Hielscher faka'ata tekinolosia

Ultrasonic Nanostructuring ʻo Antibiotics

ʻE lava ʻe he ultrasonically ʻoku tokoniʻi ʻe he antibiotics ʻo fakatupulaki ʻenau lavameʻa, ʻa e peni mei he pekitilia ʻoku ne matuʻuaki e faitoʻo konatapu: ko e fakautuutu ko ia ʻo e antibiotic ʻa e pekitilia, ko ha palopalema ia ʻoku teʻeki ai fakaleleiʻi, ʻa ia kuo ola lelei hono ngaohi ʻaki e antibiotics ʻi he ngaahi taʻu kuo hili, ko ha fakamanamana ki he moʻui lelei fakaemamani lahi. Ko ultrasonic nano-structuring ʻo antibiotics ko ha founga palomesi ia ke fakatupulaki e ola lelei ʻo e antibiotics hange ko e tetracycline mei he pekitilia ʻoku ne matuʻuaki e faitoʻo konatapu.

Antibiotics mo e Antibiotic-matuʻuaki e pekitilia

'Oku ngata lysed 'a Escherichia coli pekitilia 'o ngaue 'aki 'a e kupu ultrasonic homogenizers.ʻOku hoko ʻa e fakafepaki Antibiotic ʻi he taimi ʻoku hoko ai ʻa e ngaahi siemu hange ko e pekitilia mo e fungi fakatupulaki ʻa e malava ko ia ke ikunaʻi ʻa e faitoʻo konatapu naʻe fakataumuʻa ke tamateʻi kinautolu. ʻOku ʻuhinga ia ʻoku ʻikai tamateʻi ʻa e ngaahi siemu pea hokohoko atu ʻene tupulaki. ʻOku faingataʻa ʻa e mahaki ʻoku fakatupu ʻe he antibiotic ke matuʻuaki ʻaki e ngaahi siemu, pea taimi ʻe niʻihi ʻoku faingataʻa ke fai ha meʻa.
Ko e fakafepaki Antibiotic ʻo e pekitilia ʻoku fekauʻaki ia mo hono fakaʻaongaʻi ʻi he mis pea pehe ki hono fakaʻaongaʻi ʻo e faitoʻo konatapu antibiotic. ʻOku ʻuhinga pe ʻa e Overuse mo e ngaue hala ʻaki ki he prescriptions taʻefeʻunga mo hono fakaʻaongaʻi ʻo e ngoue
Ki he ngaahi antibiotics angamaheni hange ko e penicilin, tetracycline, methicillin, erythromycin, gentamicin, vancomycin, imipemen, ceftazidime, levofloxacin, linezolid, daptomycin, mo ceftraroline, kuo mutated mo fakatupulaki ha fakafepaki antibiotic.
Ko e tefitoʻi tupuʻanga ʻo hono fakatupulaki ʻo e antibiotic ʻoku ʻi he overuse mo hono fakaʻaongaʻi hala ʻo e faitoʻo konatapu antibiotic. Ko e taimi kotoa pe ʻoku fakahoko ai ha mahaki antibiotics, ʻoku tamateʻi leva ʻa e pekitilia pelepelengesi. Neongo ia, kapau ʻoku ʻi ai ha pekitilia, ʻa ia ʻoku ʻikai kuo taʻaki fuʻu ʻe he faitoʻo konatapu, ʻoku nau tupulaki mo fakatokolahi. ʻI heʻene pehee, ʻoku fakatupu ʻe hono toutou fakaʻaongaʻi mo taʻetotonu ʻo e antibiotics ʻa e fakautuutu ʻo e pekitilia ʻoku ne matuʻuaki e faitoʻo konatapu.
ʻOku hoko ʻa e pekitilia fakavahaʻa-faitoʻo konatapu (MDR) ko ha fakamanamana ki he moʻui lelei koeʻuhi he ʻoku ʻikai ke nau tali ʻa e faitoʻo antibiotic angamaheni, ʻa ia ʻoku totonu ke tamateʻi ʻa e ngaahi siemu.
ʻI he lotolotonga ʻo gram pathogens lelei, ko ha pandemic fakamamani lahi ʻo e matuʻuaki ʻa e S. (e.g., methicillin-matuʻuaki Staphylococcus au; MRSA) mo Enterococcus fakafaʻahinga ʻoku lolotonga ʻi ai e fakamanamana lahi taha. Gram-kovi pathogens hange ko Enterobacteriaceae (e.g., Klebsiella pneumoniae), Pseudomonas aeruginosa, mo Acinetobacterare ke matuʻuaki ʻa e meimei kotoa ʻo e ngaahi founga faitoʻo konatapu antibiotic ʻoku lava ke maʻu.

