Hielscher faka'ata tekinolosia

Nootropics mo e Smart ngaahi Faitoʻo konatapu Formulations mo Ultrasonics

ʻoku "tutu ʻa e faitoʻo konatapu mo e fakalahi ki he ngaahi nootropic ko e" fakaʻatamai enhancers "kae lava ke fakatupulaki ʻa e ngaue fakaʻatamai, lava ʻa e ʻatamai, tokanga, manatu mo e mohu founga, ke maʻu ha poupou mo e ivi fakaʻatamai pea pehe ki he moʻui lelei. Ke fakaʻaiʻai ʻa e bioactive me'a ko'eni hange ko e nootropics, mapuleʻi ʻo e ngaahi faitoʻo kona tapu mo e e ngaahi meʻa ʻoku ne taʻofi ʻa e ngaahi meʻa ʻoku ne taʻofi ʻa e ʻatamai (BBB), ʻoku totonu ke fai ʻa e molecules ʻi ha foomu ʻoku fakatupulaki. Kuo teuteuʻi ʻe Ultrasonically nano-liposomes, micelles, misini ke lahi nanoparticles, nanostructured nano ʻa e kau fata mo nano-emulsions ke fakalahi ʻa e bioavailability ʻo e bioactive molecules, vaitamini mo e phytochemicals.

Nootropics pe poto ʻi he faitoʻo konatapu ko e ʻatamai mo e sino ʻoku ne fakaʻaiʻai molecules – enhancers fakaʻatamai – , ʻa ia ʻe lava ke fakaʻilongaʻi ki he ngaahi faʻahinga ko ʻeni racetams, stimulants, adaptogens, cholinergics, serotonergics, dopaminergics, metabolic ngaue ʻaki ʻa e ngaahi faitoʻo konatapu mo e ngaahi faʻahinga lahi ange.
Mahuʻingaʻia ʻi he ngaahi faʻahinga kehekehe ʻo e nootropics? Lomiʻi heni ke laukonga lahi ange fekauʻaki mo nootropics mo ʻenau categorization!

Ko e ha ʻa e Liposomes mo Lie misini Nanocarriers ʻoku Makatuʻunga ai?

ʻoku ʻiloa ʻa e Liposomes mo e nano ʻo e ngaahi satelaite hange ko nano-emulsions, nano-suspensions, ngaahi misini ke ʻoua nanoparticles (SLNs) mo nanostructured ke misini ki he kau fata (Nlthf) ko ha kautaha faitoʻo konatapu, ʻa ia ʻoku ʻomi bioactive molecules mo e ivi ki he feituʻu ʻoku nau fakataumuʻa ki ai ʻa ia ʻoku maʻolunga ʻenau mo bioavailability tupu.

liposomes

Ko e founga 'oku fie Ultrasonication ki ai ke fa'u liposomes 'aki ha uta lahi 'o e bioactive me'a ko'eni.ʻe lava ke lau ʻoku Liposomes ko ha founga pau ia ʻo nanostructured ʻa e misini ke fakasiʻisiʻi nanocarriers. ʻoku spherical ha vesicles ʻe taha pe lahi ange ai e ngaahi tefitoʻi Liposomes ʻa ia ʻoku ʻi ai ha kiʻi misini ke fakasiʻisiʻi ai ʻene hoko. Koeʻuhi liposomes fakahaaʻi ʻa e malava ko ia ke lipophilic, mo hydrophilic molecules, kuo nau lava ʻo tali ai ia ko ha founga faitoʻo ʻoku lahi ʻaupito. ʻi hono ngaahi tuʻunga kuo fokotuʻutuʻu lelei pe, ʻoku lava ke liposome ʻe ha taha ʻa e ngaahi bioactive me'a ko'eni (i.e pe ko ha meʻatokoni pe fakafiemalie molecules) he taimi pe ko ia. ʻoku hanga ʻe hono phospholipidic ʻo maluʻi e kau bioactive, ʻo molecules ʻa hydrolysis mo oxidative maʻulalo. Koeʻuhi ʻoku faitatau e faʻunga ʻo e liposome e fale ʻo e mammalian ki he toʻotoʻo, ʻe lava leva liposomes ke ʻave ʻa e bioactive me'a ko'eni ki he ngaahi selo mo e ngaahi saiti ʻoku toʻotoʻo holo pe. ʻoku kau ʻi he ngaahi lelei ʻoku ʻiloʻi ʻa e founga liposomal ʻo e ʻomi ʻa honau maluʻi mei he enzymatic maʻulalo, honau toxicity maʻulalo, biocompatibility maʻolunga, biodegradability mo e ʻikai ke immunogenicity.

Ultrasonication is a fast and reliable technique to produce superior liposomes, nanoliposomes and nano-structured lipid carriers.

UP400St, ko ha 400 Watts malohi ultrasonic homogeniser, ki he Production nano-liposomes.

Kole 'a e fakamatala




Fakatokanga'i ange 'etau Tu'utu'uni totonu fakatautaha.


