I-Hielscher Ultrasound Technology

Kusetshenziswe Kakhulu i-Cannabidiol (CBD) evela eCannabis

I-hielscher ultrasonic extractors yiyona ndlela yokusebenza yobuciko uma kuziwa endaweni ethembekile futhi ephumelelayo yamafutha we-hemp ne-CBD. I-ultrasonication yaziwa kakhulu njengendlela yokukhishwa kakhulu enamandla yokukhipha izici eziwusizo kusuka ku-botanicals. Uma kuqhathaniswa nezinye izindlela zokufakelwa njenge-extraction CO2 extraction, inqubo ye-ultrasonic idlula ekusebenzeni kahle, ukusebenza okulula nokusetshenziswa okunemisebenzi eminingi.

Isizinda se-Ultrasonic

Isizinda se-Ultrasonic siyaziwa kahle futhi inqubo eyisikhathi eside esungulwe ukuze kukhishwe amakhemikhali abalulekile kusuka ku-botanicals. Ngakho-ke, i-sonification iyindlela enhle yokukhiqiza amafutha e-CBD aphezulu. Nge-cavitation e-ultrasonic elawulwa ngokucophelela, amangqamuzana okutshala ahlanjululwa futhi i-solvent iphoqelelwa ngaphakathi esitokisini, lapho ithatha khona izinhlanganisela ze-intracellular ezifana ne-cannabinoids, i-terpenes, i-flavonoids njll.

Ukukhishwa kwe-Ultrasonic kusetshenziselwa kabanzi ukukhiqizwa kokukhishwa kwe-botanical njenge-CBD kusuka ku-cannabis ne-hemp. I-Ultrasonication isebenza kahle futhi iyashesha.

Isizinda se-Ultrasonic of Botanicals njenge-CBD kusuka ku-Cannabis

Inzuzo enkulu ye-ultrasonication yi-range lokushisa, lapho isizinda singenziwa khona. Isizinda se-Ultrasonic singenziwa kusuka ku-ethanol eshisayo / efudumele kuze kufike ku-ethanol ye-cryogenic (-70 ° C). Lokhu kuvumela ukuhlukaniswa okuhlosiwe kwama-compounds oyifunayo. I-Sonication ekwenzeni i-ethanol e-cryogenic i-ethanol ikakhulukazi emathangeni angama-cannabinoids kanye ne-terpenes, ngenkathi isithwathwa eshisayo / eshisayo se-ethanol siphumela ezinhlobonhlobo ezihlukahlukene zama-phytochemical (eg aldehydes, esters, ethyls, ketones). Izitshalo ezigcwele izimboni ziqukethe ubuningi bezinhlanzi ezinamagciwane, amathepenethi namanye ama-phytochemicals. Ngokusho komthelela we-entourage, amakhemikhali amakhemikhali (isib. Ama-cannabinoids) anemiphumela emihle futhi asebenze kangcono kanye namanye amakhemikhali e-botanical. Lokhu kusho ukuthi amafutha e-CBD aqukethe i-CBD kanye namanye ama-cannabinoids, ama-terpenes nama-phytochemicals azoba nemthelela ephakeme kakhulu yokwelashwa kunamafutha e-CBD aqukethe i-CBD kuphela. Noma kunjalo, isikhumba se-chlorophyll sigwenywe ngoba sinikeza ukukhipha ukunambitheka okungathandeki.

Igxathu emvakwe gxathu

  1. Isizinda se-ultrasonic: Isizinda se-ultrasonic singenziwa kalula ku-batch noma i-flow-through mode eqhubekayo – kuye ngokuthi inqubo yakho ivolumu. Inqubo yokucubungula iyashesha kakhulu futhi iveza inani eliphakeme lamahlanganisi asebenzayo.
  2. Ukuhlunga: Hlunga ingxube ye-plant-liquid ngokusebenzisa isihlungi sephepha noma isikhwama sokuhlunga ukususa izitshalo eziqinile ezitshalweni.
  3. I-evaporation: Ukuze kuhlukaniswe amafutha e-CBD kusukela ku-solvent, ngokuvamile kusetshenziswa i-rotor-evaporator. I-solvent, isib. I-ethanol, ingabuyiselwa futhi iphinde isetshenziswe kabusha.
  4. I-Nano-Emulsification: Nge-sonication, i-CBD ehlanzekile ingacubungulwa ibe yi-nanoemulsion ezinzile, ehlinzeka nge-bioavailability enhle kakhulu.

