Isihloko sokusetshenziswa: "Ukukhiqizwa kwe-Ultrasonic liposome nezinzuzo zayo" I-liposome iyi-vesicle eyindilinga okungenani ne-lipid bilayer. AmaLiposomes asetshenziswa kabanzi njengezimoto zokulethwa kwezidakamizwa kanye nezakhi zomzimba. Ngenxa yokwakheka nosayizi wayo, ama-liposomes anikeza i-bioavailability enkulu nesilinganiso sokumunca emzimbeni. I-Sonication iyindlela ekhethiwe yokulungiselela ama-liposomes alayishiwe, njengemincane, i-unilamellar vesicles (SUV) ene-diameter ebangeni le-15-50nm noma elikhulu, i-multilamellar vesicles (LMV) enobukhulu obunobubanzi obungu-120-140nm. Iningi lama-liposomes lakhiwa ama-phospholipids, isib. Phosphatidylcholine, kepha amanye ama-lipid, anjengeqanda phosphatidylethanolamine, nawo asetshenziswa ngempumelelo, uma esebenzisana nesakhiwo se-lipid bilayer. Ama-ultrasonicators ama-Hielscher angamathuluzi athembekile ukukhiqiza ama-liposomes nano-sized futhi enze imikhiqizo ye-liposomal. Ukuqinisekisa ukuphindukuzalwa kanye namazinga aphezulu kakhulu wemikhiqizo ye-liposomal, ama-Hielscher ultrasonicators angalawulwa ngokuqondile. Amapharamitha wenqubo ebaluleke kakhulu we-ultrasonic anjenge-amplitude, isikhathi, izinga lokushisa, nengcindezi angabekwa ngqo futhi aqashwe. Ikhadi le-SD elihlanganisiwe lisebenza ngokuzenzakalelayo ngamapharamitha e-ultrasonic futhi lisize ukuzalwa kabusha kwalapho kanye nokulawulwa kwekhwalithi. Funda kabanzi ngokusetshenziswa kweprosesa ye-ultrasonic ukulungiselela ama-liposomes! Amakhasi angu-12 ngalesi sihloko ayakhonjiswa: Izinqubo Zokukhiqiza Ezingasheshi Nezinganele I-Ultrasonication inqubo esungulwe kahle yokuqinisa inqubo, esetshenziswa ezinhlotsheni eziningi zezicelo zamanzi ezifana ne-homogenization, ukuxuba, ukusabalalisa, ukugaya okumanzi, i-emulsification kanye nokwenza ngcono ukusabela kwamakhemikhali okungafani. Uma inqubo yakho yokukhiqiza ingasebenzi kahle futhi ingasebenzi… https://www.hielscher.com/ramp-up-slow-and-insufficient-manufacturing-processes.htm Emulsifiers Ultrasonic I-emulsion uhlelo olunezigaba ezimbili lweziphuzo ezimbili ezingafundeki, lapho isigaba esisodwa, isigaba esibizwa ngokuthi sangaphakathi noma esihlakazekile, sisatshalaliswa njengamaconsi amancane kwesinye, isigaba esibizwa ngokuthi sangaphandle noma esiqhubekayo. Ukulungiselela i-emulsion, okokufaka okuvamile kwamandla… https://www.hielscher.com/ultrasonic-emulsifiers.htm I-Ultrasonic Nanostructuring yama-Antibiotic Ukukhiqizwa kwama-antibiotic okusizwa nge-Ultrasonically kungakhuphula ukusebenza kwawo, eben ngokumelene namagciwane amelana nemithi: Inani elandayo lamagciwane amelana nemithi elwa namagciwane kuyinkinga engakaxazululwa yokwenza ukutheleleka kwamagciwane, okuphathwe ngempumelelo ngama-antibiotic emashumini eminyaka edlule, a… https://www.hielscher.com/ultrasonic-nanostructuring-of-antibiotics.htm Isizinda se-Ultrasonic Elderberry Ukukhishwa kwe-Elderberry kuyaziwa ngezindawo zazo zokulwa namagciwane futhi ngaleyo ndlela kusetshenziswa kakhulu njengekhambi lemvelo lokunciphisa izimpawu zomkhuhlane ezifana nomkhuhlane, ukukhwehlela, nomphimbo obuhlungu. Ukukhiqiza ukukhishwa kwe-elderberry nge-polyphenol ephezulu nokuqukethwe