi lwe-sonotrodes (i-phenes) nemikhumbi ye-reactor iyatholakala ukuqinisekisa ukusethwa okulungile komkhiqizo wakho we-liposome. Ukuba namandla kwemishini yokusebenza kwe-Hielscher sika-Hielscher kuvumela ukusebenza kwe-24/7 ngaphansi komsebenzi osindayo ezindaweni ezifunwayo futhi kuqinisekiswe umjikelezo wempilo ende we-ultrasonicators.
Hielscher's industrial processors of the hdT series can be comfortable and user-friendly operated via browser remote control.Ukulawulwa okuqondile kwawo wonke amapharamitha wenqubo ebalulekile anjenge-amplitude, ingcindezi, izinga lokushisa nesikhathi se-sonication kwenza inqubo ye-ultrasonic ithembeke futhi izalwe kabusha. I-Hielscher Ultrasonics iyazi ngokubaluleka kwekhwalithi ephezulu yomkhiqizo futhi isekela abakhiqizi abongezayo nabezokwelapha ukuze basebenzise inqubo yokuma kanye ne-GMP (Izindlela Ezinhle Zokukhiqiza) nge-software ehlakaniphile nokuqoshwa kwedatha okuzenzakalelayo. Ama-homogenizer ethu edijithali arekhoda ngokuzenzakalelayo wonke amapharamitha enqubo we-ultrasonic ekhadini le-SD-khadi elakhelwe ngaphakathi. Izithombisi zokuthinta kwedijithali kanye nokulawulwa kude kwesiphequluli kuvumela inqubo eqhubekayo yokuqapha futhi inike amandla ukulungisa amapharamitha wenqubo ngokunembile noma nini lapho kudingeka. Lokhu kusiza ukuqapha kwenqubo kanye nokulawulwa kwekhwalithi kakhulu.
Ithebula elingezansi linikeza isibonakaliso somthamo wokucubungula we-ultrasonicators wethu:

Iqoqwana Ivolumu flow Rate Amadivayisi ezinconyiwe
1 kuya ku-500mL 10 kuya ku-200mL / min UP100H
10 kuya ku-2000mL 20 kuya ku-400mL / min UP200Ht, UP400St
0.1 kuya ku-20L 0.2 kuya ku-4L / min I-UIP2000hdT
10 kuya ku-100L 2 kuya ku-10L / iminithi I-UIP4000hdT
na 10 kuya ku-100L / iminithi UIP16000
na sikhulu yinhlanganisela UIP16000

Xhumana nathi! / Cela Us!

Cela ulwazi oluthe xaxa

Uyacelwa ukuthi usebenzise ifomu elingezansi ukucela ulwazi olungeziwe mayelana nezinhlelo zokusebenza ze-ultrasonic, izinhlelo zokusebenza nentengo. Sizokujabulela ukuxoxa ngenqubo yakho nawe futhi sikunikeze uhlelo lwe-ultrasonic oluhlangabezana nezidingo zakho!









Sicela uqaphele wethu Inqubomgomo yobumfihlo.


I-Hielscher Ultrasonics yenza ama-homogenizer aphezulu we-ultrasonic wokuhlakazeka, i-emulsation kanye nokukhishwa kweseli.

Amandla aphezulu we-homogenizer ephezulu I-Lab kuya umshayeli futhi Izimboni isikali.

Izincwadi / Izikhombo



Amaqiniso Okufanele Ukwazi

Ama-Nootropics nezidakamizwa ezi-Smart

Igama “i-nootropic” lisuselwa kumagama esiGreek asendulo όόός (nóos), amele “ingqondo” kanye ne-τροπή (tropḗ), enencazelo “ukuguquka ”. Ama-Nootropics, abizwa nangokuthi izidakamizwa ezi-smart, "izinto eziguqula ingqondo", okuwukuthi, izinto ezi-bioactive ezithinta ubuchopho ngokwandisa ukusebenza kwengqondo, ikakhulukazi ubuhlakani, imisebenzi ephezulu, inkumbulo, ubuqambi, ukuqaphela, kanye nogqozi. Zisetshenziswa njengezithuthukisi eziqondayo noma njengokuphamba kwengqondo. Ama-nootropics adumile afaka ama-racetams. Ifomu lokuqala elenziwe nge-racetam lasuselwa ku-GABA futhi laziwa ngokuthi yi-piracetam, elibhekwa njengelingelobuthi futhi liphenya isikhathi eside. I-Aniracetam, i-oxiracetam, i-pramiracetam ne-phenylpiracetam ziyefana ngesakhiwo se-piracetam, kepha zibonisa amandla aphezulu okuvusa amandla. Izinhlobo ezintsha ze-racetam ezinjenge-coluracetam, i-fasoracetam, i-nefiracetam, noma i-noopept azinakho ukufana kwesakhiwo ne-piracetam.
Amanye ama-nootropics angaba nemiphumela ye-psychedelic noma i-psycho-active / psychotropic, futhi futhi athinte izinqubo zengqondo, isb. Ukuqonda, ukwazi, ukuqonda, ukuphendula, imizwa nemizwelo.