Liposomes, niosomes, nanoemulsions, solid-lipid nanoparticles, and nanostructured lipid carriers can be produced by ultrasonic emulsification.

Ko hono fokotuʻutuʻu ʻo e faʻunga ʻo e liposomes, niosomes, nanoemulsions, misini ʻo e paʻanga ʻoku ʻikai fuʻu malohi nanoparticles, nanostructured ke misini ke kau
ʻimisi: Poonia et Al. 2016

Lipidic kehe Nano-satelaite

Famotidine teuteu'i ha misini ke fakasi'isi'i e pa'anga nanoparticles (SLNs) 'e ultrasonicationʻoku fakaʻuhingaʻi ʻa e Lipidic nano-ʻoku puleʻi ʻe he ngaahi kautaha ʻoku fakahoko pe ʻoku lolotonga ngaue ʻaki ʻa e-fakaleleiʻi ko ha founga ʻoku lahi pe nano e faitoʻo ʻoku fakaʻaongaʻi, ʻa ia ʻoku ngaueʻaki ai ʻa e ngaahi sinoʻi paʻanga ʻe maʻu ai ha ngaahi meʻa naʻa ne fakaleleiʻi ʻa ia ko molecule bioactive ke lava ʻo aʻu ki ha molecules kuo toe lelei ange mo ha maluʻi mei he ngaahi meʻa maʻulalo mo ʻoku kau ʻi he Nanostructured ha misini ke fakasiʻisiʻi ʻa e ngaahi misini ʻo e% nanoparticles (SLN), Nanostructured pe ha misini ke ala ki ai (NLC), nanoliposomes, micelles, nanoemulsions, nanosuspensions mo limisini ke fakasiʻisiʻi e nanotubes. ʻoku ʻoange ʻe he ngaahi ʻulungaanga pau ʻo e kemikale mo hono ngaahi physicochemical ʻa e ngaahi lelei makehe takitaha, ʻa ia ʻoku ne ʻai ke feʻunga mo e ngaahi foomu pule pau (e.g. fakamatala, intravenous, intranasal, transdermal mo e ala meʻa pehee), molecule ngaahi kautaha, fetongi pe ʻi ai ha meʻa ʻoku malava pe tuku atu ki he taimi-.
ʻoku fakaʻuhingaʻi ʻa e misini ke fakasiʻisiʻi e nanoparticles (SLN) mo nanostructured ha misini ke fakasiʻisiʻi e ngaahi fetuʻutaki (NLC) ko ha ngaahi konga ongo malohi ʻoku kau ki ha misini ke ʻoua naʻa ʻi ha konga matrix ʻoku fakatolonga ʻe aqueous.
Liposomal mo e ngaahi nano kehe (e.g. SLNs, Nlthf) ko e fakalahi ʻo ha bioavailability maʻolunga ange, ʻa ia ʻoku ʻuhinga ia ko e peseti maʻolunga ʻo e ngaahi meʻa bioactive (e.g. vaitamini, antioxidant, flavonoid etc.) ʻoku lava pe ke metabolized e ngaahi selo ʻo e sino. Ko e kiʻi tokosiʻi pe ʻoku mole koeʻuhi ko e ʻikai ke ne excreted ʻi he sino. ʻoku hanga ʻe he meʻa ni ʻo ʻai ke nano ʻa e liposomal formulations, malohi mo falalaʻanga talu mei he meimei kotoa ʻo e bioactive kuo ʻave ki he ngaahi selo ʻo e feituʻu.

Ultrasonic ki hono Fakaʻaiʻai Molecules ʻaki ʻa e Bioavailability Maʻolunga taha

ʻoku ngaohi ʻe ultrasonic nano-emulsification mo nano-encapsulation ʻa e nootropic mo e psychoactive molecules vai-soluble ʻo nau absorbable mo bioavailable. Ko ha absorption maʻolunga ange pea mo e tupulaki bioavailability mo e biocompatibility ʻai e koloa bioactive ke toe malohi ange pea lava ke ne folaua e meʻa ʻoku ne taʻofi ʻa e toto.

Ultrasonic encapsulation 'o e ngaahi me'a fakafaito'o 'i ha misini ke fakasi'isi'i e nanoparticles (SLNs)

Ultrasonic Preparation 'o e misini ke fakasi'isi'i e pa'anga Nanoparticles
(Kuma et Al. 2019)

Ultrasonic e ʻs Nootropics

  • liposomes
  • Tutu'u-Emulsions
  • Micelles
  • Misini ke fakasiʻisiʻi e Nanoparticles (SLN)
  • Nanostructured Lie misini ke (NLC)
  • Ko hono fakakau e fihi (e.g. cyclodextrin)
  • Niosomes
Ultrasonic processor UIP2000hdT (2kW) 'i hono ue'i 'o e batch Seinopolo

Ultrasonic homogenizer UIP2000hdT (2kW) mo e hokohoko atu hono ue'i 'o e kulupu Seinopolo

ʻoku ʻi ai e moʻui lelei manifold ʻuto mo e ivi poupou molecules, ngaahi ivi mo e phytochemicals, ʻa ia ʻe lava ke maʻu mo/pe faʻu ki ha ngaahi fakalahi ʻe nano, hange ko e viviku, tinctures, capsules, ʻa e kuo ne fakamalohia mo maluʻi ʻa e meʻatokoni ʻaki e ngaahi meʻakai mo e ala meʻa pehe.

