I-Hielscher Ultrasound Technology

Kusetshenziswe Kakhulu i-Cannabidiol (CBD) evela eCannabis

I-hielscher ultrasonic extractors yiyona ndlela yokusebenza yobuciko uma kuziwa endaweni ethembekile futhi ephumelelayo yamafutha we-hemp ne-CBD. I-ultrasonication yaziwa kakhulu njengendlela yokukhishwa kakhulu enamandla yokukhipha izici eziwusizo kusuka ku-botanicals. Uma kuqhathaniswa nezinye izindlela zokufakelwa njenge-extraction CO2 extraction, inqubo ye-ultrasonic idlula ekusebenzeni kahle, ukusebenza okulula nokusetshenziswa okunemisebenzi eminingi.

Isizinda se-Ultrasonic

Isizinda se-Ultrasonic siyaziwa kahle futhi inqubo eyisikhathi eside esungulwe ukuze kukhishwe amakhemikhali abalulekile kusuka ku-botanicals. Ngakho-ke, i-sonification iyindlela enhle yokukhiqiza amafutha e-CBD aphezulu. Nge-cavitation e-ultrasonic elawulwa ngokucophelela, amangqamuzana okutshala ahlanjululwa futhi i-solvent iphoqelelwa ngaphakathi esitokisini, lapho ithatha khona izinhlanganisela ze-intracellular ezifana ne-cannabinoids, i-terpenes, i-flavonoids njll.

 

Inzuzo enkulu ye-ultrasonication yi-range lokushisa, lapho isizinda singenziwa khona. Isizinda se-Ultrasonic singenziwa kusuka ku-ethanol eshisayo / efudumele kuze kufike ku-ethanol ye-cryogenic (-70 ° C). Lokhu kuvumela ukuhlukaniswa okuhlosiwe kwama-compounds oyifunayo. I-Sonication ekwenzeni i-ethanol e-cryogenic i-ethanol ikakhulukazi emathangeni angama-cannabinoids kanye ne-terpenes, ngenkathi isithwathwa eshisayo / eshisayo se-ethanol siphumela ezinhlobonhlobo ezihlukahlukene zama-phytochemical (eg aldehydes, esters, ethyls, ketones). Izitshalo ezigcwele izimboni ziqukethe ubuningi bezinhlanzi ezinamagciwane, amathepenethi namanye ama-phytochemicals. Ngokusho komthelela we-entourage, amakhemikhali amakhemikhali (isib. Ama-cannabinoids) anemiphumela emihle futhi asebenze kangcono kanye namanye amakhemikhali e-botanical. Lokhu kusho ukuthi amafutha e-CBD aqukethe i-CBD kanye namanye ama-cannabinoids, ama-terpenes nama-phytochemicals azoba nemthelela ephakeme kakhulu yokwelashwa kunamafutha e-CBD aqukethe i-CBD kuphela. Noma kunjalo, isikhumba se-chlorophyll sigwenywe ngoba sinikeza ukukhipha ukunambitheka okungathandeki.

Igxathu emvakwe gxathu

  1. Isizinda se-ultrasonic: Isizinda se-ultrasonic singenziwa kalula ku-batch noma i-flow-through mode eqhubekayo – kuye ngokuthi inqubo yakho ivolumu. Inqubo yokucubungula iyashesha kakhulu futhi iveza inani eliphakeme lamahlanganisi asebenzayo.
  2. Ukuhlunga: Hlunga ingxube ye-plant-liquid ngokusebenzisa isihlungi sephepha noma isikhwama sokuhlunga ukususa izitshalo eziqinile ezitshalweni.
  3. I-evaporation: Ukuze kuhlukaniswe amafutha e-CBD kusukela ku-solvent, ngokuvamile kusetshenziswa i-rotor-evaporator. I-solvent, isib. I-ethanol, ingabuyiselwa futhi iphinde isetshenziswe kabusha.
  4. I-Nano-Emulsification: Nge-sonication, i-CBD ehlanzekile ingacubungulwa ibe yi-nanoemulsion ezinzile, ehlinzeka nge-bioavailability enhle kakhulu.