Ultrasonic processor UIP1000hdT for the nano-structuring of antibiotics in order to increase their effectiveness against antibiotic-resistant bacteria strains.

UIP1000hdT – ko ha ultrasonic malohi ʻi he processor ki he nano structuring ʻo antibiotics hange ko tetracycline ke fakatupulaki ʻenau ola lelei mei he pekitilia antibiotic

Kole 'a e fakamatala




Fakatokanga'i ange 'etau Tu'utu'uni totonu fakatautaha.


Ultrasonically Nano-antibiotics

ʻOku ʻiloa ʻa e Pharmaceuticals Nano ke fakalakalaka micron e faitoʻo konatapu molecules faʻa tupu mei he lahi ange ʻa e absorption, bioavailability maʻolunga ange, mo e ola lelei ange. ʻOku lahi hono fakaʻaongaʻi ʻo e Antibiotics ke ngaohi ʻaki hangatamaki mahaki. Neongo ia, ʻoku hanga ʻe he fakalakalaka vave ʻo e lahi ange ʻa e faitoʻo konatapu ʻo ʻai ke fakalakalaka ʻa e ngaahi faitoʻo konatapu foʻou pe ko e liliu ʻo e ngaahi faitoʻo antibiotic ʻoku fie maʻu. Fakasiʻisiʻi ʻa e lahi ʻo e antibiotics hange ko e tetracycline ʻo fakafou ʻi sonication ko ha founga faingofua, vave mo palomesi ke fakaleleiʻi ʻaki e ola lelei ʻo e antibiotics mei he ʻikai ke ne matuʻuaki mo matuʻuaki e pekitilia.

Ultrasonically NanoStructured Tetracycline

'E lava ke faka'aonga'i e UIP1000hdT ki he beaker sonication pea pehe mo tafe to'oto'o pA 'atomi (lomi'i ke fakalahi!)Kassirov et Al. (2018) ngaohi tetracycline ultrasonically ke fakaleleiʻi e ola lelei ʻo e faitoʻo konatapu mei pathogens. ʻI heʻenau ako, naʻa nau fakaʻaongaʻi ʻa e Escherichia kololi Nova puluu TCR, faingataʻaʻia ʻi he fakafepaki antibiotic, mo E. kololi 292 – 116 (ʻikai ha fakafepaki ki he faitoʻo konatapu). Naʻe liliu ʻa Tetracycline, ko ha antibiotic angamaheni, ʻo fakaʻaongaʻi ha ngaahi ultrasonicator lalahi UIP1000hdT (Hielscher, Siamane; vakai ki he fakatata toʻohema). Naʻe ʻilo ʻe he timi fekumi ʻoku fakatupulaki ʻe he faitoʻo sonochemical mo e UIP1000hdT ʻa e ola lelei ʻo antibacterial ngaahi koloa ʻo aʻu ki he 25% ki he faingataʻaʻia mo e 100% ki he faingataʻaʻia pelepelengesi. Naʻa mo ha tukuʻanga koloa taimi loloa ʻo e nanostructured tetracycline ʻi he + 4ºC ʻoku ʻikai fakasiʻisiʻi ai ʻa e ngaahi koloa antimicrobial.
Naʻe fakapapauʻi ʻa e ngaahi fakangatangata ʻo e ngaue ultrasonic hange ko e amplitude, input ʻo e ivi, mo e taimi sonication ko ha ngaahi moʻoniʻi meʻa mahuʻinga ʻoku ne takiekina ʻa e liliu ʻi antimicrobial ngaahi koloa ki he ongoʻingofua mo e matuʻuaki fakatouʻosi.
Ko e ola ʻo e faitoʻo ultrasonic ʻi ha konga lahi ange ʻo e ngaahi faitoʻo konatapu nano, ʻa ia ʻe ala iku ki ha bioavailability maʻolunga ange, bioaccessibility pea ola lelei ai ʻa e tetracycline molecules.
ʻOku fakahaaʻi ʻe he fakamatala ʻoku maʻu sonochemical ʻe lava ke hoko ʻa e liliu ʻo e antibiotics ko ha founga palomesi foʻou mo fakama ki hono fakatupulaki ʻo e faitoʻo konatapu foʻou ʻoku ʻaonga ki antibiotic fakamalohisino ki he fakafepaki ki he faitoʻo konatapu.

