Isihloko sokusetshenziswa: "Liposomes"
I-liposome iyi-vesicle eyindilinga okungenani ne-lipid bilayer. AmaLiposomes asetshenziswa kabanzi njengezimoto zokulethwa kwezidakamizwa kanye nezakhi zomzimba. Ngenxa yokwakheka nosayizi wayo, ama-liposomes anikeza i-bioavailability enkulu nesilinganiso sokumunca emzimbeni. I-Sonication iyindlela ekhethiwe yokulungiselela ama-liposomes alayishiwe, njengemincane, i-unilamellar vesicles (SUV) ene-diameter ebangeni le-15-50nm noma elikhulu, i-multilamellar vesicles (LMV) enobukhulu obunobubanzi obungu-120-140nm. Iningi lama-liposomes lakhiwa ama-phospholipids, isib. Phosphatidylcholine, kepha amanye ama-lipid, anjengeqanda phosphatidylethanolamine, nawo asetshenziswa ngempumelelo, uma esebenzisana nesakhiwo se-lipid bilayer.
Ama-ultrasonicators ama-Hielscher angamathuluzi athembekile ukukhiqiza ama-liposomes nano-sized futhi enze imikhiqizo ye-liposomal. Ukuqinisekisa ukuphindukuzalwa kanye namazinga aphezulu kakhulu wemikhiqizo ye-liposomal, ama-Hielscher ultrasonicators angalawulwa ngokuqondile. Amapharamitha wenqubo ebaluleke kakhulu we-ultrasonic anjenge-amplitude, isikhathi, izinga lokushisa, nengcindezi angabekwa ngqo futhi aqashwe. Ikhadi le-SD elihlanganisiwe lisebenza ngokuzenzakalelayo ngamapharamitha e-ultrasonic futhi lisize ukuzalwa kabusha kwalapho kanye nokulawulwa kwekhwalithi.
Funda kabanzi ngokusetshenziswa kweprosesa ye-ultrasonic ukulungiselela ama-liposomes!
Amakhasi angu-12 ngalesi sihloko ayakhonjiswa:
I-Ultrasonically Emulsified Cremes Nemikhiqizo Yezimonyo
Imikhiqizo yokunakekelwa kwesikhumba efana ne-cremes, i-lotion, ama-moisturizer, ama-balms kanye namafutha okugcoba ngokuvamile asuselwa ku-submicron- enhle nase-nano-sized emulsions. I-Ultrasonic emulsation idala amabutho aphezulu-abamba futhi isungulwe kahle njengendlela enamandla yokuhlanganisa yesikhumba enokwethenjelwa…
https://www.hielscher.com/ultrasonically-emulsified-cremes-and-cosmetic-products.htm
I-Ultrasonic Milling yeLipstick Production
Ukukhiqizwa kweLipstick kufaka ukugaya nokuxubha kwama-waxes kanye nemibala yemibala ezingeni eliqondakala kahle ukuze kuqinisekiswe iphrofayili ethile yokuthungwa kwemibala. Ukugaya nokuxubha kwe-Ultrasonic kungokwethenjwa, kusebenza kahle, futhi kungashintshana ngokuqondile…
https://www.hielscher.com/ultrasonic-milling-for-lipstick-manufacturing.htm
I-Ultrasonically Ihlelwe i-Famotidine Solid-Lipid Nanoparticles
I-Famotidine yi-molecule ejwayelekile yezokwelapha esetshenziswa emithini yesishisa. Ukuze unqobe i-solubility empofu kanye ne-bioavailability ebumpofu, i-Famotidine ingakhiwa ibe yi-nanoparticles eqinile-i-lipid isebenzisa i-sonication njenge ndlela yokufunda. I-Ultrasonically Famotidine-Loaded Solid Lipid Nanoparticles…
https://www.hielscher.com/ultrasonically-formulated-famotidine-solid-lipid-nanoparticles.htm
Ukwenziwa kwe-Ultrasonic kweNanostructured Lipid Drug Carriers
Ama-Nanostructure lipid carriers (NLCs) ayindlela esezingeni eliphakeme yezinhlelo zokulethwa kwezidakamizwa ezinobukhulu be-nano ezinomgogodla we-lipid negobolondo elinamanzi. Ama-NLC anokuqina okuphezulu, avikela ama-molecule e-bio asebenzayo ekulimaleni futhi anikeze ukukhululwa kwezidakamizwa okuqhubekayo. Ultrasonication kuyinto…
https://www.hielscher.com/ultrasonic-formulation-of-nanostructured-lipid-drug-carriers.htm
I-Nantriposomes ye-Ultrasonic Yezindlela Zokuqina Ezihlanganisiwe
