Soluble-Nano-THC Formulations mo e Sonication

ʻoku faingataʻa ʻa e ngaahi meʻa ʻa e THC-hoʻomo paʻanga. – THC-Waldensians kuo pau ke nano emulsified ʻa e ngaahi inu ke lava ʻo maʻu ha bioavailability maʻolunga pea mo ha ngaahi fotunga taimi loloa mo mahino. Ultrasonic nano-emulsification ʻo e THC ki he kia, ʻoku lelei ʻaupito mo ʻaonga lahi ia ki he TH.

Ultrasonically Nano-Emulsified THC

Koeʻuhi ke lava ʻo ʻasi ha ngaahi founga foʻou ʻo e fakaʻauha ʻa e THC, ʻa ia ko e tali hange ko e THC-ʻoku lahi e edibles ʻoku fakahoko. ʻoku fakaʻaongaʻi ʻa e ngaahi device ultrasonic emulsifying ke foaki ʻa e maaka ʻo e meʻakai, fakaʻilonga maʻa mo e taimi loloa nano-emulsions. ʻoku ultrasonic e emulsification ʻi he maaka stabilisers (e.g. Taʻepau Ph nano-emulsifier), ʻa ia ʻoku ne tokoniʻi koe ke teuteuʻi ha tuʻunga lelei maʻolunga, ke fakaʻataʻata ai ha taimi loloa nano emulsions ʻaki ha bioavailability maʻolunga. Ultrasonic nano-emulsions, ko e Turn c ki ha soluble vai, nano ke tuifio, ʻa ia ʻe lava pe ke tanaki atu ki he meʻakai mo e inu. ʻoku ʻikai kaunoa ʻa ultrasonic emulsification ia ʻi he flavour totonu ʻo hoʻo ngaahi fakamatala.
Fekumi-Type ultrasonicators ʻomi nano toe fakalahi, vai-soluble THF nano-emulsions ki he inu pea mo e maʻu ʻo e ngaahi founga feimeʻatokoni ʻoku maʻolunga ange!

Saiʻia ʻi hono fakamahino, "vakai," emulsions BD nano-? Pea ke lomiʻi heni ke ako lahi ange ki he sonication ʻi he FBD mo hemp e lolo nanoemulsions!

Ko e ʻuhinga ʻoku Nanoemulsions ai?

THC-nano-emulsions ko e-ʻoku nano lahi ʻi he-vai ko e ʻ (O/W) emulsions, ʻa ia ʻoku ʻi ai hono fotunga mahino/ʻikai ke haohaoa pea mo ha taimi loloa. ʻoku hoko ʻa e THC ko ha meʻa oily, ʻa ia ʻoku ʻikai lava ke tuifio ai ha vai ʻi ha ngaahi tukunga fakanatula talu mei he lolo mo e vai ʻoku ne fakasituʻaʻi. ʻoku ʻomai ʻe Ultrasonication ʻa e tumuʻaki, ʻa ia ʻoku fakahoha'asi ʻa e lolo mo e vai droplets ki he nano lahi. Koeʻuhi ko e lalahi nano foʻi tulutaa, ʻoku ʻi ai e fotunga ʻo e nano ʻoku ʻikai ke ʻasi lelei, fotu mai pea kinetically ke malu, ʻa ia ʻoku ʻuhinga ia ʻoku ʻikai ke mavahevahe ʻa e lolo mo e vai. ʻoku lomekina ʻa e kiʻi droplets iiki ʻo e oily bioactive, ʻa ia ko e, a. THC, ʻe he kiʻi vai siʻisiʻi ko e droplets. ʻoku tokoni ha emulsifier/surfactant ke fakahoko ʻa e tauhi paʻanga nano taimi loloa.

Ultrasonic nano-emulsions fai ha bioavailability lelei ange, ʻa ia ʻoku mahuʻinga ki he bioactive me'a ko'eni hange ko e t BD, THC, vaitamini, polyphenols mo e ala meʻa pehee, ka ke nau lava ʻo fakahoko kakato mo peluki ʻenau koloa lelei. ʻi heʻene pehee, ko ultrasonically teuteu nano-emulsions ko ha meʻa lelei ia ki he formulations ʻo e meʻakai, kia ku pea mo ha ngaahi ngaue naʻa nau maʻu. Ko hono ngaohi nano emulsions mo ha bioavailability lelei, ultrasonic ko ha founga faingofua mo falalaʻanga ke faʻu ha paa, nano, ngaahi meʻa fakalahi ʻo e meʻakai, mo e emulsification ʻoku ʻi ai ha meʻa mahuʻinga edibles THC.