Ko e tokolahi taha nootropics ʻoku ʻiloʻi ko ha ngaahi meʻa ʻo e kalasi racetam, hange ko e piracetam, aniracetam, oxiracetam, pramiracetam mo e phenylpiracetam. ʻoku lipophilic ha ngaahi Racetams lahi (= momona-soluble). ʻi hono ngaue ʻaki ʻo e faitoʻo ultrasonic, ʻoku leva me'a encapsulated ai ʻa e soluble ngako racetam ʻi ha founga nano ʻo hange ko e nano-emulsions, liposomes, misini ke vave nanoparticles (SLNs), mo e nanostructured liʻu ka ki he kau fata (Nlthf). ʻoku liliu ʻe he nano ko ʻeni formulations ʻa e vai repellant, soluble racetam ki ha koloa ʻoku soluble vai. Koeʻuhi ko e tokoni ʻa e taʻataʻa ʻi he sino ʻo e tangata ko e meʻa ʻoku fakavaʻe ʻi he vai nano-soluble formulations ʻomi ai ha bioavailability ʻoku maʻolunga ange.

Ultrasonically Nano-fakaleleiʻi ʻa e Faitoʻo konatapu

ʻoku malava ʻa e tekinolosia ʻo e encapsulation mo e ultrasonic nano ke teuteu ki ha fakalahi mo ha therapeutics lahi. Bioactive molecules ʻa ia ʻoku maʻu ʻa e lelei mei hono faʻu ultrasonically faʻu ʻo e misini liposomal pe ʻi ha faʻunga kehe ʻe nano ʻoku kau ai ʻa e vaitamini, antioxidants, flavonoids, botanical ngaahi meʻa ʻoku fai, makakoloa, 'amino ʻesiti mo peptides.

  • Ko e vaitamini mo e antioxidants, ʻa ia ʻe lava ke maʻu mei ha maʻuʻanga tokoni fakanatula pe ke synthesized, kau ai ʻa e vaitamini C, f vaitamini, glutathione, resveratrol, CoQ10 (ubiquinone), etc.
  • Herbal mo e botanical molecules hange ko e FBD, THC, FBG (cannabis), ti lanu mata catechins (e.g. EGCG), hala, he kefini, ashwagandha, berberine, kratom mo e ala meʻa pehe.
  • Fungi/mushroom ʻa e ngaahi meʻa hange ko e astragalus, mane e laione, ʻa e pipi, GA, psilocybin (fiemana talingelinga), mo e ala meʻa pehe.
  • 'Amino ʻa e ʻesiti hange ko e creatine, glycine, 5-HTP (5-hydroxytryptophan), phenylalanine, L-theanine ('amino (analogue-gamma), aminobutyric, N-ha ʻesiti (NAC), L-taurine, mo e ala meʻa pehe. ʻ
  • Ko e makakoloa hange ko e magnesium chelates (hange ko e magnesium threonate, magnesium orotate) ʻe lava ke ultrasonically leva me'a encapsulated nano ki he particulates.
  • Meʻatokoni fakatupu-ivi, peptides, mo e molecules kehe hange ko e PC-GEA e Alpha, melatonin, choline (choline bitartrate, choline chloride), (racemic) ketau, ʻe he ʻomeka ʻa e ʻesiti (EPA, UEHEKITEA), α-lipoic eʻesiti (ALA), selegiline (L-deprenyl), centrophenoxine, oxytocin, puluu, etc.

ʻoku hanga ʻe he liposomal nano fakaleleiʻi ʻo e bioactive molecules mo e ngaahi ivi malohi ʻo ʻomi ha bioavailability lelei ange pea lava ke ne fakaʻata e ngaahi meʻa ʻoku fakataumuʻa ke ne folaua e paa ʻo e ʻatamai toto. ʻoku taʻofi ʻe he encapsulation ʻa e bioactive molecules mei he ngaahi hydrolysis ʻo e langa ʻi he kete mo enzymatic ha ngaahi feituʻu maʻulalo ʻi he gastrointestinal, koeʻuhi ke lava ʻo ʻave ha peseti maʻolunga ʻo e e ʻo maumau ki he saiti ʻo e ngaahi selo.