I-Allicin iyindawo esebenza kahle, engakhishwa kuma-clove egalikhi amasha. I-Allicin ithambekele ekuwohlokeni ngakho-ke kufanele yenziwe ifomu lokwengezelelwa okuzinzile ukuze ithole ifomula elinamandla lesikhathi eside. Ukubethelwa kwe-Ultrasonic kwe…
https://www.hielscher.com/ultrasonic-nanoliposomes-for-stabilised-allicin-formulations.htm
Ultrasonic Solvent-Free Garlic Extraction
I-Garlic (Allium sativum) inothile ngama-organosulfur compounds (isib. Allicin, glutathione), ezikhuthaza izinzuzo eziningi zezempilo. Ukukhishwa kwe-Ultrasonic kuyindlela ethembekile futhi ephumelelayo yokukhiqiza okukhishwe kakhulu kwegalikhi. I-Ultrasonication iphumela ezithelweni eziphakeme zekhwalithi ephezulu, egcwele…
https://www.hielscher.com/ultrasonic-solvent-free-garlic-extraction.htm
Ukukhiqizwa kwe-Ultrasonic kweLiposomal Omega-3 Fatty Acids
AmaNanoliposomes yizithwali zezidakamizwa ezisebenza kahle ezisetshenziselwa ukuthuthukisa i-bioavailability yezakhi ze-bioactive ezinjenge-omega-2 fatty acids, amavithamini nezinye izinto. Ukubethelwa kwe-Ultrasonic kwezakhi ezixubile kuyindlela esheshayo nelula yokulungiselela ama-nanoliposomes aphezulu…
https://www.hielscher.com/ultrasonic-production-of-liposomal-omega-3-fatty-acids.htm
Kuthuthukisiwe Remdesivir Solubility ngu Sonication
I-Remdesivir (GS-5734) umuthi olwa negciwane, ophansi kocwaningo lokwelapha isifo se-Ebola virus and COVID-19, obangelwa yi-Sars-CoV-2 coronavirus. I-Remdesivir yikhambi lezemithi, elilawulwa ngaphakathi. Ngenkathi ukuqeda okufushane kwe-ultrasonic kukodwa kukhulisa…
https://www.hielscher.com/improved-remdesivir-solubility-by-sonication.htm
I-Ultrasonic Nano-Encapsulation ye-Ivermectin
Izidakamizwa ezinje nge-avermectin ne-ivermectin zivame ukufakelwa kwizithwali zezidakamizwa ezingekho nano ukuze zithuthukise isilinganiso sokuncipha kanye ne-bioavailability kanye nokuthola umphumela ‑ wokukhululwa. I-Ultrasonic nano-emulsation iyindlela ephumelelayo nethembekile yokufaka amakhompiyutha ezokwelapha asebenza kuwo…
https://www.hielscher.com/ultrasonic-nano-encapsulation-of-ivermectin.htm
I-Nano-Encasised Intranasal Vaccine Against I-Pneumoniae ene-Ultrasonics
Izithwali zezidakamizwa ezenzelwe iNanoparticle zingubuchwepheshe obuguqukayo, obuvumela ukwakheka kwezinhlelo zokulethwa komjovo ngesilinganiso esiphakeme sokuvikela ezifweni ezahlukahlukene. I-Ultrasonic emulsation kanye ne-encapsulation kuyindlela ephumelela kakhulu yokulungiselela ukuthwala izidakamizwa ze-nano…
https://www.hielscher.com/nano-encasulated-intranasal-vaccine-against-s-pneumoniae-with-ultrasonics.htm
ICoronavirus (COVID-19, SARS-CoV-2) ne-Ultrasonics
I-Ultrasonication iyithuluzi elinamandla elisetshenziswa ku-biology, chemistry chemistry kanye ne-biochemistry nasekukhiqizweni kwemithi yemithi. I-Bio-science isebenzisa ama-homogenizer e-ultrasonic ukwenza ama-lyse cell futhi akhiphe amaprotheni nezinye izinto eziwusizo, imboni ye-pharma isebenzisa ama-ultrasonics…
https://www.hielscher.com/coronavirus-covid-19-sars-cov-2-and-ultrasonics.htm
I-Ultrasonic Synthesis ye-Pharma-grade Chloroquine
IChloroquine ibukeka njengesidakamizwa esithembisayo ekulweni nobhubhane lwe-COVID-19. Ngenkathi i-chloroquine iyisidakamizwa esidumile, eshibhile, ukulethwa kumele kuklanywe kakhulu ukuze kufezekiswe isidingo samanje. I-Ultrasonic synthesis ilula, iphephile…
https://www.hielscher.com/ultrasonic-synthesis-of-pharma-grade-chloroquine.htm