Landa imiyalelo yakho eningiliziwe ngesinyathelo-nese lapha!

izinga eliphezulu lokukhipha

I-UP400St ne-agitator yesikhumba se-cannabisIzidakamizwa ze-ultrasonic ze-Hielscher zingacutshungulwa ngokuqondile ezimweni ezifanele zokukhipha – ukukhipha inani eliphakeme kanye nekhwalithi evela kuzinto zakho eziluhlaza (amaqabunga e-cannabis, amaqabunga, iziqu njll). Ukuqina kwe-ultrasound kubalulekile uma kuziwa ekufakweni kwamakhemikhali e-botanical njengamafutha aphezulu e-CBD kusuka ku-cannabis. Ama-ultrasonicators ethu UP400St, UIP500hdT, I-UIP1000hdT futhi I-UIP2000hdT zihlonywe ngokulawula okucacile kwe-amplitude, inzwa yokushisa nokulawula isikhathi ukuvumela ukuthi usebenze ngaphansi kwezimo ezifanele. Isikrini sokuthinta imibala nesilawuli sesiphequluli senza umsebenzi nokuqapha okulula futhi okunokwethenjelwa.

Isethaphu ye-sonch ye-2kW ye-sonication ekhipha i-cannabis

I-120L Ultrasonic Batch CBD Isizinda seCannabis nge-UIP2000hdT ne-Agitator

Isicelo solwazi




Qaphela kwethu Inqubomgomo yobumfihlo.


U-UP400St we-Hielscher ungumbonisi onamandla we-ultrasonic (Chofoza ukuze ukhulise!)

UP400St ukukhishwa kwama-cannabinoid kusuka ku-cannabis

Izixazululo

I-ethanol isetshenziselwa kabanzi njenge-solvent for the extraction of cannabinoids. Ama-ultrasonicators ama-Hielscher avula ukukhethwa kwakho kwe-solvents kakhulu: ingxube yamanzi-i-ethanol, i-ethanol cryogenic, i-ethanol, i-over-proof alcohol, i-glycerin njll.
I-ethanol iyinhlanganisela ethandwa kakhulu kusukela i-ethanol ichitheka kokubili izinto ezinama-polar (hydrophilic) ne-nonpolar (hydrophobic / lipophilic). Izingxube ze-ethanol / amanzi ezilinganisweni ezingafani zingasetshenziselwa isizinda se-ultrasonic, futhi. Izinzuzo ze-ethanol / amanzi zifaka izindleko ezincishisiwe (ngenxa ye-ethanol encane) nokuphepha okuphakeme kusukela okungenakuvutha. Isizinda se-ultrasonic ne-ethanol cryogenic (cishe -70 ° C) sinikeza isivuno esikhulu kanye nekhwalithi.

Ukusetshenziswa Okulula

I-cannabis ene-Macerated ngaphambi kokukhishwa kwamakhemikhali e-bioactive.Amadivaysi ethu e-ultrasonic aklanyelwe ukusebenzisana okuhle komsebenzisi, okusho ukuthi extractors zethu ze-ultrasonic zingaba lula futhi ziqhutshwa ngokuphepha. Siyajabula ukusiza amaklayenti ethu ngesikhathi sokusetha kwabo futhi sibanikeza izincomo mayelana nokuhlelwa kwe-ultrasonic nemingcele. Sikunikeza idivayisi efanelekayo – for processing kanye inline processing.

Izinzuzo ngaphezu kwe-CO2 Ukukhipha

I-CO eqoshiwe2 I-extractors iyabiza ukuthenga nokusebenza. Ukusebenza kwe-CO2 ukukhipha kuyinkimbinkimbi futhi kudinga ochwepheshe owaziyo ukuthi yiziphi izingcindezi namazinga okushisa afanelekile ukuthola ama-cannabinoids ayifunayo nama-terpenes. Izingcindezi eziphakeme kanye nokushisa okuphezulu kunomthelela omkhulu ekunyuseni kwezindleko uma kuqhathaniswa nesakhiwo esijwayelekile samanzi. Uma kuqhathaniswa, isizinda se-ultrasonic asithengi ukuthenga nokugijima, kuvumela ukukhishwa okuphezulu, okutholakala kungakapheli imizuzu embalwa. Njengoba i-sonication yenziwa ngokucindezela (noma ukuphakama kancane) nokushisa okuphansi, isizinda se-ultrasonic kulula futhi siphephile ukusebenza. Isizinda se-ultrasonic sika-Hielscher siyaqaphela futhi sithandwa ngesilinganiso sabo sezinga eliphezulu, ukusetshenziswa nge-solvents ehlukahlukene, ukusetshenziswa okulula nokusabalalisa okulinganayo.