Landa imiyalelo yakho eningiliziwe ngesinyathelo-nese lapha!

izinga eliphezulu lokukhipha

I-UP400St ne-agitator yesikhumba se-cannabisIzidakamizwa ze-ultrasonic ze-Hielscher zingacutshungulwa ngokuqondile ezimweni ezifanele zokukhipha – ukukhipha inani eliphakeme kanye nekhwalithi evela kuzinto zakho eziluhlaza (amaqabunga e-cannabis, amaqabunga, iziqu njll). Ukuqina kwe-ultrasound kubalulekile uma kuziwa ekufakweni kwamakhemikhali e-botanical njengamafutha aphezulu e-CBD kusuka ku-cannabis. Ama-ultrasonicators ethu UP400St, UIP500hdT, I-UIP1000hdT futhi I-UIP2000hdT zihlonywe ngokulawula okucacile kwe-amplitude, inzwa yokushisa nokulawula isikhathi ukuvumela ukuthi usebenze ngaphansi kwezimo ezifanele. Isikrini sokuthinta imibala nesilawuli sesiphequluli senza umsebenzi nokuqapha okulula futhi okunokwethenjelwa.

Isethaphu ye-sonch ye-2kW ye-sonication ekhipha i-cannabis

I-120L Ultrasonic Batch CBD Isizinda seCannabis nge-UIP2000hdT ne-Agitator

Isicelo solwazi




Qaphela kwethu Inqubomgomo yobumfihlo.


U-UP400St we-Hielscher ungumbonisi onamandla we-ultrasonic (Chofoza ukuze ukhulise!)

UP400St ukukhishwa kwama-cannabinoid kusuka ku-cannabis

Izixazululo

I-ethanol isetshenziselwa kabanzi njenge-solvent for the extraction of cannabinoids. Ama-ultrasonicators ama-Hielscher avula ukukhethwa kwakho kwe-solvents kakhulu: ingxube yamanzi-i-ethanol, i-ethanol cryogenic, i-ethanol, i-over-proof alcohol, i-glycerin njll.
I-ethanol iyinhlanganisela ethandwa kakhulu kusukela i-ethanol ichitheka kokubili izinto ezinama-polar (hydrophilic) ne-nonpolar (hydrophobic / lipophilic). Izingxube ze-ethanol / amanzi ezilinganisweni ezingafani zingasetshenziselwa isizinda se-ultrasonic, futhi. Izinzuzo ze-ethanol / amanzi zifaka izindleko ezincishisiwe (ngenxa ye-ethanol encane) nokuphepha okuphakeme kusukela okungenakuvutha. Isizinda se-ultrasonic ne-ethanol cryogenic (cishe -70 ° C) sinikeza isivuno esikhulu kanye nekhwalithi.

Ukusetshenziswa Okulula

I-cannabis ene-Macerated ngaphambi kokukhishwa kwamakhemikhali e-bioactive.Amadivaysi ethu e-ultrasonic aklanyelwe ukusebenzisana okuhle komsebenzisi, okusho ukuthi extractors zethu ze-ultrasonic zingaba lula futhi ziqhutshwa ngokuphepha. Siyajabula ukusiza amaklayenti ethu ngesikhathi sokusetha kwabo futhi sibanikeza izincomo mayelana nokuhlelwa kwe-ultrasonic nemingcele. Sikunikeza idivayisi efanelekayo – for processing kanye inline processing.

Izinzuzo ngaphezu kwe-CO2 Ukukhipha

I-CO eqoshiwe2 I-extractors iyabiza ukuthenga nokusebenza. Ukusebenza kwe-CO2 ukukhipha kuyinkimbinkimbi futhi kudinga ochwepheshe owaziyo ukuthi yiziphi izingcindezi namazinga okushisa afanelekile ukuthola ama-cannabinoids ayifunayo nama-terpenes. Izingcindezi eziphakeme kanye nokushisa okuphezulu kunomthelela omkhulu ekunyuseni kwezindleko uma kuqhathaniswa nesakhiwo esijwayelekile samanzi. Uma kuqhathaniswa, isizinda se-ultrasonic asithengi ukuthenga nokugijima, kuvumela ukukhishwa okuphezulu, okutholakala kungakapheli imizuzu embalwa. Njengoba i-sonication yenziwa ngokucindezela (noma ukuphakama kancane) nokushisa okuphansi, isizinda se-ultrasonic kulula futhi siphephile ukusebenza. Isizinda se-ultrasonic sika-Hielscher siyaqaphela futhi sithandwa ngesilinganiso sabo sezinga eliphezulu, ukusetshenziswa nge-solvents ehlukahlukene, ukusetshenziswa okulula nokusabalalisa okulinganayo.