Ultrasonic nanostructuring of the antibiotic drug tetracycline increases the effectiveness against drug-resistant bacteria.

Sonication ʻo tetracycline mo e UIP1000hdT.
A – FTIR spectra ʻo e "tauʻataina" tetracycline; B – FTIR spectra ʻo SN tetracycline hili ha miniti ʻe 5 sonication; C – lahi hono tufaki histogram ʻo e "tauʻataina" tetracycline; H – Lahi ʻo e histogram tufakiʻanga naunau ʻo SN tetracycline hili ha miniti ʻe 5 sonication.
Ako mo e fakatata ʻe Kassirov et Al. 2018.

Ultrasonic processor UIP2000hdT (2kW) 'i hono ue'i 'o e batch Seinopolo

Ultrasonic processor UIP2000hdT (2kW) mo e kulupu (batch) Seinopolo

Ngaahi lelei ʻo ultrasonic Nanostructured faitoʻo konatapu

ʻOku ʻomi ʻe he Ultrasonication ha ngaahi faingamalie lahi ki he synthesis ʻo ha ngaahi naunau nanostructured lahi pea ʻoku fakaʻaongaʻi ia ʻi ha ngaahi ngaueʻanga lahi. ʻOku matuʻaki palomesi ʻa e ultrasonic ʻo e nano pharmaceuticals hange ko e antibiotics, ko e fili ʻo e virals mo e faitoʻo kehe talu mei hono fakahaaʻi ʻe he ngaahi faitoʻo konatapu ko ʻeni ha tuʻunga maʻolunga ange absorption, bioavailability mo ola lelei. Ko ia ai, ʻoku kau ʻi he ngaahi formulations ʻo e faitoʻo konatapu ʻa e ultrasonication kae lava ke nanostructure ʻa e faitoʻo konatapu molecules, ʻa e faitoʻo konatapu ki he nano-emulsions, nano-liposomes, niosomes, mo e ngaahi meʻa kehe ʻoku ʻikai ke nau lava ʻo fakakau

Fakaʻata e ngaahi faitoʻo konatapu

  • Ultrasonic tutu'u-Emulsions
  • Ultrasonic Liposomes
  • Ultrasonic Niosomes
  • Ultrasonic fefeka Nanoparticles (SLNs)
  • Ultrasonic Nanostructured misini lipid kau fata (NLTHF)
  • Ultrasonic fakakau ʻa e faingataʻa
  • Ultrasonically Doped mo Functionalized Nanoparticles
  • Ultrasonic huhu maluʻi Formulations
  • Ultrasonic e huhu maluʻi ʻo e Intranasal

ʻOku toe fakaʻaongaʻi foki ʻa e faitoʻo ultrasonic ʻo e nanomaterials mo antibacterial ngaahi koloa ke synthesize nano e ngaahi naunau ki he faʻunga (e.g. nano-siliva, nano ZnO) pea fakaʻaongaʻi kinautolu ki koloa tupenu kae lava ke faʻu antibacterial koloa tupenu fakafaitoʻo mo e ngaahi tupenu kehe ʻoku lele lelei. Hange ko ʻeni, ʻoku fakaʻaongaʻi ha founga ultrasonic sitepu ʻe taha ke fabricate tolonga coatings e tupenu ʻo e vavae mo antibacterial ZnO nanoparticles.