Ama-nanoemulsions

Ukuze uthole ukutholakala okukhulu kwezinto eziphilayo kanye nemiphumela emihle ye-CBD, amaconsi amafutha e-CBD kufanele alawulwe ku-nanoform.
Ubuhle bamadivayisi ase-Hielscher ultrasonic busetshenziswa ekusetshenzisweni kwazo okuhlukahlukene: Izindlela zethu ze-ultrasonic zingasetshenziselwa ukukhishwa kwe-cannabis kanye nokukhiqizwa kwe-nanoemulsions. Kufanele uthenge idivaysi eyodwa kuphela ukukhipha i-CBD kusuka ku-cannabis nokucubungula amafutha e-CBD ngemuva kwalokho ibe ne-nanoemulsion enhle kakhulu.
Chofoza lapha ukuze ufunde kabanzi mayelana ne-nanoemulsification ye-ultrasonic ye-CBD!

Hielscher Ultrasonics ikhiqiza ultrasonicators eliphezulu ukusebenza.

Ama-high-power ultrasonic izinhlelo kusukela ebhayisini kuya ku-pilot kanye nezilinganiso zezimboni.

Ukusebenza okuphezulu kwe-Ultrasonic Extractors

Hielscher Ultrasonics inikeza ultrasonic isizinda imishini for cannabis isizinda kanye emulsification of nano-formulations.
Ngaphandle kokulawulwa kwazo okuqondile nobungani bomsebenzisi, wonke amadivayisi wethu we-ultrasonic akhelwe ukusebenza kwe-24/7. Amasistimu ethu ayakwazi ukuletha kusuka kokuphansi kuya kokuphakeme kakhulu. Ngokukhishwa kwama-cannabinoids nama-terpenes, sinikela ngama-sonotrode akhethekile e-ultrasonic (awaziwa nangokuthi ama-ultrasonic probes noma izimpondo) enzelwe ukuhlukaniswa okubucayi kwezinto ezisezingeni eliphakeme ezisebenzayo. Zonke izinhlelo zethu zingasetshenziselwa ukukhipha kanye nokufakwa emulsification ngemuva kwalokho kwama-cannabinoids.
Ukuqina kwemishini ye-ultrasonic ye-Hielscher kuvumela ukusebenza komsebenzi we-24/7 emsebenzini obuthakathaka nasezindaweni ezinzima.
Xhumana nathi namuhla! Siyajabula ukutusa wena ukusetha okuhle kakhulu kwe-ultrasonic ngezidingo zakho zesitokisi!

Xhumana nathi! / Cela Us!

Sicela usebenzise ifomu elingezansi, uma ufisa ukucela ulwazi oluthe xaxa mayelana ne-homogenization yama-ultrasonic. Sizojabula ukukunikeza uhlelo lwe-ultrasonic ukuhlangabezana nezidingo zakho.









Sicela uqaphele wethu Inqubomgomo yobumfihlo.


Izinzuzo ze-Ultrasonic Extraction

  • Izitshalo eziphezulu zekhwalithi
  • isizinda esiphelele ngokwengeziwe
  • izinga eliphezulu lokukhipha
  • Ukukhishwa kwe-spectrum ephelele
  • Ukusetshenziswa kwama-solvents ahlukahlukene
  • non-toxic
  • Indlela engeyona eyashisayo (ebandayo)
  • Inqubo yokukhipha ngokushesha
  • Kuphephile futhi kulula ukuyisebenzisa
  • ukusabalalisa okulinganayo

Izincwadi / Izinkomba

  • I-Brenneisen R. (2007): I-Chemistry kanye nokuhlaziywa kwe-Phytocannabinoids nezinye izidakamizwa ze-Cannabis. Ku: i-ElSohly MA (eds) i-Marijuana kanye ne-Cannabinoids. I-Science and Forensic Science.


Amaqiniso Okufanele Ukwazi

Izinzuzo ze-Ultrasound Extraction

Isizinda se-ultrasonic sisekelwe esimisweni se-acoustic cavitation. Cavitation occurs as the results of high-performance ultrasound in liquid and is characterized by energy-dense mechanical effects, which take place in so-called hot-spots.