kwe-antioxidant, kumnene… https://www.hielscher.com/ultrasonic-elderberry-extraction.htm Izingxube eziphezulu ze-Shear Zezokwakha Izilwane Zokudla Ekhiqizweni kokudla kwezilwane kudinga imishini yokuxuba ephezulu ye-shear ephezulu yokupheka ukuze kulungiswe ukuxutshwa okuxubile kwezithako ezahlukahlukene. Abaxube be-Ultrasonic bahlinzeka ngemikhosi ye-shemas ephezulu ephezulu engacubungula amaslayidi we-viscous kakhulu nezinhlama. Ngaphezu kwalokho, abahlanganisi be-ultrasonic bayasetshenziselwa ukukhiqiza ama-nano-emulsions azinzile futhi… https://www.hielscher.com/high-shear-mixers-for-pet-food-manufacturing.htm Indlela Esebenzayo Yokuyisusa Esetshenzisiwe Ye-Botanical Extracts Ngabe ufuna isethaphu esinamandla nesinokwethenjelwa sokukhishwa ukuze ukhiqize izingcwecwe ezisezingeni eliphakeme ze-botanical? Lapha ungathola ukuqhathanisa kwamasu wokukhishwa okujwayelekile kufaka phakathi isizinda se-ultrasonic, isizinda se-supercritical CO2, isizinda se-ethanol, i-maceration phakathi kwabanye nezinzuzo zabo… https://www.hielscher.com/most-efficient-botanical-extracts.htm Ama-Nootropics kanye nama-Smart Drug formulations ane-Ultrasonics Izidakamizwa ezi-Smart nezithasiselo ze-nootropic zidliwa "njengezithuthukisi eziqondayo" ukuze zikhulise ukusebenza kwengqondo, umthamo wobuchopho, ukugxilisa ingqondo, inkumbulo nobuqambi, ukuqinisa ugqozi namandla engqondo kanye nokusekela impilo yobuchopho. Ukukhuthaza ezokuthutha… https://www.hielscher.com/nootropics-and-smart-drug-formulations-with-ultrasonics.htm I-Liposomal encapsured Bioactive Molecule enama-Ultrasonics I-Ultrasonication yaziwa kahle ukuthi isebenza kahle kakhulu ekuhlelweni kwamakhemikhali we-liposomal. Izinhlobo zokwenziwa kwe-liposome ejwayelekile zihlanganisa i-vitamin C, i-CBD, i-curcumin, i-quercitin, i-astaxanthin, ama-peptides kanye nezinye izinto eziyinkimbinkimbi ngokusebenzisa i-ultrasonication. I-Ultrasonic liposome encapsulation elula, esheshayo… https://www.hielscher.com/liposomal-encapsulated-bioactive-molecules-with-ultrasonics.htm Amakhemikhali Amanzi Nolan-Nano-THC Amanzi nge-Solution Ukwakhiwa kweziphuzo ezithuthukisiwe ze-THC kuyinselele. - Iziphuzo ezisetshenziswe yi-THC kufanele zithuthukiswe ukuze zinikeze i-bioavailability ephezulu kanye ne-potency, ukuqina kwesikhathi eside nokubukeka okucacile. I-Ultrasonic nano-emulsization ye-THC ibe isiphuzo isebenza ngempumelelo futhi iyasebenza… https://www.hielscher.com/water-soluble-nano-thc-formulations-with-sonication.htm I-Ultrasonically Emulsified Cremes Nemikhiqizo Yezimonyo Imikhiqizo yokunakekelwa kwesikhumba efana ne-cremes, i-lotion, ama-moisturizer, ama-balms kanye namafutha okugcoba ngokuvamile asuselwa ku-submicron- enhle nase-nano-sized emulsions. I-Ultrasonic emulsation idala amabutho aphezulu-abamba futhi isungulwe kahle njengendlela enamandla yokuhlanganisa yesikhumba enokwethenjelwa… https://www.hielscher.com/ultrasonically-emulsified-cremes-and-cosmetic-products.htm I-Ultrasonic Milling yeLipstick Production Ukukhiqizwa kweLipstick kufaka ukugaya nokuxubha kwama-waxes kanye nemibala yemibala ezingeni eliqondakala kahle ukuze kuqinisekiswe iphrofayili ethile yokuthungwa kwemibala. Ukugaya nokuxubha