Ultrasonication is a fast and reliable technique to produce superior THC-nano-emulsified beverages.

UP400St, ko ha 400 Watts malohi ultrasonic homogeniser, ki he faiva nano-emulsified THC.

Kole 'a e fakamatala




Fakatokanga'i ange 'etau Tu'utu'uni totonu fakatautaha.


Founga ke teuteu ai, vai-Soluble THC Nanoemulsions ʻo fakafou ʻi he Sonication

Ko e ultrasonic emulsifiers ko ha ngaahi meʻangaue faingofua ia ke fakaʻaongaʻi, ʻa ia te ke lava ai ke faʻu haʻo. Koeʻuhi he ultrasonicators fakaʻaongaʻi pe ʻa e tumuʻaki fakamisini ki hoʻo tuifio, e.g. THC ʻi he vai, ko e tokotaha ʻoku ne kumi e meʻakai. ʻoku fenapasi e Sonication mo ha meimei fakafofonga pe ʻe emulsifying (naʻe toe ʻiloa pe ko stabilizer/surfactant). Ko hono fili emulsifying kau fakafofonga ʻo e meʻakai (e.g. Taʻepau Ph nano-emulsifier) tokoni atu ke ke teuteu ha maaka ʻoku fisifisimuʻa, maʻa e kalasi nano e ʻikai ke nau maʻa ʻi ha founga ʻoku bioavailable lahi.
ʻi he taimi ʻoku teuteuʻi ai ha nano-emulsion ʻoku ʻi ai ʻa e lolo (THC), ʻe lava ke fulihi ʻa e konga ʻo e lolo kuo fakamaʻu ʻaki ha lolo, hange ko e, hemp ha lolo pe MCT lolo. Hili ia, ʻoku emulsified ʻa e konga ʻo e lolo ki he vai (aqueous) ʻo fakaʻaongaʻi ha ultrasonicator hange ko e UP400St. ʻoku ʻomi ʻe he Sonication ha founga nano ʻoku vave mo lelei emulsification. Hili ha ngaahi miniti siʻi, kuo maau ʻa e meʻa ʻoku ʻikai ke ha ai e lolo ʻi he vai nanoemulsion taimi loloa.
ʻi heʻene ultrasonication, ʻoku faingofua leva hono ngaohi ʻo e nanoemulsions!

Ngaahi lelei ʻo ultrasonic Nano-Emulsification

  • Fakaʻataʻata ʻa e Nanoemulsions ʻaki ʻa e Bioavailability High
  • vave & lelei
  • Tolonga taimi loloa
  • Ki he Meʻakai mo e Pharma
  • malu & Faingofua ke Fakaʻaongaʻi