Isizinda se-Ultrasonic – Imiphumela yeCavitational

When power ultrasound waves are couples into a liquid (e.g. a suspension consisting of botanical material in a solvent), the ultrasonic waves travel through the liquid causing alternating high-pressure / low-pressure cycles. During low-pressure cycles, minute vacuum bubbles (so-called cavitation bubbles) are created, which grow over several pressure cycles. At a certain size, when the bubbles cannot absorb more energy, they implode violently during a high-pressure cycle. The bubble implosion is characterised by intense cavitational forces, including micro-turbulences and liquid streams with velocities of up to 100m/s. These cavitational shear effects are also known as sonomechanical effects. Ultrasonic extraction of bioactive molecules is mainly caused by sonomechanical effects:
Izimo ezingavamile ze-ultrasonic cavitation perforate kanye / noma ukuphazamisa izindonga zezingqimba namagundane futhi unike amandla ukungena okukhulu kwe-solvent kwisampula. Isizinda se-ultrasonic sizuza ngaleyo ndlela ukuhlukaniswa okusheshayo kwamakhemikhali – outperforming conventional extraction methods in shorter process time, higher yield, and at lower temperatures. As a mild (sono-)mechanical treatment, ultrasound extraction prevents the thermal degradation of bioactive compounds and outperforms other techniques such as conventional solvent extraction, hydrodistillation, or Soxhlet extraction, which are known to destruct heat-sensitive molecules. These advantages makes ultrasonic extraction the preferred technique for the release of temperature-sensitive active compounds from botanicals.
Therefore ultrasonic extraction is the preferred technique to extract bioactive molecules such as polyphenols, terpenes, essential oils and cannabinoids from the plant materials.

Izimo ezingavamile ze-ultrasonic cavitation perforate kanye / noma ukuphazamisa izindonga zezingqimba namagundane futhi unike amandla ukungena okukhulu kwe-solvent kwisampula. Isizinda se-ultrasonic sizuza ngaleyo ndlela ukuhlukaniswa okusheshayo kwamakhemikhali – ukuphazamisa izindlela ezijwayelekile zokukhipha ngesikhathi sokucubungula okufutshane, isivuno esiphezulu, nasezingeni eliphansi lokushisa. Njengendlela yokwelashwa okunomsoco, i-ultrasound extraction ivimbela ukuchithwa okushisayo kwama-bioactive compounds futhi ngaphandle kwezinye izindlela ezifana ne-conventional solvent extraction, i-hydrodistillation, noma isizinda so-Soxhlet, esaziwa ukubhubhisa ama-molecule azwela ukushisa. Lezi zinzuzo zenza isizinda se-ultrasonic inqubo ethandwayo yokukhululwa kwamakhemikhali asebenzayo okushisa aphezulu avela ku-botanicals.

Iziphazamisi ze-Ultrasonic zisetshenziselwa ukuchithwa okuvela emithonjeni ye-phyto (isb. Izitshalo, i-algae, isikhunta)

Isizinda se-Ultrasonic esivela kumaseli esitshalo: isigaba esincane esithintekayo (TS) sibonisa indlela yokwenza phakathi kwesikhumba se ultrasonic kusuka kumangqamuzana (ukukhulisa 2000x) [isisetshenziswa: Vilkhu et al. 2011]

I-Cannabinoids

Ama-cannabinoids ayizinhlanganisela ezenzeka ngokwemvelo ezitholakala esitshalweni se-Cannabis sativa. Kunezinhlanganisela ezingaphezu kuka-480 ezahlukahlukene ezikhona kulesi sitshalo se-cannabis. Insangu (ebizwa nangokuthi insangu) umuthi onamandla owedlula wonke wokulapha. Ezinhlobonhlobo zamakhemikhali asebenzayo ngokwelashwa, ama-phytochemicals angama-85 abizwa ngama-cannabinoids (nokuningi kungatholakala). I-CBD ne-THC (i-tetrahydrocannabinol / Δ9-THC) yi-cannabinoids evelele kakhulu. Isici esibaluleke kunazo zonke esihlukanisayo ukuthi i-CBD ayiyona i-psychotropic, ngenkathi i-THC ikhombisa imiphumela yengqondo.
Ama-cannabinoid asetshenziselwa izizathu zokuzilibazisa nezizokwelapha.
Idatha ye-Pharmacokinetic ye-CBD:
ukutholakala kwemvelo – I-Oral: 13-19%, ifakiwe: 11-45% (kusho 31%)
ukuqeda isigamu-ukuphila: amahora angu-9
EU.SA, imikhiqizo ye-CBD equkethe ngaphansi kuka -03% i-THC, ekhishwe imbewu noma izitshalo ze-hemp zezimboni, ilawulwa ngokwezomthetho futhi ingathengwa ngokomthetho kuzo zonke izifundazwe, kungakhathaliseki ukuthi imayini yayo.
Idatha ye-Pharmacokinetic ye-THC:
ukutholakala kwemvelo – I-Oral: 6-20%, inhale: 10-35%
ukuqeda isigamu-ukuphila: amahora angu-1.6-59, amahora angu-25-36 (i-dronabinol esebenzisa ngomlomo)