Ko e faingamalie ʻo ultrasonic Synthesis ʻo e faitoʻo konatapu Nano

  • Fakasiʻisiʻi e lahi ʻo e ngaue maʻolunga
  • Pule'i totonu e ngaahi fakangatangata ki he founga ngaue
  • Founga 'aukai
  • 'Ikai ke mapule'i, mafana lolotonga pau hono pule'i
  • ngaahi scalability
  • Reproducibility
  • Founga ngaue standardisation/GMP
  • Autoclavable probes mo e ni'ihi ne toe
  • CIP / SIP
  • Mapuleʻi totonu hono lahi mo e encapsulation
  • ʻOku load ʻe he faitoʻo konatapu ʻa e ngaahi meʻa longomoʻui

ʻOku ngaue fefe ʻa ultrasonic Synthesis ʻo e ngaahi naunau ʻo e Nano-fale?

Ko e Ultrasonication mo e sonochemistry, ʻa ia ko hono fakaʻaongaʻi ʻo e malohi maʻolunga fakaʻata ki he ngaahi kemikale, ʻoku fakaʻaongaʻi lahi ia ke maʻu ai ha ngaahi naunau ʻoku maʻolunga nano (e.g., nanoparticles, nano-emulsions). Sonication mo sonochemistry malava pe fakafaingofuaʻi hono faʻu ʻo ha ngaahi naunau nano maʻolunga. Ko e faingamalie ʻo ultrasonic synthesis ʻo e ngaahi momoʻi meʻa nano ko e faingofua mo e ola lelei. Lolotonga ia ʻoku fie maʻu ʻe he ngaahi founga ngaue nano ʻo e faʻunga ʻo e faʻunga ha mafana lahi, faingataʻa, mo e/pe taimi loloa, ultrasonic synthesis faʻa fakaʻata ki ha facile, vave mo lelei ʻo e nanomaterials. ʻOku fakatou fatongia ʻaki ʻe he sonochemical mo e sonomechanical ʻa e ngaahi ola ʻoku ʻomi ʻe he ultrasonics malohi ki he synthesis pe functionalization/liliu ʻo e ngaahi momoʻi meʻa nano. Coupling e ngaahi peau ultrasonic maʻolunga ki he ngaahi ola ʻo e huhuʻa ʻi he cavitation: ko hono faʻu, tupulaki, mo implosive holoa ʻa e bubbles, pea ʻe lava pe ke lau ia ko e Palaimeli sonochemistry (konga ʻo e kemisitulii kasa ʻoku hoko ʻi loto ʻauha bubbles), ua sonochemistry (konga ki tuʻa ʻo e kemisitulii), mo e sonomechanical/physicalifications (fakatupu ʻe he ngaahi vakapuna ʻoku vave ʻene lele, (FF. Hinman mo Suslick, 2017) ʻOku cavitational ʻa e ola ʻo e ngaahi momoʻi meʻa ʻi hono fakasiʻisiʻi, nano-structuring (nano-fakamovetevetea, nano-emulsification), pea pehe ki he kihiʻi functionalization mo e liliu.
Laukonga lahi ange kau ki ultrasonic milling mo dispersing e ngaahi momo'i me'a!