Ama-Racetams

Ama-Racetams ayaziwa njengohlobo lokuqala lwesidakamizwa esihlakaniphile nge-piracetam njengohlanga lokuqala olwenziwe ngohlobo oluthile okwaziwa ngokuthi yi-nootropic yokuqala eyake yaba khona. IPiracetam iyimolekyulu eqenjini le-racetams enegama lamakhemikhali i-2-oxo-1-pyrrolidine acetamide. Kususelwa ku-neurotransmitter GABA (gamma-aminobutyric acid). IPiracetam iyi-molekyule yezidakamizwa enomgogodla we-pyrrolidone, ovame ukubekelwa iziguli ezinezimpawu ze-Alzheimer's noma pre-dementia. Kodwa-ke, i-piracetam namanye ama-racetam asetshenziswa futhi ngabantu abadala abanempilo ukuze kuqiniswe ukudluliselwa kwamakhemikhali phakathi kwamaseli obuchopho. Ama-Racetams angakhuphula i-IQ ejwayelekile, imisebenzi yememori nokufunda, ukucaca kwengqondo nokukhuthaza. Amanye ama-molecule esigabeni se-racetam yi-pramiracetam, i-oxiracetam, kanye ne-aniracetam.
Njengoba ama-racetams ewela esigabeni sezinto ezingalawulwa e-USA noma kwamanye amazwe amaningi emhlabeni, ama-racetam angathengwa njengama-OTC (ngaphezulu-the-counter) supplements ngaphandle kadokotela. Ama-Racetams abhekwa njengemiphumela emibi engeyona enobuthi futhi ejwayelekile ibandakanya ukuqaqamba kwekhanda, okuwumphumela wokuphelelwa ngamandla kwezinhlanga ezinjenge-choline ebuchosheni. Ngakho-ke, abasebenzisi bavame ukuhlanganisa umthamo wabo we-racetam nesengezo se-choline (isb. I-choline bitartrate. Ama-racetams amaningi anemiphumela emibi ukukhanya kuphela, efana nokusetshenziswa kwe-caffeine ngokweqile.

Izithuthukisi

Izinto ezivuselelayo ezifana ne-caffeine ne-nicotine ziyizidakamizwa ezihle ezisakazeka kakhulu emhlabeni wonke. I-Caffeine ne-nicotine zingama-psychostimulants asemthethweni, kanti ukusetshenziswa kwe-amphetamines okungekho emthethweni akukho emthethweni. Isigaba sezinto ezikhuthazayo sifaka cishe noma isiphi i-molecule ekhuthaza ukuvuka nokuqwashisa jikelele, sinciphise umuzwa wokukhathala nokudangala futhi sikhuphuke ngasikhathi sinye ukusebenza kobuchopho kanye ne-intelligence quotient (IQ). Umuthi olwa ne-narcolepsy Modafinil ungomunye wezidakamizwa ezivelele, ezisetshenziswa ngabantu abanempilo njenge- "off-label cognitive enhancer" ukuthuthukisa umsebenzi wokuqonda. Esinye isidakamizwa esisetshenziswe ngaphandle kwelebuli yi-methylphenidate, umuthi osetshenziselwa ukwelapha i-Attention Deficit Hyperacaction Disorder (ADHD) futhi osetshenziswa ngabantu abanempilo njenge-enhancer cognitive.
Chofoza lapha ukuze ufunde kabanzi mayelana nokukhishwa kwe-ultrasonic kwe i-caffeine futhi i-nicotine!

