I-Hielscher Ultrasound Technology

ICoronavirus (COVID-19, SARS-CoV-2) ne-Ultrasonics

I-Ultrasonication iyithuluzi elinamandla elisetshenziswa ku-biology, chemistry chemistry kanye ne-biochemistry nasekukhiqizweni kwemithi yemithi. Ama-biio-science asebenzisa ama-homogenizer e-ultrasonic ukwenza ama-lyse cell futhi akhiphe amaprotheni nezinye izinto ezisetshenziswayo, imboni yama-pharma isebenzisa ama-ultrasonics ekwakheni ama-molecule asebenza emakhemikhali, ukukhiqiza imigomo futhi ibenze babe ngabathwali bezidakamizwa ababi nano. Ngesikhathi sokulwa nenoveli coronavirus SARS-CoV-2 ultrasonicators asetshenziselwa izinhlelo ezahlukahlukene ocwaningweni, i-bio-science ne pharma.

I-Ultrasonication for Development and Production of Pharmaceuticals

Synthesis of Pharmacologic Active Molecule
I-Ultrasonic Synthesis yeChoroquine ne-Analogues
Ukukhishwa kwe-Ultrasonic yezinto eziphilayo ze-Bioactive kusuka ku-Botanicals


I-Ultrasonic Vaccine Production
Izicelo ze-Ultrasonic ze-Vaccine Production
Ukwenza Ukuthuthukiswa Kwe-Vaccine Ngamandla Nge-Ultrasound
Ukukhiqizwa kwemithi yokugoma ye-RNA nge-Ultrasonics


Ukwenziwa kwe-Ultrasonic Kwemithi
Ultrasonic Liposome Ukulungiselela
Ukukhiqizwa kwe-Ultrasonic kweVitamin C Liposomes
Ukukhiqizwa kwe-Ultrasonic kweSolid Lipid Nanoparticles
Ukulungiswa kwe-Ultrasonic kweCyclodextrin Complexes
I-Ultrasonic Nano-Emulsification
I-Ultrasonic Nano-Emulsification ye-Microencapsulation ngaphambi kokufiphaza-Ukumisa
Ukuncishiswa kwe-Ultrasonic Viscosity ngaphambi kokufafaza

Amagciwane angakhishwa kumasiko weseli nezicubu zezitho nge-homogenisation ye-ultrasonic.

Igciwane

Isicelo solwazi




Qaphela kwethu Inqubomgomo yobumfihlo.


Ukuqedela ukusethwa kwe-VialTweeter: i-sonotrode ye-VialTweeter ku-proxy ultrasonic UP200St

Iyunithi yokulungiselela isampula ye-Ultrasonic I-VialTweeter: I-sonline ye-VialTweeter ku-processor ye-ultrasonic UP200St

Ama-Ultrasonicators aphezulu okusebenza kwe-Pharma ne-Bio-Science

Ukulawulwa okuqondile kwamapharamitha wenqubo we-ultrasonic yi-software ekhaliphile ye-Hielscher UltrasonicsIzinhlelo ze-Hielscher Ultrasonics 'zisetshenziselwa kabanzi ekwenziweni kwemithi ukuhlanganisa ama-molecule asezingeni eliphakeme futhi kwakhiwe ama-nanoparticles e-lipid aqinile kanye nama-liposomes athwala izinto zemithi, amavithamini, ama-antioxidants, ama-peptides nezinye izinto ezixubile. Ukuhlangabezana nezidingo zamakhasimende ayo, ama-Hielscher anikezela ngama-ultrasonicators avela ku-compact, nokho ama-hand homogenizer aphethwe ngesandla anamandla aphezulu okubeka ezinhlelweni ze-ultrasonic zezimboni ngokugcwele zokukhiqiza izimfanelo eziphakeme zezinto zokwenziwa kwemithi nokwakhiwa. Uhla olubanzi lwama-sonotrodes we-ultrasonic kanye nama-reactors atholakalayo ukuqinisekisa ukusethwa okuphezulu komkhiqizo wakho wemithi. Ukuba namandla kwemishini yokusebenza kwe-Hielscher sika-Hielscher kuvumela ukusebenza kwe-24/7 emsebenzini osindayo nasezindaweni ezifunwayo.
Ukuze uvumele amakhasimende ethu ukuthi afeze i-Good yokukhiqiza imisebenzi (i-GMP) futhi asungule izinqubo ezihleliwe, wonke ama-ultrasonicators edijithali afakwe isoftware ehlakaniphile yokusetha ngokunembile ipharamitha ye-sonication, ukulawulwa kwenqubo okuqhubekayo nokuqoshwa okuzenzakalelayo kwawo wonke amapharamitha wenqubo abalulekile esakhiweni -Kukhadi le-SD. Ikhwalithi ephezulu yomkhiqizo incike ekulawulweni kwenqubo nakumazinga wokuphakama aphezulu ngokuqhubekayo. Ama-ultrasonicators we-Hielscher akusiza ukuthi uqaphele futhi wenze inqubo yakho ibe ng linye!