Ultrasonic Nanostructuring ʻo e fanga kiʻi momoʻi meʻa

Ultrasonic Probes ki he Synthesis ʻo Nano-faʻunga Pharmaceuticals

'Oku taukei 'aupito 'a Hielscher ultrasonic 'i hono fokotu'utu'u, ngaohi 'o e koloa, tufaki'anga naunau mo e tokoni ki he ngaahi ngaue 'oku ngaue-ma'olunga ultrasonic homogenisers ma'a e ngaahi ngaue'anga fakafaito'o mo e me'atokoni.
Ko hono teuteuʻi ko ia ʻo e ngaahi faitoʻo konatapu nano lahi, liposomes, misini fakasiʻisiʻi nanoparticles, polymeric nanoparticles, cyclodextrin complexes, mo vaccines ko e founga ngaue, ʻa ia ʻoku fakaʻaongaʻi lahi ai Hielscher ultrasonic systems ki honau tuʻunga falalaʻanga maʻolunga mo lelei ange. Hielscher ultrasonicators fakaʻata ke mapuleʻi totonu ʻa e ngaahi fakangatangata kotoa pe, hange ko e amplitude, ʻea, malohi mo e ivi sonication. ʻOku ʻotometiki pe hono maʻu ʻe he polokalama fakakomipiuta poto ʻa e ngaahi fakangatangata sonication kotoa pe (taimi, ʻaho, amplitude, ivi kupenga, ivi fakakatoa, mafana, malohi) ʻi he kaati SD. ʻOku hanga ʻe he meʻá ni ʻo fakafaingofuaʻi hono fakahoko mo mapuleʻi lelei e ngaahi meʻá ni mo tokoni ke fakahoko e Ngaahi Founga Ngaohi Lelei ʻo e Koloá (GMP).

Ultrasonic Mixers ki he ngaahi koloa kotoa pe

Mapule'i totonu ho'o ngaahi founga ultrasonic fakangatangata 'e Hielscher Ultrasonics' polokalama fakakomipiuta potoʻOku ʻufiʻufi ʻe Hielscher Ultrasonics ʻa e tuʻunga kakato ʻo ultrasonic processors mei he loki fakatotolo fakakemi ultrasonicators ʻi he ngaahi founga ʻa e sea ki ʻolunga mo e pailate ki he ngaahi ultrasonic processors mo e malava ko ia ke ngaue fonu fonu loli ʻenau he houa. ʻOku fakaʻata kitautolu ʻe he koloa kakato ke tau ʻoatu ʻa e ultrasonic e mixer ʻoku feʻunga taha ki hoʻo founga ngaue mo e ngaahi taumuʻa. ʻOku fakaʻata koe heni ke ke fakatupulaki mo siviʻi hoʻo tohi kole ʻi ha kiʻi fale fakatotolo siʻisiʻi pea fakafuofuaʻi ia pea ke toki lava leva ʻo ngaohi. ʻOku fuʻu faingofua ʻaupito ʻa e meʻafua mei ha ultrasonic siʻisiʻi ange ki he ngaahi ngaue ʻoku maʻolunga ange koeʻuhi he ʻe lava ke hoko ʻa e ultrasonic fefiofi ko ha telinga kaka mei he ngaahi fakangatangata kuo ke fokotuʻu. ʻE lava ke fai ʻa e Scaling ʻaki hano fola ha ʻiuniti malohi ange ultrasonic mixer pe clustering ha ultrasonicators ʻoku faitatau mo ia.

Amplitudes maʻolunga ki Nanostructure ngaahi momoʻi meʻa ʻi he lavameʻa maʻolunga

Ultrasonics 'o e Hielscher’ ʻe lava ʻe he ultrasonic lalahi processors ʻo fakahaofi ha amplitudes maʻolunga ʻaupito. Amplitudes ʻo aʻu ki 200μm ʻe faingofua pe ke lele hokohoko ʻi he tafa 24/7. ʻOku lava ke maʻu ha amplitudes maʻolunga ange fakapatonu ultrasonic sonotrodes. ʻOku autoclavable ʻa ultrasonic sonotrodes (meʻatui, probes) mo e niʻihi ʻoku nau autoclavable. ʻOku fakaʻata ʻe he robustness ʻo e meʻangaue ultrasonic ʻa Hielscher ʻa e ngaue ʻe 24/7 ʻi he fatongia mamafa pea mo e ngaahi ʻatakai ʻoku femoʻuekina.

Faingofua, Siviʻi ke Fakatuʻutamaki

ʻe lava ke ultrasonic e ngaahi founga ngaue ʻi he telinga kakato kaka. ʻoku ʻuhinga ʻeni ki he meʻa kotoa pe kuo ke aʻusia ʻi hono ngaue ʻaki ha fale fakakemi pe ultrasonicator sea, ʻe lava ke kaka ke tatau tofu pe ʻa e fika ʻo e ngaahi fakangatangata ʻo e founga tatau. ʻoku ʻai ʻe he meʻa ni ultrasonication lelei taha ki he fakalakalaka ʻo e koloa pea mo hono fakahoko ʻi he ngaahi ngaohiʻanga fakakomesiale.