I-Adaptogens

Izinto ze-Adaptogenic ziyizinhlanganisela ze-phyto-chemical, okusho ama-molecule asuselwa ezitshalweni, aphathwa ukuze kuqiniswe ukuphendula komzimba namasosha omzimba wakho ezimweni ezicindezelayo. Ama-Adaptogener angachazwa njengezakhi “zokugcizelela”, ezivusa umzimba ukuzivumelanisa nokugcina noma ukuphinda uthole i-homeostasis (ukulingana phakathi kwezinqubo ze-metabolic zomzimba). Indlela eyinhloko yesenzo se-adaptogenic ithinta i-hypothalamic-pituitary-adrenal (i-HPA axis) ephendula ukukhuthaza ukucindezelwa kwangaphandle. Cishe wonke ama-adaptogens awela esigabeni semithi engalawulwa, engathengwa njengokwengezekelwa ngaphezulu kwe-counter (OTC). Ama-adaptogen adume kakhulu futhi asetshenziswa kakhulu yi-ginseng, gingerol (ginger), ashwagandha, eleutherococcus senticosus (Sibinsan ginseng), i-Rhodiola rosea (i-Arctic izimpande), i-schisandra chinensis, kava kava, imbali yesifiso, iSt Johns Wort, ne-scutellaria baicalensis (isiChinese isikhumba).
Ingabe iCannabis yi-Adaptogen? I-Cannabis ithole ukunakwa okukhulu eminyakeni yokugcina, ikakhulukazi ngenxa yezingxube zayo zokulwa nokuvuvukala (cannabidiol (CBD)) ne-cannabigerol (CBG). Ngisho nama-cannabinoids ayizithako ezingezona ezinobuthi ezithathwe ezitshalweni futhi anemiphumela yokunciphisa ingcindezi emzimbeni, ama-cannabis nama-cannabinoids awahlukaniswa ngokusemthethweni njengezinto ze-adaptogenic. Kepha njengoba i-CBD, i-CBG nama-adaptogenics eqiniso ekhombisa ukufana ekusebenzeni nasemiphumeleni yawo, kuvame ukusetshenziswa ngokubambisana ukuze kwandiswe ukusebenza kahle kwe-cannabinoid kanye ne-adaptogen.
Ngenkathi ama-adaptogenthi eba nemiphumela ekhuthaza impilo nokunciphisa ingcindezi, akhombisa imiphumela emincane kuphela njengabathuthukisi bokuqonda, "ngese". Ukuthuthukiswa kokuqonda okuvela kuma-adaptogens ikakhulukazi kutholakala ngokulinganisa ukusabela kokuphendula kwengcindezi yomzimba, ukuqina nokuqina kwempilo, kunokuba kuqale ngokuqondile ukukhula kwamangqamuzana obuchopho amasha noma ukuxhumeka kwe-neural.
Qhafaza lapha ukuze ufunde kabanzi mayelana nokukhishwa kwe-adaptha yama-adaptha kusuka kuma-botanicals!

Ama-Cholinergics

Izinto ze-Cholinergic zingxube zamakhemikhali alingisa isenzo se-acetylcholine kanye / noma i-butyrylcholine. Izidakamizwa ezi-based-choline ezisebenzisa i-Choline zidliwe ngemiphumela yazo kwimemori, ukunakwa, kanye nokulawulwa kwemizwa. I-Acetylcholine ingenye yama-neurotransmitters amakhulu ebuchosheni. Futhi kuyingxenye ebalulekile yokusebenza kahle kohlelo lwezinzwa olungemuva. I-Choline ingathathwa njenge-supplement, kepha futhi ikhona ekudleni, isb. Amaqanda amaqanda no-soya abacebile ikakhulukazi kwi-choline.
I-Sulbutiamine (etholakala kwezentengiselwano njenge-OTC (ngaphezulu kwekhawuntari) ngaphansi kwegama lomkhiqizo i-Arcalion) isuselwa ku-thiamine (uvithamini B1), onqamula emngceleni wegazi lobuchopho futhi okwaziyo ukukhulisa amazinga e-thiamine ebuchosheni. Yaziwa ukuthi ithuthukise inkumbulo futhi inqobe ubuthakathaka nokukhathala ngenkathi inciphisa ukuvinjwa kokuziphatha kwengqondo, i-sulbutiamine nayo isetshenziswa ngabasubathi. I-Sulbutiamine ihlukaniswa njengesidakamizwa esihlakaniphile se-cholinergic ngoba le nto isebenza njengomlawuli we-cholinergic ngaphakathi kwe-hippocampus. Lapho isetshenziswa kwimithamo yokwelapha, akukho miphumela emibi eye yabonwa.

I-Serotonergics

I-Serotonin, noma i-5-hydroxytryptamine (5-HT), iyi-monoamine neurotransmitter ebamba iqhaza futhi ilawule imizwa (inhlala-kahle, injabulo), futhi ilinganise ukulala, isifiso sokudla, ukuqonda, ukufunda, inkumbulo, uhlelo lomvuzo nezinqubo eziningi zomzimba ezifana ukuhlanza kanye ne-vasoconstriction. ISerotonin ikhiqizwa ngaphakathi komzimba ngokuchayeka elangeni. Amakhemikhali we-serotonergic wemvelo (i-serotonin-ekhuthaza noma ekhulula), efana ne-L-tryptophan, nawo akhona emithonjeni yokudla.

