Hielscher faka'ata tekinolosia

Liposomal leva me'a encapsulated Bioactive Molecules mo Ultrasonics

ʻoku ʻiloa ʻa e Ultrasonication ʻi hono teuteuʻi ʻo liposomal formulations. Liposome angamaheni formulations ko e tokotaha vaitamini f, FBD, curcumin, quercitin, astaxanthin, peptides mo manifiold bioactive me'a ko'eni ʻaki e ultrasonication. Ko e ultrasonic liposome encapsulation, ko ha founga faingofua mo vave ia ʻoku lava ke maʻu ai ha meʻa ke ne ngaohi ha tuʻunga lelei, ha uta maʻolunga vesicles. Ultrasonically leva me'a encapsulated lelei ange ʻa e ivi malohi ʻo e bioavailability.

Ko e ha ʻa e Liposomes pea ko e ha honau ngaahi lelei?

Liposomes ʻoku vesicles kau ia ʻi ha aqueous tefito ʻe taha pe lahi ange phospholipid. Koeʻuhi kuo liposomes ʻa e konga ko e aqueous ʻoku ʻatakaiʻi ʻaki ha ngeʻesi kapa, pea mo ha hydrophilic ʻi tuʻa, liposomes ko ha vai-soluble ia pea te ne lava pe ke ʻave ʻa e vai mo e soluble ʻi he soluble takitaha ʻo e me'a ko'eni. ʻoku hoko ʻeni liposomes ha founga tufa lelei ʻaupito ki therapeutically molecules malohi. ʻoku fakatupu ʻa e Liposomes ʻaki hono maumauʻi ʻo e ngaahi membranes totonu, ko ha founga ʻoku poupouʻi mo toe fakalalahi ange ʻi ultrasonication. Ko e fokotu'utu'u 'o ha liposomeKo e Liposomes ʻoku faʻa kau ai ʻa e phospholipids, tautautefito ki he phosphatidylcholine, ka ʻe toe kau ai mo ha ngaahi lipids kehe, hange ko e fuaʻimoa phosphatidylethanolamine, kapau ʻoku fenapasi mo e misini ke maʻu ai ha meʻa ʻe lava ke maʻu. ʻoku Liposomes ʻi he foomu phospholipids ʻi hono inu va'inga. ʻi he ʻuluaki sitepu – Ko e konga hydration – ʻoku fakaʻaongaʻi ʻa e sonication ke nano ʻa e lipids mo e konga aqueous ke lava ʻo paotoloaki ʻa hono fokotuʻu ʻo e fakaheka lahi ki he ngaahi lamellar vesicles (Mlv). Ko ia ai, ʻe lava ke sonification ngaue ʻaki ke fakasiʻisiʻi ʻa e lahi ʻo e liposome kapau ʻe fie maʻu. Ke maʻu ha kiʻi vesicle siʻisiʻi ange, ʻoku fakaʻaongaʻi ʻa e sonication ke matoʻo pea fakasiʻisiʻi ʻa e lahi ʻo e liposome ki he mono-Uni lahi lamellar vesicles (Luv) pe ko e Uni lamellar (Suv).
Ko e founga ultrasonic liposome hono faʻu mo hono lahi ʻo e liposomal ʻoku falalaʻanga, vave, lelei, faingofua mo malu. ʻoku fakahaaʻi ʻe he liposomes ha ngaue lahi bioactive, tuʻu ʻaliʻaliaki mo maʻolunga bioavailability.

Ultrasonication is a fast and reliable technique to produce superior liposomes and nanoliposomes.

UP400St, ko ha 400 Watts malohi ultrasonic homogeniser, ki he Production nano-liposomes.

Kole 'a e fakamatala




Fakatokanga'i ange 'etau Tu'utu'uni totonu fakatautaha.


Ko e ha ʻoku ʻikai lava ai ultrasonic ʻa e vaia (High-Cleaning) ke maʻu ha liposomes ʻoku lelei ʻaupito?

