Imọ-ẹrọ olutirasandi Hielscher

Ultrasonication n mu Imudani Suzuki pọ

Awọn Suzuki Cross-couplage (tun mọ Suzuki-Miyaurapọpọ) jẹ iṣeduro ohun ti o ni imọran lati ṣe apejuwe awọn itọjade biphenyl, awọn ohun-ọti-waini-ajara (fun apẹẹrẹ styrenes), poly-olefins, ati alkyl bromides. Awọn ohun elo ipilẹ awọn ohun elo jẹ ohun aryl- tabi vinyl-boronic acid pẹlu aryl- tabi vinyl-halide catalyzed nipasẹ itọju palladium (0), eyiti o le tun wa ni irisi ayọkẹlẹ ti o wa ni nanomaterial.
Fun Suzuki powder reaction, olutirasandi ti a ti ri lati mu yara gbogbo han. Àkọlé yìí n fúnni ni àyẹwò nípa àwọn àbájáde ti awọn ijinlẹ ti o yatọ nipa imudarasi ultrasonic ti Imudani Suzuki Coupling.

Iwadi ti Zhang et al. (2008) fi hàn pe olutirasandi ṣe itọju ailera-ara ti Suzuki ibapọ ti phenylboronic acid pẹlu awọn arylhalides niwaju TBAB nipasẹ awọn iṣọrọ gba awọn ferrocenylimini cyclopalladated lai-iṣan ni omi omi. Fun idapọ awọn arylchlorides, awọn aṣeyọri ti o dara julọ si awọn eso ti o dara ni a ti royin. Ni afiwe pẹlu alapapo ti o wọpọ, a ṣe itesiwaju ibaṣepọ iṣọkan ultrasonically-assisted reaction drastically. Pẹlupẹlu, imudarasi imudarasi iṣiṣe yii ni anfani nla ti lilo oniduro ti ko ni ipalara, solusan ti ko le flammable ti o ṣe atilẹyin ati pe o ni igbaradi.
Rajagopal et al. se ayewo ninu iṣẹ wọn pe Suzuki ti a ṣe agbelebu-palladium pẹlu awọn reactions ti halobenzenes pẹlu chlorobenzenes pẹlu phenylboronic acid ti waye ni iwọn otutu otutu (30 ° C) ni isansa ti ligand phosphine nipa lilo omi 1,3-di-ionic ionic.–butylimidazolium tetrafluoroborate [bbim] [BF4] pẹlu methanol bi iṣọpọ-inu labẹ irradiation ultrasonic. [Rajagopal et al. 2002, p. 616]

Ọpọlọpọ awọn ọna kemikali bi Suzuki iba ṣe le ṣe anfani lati ultrasonication.

Equ.1: Agbara olutirasandi-iranlọwọ Suzuki powder [Rajagopal et al. 2002, p. 616]

Hielscher Ultrasonics UIP1500hd jẹ ultrasonic homogeniser alagbara ti o ti lo fun ipele ati sonication sonication.

Hielscher's UIP1500hd pẹlu alagbeka sisan - 1.5kW ultrasonic procesor fun awọn ilana kemikali ni ipo ṣiṣan-nipasẹ

Sonogashira idibajẹ agbelebu

Olutirasandi tun ti ri lati ṣe igbelaruge iṣeduro ibaramu Sonogashira gan-an. Sopogashira agbekọja Sonogashira ti wa ni palladium-catalyzed ju ati pe a lo fun awọn isopọ ti kolopin ti carbon-carbon (CC) iwe labẹ awọn ipo ailera, gẹgẹbi ni iwọn otutu otutu, ni media media ati lilo ipilẹ kekere. O ti wa ni lilo pupọ ni ile-iṣẹ oogun ati kemikali lati ṣajọpọ awọn ohun ti eka.
O rọrun ligandu-, copper-, ati amine-free palladium-catalyzed one-pot synthesis of benzo [B] furans / nitro benzo [B] furans nipasẹ ọna Sonogashira-5-endo-dig-cyclization using ultrasonication at ambient temperature. Awọn ifarahan ti ni ipa pupọ nipasẹ awọn ipa-ọmọ sonochemical. [cf. Palimkar et al. 2008]

Kan si wa / Beere fun Alaye siwaju sii

Ọrọ lati wa nipa rẹ processing awọn ibeere. A yoo so ti o dara julọ oso ati processing sile fun ise agbese rẹ.





Jọwọ ṣe akiyesi wa Ìpamọ Afihan.


Iwe-iwe / Awọn itọkasi

  • Oxley, JD; Prozorov, T .; Suslick, KS (2003): Sonochemistry ati Ọmọ-imọlẹ-ara ti Yara-otutu Ionic Liquids. Ni: Iwe akosile ti American Chemical Society 125/2003. pp 11138-11139.
  • Palimkar, SS; Die, VS; Srinivasan, KV (2008): Olutirasandi ni igbelaruge epo-, ligand- ati iyasọtọ amine ti benzo [b] furans / nitro benzo [b] furans nipasẹ ọna asopọ Sonogashira-5-endo-dig-cyclization. Ni: Ultrasonics Sonochemistry 15/2008. pp 853-862.
  • Rajagopal, R .; Jarikote, DV; Srinivasan, KV (2002): Awọn olutirasandi ni igbega Suzuki agbelebu-ibaṣepọ inu awọn omi ti omi ionic ni awọn ipo ibaramu. Ni: Awọn imọran Kemikali 6/2002. pp. 616-617.
  • Zhang, J .; Yang, F,; Ren, G .; Mak, Th. CW; Song, M .; Wu, Y. (2008): Imudarasi ti ultrasonic ti awọn cyro-tile-ferrocenylimines cyclopalladated ṣe ayipada Suzuki ikolu ninu omi omi. Ni: Ultrasonics Sonochemistry 15/2008. pp 115-118.