Ukulinganisa

Inani eliphakeme lamacala e-COVID-19 ayinselelo enkulu ohlelweni lwezempilo kubandakanya nokucwaninga nokukhiqizwa kwezemithi. Ngenkathi okwamanje kunezinto eziningi zemithi ezingaphansi kophenyo (in vitro and vivo), kusukela manje sekutholakele ukwelashwa kweziguli ze-COVID-19, inani elikhulu lezidakamizwa kumele likhiqizwe esikhathini esifushane.
Ukuhlanganiswa kwe-ultrasonic kwe-chloroquine ne-chloroquine kuyinqubo esheshayo, elula nephephile, engalinganiswa ngokuqondile kusuka kwelebhu nesitshalo somshayeli kuya ekukhiqizeni okugcwele okuthengiswayo. Abasebenzi bethu abaqeqeshiwe nabanesipiliyoni eside bazokusiza ngobuchwepheshe kusuka ekuvivinyweni komshayeli kuya ekukhiqizweni kwenani elikhulu.

Ithebula elingezansi linikeza isibonakaliso somthamo wokucubungula we-ultrasonicators wethu:

Iqoqwana Ivolumu flow Rate Amadivayisi ezinconyiwe
1 kuya ku-500mL 10 kuya ku-200mL / min UP100H
10 kuya ku-2000mL 20 kuya ku-400mL / min UP200Ht, UP400St
0.1 kuya ku-20L 0.2 kuya ku-4L / min I-UIP2000hdT
10 kuya ku-100L 2 kuya ku-10L / iminithi I-UIP4000hdT
na 10 kuya ku-100L / iminithi UIP16000
na sikhulu yinhlanganisela UIP16000

Xhumana nathi! / Cela Us!

Cela ulwazi oluthe xaxa

Uyacelwa ukuthi usebenzise ifomu elingezansi ukucela ulwazi olungeziwe mayelana nezinhlelo zokusebenza ze-ultrasonic, izinhlelo zokusebenza nentengo. Sizokujabulela ukuxoxa ngenqubo yakho nawe futhi sikunikeze uhlelo lwe-ultrasonic oluhlangabezana nezidingo zakho!









Sicela uqaphele wethu Inqubomgomo yobumfihlo.


I-Hielscher Ultrasonics yenza ama-homogenizer aphezulu we-ultrasonic wokuhlakazeka, i-emulsation kanye nokukhishwa kweseli.

Amandla aphezulu we-homogenizer ephezulu I-Lab kuya umshayeli futhi Izimboni isikali.