ʻoku fie maʻu ʻi hono fokotuʻu ʻo e liposomes ha meʻangaue ultrasonic te ne lava ʻo fakatauʻatainaʻi ha ivi feʻunga ke fakatupu ha teunga mo ha ngaahi momoʻi meʻa nano. Ko e liposomes ʻi hono fakaʻaongaʻi ʻo ha ultrasonic fakamaʻa jewellery ʻoku faʻa fuʻu lelei ia talu mei he fakahaaʻi ko ia ʻo e liposomes ʻoku ʻikai fie maʻu ke lahi nano pe ʻoku nau ki he ivi ʻo e bioactive ʻi ha founga lelei mo taimi loloa. Ke lava ʻo teuteuʻi e liposomes lelei, ko ha fekumi ultrasonicator ko e tekinolosia ia ʻoku fie maʻu, ʻa ia ko e (sonotrode) ʻoku ne ʻomi e ivi fakaʻeiʻeiki ko ia ki hono faʻu ʻo ha tuʻunga pau ʻo e koloa liposomes ki he founga Lotoloto. Ko hono fakalukufua, ko e liposomes ko ia ʻoku faʻu ʻaki ha ultrasonic fekumi ʻoku ʻi ai hono size ʻe 100-500nm, ʻa ia ʻoku tokolahi lelei ki ha loadings maʻolunga mo maʻolunga ange.
ʻoku hanga ʻe hono ngaue ʻaki ʻo e ultrasonic ki he Seinopolo ʻo teuteuʻi e liposomes ʻi ha ʻatakai ʻoku ʻikai ke ʻi ai ha ʻosikena ke ne taʻofi ʻa e maʻulalo.
ʻoku ʻomai ʻe fekumi faʻahinga ultrasonicators ʻa e ivi ʻoku fie maʻu ke ngaohi ʻaki liposomes ʻa e:

  • uta lahi
  • ngaahi nano iiki
  • 'ai'angakai 'o e manu
  • monodisperse
  • bioavailable
  • biocompatible
  • ngaahi

Liposomal leva me'a encapsulated Molecules mo Ultrasonics

ʻoku ʻomi ʻe he lisi ʻi lalo ha fakaʻilonga kuo ʻosi leva me'a encapsulated lelei ki he liposome formulations ʻi hono ngaue ʻaki e ultrasonic teuteu.

  • antioxidants hange ko e glutathione, vaitamini f, methylated B vaitamini, resveratrol, CoQ10 etc.
  • phenolics: flavonoids hange ko fisetin, quercitin, oligomeric proanthocyanidins (OPC); saponins hange ko e astralgaloside; alkaloids
  • makakoloa hange ko magnesium chelates (e.g. magnesium threonate, magnesium orotate), singiki, kopa mo e ala meʻa pehe.
  • terpenes hange ko e astaxanthin, limonene, pinene, humulene, linalool, beta-caryophyllene, phytol, geraniol, terpinolene mo e ala meʻa pehe.
  • lipids hange ko e hoko ʻa e ʻomeka-3 fatty ʻa e ʻesiti ko e FAʻAEPA mo TOHEKITEA; dipalmitoyl-phosphatidylcholine (DPPC) etc.
  • 'amino ʻa e ʻesiti hange ko e creatine, glycine, 5-HTP (5-hydroxytryptophan), phenylalanine, L-theanine, GʻAPA (gamma-aminobutyric ʻesiti), taurine, N-acetylcysteine (NAC), L-tyrosine, etc.
  • peptides, hange ko oxytocin, collagen peptides etc.
  • polysaccharides hange ko hyaluronic ʻesiti, mushroom polisaccharides mo e ala meʻa pehe.
  • cannabinoids hange ko e t BD, mo e BH, THC
  • nootropics, fakapotopoto e faitoʻo konatapu, mo e enhancers fakaʻatamai, ʻa ia ʻe lava ke kau ai ʻa e ngaahi meʻa ʻoku fakamatala ki ʻolunga mo ha niʻihi kehe molecules

ʻoku liposomal ʻe he nano fakatupulaki ʻo e bioactive ʻa e molecules ʻoku maʻolunga ange, ʻa ia ʻoku maʻu ʻe he absorption ʻi he bioavailability pea te ne ala fakaʻata ha meʻa ke ne folaua e ʻa ʻo e ʻuto ʻo e ʻatamai.
Ko e founga ʻoku fetongi ʻaki ʻa e misini faitoʻo konatapu ko e nano-emulsions mo e liʻoku ʻikai ko ha meʻa ke ne veteki ʻa e kau colloidal ʻo hange ko ha misini ke ne fetongi fefeka nanoparticles (SLN) mo nanostructured Lie misini ke fetongi (NLC). ʻe lava ke reliably kotoa kinautolu nano-emulsions, SLNs mo Nlthf ʻi he sonication.