Excursus: ultrasonic Toʻo hingoa ʻo e ngaahi kemikale Phyto

Ko Sonication e tekinolosia maʻolunga ke tukuange bioactive molecules mei he ʻakau, fungi mo e pekitilia. Ko e toʻo hingoa ultrasonic ko ha founga ʻoku ʻikai fakafuofuaʻi, ʻa ia ʻoku makatuʻunga ʻa e tefitoʻi moʻoni fakangaue ʻi he cavitation. ʻoku fakatupu ʻe he ultrasonic/cavitation ʻa e tumuʻaki ʻo e ngaahi meʻa fakamisini mo e turbulences, ʻa ia ʻoku perforate mo veuki ʻa e holisi mo e membranes pea ʻoku ne tuʻuaki ha paʻanga lahi ke ʻave. Sonication ai, tukuange ʻa e ngaahi meʻa bioactive mei he loto pilisone kae ʻave ia ki he Solvent (e.g. vai, ethanol, glycerine, lolo vesitapolo mo e ala meʻa pehe.)
Ako lahi ange fekauʻaki mo ultrasonic toʻo hingoa ʻo bioactive molecules mei he botanicals!

Ngaue Ultrasonicators-maʻolunga maʻa Nootropic Formulations

Ko e ngaahi founga falalaʻanga ʻo Hielscher Ultrasonics ʻ ʻoku fakaʻaongaʻi ʻi he fakafaitoʻo pea tanaki atu ki ai ʻa e faʻu ʻo ha ngaahi faitoʻo ʻoku lelei ange nootropics mo fakapotopoto, ʻa ia ʻoku mei he nano-emulsions ki he liposomes, nanostructured ke maʻu ha misini ke fetongi ʻaki ha misini, nanoparticles, inclusions, complexes, antioxidants mo ha ngaahi flavonoids mo ha toe peptides maʻolunga taha, ʻa ia ko ha ngaahi meʻa Ke feau e ngaahi fie maʻu ʻa e kau fakatau, ʻoku ultrasonicators ʻa e ngaahi naunau ʻo e Hielscher mei he fale kumi paʻanga homogenizer mo e sea ʻi ʻolunga ʻo ultrasonicators ki he ngaahi maʻuʻanga tokoni lalahi ultrasonic ke ngaohi ʻaki ʻa e ngaahi tohi ʻo e nootropics pea poto ʻi he faitoʻo konatapu formulations. ʻoku lava ke fai e ultrasonic hono fokotuʻutuʻu taimi tatau pe ko e kulupu (batch) pe founga ʻoku hokohoko ʻaki hono ultrasonic ʻo fakafou ʻi he Seinopolo. ʻoku ʻi ai ha ngaahi ultrasonic sonotrodes (probes) mo Seinopolo ngaahi vaka ʻoku lava ke maʻu ke fakapapauʻi ko ha fokotuʻutuʻu tokolahi lelei ki hoʻo liposome. ʻoku fakaʻata ʻe he robustness ʻo Hielscher e meʻangaue ultrasonic ʻa e 24/7 ʻa e ngaue mamafa ʻi hono fai ha ngaue lahi ʻi ha ngaahi ʻatakai lahi pea fakapapauʻi ʻoku ʻi ai ha siakale ʻo e ultrasonicators ʻi he moʻui loloa.
Hielscher's industrial processors of the hdT series can be comfortable and user-friendly operated via browser remote control.ʻoku hanga ʻe hono mapuleʻi tatau ʻi he ngaahi founga mahuʻinga kotoa ʻo hange ko e amplitude, malohi, mafana mo e taimi sonication ʻo ʻai ke falalaʻanga mo reproducible ʻa e ultrasonic. Hielscher ʻoku ʻiloʻi ʻe he Ultrasonics ʻa hono mahuʻinga ke kei hokohoko atu ʻa e faitoʻo ki he tuʻunga maʻolunga pea tokoni ki ai mo therapeutics ha ngaahi ngaue ki hono fakahoko ʻo e founga standardisation mo e GMP (founga ʻo e Ngaohiʻanga koloa lelei) ʻi he ngaahi polokalama fakakomipiuta mo e fakamatala ʻotometiki ʻoku lekooti. ʻoku hanga ʻe heʻetau ultrasonic fakaʻilekitulonika ʻo lekooti ʻa e fakangatangata kotoa pe ki he founga hono langa ʻi ha kaati SD. Lomiʻi ʻi he Digital Touch ʻoku lava ʻa e ngaahi founga ʻoku ʻasi mo e browser ke puleʻi ʻaki hono toutou vakaiʻi pea lava ke fakaleleiʻi e fakangatangata ʻo e founga ʻi he taimi kotoa pe ʻe fie maʻu ai. ʻoku hanga ʻe he founga ko ʻeni ʻo fakafuofuaʻi ʻa hono tokangaʻi mo hono mapuleʻi lelei ʻo e ngaue.
'Oku 'omi 'e he e tepile 'i lalo ha faka'ilonga ia 'o e tu'unga 'o e ngaue ki he fakafuofua'i 'o e hotau ultrasonicators:

Kulupu (batch) 'o e tohi 'Oku tafe mai 'a e 'ea 'Oku fokotu'u atu 'a e ngaahi me'angaue
mL 'o e 1 ki he 500 10 ki he 200mL/miniti 'e UP100H
mL 'i he 10 ki he 2000 20 ki he 400mL/miniti 'e UP200Ht, UP400St
0.1 ki he 20L 0.2 ke 4L/miniti 'e UIP2000hdT
10 ki he 100L 2 ki he 10L/miniti 'e UIP4000hdT
n.a. 10 ki he 100L/miniti 'e UIP16000
n.a. lalahi fakataha'i 'o e UIP16000

Fetu'utaki mai kiate kimautolu! / Kole kiate kitautolu!