Ama-nanoemulsions

Ukuze uthole ukutholakala okukhulu kwezinto eziphilayo kanye nemiphumela emihle ye-CBD, amaconsi amafutha e-CBD kufanele alawulwe ku-nanoform.
Ubuhle bamadivayisi ase-Hielscher ultrasonic busetshenziswa ekusetshenzisweni kwazo okuhlukahlukene: Izindlela zethu ze-ultrasonic zingasetshenziselwa ukukhishwa kwe-cannabis kanye nokukhiqizwa kwe-nanoemulsions. Kufanele uthenge idivaysi eyodwa kuphela ukukhipha i-CBD kusuka ku-cannabis nokucubungula amafutha e-CBD ngemuva kwalokho ibe ne-nanoemulsion enhle kakhulu.
Chofoza lapha ukuze ufunde kabanzi mayelana ne-nanoemulsification ye-ultrasonic ye-CBD!

Hielscher Ultrasonics ikhiqiza ultrasonicators eliphezulu ukusebenza.

Ama-high-power ultrasonic izinhlelo kusukela ebhayisini kuya ku-pilot kanye nezilinganiso zezimboni.

Ukusebenza okuphezulu kwe-Ultrasonic Extractors

Hielscher Ultrasonics inikeza ultrasonic isizinda imishini for cannabis isizinda kanye emulsification of nano-formulations.
Ngaphandle kokulawula kwabo okuqondile kanye nobungane bomsebenzisi, wonke amadivaysi ethu e-ultrasonic akhiwe ngomsebenzi we-24/7. Amasistimu ethu akwazi ukuletha kusuka phansi kuya kuma-amplitudes aphakeme kakhulu. Ukukhishwa kwe-cannabinoids ne-terpenes, sinikeza i-sonotrodes ekhethekile ye-ultrasonic (eyaziwa ngokuthi i-ultrasonic probes noma izimpondo) ezilungiselelwe ukuhlukaniswa okunengqondo kwezinto eziphezulu ezisebenzayo. Zonke izinhlelo zethu zingasetshenziselwa ukukhipha futhi emva kwalokho ku-emulsification yamagciwane.
Ukuqina kwemishini ye-ultrasonic ye-Hielscher kuvumela ukusebenza komsebenzi we-24/7 emsebenzini obuthakathaka nasezindaweni ezinzima.
Xhumana nathi namuhla! Siyajabula ukutusa wena ukusetha okuhle kakhulu kwe-ultrasonic ngezidingo zakho zesitokisi!

Xhumana nathi! / Cela Us!

Sicela usebenzise ifomu elingezansi, uma ufisa ukucela ulwazi oluthe xaxa mayelana ne-homogenization yama-ultrasonic. Sizojabula ukukunikeza uhlelo lwe-ultrasonic ukuhlangabezana nezidingo zakho.









Sicela uqaphele wethu Inqubomgomo yobumfihlo.


Izinzuzo ze-Ultrasonic Extraction

  • Izitshalo eziphezulu zekhwalithi
  • isizinda esiphelele ngokwengeziwe
  • izinga eliphezulu lokukhipha
  • Ukukhishwa kwe-spectrum ephelele
  • Ukusetshenziswa kwama-solvents ahlukahlukene
  • non-toxic
  • Indlela engeyona eyashisayo (ebandayo)
  • Inqubo yokukhipha ngokushesha
  • Kuphephile futhi kulula ukuyisebenzisa
  • ukusabalalisa okulinganayo

Izincwadi / Izinkomba

  • I-Brenneisen R. (2007): I-Chemistry kanye nokuhlaziywa kwe-Phytocannabinoids nezinye izidakamizwa ze-Cannabis. Ku: i-ElSohly MA (eds) i-Marijuana kanye ne-Cannabinoids. I-Science and Forensic Science.