Ultrasonic processor UIP2000hdT (2kW) 'i hono ue'i 'o e batch Seinopolo

Ultrasonic homogenizer UIP2000hdT (2kW) mo e 'a e kulupu (batch) foaki hokohoko Seinopolo

ʻoku ne takiekina e Tuʻunga lelei Liposome

Ko e founga 'oku fie Ultrasonication ki ai ke fa'u liposomes 'aki ha uta lahi 'o e bioactive me'a ko'eni.ʻoku makatuʻunga Liposome ʻulungaanga lelei ʻi he faitaha ʻa e tokolahi mo e lamellarity, lavameʻa (% EE)/encapsulation kavenga, mo e taʻeueʻia. Ko e founga teuteu, ko e ngaue ki he ngaahi tuʻunga, naunau ʻoku ngaohi ʻaki, mo e tukuʻanga koloa, ko ha ngaahi moʻoniʻi meʻa mahuʻinga ia ʻoku tokoni ki he tuʻunga lelei ʻo e liposomal formulations. ʻoku ha ʻi he ʻimisi ʻo e tokotaha semineli ʻa e ultrasonically mateuteu liposomes kuo teuteuʻi ʻaki ʻa e ngaahi ngaue ʻa EFAFAʻAPA mo e ʻesiti ʻo fakaʻaongaʻi ha Hielscher ultrasonicator UP200S (Ako mo e fakatataa: Hadian et Al. 2014).
Ko e teuteu ki he ultrasonic ʻo e liposomes ko ha founga falalaʻanga ia, ʻa ia ʻoku ne ʻomai ha kihiʻi konga siʻi ʻo e teunga liposomal ʻaki ha lahi bioactive molecules. Ko e fakangatangata ultrasonic founga ngaue (hange ko e amplitude, fakakatoa, taimi, pulsation, mafana, malohi) ko e adjustable. Ko ha founga ngaue ia ʻoku ʻikai fakafuofuaʻi, ʻoku fakatefito ʻa e tefitoʻi moʻoni ʻo e ngaue sonification ʻi he tumuʻaki ʻo e ngaahi meʻa fakamisini. ʻoku tuʻu hake ʻa e mafana ʻi he vai sonicated ke fakamatalaʻi ʻe he fono hono ua ʻo e ivi 'ea, ʻa ia ʻoku ne fakahaaʻi ʻoku ʻi ai ha ivi ʻaonga kuo faifai pea liliu ke vela. ʻoku ʻomai ʻe he Hielscher Ultrasonics ha ngaahi founga ke fakaleleiʻi ʻaki e ngaahi liposomal ʻoku ʻikai fuʻu lelei, hange ko e ngaahi loki he ʻaisi ʻoku nau kau mai mo e ngaahi selo ʻo e saketi. Ko e ola ʻo e ultrasonic liposome ʻoku reproducible, ʻa ia ʻoku mahuʻinga ki ha founga standardised mo maʻu ai ha ola maʻolunga.
Ko e ʻulungaanga lelei ʻoku phospholipids ʻoku ne ʻoatu ha peseti lahi ʻo e phosphatidylcholine mo e phosphatidylethanolamine ʻoku nau ʻomi ha ngeʻesi fale ʻoku ne taʻofi ʻa e mama ʻo e ivi. ʻoku hanga foki ʻe ha phospholipid malohi ʻo maluʻi ʻa e ivi leva me'a encapsulated ko ia mei he oxidative mo e valaloto maʻulalo. Ko ia ai, ʻoku mahuʻinga ke potupotutatau hoʻo phosopholipids ki aqueous konga leva me'a encapsulated e ivi ke maʻu ai ha meʻa, (bioactive molecules).

Ngaahi lelei ʻo e ultrasonic Liposome Production

  • Maʻolunga encapsulation/ʻefihia (% EE)
  • 'Olunga bioavailability
  • vave & lelei
  • Tolonga taimi loloa
  • Ki he Meʻakai mo e Pharma
  • malu & Faingofua ke Fakaʻaongaʻi