Izincwadi / Izinkomba



Amaqiniso Okufanele Ukwazi

I-SARS-CoV-2

I-SARS-CoV-2 coronavirus, eyaziwa nangokuthi yi-2019-nCoV noma i-novel coronavirus 2019, inesibopho sengozi yobhubhane i-COVID-19, eyaqala ngoZibandlela wezi-2019 eWuhan, eChina futhi yasakazekela lapho wonke umhlaba.
Ngokwesilinganiso sokutheleleka okuphezulu / izinga lokudlulisela, abakwaSARS-CoV-2 basakazeka ikakhulu ngokutheleleka nge-droplet kanye nokudluliselwa kwefomite. Kodwa-ke, njengoba izinhlayiya zegciwane zingatholakala futhi ezindlebeni, ukudluliswa komgudu wokulinganisa ngomlomo kungenzeka, nakho. Indlela enkulu yokudluliselwa komuntu kumuntu nge-SARS-CoV-2 ukuxhumana nabantu abasondelethekile: Amaconsi wokuphefumula akhiqizwa ngokunyenya nokukhwehlela komuntu onegciwane kudonswa abanye, ukuze kamuva atheleleke.
ICoronavirus ngamaphrotheni ayo amangalisayo wespikeAma-Coronavirus anjenge-SARS-CoV-2 anamathela ku-angiotensin-converting enzyme 2 (ACE2), atholakala kakhulu emaphashini (futhi ngezinga elincane enhliziyweni, emathunjini, emithanjeni nasezinso). Amaprotheni e-coronavirus spike (S-protein / glycoproteins), aphuma emvilophini ye-coronavirus, abopha i-ACE2 receptor, ahlangane ne-membrane ye-host cell bese engena ngale ndlela yeseli eliphethe. Njengawo wonke ama-virus, ama-coronaviruse asebenzisa iseli eliyisebenzisayo ukuphinda i-genome yawo futhi enze ngayo izinhlayiya ezintsha zegciwane.
Ama-Coronaviruses aqukethe i-genNA eqondile, enomugqa owodwa. Ngokungafani namagciwane omkhuhlane, i-coronavirus yigciwane elingabaliwe. I-Sars-CoV-2 ine-genome emfushane eyenziwe ngentambo eyodwa nje ende yamangqamuzana zofuzo. Lokhu kusho ukuthi amagciwane we-SARS-CoV-2 aqukethe ingxenye eyodwa, kuphela. Amagciwane omkhuhlane, angamagciwane we-RNA afana nama-coronavirus, anezakhi zofuzo ezihlukaniswe ngezigaba eziyisishiyagalombili zofuzo. Lokhu kunikeza igciwane lomkhuhlane ikhono elikhethekile lokuphinda lihlanganise / ukuguqula izakhi zofuzo.

Ama-Coronaviruses

Igama lesayensi le-coronavirus yi-Orthocoronavirinae noma iCoronavirinae, iCoronavirus ingeyomndeni wakwaCoronaviridae.
Ama-Coronaviruses yiqembu lamagciwane ahlobene adala izifo ezincelisayo nasezinyoni. Ngokwesibalo sabantu, ukutheleleka kwe-coronavirus kuphumela ekuthelelekeni kwezifo zokuphefumula. Ukutheleleka kwezifo zokuphefumula okunjalo kungaba nemiphumela emincane, kuvezwe njengamakhaza ajwayelekile (isib. Obhejane), kanti ezinye izifo ze-coronavirus zingabulala, njenge-SARS (Severe Acute Respiratory Syndrome), i-MERS (Middle East Respiratory Syndrome), ne-COVID-19 (iCoronavirus) Izifo 2019).

Ama-Coronaviruses wesintu

Mayelana nama-coronavirus esintu, izinhlobo eziyisikhombisa ziyaziwa. Ezine zalezi zinto eziyisikhombisa ze-coronavirus zivusa izimpawu ezithambile ngokuvamile, ezaziwa ngokuthi umkhuhlane ovamile:

  • I-human coronavirus OC43 (HCoV-OC43)
  • I-human coronavirus HKU1
  • I-human coronavirus NL63 (HCoV-NL63, i-New Haven coronavirus)
  • I-human coronavirus 229E (HCoV-229E)

Ama-coronaviruses HCoV-229E, -NL63, -OC43, kanye -HKU1 ajikeleza ngokuphelele inani labantu futhi abangela izifo eziphefumula eziphakathi nendawo kubantu abadala nezingane emhlabeni jikelele.
Kodwa-ke, izinhlobo ezintathu ze-coronavirus ezingezansi ziyaziwa ngezimpawu zazo ezinzima:

  • I-coronavirus ehlobene ne-Middle East yokuphefumula i-coronavirus (MERS-CoV), eyaziwa nangokuthi yi-novel coronavirus 2012 ne-HCoV-EMC
  • I-corvevirus enamandla ye-acute acute yokuphefumula (i-SARS-CoV / SARS-classic)
  • I-acute acute respiratory syndrome coronavirus 2 (SARS-CoV-2), eyaziwa nangokuthi yi-2019-nCoV noma i-novelos coronavirus 2019