I-Hielscher Ultrasound Technology

ILiposomal Vitamin C Production ne-Ultrasonics

Izindlela zokuqamba ze-liposomal ze-biososal ziyaziwa ngokuma kwazo okuphakeme kwe-bioavailability kanye nesilinganiso sokumunca. IVithamini C, i-antioxidant, iyisengezo esivamile esisetshenziswa kwezidakamizwa ezinomsoco nezokwelapha ukusekela amasosha omzimba womuntu uqobo. I-Ultrasonication iyindlela ethembekile nephephile yokwenza ama-liposomes asezingeni eliphakeme nama-nano-liposomes. Inqubo yokubhuqwa kwe-ultrasonic ikhiqiza ama-liposomes anomthwalo ophakeme wezinto ezisebenzayo, njengevithamini C.

I-Liposomal Vitamin C

Inzuzo yamavithamini we-liposomal ukuthi awalawulwa ngefomu lethebhulethi elijwayelekile noma ifomu le-powder, kepha njengokwakhiwa kwe-liquid okunokwanda kwe-bioavailability. Lokhu kusho ukuthi, amavithamini afakwa emgogodleni wamaseli we-phospholipid spherical, okuthiwa ama-liposomes. Njengoba ama-liposomes anokwakheka okufanayo kwe-phospholipid kulwelwesi lwe-lipid lwamangqamuzana omuntu, angena kalula amangqamuzana omzimba. Ngakho-ke ama-liposomes asetshenziswa ekwakhekeni okwelapha nakwezemithi, kwezithasiselo nakwezondlamzimba, kumkhathi wemvelo nasemkhiqizweni wezimonyo.

Izinzuzo ze-Ultrasonic Liposome Ukulungiselela

  • Ukusebenza kokufakwa okuphezulu
  • Ukusebenza Kokuqina Okuphezulu (EE%)
  • ukuzinza okukhulu
  • Ukwelashwa okungewona owamandla (kuvimbela ukonakaliswa)
  • Ihambisana nokwenziwa okuhlukahlukene
  • inqubo esheshayo
I-Ultrasonic Liposomes – bioavailability Uphakeme
Ama-liposomes alungiselelwe i-ultrasonically asiza ukunqoba isikhathi esifushane sempilo, ukuphakama kwamaseli-ulwelwesi lwesibeletho, kanye nokulimazeka komlomo okungekuhle ngenxa yokuwohloka kwesisu nokulimala kwe-enzymatic kwalezi zinhlanganisela ze-bioactive. Ukuvikelwa ku-biloser ye-phospholipid kuvikela izithako ezisebenzayo ekonakalisweni futhi kukhuphule izinga lokufakwa kwamangqamuzana.
I-encapsulation ye-Ultrasonic isetshenziselwa ukukhiqiza umthamo omkhulu we-liposomes ebangeni lezemithi ngomthwalo ophakeme wezinto ezisebenzayo.

I-UIP1000hdT nge-flow flow reaction ye-liposome

Isicelo solwazi




Qaphela kwethu Inqubomgomo yobumfihlo.


Formation Ultrasonic Liposome

Njengoba ukwakheka kwama-liposomes nama-nanoliposomes akwenzeki njengenqubo ezenzakalelayo, isisetshenziswa samandla siyadingeka ukukhuthaza inqubo yokugoqa. AmaLiposomes angama-vesidle we-lipid, akhiwa lapho ama-phospholipids, isib. Lecithin, engezwa emanzini, lapho enza khona izakhiwo ze-bilayer lapho kusetshenziswa amandla anele, isb nge-sonication. I-Ultrasonication isiza ukuhlelwa kwama-molecule we-lipid, ukuze kutholakale isigaba samanzi esizinzile ngokuqina. I-Sonication ayikhuthazi kuphela ukwakheka kwama-liposomes, futhi inciphisa nosayizi wama-liposomes aphumela kuma-nanoliposomes. Ubungako be-liposome yinto ebalulekile uma kukhulunywa nge-bioavailability kanye nesilinganiso sokumunca ngoba ama-liposomes amancane angangena kalula kulwelwesi lweseli.

Ultrasonic Liposome Size Reduction

Ukuhlakazeka kwe-Ultrasonic kuyindlela elula nesebenzayo yokunciphisa usayizi we-liposomes nokukhiqiza ama-nanoliposomes. Ukuze ulungiselele ama-liposomes amancane, ama-vesicles e-hydrate afakwa amazinyane imizuzu embalwa nge-probe-hlobo ultrasonicator ku-reactionor eqondiswa amazinga okushisa. Njengendlela engashisiyo, engeyona eyemishini, ukuncishiswa kosayizi be-ultrasonic akudicileli phansi ama-phospholipids noma amakhompiyutha we-biioactive.

I-Ultrasonication iyindlela esheshayo nethembekile yokukhiqiza i-nano-liposomes ephakeme.

I-UP400St, i-400 Watts homogeniser enamandla e-ultrasonics, yokwenza ama-liposomes

Ama-Ultrasonic processors weLiposome Production

Hielscher Ultrasonics’ Amasistimu asetshenziswa kabanzi emkhakheni wezemithi nokwengezwa ukwakha ama-liposomes asezingeni eliphakeme alayishwe amavithamini, ama-antioxidants, ama-peptides, ama-polyphenols nezinye izinto ezihlanganisiwe. Ukuhlangana nabathengi bayo’ izimfuno, uHielscher unikeza ama-ultrasonicators avela kuma-compact hand-hand lab homogeniser nama-bench-top ultarsonicators ezinhlelweni ze-ultrasonic zezimboni ngokuphelele zokukhiqizwa kwamanani aphezulu we-liposomal formuction. Uhla olubanzi lwama-sonotrodes we-ultrasonic kanye nama-reactors ayatholakala ukuqinisekisa ukusethwa okuphezulu komkhiqizo wakho we-liposome. Ukuba namandla kwemishini yokusebenza kwe-Hielscher sika-Hielscher kuvumela ukusebenza kwe-24/7 emsebenzini osindayo nasezindaweni ezifunwayo.
Ithebula elingezansi linikeza isibonakaliso somthamo wokucubungula we-ultrasonicators wethu:

Iqoqwana Ivolumu flow Rate Amadivayisi ezinconyiwe
1 kuya ku-500mL 10 kuya ku-200mL / min UP100H
10 kuya ku-2000mL 20 kuya ku-400mL / min UP200Ht, UP400St
0.1 kuya ku-20L 0.2 kuya ku-4L / min I-UIP2000hdT
10 kuya ku-100L 2 kuya ku-10L / iminithi I-UIP4000hdT
na 10 kuya ku-100L / iminithi UIP16000
na sikhulu yinhlanganisela UIP16000

Xhumana nathi! / Cela Us!

Cela ulwazi oluthe xaxa

Uyacelwa ukuthi usebenzise ifomu elingezansi ukucela ulwazi olungeziwe mayelana nezinhlelo zokusebenza ze-ultrasonic, izinhlelo zokusebenza nentengo. Sizokujabulela ukuxoxa ngenqubo yakho nawe futhi sikunikeze uhlelo lwe-ultrasonic oluhlangabezana nezidingo zakho!









Sicela uqaphele wethu Inqubomgomo yobumfihlo.


I-Hielscher Ultrasonics yenza ama-homogenizer aphezulu we-ultrasonic wokuhlakazeka, i-emulsation kanye nokukhishwa kweseli.

Amandla aphezulu we-homogenizer ephezulu I-Lab kuya umshayeli futhi Izimboni isikali.

Izincwadi / Izinkomba



Amaqiniso Okufanele Ukwazi

Vitamin C

IVitamin C, eyaziwa nangokuthi yi-L-ascorbic acid noma i-ascorbate, iyi-antioxidant encibilikiswa ngamanzi enefomula yamakhemikhali engu-C6H8O6. Njenge-anitioxidant, uvithamini C usebenza njengonikela nge-elektrikhi ekuphenduleni okuhlukahlukene kwe-enzymatic kanye ne-non-enzymatic. Ngaphezu kwalokho, i-Vitamin C iyi-cofactor ekuphenduleni okuningi kwe-enzymatic okulawula imisebenzi ebalulekile yemvelo njengokupholisa amanxeba kanye nokuqanjwa kwe-collagen. I-Scurvy iyindlela eyaziwa kakhulu yokushoda kwe-Vitamin C okunzima okwenzeka ngenxa yokulimala kokuhlanganiswa kwe-collagen.
Njengovithamini, i-ascorbic acid ibalulekile emzimbeni womuntu, okusho ukuthi umzimba awukwazi ukwengeza u-Vitamin C, kepha kufanele udliwe ngokudla. Ukudla okune-vitamin C kufaka phakathi izithelo zosawolintshi, i-camu camu, i-acerola, i-kale, i-roseship, i-currant emnyama, i-guava kanye nezinye izithelo nemifino.
Ngenkathi ukudla okulinganisela kahle kukhipha kalula inani elanele le-Vitamin C. Noma kunjalo, izithasiselo zokudla ezifana namaconsi e-vithamini, amaphilisi, amaphilisi, izimpuphu kanye nama-gummies zivame ukusetshenziswa. Ukudla okunconywe nsuku zonke kwe-Vitamin C okwenziwa yi-European Food Safety Authority kungu-110 mg / usuku kwabesilisa nabesifazane abangama-95 mg / usuku lwabantu abadala besifazane.
Ezokwelapha, uvithamini C uphathwa ngemithamo ephezulu ngaphansi kokuqashwa kwezokwelapha ukuze kusekele ukwelashwa komdlavuza nokuqinisa amasosha omzimba. Isibonelo, ucwaningo luthole ukuthi ukudla njalo amavithamini C okunciphisayo ubude nobunzima bokubanda nokubanda komkhuhlane.

Yini iLiposome?

AmaLiposomes ama-vesicles ayindilinga obukhulu be-microsc tropical, angaqala ukusuka kuma-30nm kuya kuma-micrometer ambalwa. Indlela ethembekile yokwakha ama-liposomes ngaphansi kwezimo ezilawulwayo ukugoqa kwe-ultrasonic. Kakhulu, ama-liposomes abunjwe ama-phospholipids, ikakhulukazi i-phosphatidylcholine, kodwa futhi angafaka nezinye izinhlanganisela ze-lipid, njengeqanda phosphatidylethanolamine.
Ukuba ama-vesicles enziwe ngama-phospholipids, ama-liposomes asebenza njengama-microcontainers afaka amakhompiyutha we-bioactive njengamavithamini, ama-antioxidants, ama-polyphenols, ama-peptides, izinto zezidakamizwa (isib. Imigomo, amakhambi okwelapha). I-phospholipid bilayer ifaka umuthi wezinto eziphilayo futhi uyihambise ibe amaseli. Njengoba ama-bilosome bilayers enziwe kusuka kuma-phospholipids afanayo njengama-membranes eseli, ama-liposomes anganqamula ulwelwesi lwamaseli kalula futhi alethe izinto eziwusizo ezingqamuzaneni. Lokhu kwenza ama-liposomes abe ngumthwali wezidakamizwa onamandla kakhulu nge-bioavailability ephezulu kanye nesilinganiso sokumuncwa. Izici ze-amphiphilic zama-bilosers we-phospholipid zenza ukuba i-liposomes inyibilike ku-liquids lwamanzi nolwe-polar.