Polokalama Ultrasonicators-maʻolunga ki Liposome ngaohi

Ko e polokalama Hielscher Ultrasonics ʻ ko ha ngaahi misini falalaʻanga ia ʻoku fakaʻaongaʻi ʻi he fakafaitoʻo pea tanaki atu ki ai ʻa e ngaahi ʻe faʻu ʻaki ha ngaahi vaitamini, antioxidants, flavonoids, peptides, polyphenols mo ha bioactive me'a ko'eni/meʻatokoni fakatupu ivi. Ke feau e ngaahi fie maʻu ʻa e kau fakatau, ʻoku ultrasonicators ʻa e ngaahi naunau Hielscher mei he fale kumi paʻanga homogenizer mo e sea ʻi ʻolunga ʻo e ultrasonicators ki he ngaahi founga maʻolunga ʻo e ʻo e ultrasonic liposomal. Ko e ultrasonic liposome ʻe lava pe ke fai e ngaue ko ha kulupu (batch) pe founga ʻoku ʻikai ngaue ʻaki ʻo fakaʻaongaʻi ha ultrasonic Seinopolo. ʻoku ʻi ai ha ngaahi ultrasonic sonotrodes (probes) mo Seinopolo ngaahi vaka ʻoku lava ke maʻu ke fakapapauʻi ko ha fokotuʻutuʻu tokolahi lelei ki hoʻo liposome. ʻoku fakaʻata ʻe he robustness ʻo Hielscher e meʻangaue ultrasonic ʻa e 24/7 ke ngaue mamafa ʻi he fatongia mo e ngaahi ʻatakai ʻoku femoʻuekina.
Hielscher's industrial processors of the hdT series can be comfortable and user-friendly operated via browser remote control.ʻoku hanga ʻe hono mapuleʻi tatau ʻi he ngaahi founga mahuʻinga kotoa ʻo hange ko e amplitude, malohi, mafana mo e taimi sonication ʻo ʻai ke falalaʻanga mo reproducible ʻa e ultrasonic. Hielscher ʻoku ʻiloʻi ʻe he Ultrasonics ʻa hono mahuʻinga ke kei hokohoko atu ʻa e faitoʻo ki he tuʻunga maʻolunga pea tokoni ki ai mo therapeutics ha ngaahi ngaue ki hono fakahoko ʻo e founga standardisation mo e GMP (founga ʻo e Ngaohiʻanga koloa lelei) ʻi he ngaahi polokalama fakakomipiuta mo e fakamatala ʻotometiki ʻoku lekooti. ʻoku hanga ʻe heʻetau ultrasonic fakaʻilekitulonika ʻo lekooti ʻa e fakangatangata kotoa pe ki he founga hono langa ʻi ha kaati SD. Lomiʻi ʻi he Digital Touch ʻoku lava ʻa e ngaahi founga ʻoku ʻasi mo e browser ke puleʻi ʻaki hono toutou vakaiʻi pea lava ke fakaleleiʻi e fakangatangata ʻo e founga ʻi he taimi kotoa pe ʻe fie maʻu ai. ʻoku hanga ʻe he founga ko ʻeni ʻo fakafuofuaʻi ʻa hono tokangaʻi mo hono mapuleʻi lelei ʻo e ngaue.
'Oku 'omi 'e he e tepile 'i lalo ha faka'ilonga ia 'o e tu'unga 'o e ngaue ki he fakafuofua'i 'o e hotau ultrasonicators:

Kulupu (batch) 'o e tohi 'Oku tafe mai 'a e 'ea 'Oku fokotu'u atu 'a e ngaahi me'angaue
mL 'o e 1 ki he 500 10 ki he 200mL/miniti 'e UP100H
mL 'i he 10 ki he 2000 20 ki he 400mL/miniti 'e UP200Ht, UP400St
0.1 ki he 20L 0.2 ke 4L/miniti 'e UIP2000hdT
10 ki he 100L 2 ki he 10L/miniti 'e UIP4000hdT
n.a. 10 ki he 100L/miniti 'e UIP16000
n.a. lalahi fakataha'i 'o e UIP16000

Fetu'utaki mai kiate kimautolu! / Kole kiate kitautolu!

Kole ki ha fakamatala lahi ange

Kataki 'o ngaue 'aki e foomu 'i lalo ke kole ha toe fakamatala ki he ultrasonic processors, faka'aonga'i mo e totongi. Te mau fiefia ke alea'i e founga 'oku mo 'i ai mo ho'omou ngaahi fie ma'u ultrasonic he polokalama!









Kataki 'o fakatokanga'i ange 'etau Tu'utu'uni totonu fakatautaha.


Hielscher Ultrasonics pilisone ngaue ma'olunga ultrasonic homogenizers ki he fakamovetevetea, emulsification mo e hingoa to'oto'o.

Ko e malohi ma'olunga ultrasonic homogenizers mei Loki fakasaienisi ki he pailate mo e Lalahi me'afua.

Ngaahi tohi/fakamo'oni fakafolofola