Kole ki ha fakamatala lahi ange

Kataki 'o ngaue 'aki e foomu 'i lalo ke kole ha toe fakamatala ki he ultrasonic processors, faka'aonga'i mo e totongi. Te mau fiefia ke alea'i e founga 'oku mo 'i ai mo ho'omou ngaahi fie ma'u ultrasonic he polokalama!









Kataki 'o fakatokanga'i ange 'etau Tu'utu'uni totonu fakatautaha.


Hielscher Ultrasonics pilisone ngaue ma'olunga ultrasonic homogenizers ki he fakamovetevetea, emulsification mo e hingoa to'oto'o.

Ko e malohi ma'olunga ultrasonic homogenizers mei Loki fakasaienisi ki he pailate mo e Lalahi me'afua.

Ngaahi tohi/fakamo'oni fakafolofola



Ngaahi mo'oni'i me'a 'oku mahu'inga ke 'ilo'i

Nootropics mo e Smart ngaahi Faitoʻo konatapu

Ko e fo'i lea “nootropic” Ko e haʻu mei he ngaahi lea faka-Kalisi ʻo e kuonga Muʻa νόος (nóos), ʻa ia ʻoku ne taukaveʻi “ʻatamai” mo e τροπή (tropḗ), ʻa ia ʻoku ʻi ai e ʻuhinga “liliu ". Ko e Nootropics, ʻoku toe ʻiloa pe ko e ngaahi faitoʻo konatapu, ko e "liliu ʻo e ʻatamai", ʻo hange ko ha ngaahi meʻa bioactive ʻoku ne uesia e ʻuto ʻaki hono fakatupulaki e ngaue fakaʻatamai, tautautefito ki he ʻatamai poto, fatongia fakapule, manatu, mohu founga, tokanga, mo e fakaʻaiʻai. ʻoku fakaʻaongaʻi kinautolu ko ha enhancers fakaʻatamai pe ko ha doping ʻuto. ʻoku kau he nootropics manakoa ʻa e racetams. Ko e fuofua synthesised foomu racetam naʻe toʻo ia mei he GPEʻAPA pea ʻoku ʻiloa ia ko piracetam, pea ʻoku lau ia ko e ʻikai ke fuʻu kona mo fakatotoloʻi taimi loloa. ʻoku tatau e Aniracetam, oxiracetam, pramiracetam mo e phenylpiracetam mo e piracetam, ka ʻoku nau fakaʻaliʻali ha maʻolunga ange potencies. Ko e ngaahi foomu racetam foʻou hange ko e coluracetam, fasoracetam, nefiracetam, pe noopept ʻoku ʻikai ke ʻi ai ha ngaahi meʻa ne faitatau ai ʻa e faʻunga ke piracetam.
ʻe lava ke ʻi ai ha nootropics ʻe niʻihi ʻoku nau psychedelic pe psycho mamalohi/psychotropic, pea uesia ʻa e ngaahi founga fakaʻatamai, hange ko ʻeni. fakakaukau, ʻiloʻi, cognition, ongoʻingofua, ongo mo e loto.