kwe-Ultrasonic kungokwethenjwa, kusebenza kahle, futhi kungashintshana ngokuqondile… https://www.hielscher.com/ultrasonic-milling-for-lipstick-manufacturing.htm I-Ultrasonically Ihlelwe i-Famotidine Solid-Lipid Nanoparticles I-Famotidine yi-molecule ejwayelekile yezokwelapha esetshenziswa emithini yesishisa. Ukuze unqobe i-solubility empofu kanye ne-bioavailability ebumpofu, i-Famotidine ingakhiwa ibe yi-nanoparticles eqinile-i-lipid isebenzisa i-sonication njenge ndlela yokufunda. I-Ultrasonically Famotidine-Loaded Solid Lipid Nanoparticles… https://www.hielscher.com/ultrasonically-formulated-famotidine-solid-lipid-nanoparticles.htm Isicelo sokwaziswa okwengeziwe Uma ungakutholanga obekufuna, sicela uxhumane nathi! Igama Ikheli le-imeyili (elidingekayo) Inombolo yocingo umkhiqizo noma indawo yesithakazelo Sicela uqaphele wethu Inqubomgomo yobumfihlo. Xhumana nathi
Izinqubo Zokukhiqiza Ezingasheshi Nezinganele I-Ultrasonication inqubo esungulwe kahle yokuqinisa inqubo, esetshenziswa ezinhlotsheni eziningi zezicelo zamanzi ezifana ne-homogenization, ukuxuba, ukusabalalisa, ukugaya okumanzi, i-emulsification kanye nokwenza ngcono ukusabela kwamakhemikhali okungafani. Uma inqubo yakho yokukhiqiza ingasebenzi kahle futhi ingasebenzi… https://www.hielscher.com/ramp-up-slow-and-insufficient-manufacturing-processes.htm
Emulsifiers Ultrasonic I-emulsion uhlelo olunezigaba ezimbili lweziphuzo ezimbili ezingafundeki, lapho isigaba esisodwa, isigaba esibizwa ngokuthi sangaphakathi noma esihlakazekile, sisatshalaliswa njengamaconsi amancane kwesinye, isigaba esibizwa ngokuthi sangaphandle noma esiqhubekayo. Ukulungiselela i-emulsion, okokufaka okuvamile kwamandla… https://www.hielscher.com/ultrasonic-emulsifiers.htm
I-Ultrasonic Nanostructuring yama-Antibiotic Ukukhiqizwa kwama-antibiotic okusizwa nge-Ultrasonically kungakhuphula ukusebenza kwawo, eben ngokumelene namagciwane amelana nemithi: Inani elandayo lamagciwane amelana nemithi elwa namagciwane kuyinkinga engakaxazululwa yokwenza ukutheleleka kwamagciwane, okuphathwe ngempumelelo ngama-antibiotic emashumini eminyaka edlule, a… https://www.hielscher.com/ultrasonic-nanostructuring-of-antibiotics.htm
Isizinda se-Ultrasonic Elderberry Ukukhishwa kwe-Elderberry kuyaziwa ngezindawo zazo zokulwa namagciwane futhi ngaleyo ndlela kusetshenziswa kakhulu njengekhambi lemvelo lokunciphisa izimpawu zomkhuhlane ezifana nomkhuhlane, ukukhwehlela, nomphimbo obuhlungu. Ukukhiqiza ukukhishwa kwe-elderberry nge-polyphenol ephezulu nokuqukethwe kwe-antioxidant, kumnene… https://www.hielscher.com/ultrasonic-elderberry-extraction.htm
Izingxube eziphezulu ze-Shear Zezokwakha Izilwane Zokudla Ekhiqizweni kokudla kwezilwane kudinga imishini yokuxuba ephezulu ye-shear ephezulu yokupheka ukuze kulungiswe ukuxutshwa okuxubile kwezithako ezahlukahlukene. Abaxube be-Ultrasonic bahlinzeka ngemikhosi ye-shemas ephezulu ephezulu engacubungula amaslayidi we-viscous kakhulu nezinhlama. Ngaphezu kwalokho, abahlanganisi be-ultrasonic bayasetshenziselwa ukukhiqiza ama-nano-emulsions azinzile futhi… https://www.hielscher.com/high-shear-mixers-for-pet-food-manufacturing.htm