I-Dopaminergics

Ama-dopaminergics yizidakamizwa ezihlakaniphile ezithinta amazinga e-dopamine ngaphakathi kobuchopho. IDopamine yi-hormone ne-neurotransmitter edlala izindima eziningana ezibalulekile ebuchosheni nasemzimbeni. Isibonelo, indlela ye-dopamine inesibopho semizwa emihle nokusayinwa kwe-biochemical kwempendulo enhle maqondana nokuhlangenwe nakho okumnandi njengokudla okumnandi, ubulili, ukuzibandakanya okuhle komphakathi, njll.
I-Dopamine iyatholakala njengomuthi ngaphansi kwamagama brand we-Intropin, Dopastat, neRevimine, phakathi kokunye, okusetshenziswa kakhulu njengomuthi ovuselelayo ekwelapheni umfutho wegazi ophansi, ukushaya kwenhliziyo okuhamba kancane, nokuboshwa kwenhliziyo.
Izidakamizwa ezihlakaniphile ze-Dopaminergic ziyi-dopamine boosters ezisetshenziselwa ukunqoba amazinga aphansi we-dopamine, ngokuvamile ahambisana namazinga aphansi wamandla, ukuntuleka kwesisusa, i-anhedonia (ukungakwazi ukuzizwa ubumnandi), ukunganaki, ukucindezelwa, imikhuba yokulutha, inkumbulo emibi nokusebenza okuncishisiwe kokufunda. Izidakamizwa ezijwayelekile ze-dopaminergic smart yi-L-tyrosine, i-Yohimbine ne-selegilin (i-MAO inhibitor). Ama-dopamine boosters akhuthaza ukunakwa nokuqaphela ngokwandisa ukusebenza kwe-dopamine ngaphakathi kwengqondo, noma ngokuvimbela ama-enzyme aphule i-dopamine phansi.

Eminye imikhakha yezidakamizwa ezi-smart, izithuthukisi zomqondo, kanye ne-nootropics ifaka ama-glycinergics, adenosinergics, adrenergics, cannabinoidergics, GABAergics, histaminergics, melatonergics, monoaminergics, ne-opioidergics.
Iqembu le- “-ergic” nootropics yizinto ezishintsha uhlelo oluthile emzimbeni nasengqondweni. Uhlelo oluqondile luhlanganiswe engxenyeni yokuqala yegama. Isibonelo, ama-glycinergics alingisa ngqo uhlelo lwe-glycine emzimbeni nasengqondweni, ama-adenosinergics aguqula ngqo uhlelo lwe-adenosine emzimbeni nasengqondweni, ama-dopaminergics enza ohlelweni lwe-dopamine nokunye.

Izinkinga Zokufaka

Ingxenye yokufaka iyinkimbinkimbi lapho into eyodwa yamakhemikhali – okubizwa kanjalo “bamba” – inendawo lapho elinye khona i-mocule – okubizwa kanjalo “isivakashi” – ifakiwe.
Ama-cyclodextrins yizihlanganisela ezisetshenziswa kakhulu zokubamba, ngoba zingakha inhlanganisela yokuhlanganiswa nezinhlobonhlobo eziningi zezinto eziqinile, ezingamanzi neze-gaseous. Izakhi zomzimba zezihambeli zisukela kuma-reagents we-polar anjenge-asidi, amayini, ama-ion amancane (isib. ClO4-, SCN-, halogen anions) kuya kuma-apolar aliphatic nama-hydrocarbons amnandi namagesi angavamile. Izakhiwo zokufakelwa zingahlanganiswa ngesisombululo noma esimweni sekristali. Ukuhlanganiswa kwe-Ultrasonic ye-cyclodextrin-based inclusion complexes kuyindlela ethembekile futhi ephumelelayo yokukhiqiza ukufakwa okuhlanganisiwe, okunikeza ukuqina okuphezulu nokwanda kwe-bioavailability. Amanzi asetshenziswa kakhulu njenge-solvent, yize i-dimethyl sulfoxide ne-dimethyl formamide ezinye izindlela zokuxazulula ezisetshenziswa.
Ngaphandle kokufakwa kwamakhemikhali e-pharmaceutical / nutraceutical, i-cyclodextrin nayo isetshenziswa njengamakhemikhali ezakhamuzi zama-molecule aphunga ukuze athole ukuzinza okuphakeme nokukhipha kancane kancane.
Funda kabanzi mayelana nokukhiqizwa kokufakwa okufakwa ngaphakathi kwe-ultrasonically!