Amaqiniso Okufanele Ukwazi

Izinzuzo ze-Ultrasound Extraction

Isizinda se-ultrasonic sisekelwe esimisweni se-acoustic cavitation. I-cavitation iyinhlangano yomshini we-high-performance ultrasound ekhonjiswe okuthiwa ama-hot-spot. Kulezi zindawo ezishisayo ezinama-ultrasonic, izimo ezimbi kakhulu zendawo ezifana nokushisa okuphezulu kakhulu nokucindezela, ukushisa okukhulu kanye namazinga okupholisa kanye nokucindezela okukhulu kwegazi kanye namajetshi ahlanzekile okufika ku-100km / s.
Izimo ezingavamile ze-ultrasonic cavitation perforate kanye / noma ukuphazamisa izindonga zezingqimba namagundane futhi unike amandla ukungena okukhulu kwe-solvent kwisampula. Isizinda se-ultrasonic sizuza ngaleyo ndlela ukuhlukaniswa okusheshayo kwamakhemikhali – ukuphazamisa izindlela ezijwayelekile zokukhipha ngesikhathi sokucubungula okufutshane, isivuno esiphezulu, nasezingeni eliphansi lokushisa. Njengendlela yokwelashwa okunomsoco, i-ultrasound extraction ivimbela ukuchithwa okushisayo kwama-bioactive compounds futhi ngaphandle kwezinye izindlela ezifana ne-conventional solvent extraction, i-hydrodistillation, noma isizinda so-Soxhlet, esaziwa ukubhubhisa ama-molecule azwela ukushisa. Lezi zinzuzo zenza isizinda se-ultrasonic inqubo ethandwayo yokukhululwa kwamakhemikhali asebenzayo okushisa aphezulu avela ku-botanicals.

Iziphazamisi ze-Ultrasonic zisetshenziselwa ukuchithwa okuvela emithonjeni ye-phyto (isb. Izitshalo, i-algae, isikhunta)

Isizinda se-Ultrasonic esivela kumaseli esitshalo: isigaba esincane esithintekayo (TS) sibonisa indlela yokwenza phakathi kwesikhumba se ultrasonic kusuka kumangqamuzana (ukukhulisa 2000x) [isisetshenziswa: Vilkhu et al. 2011]

I-Cannabinoids

Ama-cannabinoids ayenzeka ngokwemvelo ngamakhemikhali atholakala esitshalweni se-Cannabis sativa. Kunamakhemikhali angaphezu kwezingu-480 avela esitshalweni se-cannabis, i-cannabis (ebizwa nangokuthi i-marijuana) isithombo semithi esingakajwayelekile esinomuthi. Ezinhlobonhlobo ezihlukahlukene zokwelashwa okusebenzayo, ama-phytochemicals angu-85 athiwa ama-cannabinoids (futhi okungaphezulu kungatholakala). I-CBD ne-THC (i-tetrahydrocannabinol / Δ9-THC) yizinhlayiya ezivelele kakhulu. Isici esibaluleke kakhulu sokuhlukanisa ukuthi i-CBD ayiyona ingqondo ye-psychotropic, kuyilapho i-THC ibonisa imiphumela ye-psychoactive.
Ama-cannabinoid asetshenziselwa izizathu zokuzilibazisa nezizokwelapha.
Idatha ye-Pharmacokinetic ye-CBD:
ukutholakala kwemvelo – I-Oral: 13-19%, ifakiwe: 11-45% (kusho 31%)
ukuqeda isigamu-ukuphila: amahora angu-9
EU.SA, imikhiqizo ye-CBD equkethe ngaphansi kuka -03% i-THC, ekhishwe imbewu noma izitshalo ze-hemp zezimboni, ilawulwa ngokwezomthetho futhi ingathengwa ngokomthetho kuzo zonke izifundazwe, kungakhathaliseki ukuthi imayini yayo.
Idatha ye-Pharmacokinetic ye-THC:
ukutholakala kwemvelo – I-Oral: 6-20%, inhale: 10-35%
ukuqeda isigamu-ukuphila: amahora angu-1.6-59, amahora angu-25-36 (i-dronabinol esebenzisa ngomlomo)