Racetams

ʻoku ʻiloa ʻa e Racetams ko e faʻahinga faitoʻo konatapu mo e piracetam ko e ʻuluaki synthesised racetam ia ʻoku ʻiloa ko e ʻuluaki nootropic. Ko Piracetam ko ha molecule ʻi he kulupu racetams fakataha mo e hingoa ʻo e kemikale fika 2-oxo-pyrrolidine acetamide. Ko ha derivative ia ʻo e neurotransmitter GʻAPA (gamma-aminobutyric). Ko e Piracetam ko ha faitoʻo konatapu ia ʻoku ʻi ai hano pyrrolidone tefito, ʻa ia ʻoku angamaheni ʻaki hono tuʻutuʻuni ki he kau mahaki ʻi he ngaahi fakaʻilonga ʻa Alzheimer pe tomuʻa manatu. Neongo ia, ʻoku toe fakaʻaongaʻi foki ʻa e piracetam mo ha ngaahi racetams kehe ʻe ha kakai lalahi moʻui lelei kae lava ke fakalahi ʻa e kemikale synaptic ʻo fakaleleiʻi ʻa e ngaahi selo ʻo e ʻuto. ʻe lava ʻe he Racetams ʻo fakalahi ʻa e ngaahi tafaʻaki fakalukufua ki he IQ, manatu mo e ako, ʻa e mahino pea mo e taumuʻa fakaʻatamai. Ko e molecules kehe ʻi he kalasi racetam ʻoku e.g. pramiracetam, oxiracetam, аnԁ aniracetam.
Koeʻuhi ʻoku racetams ʻa e ngaahi meʻa ko ia ʻoku ʻikai mapuleʻi ʻi he ʻiunaiteti Siteiti pe ngaahi fonua kehe ʻi he mamani, ʻe lava racetams fakatau mai ko ha OTC (ngaahi) fakalahi ʻo ʻikai ha ʻi ai ha faitoʻo. ʻoku lau ʻa e Racetams ʻoku ʻikai ko ha ngaahi ola kovi mo fakalukufua, ʻoku kau ai ʻa e ngaahi nunuʻa ko e tupu mei Racetams ʻavanga ʻo e choline ʻi he ʻuto. Ko ia, ʻoku faʻa fakatahaʻi ʻe kinautolu ʻoku ngaue ʻaki ʻenau racetam ʻa e huhu choline fakalahi (e.g. choline bitartrate. ʻoku maʻu ʻe Overdoses ʻo racetams ʻa e ngaahi ola pe ʻe taha ʻo e mama, ʻa ia ʻoku faitatau mo e lahi ʻo e ngaahi meʻa he kefini.

Stimulants

Ko e ngaahi meʻa ʻoku ne fakaʻaiʻai ʻa e he kefini mo e hala ʻikai ko ha faitoʻo, ʻoku fuʻu mafola lahi ʻi he kakai ʻo e mamani. Ko e he kefini mo e hala (nikotini) ko ha psychostimulants fakalao ia, lolotonga ia ʻoku taʻefakalao hono fakaʻaongaʻi ʻo e stimulant e kalasi amphetamines. ʻoku kau ʻi he kalasi ʻa e stimulants ha meimei faʻahinga molecule pe ʻoku ne poupouʻi e hake lahi mo tokanga ki ai, fakasiʻisiʻi ʻa e ongoʻi tiredness mo e drowsiness pea mo fakatupulaki ʻi he taimi tatau pe ʻa e ngaue mo e poto ʻo e ʻatamai quotient (IQ). Ko e taha ʻo e ngaahi faitoʻo konatapu ʻiloa ʻo e narcolepsy ko e Modafinil, ʻoku ngaue ʻaki ia ʻe ha niʻihi fakafoʻituitui ʻoku moʻui lelei ko e "tokotaha" ʻoku ʻikai ke nau maheni mo e ngaahi fatongia fakaʻatamai. " Ko e methylphenidate ʻe taha ʻoku ngaue ʻaki ʻa e faitoʻo konatapu ko ha meʻa ke ne tokangaʻi nounou Hyperactivity moveuveu (ADHD) pea fakaʻaongaʻi ʻe he niʻihi fakafoʻituitui moʻui lelei ko e enhancer fakaʻatamai.
Lomiʻi heni ke ʻilo lahi ange ki he toʻo ultrasonic e ʻuli ʻo he kefini mo e hala (nikotini)!

Adaptogens

Ko e Adaptogenic ko ha ngaahi meʻa ʻoku phyto ʻe he kemikale me'a ko'eni, ko e. naʻa ne molecules e ʻakau, ʻa ia ʻoku foaki kae lava ke fakamalohia ʻa e tali ʻa e sino mo e ngaahi tukunga ʻo e fakamafasia. ʻe lava ke fakamatalaʻi ʻa e Adaptogens ko e "lotomoʻua" me'a ko'eni, ʻa ia ʻoku ne fakatupu ʻa e sino ke liliu ki hono tauhi pe toe maʻu homeostasis (potupotutatau ʻi he vahaʻa ʻo e ngaahi founga metabolic ʻo e sino). Ko e tefitoʻi hala ʻo e ngaue adaptogenic ʻoku uesia ai ʻa e hypothalamic – pituitary – adrenal (HPA axis) ko e tali ke fakaʻaiʻai ʻe ha loto hohaʻa mei tuʻa. ʻoku meimei ke adaptogens kotoa pe ki he kalasi ʻoku ʻikai mapuleʻi ʻa e faitoʻo, ʻa ia ʻe lava ke fakatau ʻi he funga kanita (OTC) fakalahi. Ko e lahi taha ʻo e ngaahi adaptogens ʻoku manakoa mo lahi fau ko e e.g. ginseng, gingerol (Sinisa), ashwagandha, eleutherococcus senticosus (lelueTrans Siberian ginseng), rhodiola potutahi (Arctic), schisandra chinensis, kava kava, matalaʻi ʻakau vela, Seni Lehai Sione Wort, mo scutellaria baicalensis (faka-Siaina skullcap).
Ko Cannabis a Adaptogen? Kuo Cannabis e tokanga lahi ʻi he ngaahi taʻu fakaʻosi, ko e meimei kotoa pe ʻo hono ngaahi fili laukovi mo e fakafiefiemalie me'a ko'eni cannabidiol (FBD) mo cannabigerol (• BG). Naʻa mo e cannabinoids ʻoku ʻikai kona ʻa e ʻakau me'a ko'eni pea kuo ʻosi fakamoʻoniʻi e ʻaonga hono ngaahi nunuʻa ʻi he sino, cannabis pea ʻikai ko hano fakafaʻahinga ia ʻo e cannabinoids. Kae talu mei he hu ʻa e BD. adaptogenics mo e ngaahi meʻa ʻoku faitatau mo ia ʻi he ngaue mo e ola, ʻoku faʻa fakaʻaongaʻi kinautolu ʻi hono fakatahaʻi ke ngaahi e ngaue lelei ʻa e cannabinoid pea pehe ki he adaptogen.
ʻi he taimi adaptogens ʻoku maʻu ai ʻe he mahamahaki mo e haʻahaʻa ʻo e loto mafasia, ʻoku nau fakahaaʻi pe ʻa e ngaahi nunuʻa iiki ko e enhancers fakaʻatamai, "he ko e taha" ia. ʻoku toki aʻusia pe ʻa e ngaahi meʻa fakaʻatamai mei he adaptogens ʻaki hano fakapalanisi ʻo e tali loto hohaʻa ʻa e sino, ʻa e 'ene tolonga mo e moʻui lelei fakalukufua, kae ʻoua naʻa ne kamataʻi fakahangatonu ʻa e tupu ʻa e ngaahi selo ʻo e ʻatamai foʻou pe neural ngaahi fehokotaki.
Lomiʻi heni ke ʻilo lahi ange fekauʻaki mo e ultrasonic toʻo hingoa ʻo e adaptogens mei he botanicals!