ʻulungaanga maʻolunga taha – Faʻu mo Manufactured ʻi Siamane

ʻI he hoko ʻa Hielscher ko ha pisinisi ʻa e famili mo e fakalele fakafamili, ʻoku ne fakamuʻomuʻa ʻa e ngaahi tuʻunga moʻui lelei taha ki hono ultrasonic processors. ʻOku fokotuʻutuʻu ʻa e ultrasonicators kotoa pe, manufactured mo siviʻi fakaʻauliliki ʻi homau ʻuluʻi ʻofisi ʻi Teltow ofi ki Pealini ʻi Siamane. ʻOku hanga ʻe he Robustness mo e ala falalaʻanga ʻo e meʻangaue ultrasonic ʻa Hielscher ʻo ʻai ke hoko ia ko ha hoosi ngaue ʻi hoʻo faiva. 24/7 ngaue ʻi he uta kakato pea ʻi he ngaahi ʻatakai ʻoku femoʻuekina, ko ha ʻulungaanga fakanatula ia ʻo e ultrasonicators ngaue maʻolunga ʻa Hielscher.

Te ke lava ʻo fakatau Hielscher ultrasonic processors ʻi ha faʻahinga lahi kehekehe pea fakapolokalamaʻi ki hoʻo ngaahi fie maʻu ki he founga ngaue. Mei hono ngaohileleiʻi fluids ʻi ha kiʻi fale fakatotolo siʻisiʻi beaker ki he hokohoko atu hono tuifio ʻo e slurries mo e pastes ʻi he tuʻunga fakapisinisi, ʻoku ʻomi ʻe Hielscher Ultrasonics ha ngaue maʻolunga feʻunga maʻau! Kataki ʻo fetuʻutaki mai kiate – ʻOku mau fiefia ke fakaongoongoleleiʻi atu ʻa e fokotuʻutuʻu lelei ultrasonic!

UP400St for molecularly imprinted polymer synthesis

UP400St – 400W ultrasonic processor ki he ngaahi polokalama sonochemical

'Oku 'omi 'e he e tepile 'i lalo ha faka'ilonga ia 'o e tu'unga 'o e ngaue ki he fakafuofua'i 'o e hotau ultrasonicators:

Kulupu (batch) 'o e tohi 'Oku tafe mai 'a e 'ea 'Oku fokotu'u atu 'a e ngaahi me'angaue
mL 'o e 1 ki he 500 10 ki he 200mL/miniti 'e UP100H
mL 'i he 10 ki he 2000 20 ki he 400mL/miniti 'e UP200Ht, UP400St
0.1 ki he 20L 0.2 ke 4L/miniti 'e UIP2000hdT
10 ki he 100L 2 ki he 10L/miniti 'e UIP4000hdT
n.a. 10 ki he 100L/miniti 'e UIP16000
n.a. lalahi fakataha'i 'o e UIP16000

Fetu'utaki mai kiate kimautolu! / Kole kiate kitautolu!

Kole ki ha fakamatala lahi ange

Kataki 'o ngaue 'aki e foomu 'i lalo ke kole ha toe fakamatala ki he ultrasonic processors, faka'aonga'i mo e totongi. Te mau fiefia ke alea'i e founga 'oku mo 'i ai mo ho'omou ngaahi fie ma'u ultrasonic he polokalama!









Kataki 'o fakatokanga'i ange 'etau Tu'utu'uni totonu fakatautaha.


Ultrasonic high-shear homogenizers are used in lab, bench-top, pilot and industrial processing.

Hielscher Ultrasonics ʻa e ngaohiʻanga koloa maʻolunga ultrasonic homogenizers ki hono tuifio ʻo e ngaahi polokalama, fakamovetevetea, emulsification mo e toʻo hingoa ʻi he fale fakatotolo fakakemi, pailate mo e meʻafua ki he ngaahi meʻa fakapisinisi.

Ngaahi tohi/fakamo'oni fakafolofola