Ultrasonicators ngaue maʻolunga maʻa e THC-NanoEmulsions

Ko e polokalama Hielscher Ultrasonics ʻa e ngaahi misini falalaʻanga ʻoku fakaʻaongaʻi ʻi he fakafaitoʻo pea tanaki atu ki ai ʻa hono faʻu ʻo ha koloa ʻoku lelei lahi formulations, ʻa ia ʻoku kehekehe mei he nano-emulsions ki he liposomes, nanostructured mo e misini paʻanga ʻoku lava ke fakaleleiʻi, nanoparticles, inclusions, complexes, antioxidants mo e ngaahi flavonoids peptides polyphenols mo ha founga maʻolunga taha, tuʻu maʻu mo e ngaue lahi Ke maʻu ʻe he nano-emulsification ʻo e THC ki he inu, inu, tinctures mo e fakalahi, Hielscher foaki atu kiate koe ha ivi malohi mo falalaʻanga ultrasonicators ʻi he lahi hoʻo ngaahi fie maʻu. Ke feau e ngaahi fie maʻu ʻa e kau fakatau, ʻoku ultrasonicators ʻa e ngaahi naunau ʻo e Hielscher mei he fale kumi paʻanga homogenizer mo e sea ʻi ʻolunga ʻo ultrasonicators ki he ngaahi maʻuʻanga tokoni lalahi ultrasonic ke ngaohi ʻaki ʻa e ngaahi tohi ʻo e nootropics pea poto ʻi he faitoʻo konatapu formulations. ʻoku lava ke fai e ultrasonic hono fokotuʻutuʻu taimi tatau pe ko e kulupu (batch) pe founga ʻoku hokohoko ʻaki hono ultrasonic ʻo fakafou ʻi he Seinopolo. ʻoku ʻi ai ha ngaahi ultrasonic sonotrodes (probes) mo Seinopolo ngaahi vaka ʻoku lava ke maʻu ke fakapapauʻi ko ha fokotuʻutuʻu tokolahi lelei ki hoʻo liposome. ʻoku fakaʻata ʻe he robustness ʻo Hielscher e meʻangaue ultrasonic ʻa e 24/7 ke ngaue mamafa ʻi he fatongia mo e ngaahi ʻatakai ʻoku femoʻuekina.

'Oku 'omi 'e he e tepile 'i lalo ha faka'ilonga ia 'o e tu'unga 'o e ngaue ki he fakafuofua'i 'o e hotau ultrasonicators:

Kulupu (batch) 'o e tohi 'Oku tafe mai 'a e 'ea 'Oku fokotu'u atu 'a e ngaahi me'angaue
mL 'o e 1 ki he 500 10 ki he 200mL/miniti 'e UP100H
mL 'i he 10 ki he 2000 20 ki he 400mL/miniti 'e UP200Ht, UP400St
0.1 ki he 20L 0.2 ke 4L/miniti 'e UIP2000hdT
10 ki he 100L 2 ki he 10L/miniti 'e UIP4000hdT
n.a. 10 ki he 100L/miniti 'e UIP16000
n.a. lalahi fakataha'i 'o e UIP16000

Fetu'utaki mai kiate kimautolu! / Kole kiate kitautolu!

Kole ki ha fakamatala lahi ange

Kataki 'o ngaue 'aki e foomu 'i lalo ke kole ha toe fakamatala ki he ultrasonic processors, faka'aonga'i mo e totongi. Te mau fiefia ke alea'i e founga 'oku mo 'i ai mo ho'omou ngaahi fie ma'u ultrasonic he polokalama!









Kataki 'o fakatokanga'i ange 'etau Tu'utu'uni totonu fakatautaha.


Hielscher Ultrasonics pilisone ngaue ma'olunga ultrasonic homogenizers ki he fakamovetevetea, emulsification mo e hingoa to'oto'o.

Ko e malohi ma'olunga ultrasonic homogenizers mei Loki fakasaienisi ki he pailate mo e Lalahi me'afua.

Ngaahi tohi/fakamo'oni fakafolofola

  • Daniel G. Barrus, Kristen L. Capogrossi, Sheryl C. Cates, Camille K. Gourdet, Nicholas C. Peiper, Scott P. Novak, Timothy W. Lefever, Jenny L. Wiley (2016): Tasty THC: Promises and Challenges of Cannabis Edibles. Methods Rep RTI Press. Nov. 2016.
  • Kentish, S.; Wooster, T.; Ashokkumar, M.; Simons, L. (2008): The use of ultrasonics for nanoemulsion preparation. Innovative Food Science Emerging Technologies 9(2):170-175.
  • Campelo, Pedro Henrique; Junqueira, Luciana Affonso; de Resende, Jaime Vilela; Domingues Zacarias, Rosana; de Barros Fernandes, Regiane Victória; Alvarenga Botrel, Diego; Vilela Borges, Soraia (2017): Stability of lime essential oil emulsion prepared using biopolymers and ultrasound treatment. International Journal of Food Properties Vol.20, No.S1, 2017. 564-579.
  • Maphosa, Yvonne; Jideani, Victoria A. (2018): Factors Affecting the Stability of Emulsions Stabilised by Biopolymers. In: Science and Technology Behind Nanoemulsions (Edited by Selcan Karakuş). 2018.