I-Nanoformulations

Ama-nano-cannabinoids ama-cannabis amafutha asungulwe emulsion yamafutha-emanzini, ahlinzekela ukukhuphuka okuphezulu (ukutholakala okusheshayo nokunyuka kwempilo) futhi ngaleyo ndlela kungenziwa ngaphansi kwesilinganiso esincane. Ngaphezu kwalokho, i-nanoemulsions ye-cannabis ingahlanganiswa kalula kwimikhiqizo yezokwelapha, iziphuzo, ama-edibles, kanye nemikhiqizo yezimonyo (isib. Ama-creams, lotions). Njengoba i-nano-emulsions ivame ukushintsha, ingahle ibekwe eminye imikhiqizo ngaphandle kokuthinta ukubonakala.
Ukuze uthole i-nano-emulsion ephezulu, usayizi we-droplet, ne-polydispersity index (PDI), izici ezibalulekile ezithinta ukuzinza kwe-nanoemulsion kakhulu. Inkomba ephezulu ye-polydispersity ibonisa ukuthi kukhona khona amaconsi amakhulu, okuyinto ehlukumeza i-emulsion nge-coalescence nokuvuthwa kwe-Ostwald. Ngakho-ke ukusatshalaliswa kokusatshalaliswa okwesibalo esincane nesincane kunomthelela obalulekile wokuzinza nokuphila okwesikhashana emulsion (nano- / micro-).
I-Cannabis-Nanoemulsions: Amafutha we-hemp noma ama-nanoemulsions e-CBD, i-hemp / CBD amafutha ahlanganiswe namafutha ezingeni eliphezulu. Amafutha okutshala okuvamile amafutha e-MCT, amafutha kakhukhunathi, i-avocado amafutha, amafutha omnqumo, amafutha ashukela, amafutha omnandi ama-almond kanye namafutha ase-walnut. Njengoba i-emulsifier (i-agent efakiwe, i-agent agent, i-stabilizer) ine-polysorbate engu-80, i-lecithin, i-quillaja saponins, i-lecithin ye-soy, nesigqabhe esasetshenziswa ngokuphumelelayo. I-Xanthan gum, i-pectin, noma i-whey amaprotheni inganezelwa ngaphezu kokuthuthukisa i-rheology ne-stability emulsion.

I-CO2 Ukukhipha

I-CO2 isizinda singenziwa ngezindlela ezimbili: isizinda esiphezulu nesicacile. Uma i-CO2 lisetshenziselwa i-solvent, inezici ezihlukahlukene ezixhomeke esimweni sayo sogesi. I-CO engabhalisiwe2 ichaza i-CO2 kuhulumeni phakathi kuka-5-10 ° C (278.15-283.15K, 41-50 ° F) nokucindezela phakathi kuka-800-1500psi (54.43-102.06m, 5.51-10.24MPa). Kulo lokushisa nokucindezelwa, CO2 ziziphatha njengoketshezi obukhulu. Lapho isimo sezinga lokushisa nokucindezela landa futhi lidlula izinga lokushisa elibucayi (304.25 K, 31.10 ° C, 87.98 ° F) nokucindezeleka okukhulu (72.9mitha, 7.39MPa, 1,071psi), i-CO2 iyanda emgodini njengegesi kodwa ubukhulu obunjengokwesiketshezi. Lokhu kwaziwa ngokuthi i-carbon dioxide engaphezulu (sCO2 noma i-SC-CO2)).
I-CO engabhalisiwe2 Isizinda sisebenzisa ukushisa okuphansi nokucindezela okuphansi futhi ngaleyo ndlela kuthatha isikhathi esengeziwe. I-CO engabhalisiwe2 isizinda sinikeza isivuno esincane futhi singakwazi ukugcina ezinye ze-terpenes namafutha. I-CO ephezulu2 isizinda, amazinga okushisa aphezulu kanye nokucindezelwa okuphakeme, okungawalimaza i-terpenes namanye ama-phytochemicals. I-CO ephezulu2 ukuchithwa, inqubo engezansi – eyaziwa ngokuthi i-winterization – kudingeka ukuba ususe ama-compounds angafuneki njenge-lipids ne-chlorophyll. Ngesikhathi isinyathelo sasebusika, ukukhishwa okuluhlaza kukhishwa ethanol ukuhlukanisa ama-cannabinoid ehlanzekile namathepenethi avela kwezinye izakhi ezihlanjululwe ngesikhathi sokukhipha.