Indlela Esebenzayo Yokuyisusa Esetshenzisiwe Ye-Botanical Extracts Ngabe ufuna isethaphu esinamandla nesinokwethenjelwa sokukhishwa ukuze ukhiqize izingcwecwe ezisezingeni eliphakeme ze-botanical? Lapha ungathola ukuqhathanisa kwamasu wokukhishwa okujwayelekile kufaka phakathi isizinda se-ultrasonic, isizinda se-supercritical CO2, isizinda se-ethanol, i-maceration phakathi kwabanye nezinzuzo zabo… https://www.hielscher.com/most-efficient-botanical-extracts.htm
Ama-Nootropics kanye nama-Smart Drug formulations ane-Ultrasonics Izidakamizwa ezi-Smart nezithasiselo ze-nootropic zidliwa "njengezithuthukisi eziqondayo" ukuze zikhulise ukusebenza kwengqondo, umthamo wobuchopho, ukugxilisa ingqondo, inkumbulo nobuqambi, ukuqinisa ugqozi namandla engqondo kanye nokusekela impilo yobuchopho. Ukukhuthaza ezokuthutha… https://www.hielscher.com/nootropics-and-smart-drug-formulations-with-ultrasonics.htm
I-Liposomal encapsured Bioactive Molecule enama-Ultrasonics I-Ultrasonication yaziwa kahle ukuthi isebenza kahle kakhulu ekuhlelweni kwamakhemikhali we-liposomal. Izinhlobo zokwenziwa kwe-liposome ejwayelekile zihlanganisa i-vitamin C, i-CBD, i-curcumin, i-quercitin, i-astaxanthin, ama-peptides kanye nezinye izinto eziyinkimbinkimbi ngokusebenzisa i-ultrasonication. I-Ultrasonic liposome encapsulation elula, esheshayo… https://www.hielscher.com/liposomal-encapsulated-bioactive-molecules-with-ultrasonics.htm
Amakhemikhali Amanzi Nolan-Nano-THC Amanzi nge-Solution Ukwakhiwa kweziphuzo ezithuthukisiwe ze-THC kuyinselele. - Iziphuzo ezisetshenziswe yi-THC kufanele zithuthukiswe ukuze zinikeze i-bioavailability ephezulu kanye ne-potency, ukuqina kwesikhathi eside nokubukeka okucacile. I-Ultrasonic nano-emulsization ye-THC ibe isiphuzo isebenza ngempumelelo futhi iyasebenza… https://www.hielscher.com/water-soluble-nano-thc-formulations-with-sonication.htm
I-Ultrasonically Emulsified Cremes Nemikhiqizo Yezimonyo Imikhiqizo yokunakekelwa kwesikhumba efana ne-cremes, i-lotion, ama-moisturizer, ama-balms kanye namafutha okugcoba ngokuvamile asuselwa ku-submicron- enhle nase-nano-sized emulsions. I-Ultrasonic emulsation idala amabutho aphezulu-abamba futhi isungulwe kahle njengendlela enamandla yokuhlanganisa yesikhumba enokwethenjelwa… https://www.hielscher.com/ultrasonically-emulsified-cremes-and-cosmetic-products.htm
I-Ultrasonic Milling yeLipstick Production Ukukhiqizwa kweLipstick kufaka ukugaya nokuxubha kwama-waxes kanye nemibala yemibala ezingeni eliqondakala kahle ukuze kuqinisekiswe iphrofayili ethile yokuthungwa kwemibala. Ukugaya nokuxubha kwe-Ultrasonic kungokwethenjwa, kusebenza kahle, futhi kungashintshana ngokuqondile… https://www.hielscher.com/ultrasonic-milling-for-lipstick-manufacturing.htm
I-Ultrasonically Ihlelwe i-Famotidine Solid-Lipid Nanoparticles I-Famotidine yi-molecule ejwayelekile yezokwelapha esetshenziswa emithini yesishisa. Ukuze unqobe i-solubility empofu kanye ne-bioavailability ebumpofu, i-Famotidine ingakhiwa ibe yi-nanoparticles eqinile-i-lipid isebenzisa i-sonication njenge ndlela yokufunda. I-Ultrasonically Famotidine-Loaded Solid Lipid Nanoparticles… https://www.hielscher.com/ultrasonically-formulated-famotidine-solid-lipid-nanoparticles.htm