Cholinergics

Ko e ngaahi meʻa Cholinergic ko ha kemikale me'a ko'eni ʻoku ne faʻifaʻitaki ʻa e ngaue ʻa acetylcholine mo e/pe butyrylcholine. ʻoku maʻu ʻe he Choline ʻoku makatuʻunga ia ʻi hono mapuleʻi ʻo e ngaahi faitoʻo ʻa e ʻoku ne uesia ʻenau manatu, tokanga, mo e ongo. Ko e taha Acetylcholine ʻo e neurotransmitters lahi ʻi he ʻuto. Ko ha konga mahuʻinga foki ia ki he ngaue totonu ʻa e vakai ʻi he polokalama tailiili. ʻe lava ke fai ʻa e Choline ʻo fakalahi atu ki ai, ka ʻoku ʻi ai foki ia ʻi he meʻakai, hange ko e ngaahi foʻi moa yolks mo e piini ʻoku ʻikai fuʻu ʻaonga ʻi Choline.
Ko Sulbutiamine (ʻa ia ʻoku maʻu fakakomesiale atu ia ʻo hange ko e OTC (ʻi he funga kanita) ko e faitoʻo konatapu ʻi he malumalu ʻo e hingoa ko e laione (vaitamini sipinga b1), ʻa ia ʻoku ne kolosi ʻi he paa ʻo e toto pea lava ke fakatupulaki ha tuʻunga thiamine ʻi he ʻuto. Ke toe lelei ange hono manatuʻi pea ikunaʻi e vaivai mo e ongosia ʻi hono psycho e ʻulungaanga inhibition, ʻoku toe fakaʻaongaʻi foki ia ʻe ha kau sipoti. ʻoku fakafaʻahinga ʻa e Sulbutiamine ko cholinergic poto ʻi hono maʻu ha faitoʻo konatapu talu mei he meʻa ko ʻeni ʻoku hoko cholinergic regulator ʻi he hippocampus. ʻi hono ngaue ʻaki ʻi he dosages fakafiemalie, kuo teʻeki ai ke fai ha ngaahi nunuʻa kovi.

Serotonergics

Ko e Serotonin, pe 5-hydroxytryptamine (5-FF), ko monoamine neurotransmitter ia ʻoku tokoni mo puleʻi ʻa e loto (lelei, fiefia), mo e modulates mohe, uʻa, cognition, ako, manatu, ʻa e pale ʻo e totongi mo e ngaahi founga fakatuʻasino lahi hange ko e lua mo e vasoconstriction. ʻoku ʻomi e Serotonin ʻi hono sino ʻaki e fakafetuʻutaki ki he laʻaa. ʻoku ʻi ai foki ha ngaahi maʻuʻanga tokoni ʻo e serotonergic fakanatula (-serotonin pe tukuange) me'a ko'eni, hange ko e L-tryptophan.