I-Nanoformulations

Ama-nano-cannabinoids ama-cannabis amafutha asungulwe emulsion yamafutha-emanzini, ahlinzekela ukukhuphuka okuphezulu (ukutholakala okusheshayo nokunyuka kwempilo) futhi ngaleyo ndlela kungenziwa ngaphansi kwesilinganiso esincane. Ngaphezu kwalokho, i-nanoemulsions ye-cannabis ingahlanganiswa kalula kwimikhiqizo yezokwelapha, iziphuzo, ama-edibles, kanye nemikhiqizo yezimonyo (isib. Ama-creams, lotions). Njengoba i-nano-emulsions ivame ukushintsha, ingahle ibekwe eminye imikhiqizo ngaphandle kokuthinta ukubonakala.
Ukuze uthole i-nano-emulsion ephezulu, usayizi we-droplet, ne-polydispersity index (PDI), izici ezibalulekile ezithinta ukuzinza kwe-nanoemulsion kakhulu. Inkomba ephezulu ye-polydispersity ibonisa ukuthi kukhona khona amaconsi amakhulu, okuyinto ehlukumeza i-emulsion nge-coalescence nokuvuthwa kwe-Ostwald. Ngakho-ke ukusatshalaliswa kokusatshalaliswa okwesibalo esincane nesincane kunomthelela obalulekile wokuzinza nokuphila okwesikhashana emulsion (nano- / micro-).
I-Cannabis-Nanoemulsions: Amafutha we-hemp noma ama-nanoemulsions e-CBD, i-hemp / CBD amafutha ahlanganiswe namafutha ezingeni eliphezulu. Amafutha okutshala okuvamile amafutha e-MCT, amafutha kakhukhunathi, i-avocado amafutha, amafutha omnqumo, amafutha ashukela, amafutha omnandi ama-almond kanye namafutha ase-walnut. Njengoba i-emulsifier (i-agent efakiwe, i-agent agent, i-stabilizer) ine-polysorbate engu-80, i-lecithin, i-quillaja saponins, i-lecithin ye-soy, nesigqabhe esasetshenziswa ngokuphumelelayo. I-Xanthan gum, i-pectin, noma i-whey amaprotheni inganezelwa ngaphezu kokuthuthukisa i-rheology ne-stability emulsion.

I-CO2 Ukukhipha

I-CO2 isizinda singenziwa ngezindlela ezimbili: isizinda esiphezulu nesicacile. Uma i-CO2 lisetshenziselwa i-solvent, inezici ezihlukahlukene ezixhomeke esimweni sayo sogesi. I-CO engabhalisiwe2 ichaza i-CO2 kuhulumeni phakathi kuka-5-10 ° C (278.15-283.15K, 41-50 ° F) nokucindezela phakathi kuka-800-1500psi (54.43-102.06m, 5.51-10.24MPa). Kulo lokushisa nokucindezelwa, CO2 ziziphatha njengoketshezi obukhulu. Lapho isimo sezinga lokushisa nokucindezela landa futhi lidlula izinga lokushisa elibucayi (304.25 K, 31.10 ° C, 87.98 ° F) nokucindezeleka okukhulu (72.9mitha, 7.39MPa, 1,071psi), i-CO2 iyanda emgodini njengegesi kodwa ubukhulu obunjengokwesiketshezi. Lokhu kwaziwa ngokuthi i-carbon dioxide engaphezulu (sCO2 noma i-SC-CO2)).
I-CO engabhalisiwe2 Isizinda sisebenzisa ukushisa okuphansi nokucindezela okuphansi futhi ngaleyo ndlela kuthatha isikhathi esengeziwe. I-CO engabhalisiwe2 isizinda sinikeza isivuno esincane futhi singakwazi ukugcina ezinye ze-terpenes namafutha. I-CO ephezulu2 isizinda, amazinga okushisa aphezulu kanye nokucindezelwa okuphakeme, okungawalimaza i-terpenes namanye ama-phytochemicals. I-CO ephezulu2 ukuchithwa, inqubo engezansi – eyaziwa ngokuthi i-winterization – kudingeka ukuba ususe ama-compounds angafuneki njenge-lipids ne-chlorophyll. Ngesikhathi isinyathelo sasebusika, ukukhishwa okuluhlaza kukhishwa ethanol ukuhlukanisa ama-cannabinoid ehlanzekile namathepenethi avela kwezinye izakhi ezihlanjululwe ngesikhathi sokukhipha.