Ngaahi mo'oni'i me'a 'oku mahu'inga ke 'ilo'i

BTHD vs c

ʻe lava ke fakafaikehekeheʻi ʻa e fuʻu ʻakau ʻe Cannabis ki hemp mo e ʻakau maliuana.
ʻoku maʻu ʻa e Cannabidiol (hemp BD) ʻi mo e ʻakau maliuana, lolotonga ia ʻoku ʻi ai ʻa e me'a ko'eni tetrahydrocannabinol (THC) ʻoku nau ʻi he ʻakau maliuana. Ko e Tetrahydrocannabinol (THC) mo cannabidiol (FBD) ko e ongo cannabinoids mahuʻinga taha ia ʻo e 113 cannabinoids ne ʻiloʻi ʻi he cannabis. ʻoku fika psychoactive e ngaahi vahenga ʻo e cannabis, faito'i ʻa ia ʻoku ʻiloa ko e (−)-ʻi he liliu-Δ9-tetrahydrocannabinol. Ko e ʻuhinga, ʻoku cannabis ʻa e ʻakau hemp ko e fanga kiʻi ʻakau ʻe siʻisiʻi ange ʻi he peseti ʻe 0.3 ko e, kae cannabis ʻa e ngaahi ʻakau maliuana ko ha ʻuluʻakau ʻoku maʻolunga ange concentrations ʻa e THC. ʻoku toe tupu foki ʻa e Hemp ko e ngoue ke ngaohi ha meʻa lahi. ʻoku ʻikai ko ha meʻa psychoactive ʻa e bioactive ʻo e tau ʻi he hemp, ʻa ia ko hono ʻuhinga ko e tau ʻa e FBD ʻoku ʻikai ke ne ngaohi koe ke ke "maʻolunga". ʻoku lava ke maʻu fakakomesiale atu ʻa e t BD ʻi ha ngaahi fotunga kehekehe hange ko e tinctures, gels, gummies, lolololo, tablets, capsules, ngaahi meʻa ke fai kakato ki ai, topicals (creams, lotions, balms, lolololo mo kakala) mo e ala meʻa pehe.
THC ko e tefitoʻi psychoactive bioactive ia ʻi he maliuana ʻa ia ʻoku ne fatongia ʻaki ʻa e "ongoʻi loto foʻi" maʻolunga. ʻe lava pe ke ingested e THC ʻi hano ifi ha "loto vao" pe ko e "huo" pe ko e THC-fakaleleiʻi edibles, e.g. keke Palauni. ʻoku toe maʻu foki ia ʻi he lolololo, tinctures, capsules, pea mo ha ngaahi founga fakataki kehe.
ʻoku fakatou haʻi ʻa e ongo cannabis me'a ko'eni, t BD mo e THC ki he polokalama endocannabinoid e faʻahinga ʻo e tangata, ka ʻoku kehekehe ʻa e ola ʻo e ngaahi meʻa takitaha (e.g. ʻikai ko e psychoactive ngaahi taʻu psychoactive).
ʻoku kei ʻiloa pe ʻa e BH d mo e THC therapeutics, ʻa ia ʻoku fakaʻaongaʻi ko e faitoʻo kona tapu pe ko e tokoni fakafaitoʻo ke faitoʻo pe tokoniʻi ʻaki ha ngaahi mahaki mo e palopalema fakafaitoʻo. ʻoku ʻiloa ʻa e BFD ʻi hono ngaahi nunuʻa laukovi mo e fakafiefiemalie. Ko hono ʻuhinga ia ʻoku fakaʻaongaʻi ai ia ke tokoni ki he ngaahi tukunga kehekehe hange ko e hamu, niumonia pupula, mamahi, psychosis pe ngaahi palopalema fakaʻatamai (e.g. OCD), laukovi ki syndrome (IBS), tokakovi, ngaahi foʻi ʻulu mo e migraines, loto-mafasia, mo e loto hohaʻa.
Naʻe fakahoko ʻa e THC ke tokoniʻi e ngaahi tuʻunga fakafaitoʻo hange ko e mamahi, spasms e uoua, glaucoma, insomnia, uʻa, tokakovi, mo e loto hohaʻa.