Dopaminergics

ʻoku Dopaminergics fakapotopoto ʻa e ngaahi faitoʻo konatapu ʻoku ne uesia ʻa e ngaahi tuʻunga ʻo e dopamine ʻi he ʻuto. Ko Dopamine ko ha hormone mo ha neurotransmitter ʻoku ne fakahoko ha ngaahi fatongia mahuʻinga ʻi he ʻuto mo e sino. Hange ko ʻeni, ʻoku fatongia ʻaki ʻe he dopamine ʻa e ngaahi ongo lelei mo e biochemical signalling ʻo e fakamatala lelei, ʻo kau ki he ngaahi aʻusia fakafiefia hange ko e ifo meʻakai, tangata pe fefine, feohi fakasosiale lelei, mo e ala meʻa pehe.
ʻoku lava ke Dopamine ko ha faitoʻo ia ʻi he ngaahi hingoa ʻo Intropin, Dopastat, mo Revimine, mo ha niʻihi kehe, ʻa ia ʻoku fakaʻaongaʻi pe ko ha faitoʻo konatapu ʻi hono faitoʻo ʻo e toto fefeka, lahi ʻo e ngaahi mafu, mo e hamu.
Dopaminergic e ngaahi faitoʻo konatapu faka'ai'ai ʻoku fakaʻaongaʻi ia ke ikunaʻi ʻaki ʻa e tuʻunga maʻulalo dopamine, ʻa ia ʻoku meimei ke fekauʻaki mo e ngaahi tuʻunga maʻulalo ʻo e ivi, siʻisiʻi ʻa e fakaʻaiʻai, anhedonia (ʻikai malava ke ongoʻi fiemalie), fakafiefiemalie, loto mafasia, maʻunima behaviours, manatu kovi pea fakasiʻisiʻi e ako. ʻoku angamaheni ʻaki dopaminergic poto ʻa e ngaahi faitoʻo konatapu ko e L-tyrosine, Yohimbine mo e selegilin (a MAO inhibitor). Dopamine faka'ai'ai poupouʻi e tokanga mo e taʻetokanga ʻaki ha fakatupulaki e malohi ʻo e Dopamine ʻi he ʻatamai, pe inhibiting e enzymes ʻoku ne maumauʻi e Dopamine.

Ngaahi kulupu kehe ʻo e poto ʻi he faitoʻo konatapu, ngaahi enhancers fakaʻatamai, mo e nootropics ʻoku kau ai ʻa e glycinergics, adenosinergics, adrenergics, cannabinoidergics, GABAergics, histaminergics, melatonergics, monoaminergics, mo e opioidergics.
Ko e kulupu ʻo e "-ergic" nootropics ko ha ngaahi meʻa ia naʻa ne modulate ha founga pau ʻi he sino mo e ʻatamai. ʻoku fakakau ʻa e System pau ʻi he konga ʻuluaki ʻo e temi. Hange ko ʻeni, glycinergics fakahangatonu modulate ʻa e glycine ʻi he sino mo e ʻatamai, adenosinergics modulate e polokalama adenosine ʻi he sino mo e ʻuto, dopaminergics ngaue ʻi he founga dopamine mo e ngaahi ala meʻa pehee.

Fakakau ʻa e Complexes

ʻoku fihi ʻa e komipauni ʻoku fakakau ai ha kemikale – he ko ia 'oku ui ko “tauhi” – ʻi ai ha molecule ia ʻe taha – he ko ia 'oku ui ko “fakaafe” – 'Oku 'oatu.
Ko e Cyclodextrins ʻoku lahi taha hono fakaʻaongaʻi me'a ko'eni, he ʻoku lava ke nau faʻu ʻaki ha ngaahi faingataʻa kehekehe, ʻoku fefeka mo ha gaseous me'a ko'eni. Me'a ko'eni kau fakaafe mei he ngaahi meʻa reagents hange ko e ʻesiti, amines, ions siʻisiʻi (e.g. ClO4-, SCN-, halogen anions) ke maʻolunga apolar aliphatic pea aromatic hydrocarbons mo e ngaahi kasa ʻoku hahamolofia. ʻe lava ke synthesized hono fakakau ʻo e complexes ʻi hano fakaleleiʻi pe ʻi he tuʻunga crystalline. Ko ultrasonic complexation ʻo e cyclodextrin ʻoku makatuʻunga ai ʻa e fie maʻu ko ha founga falalaʻanga mo lelei ia ke ngaohi ʻaki ha meʻa ʻoku kau ki ai complexes, ʻa ia ʻoku ne maʻu ha tuʻunga tuʻu maʻu mo maʻolunga ange bioavailability. ʻoku fakaʻaongaʻi ʻa e vai ʻi he ngaahi meʻa ʻoku angamaheni ʻaki, neongo ʻoku hoko ʻa e dimethyl sulfoxide mo dimethyl formamide ko ha fili solvents ke fakaʻaongaʻi.
Makehe mei he fakakau 'e fakafaito'o / nutraceutical kalasiume, cyclodextrin 'oku toe faka'aonga'i kalasiume 'a e tauhi ki he molecules 'o e fragrance ke a'usia ha tu'unga ma'olunga ange pea mo ha ngaue 'oku tuai-ongoongo 'oku tuku atu.
Lau ha fakamatala lahi ange kau ki ultrasonically kuo fakakau complexes!