Lelei ʻaupito Artemisinin toʻo ʻuli mo Sonication

ʻE lava ke maʻu lelei ʻa e artemisinin ʻi hono fakaʻaongaʻi ʻo e sonication ngaue maʻolunga. ʻOku hanga ʻe ultrasonic toʻo ʻuli ʻo ʻomi ha artemisinin maʻolunga ʻo fakaʻaongaʻi ha solvents angavaivai. ʻOku vave ʻaupito hono fakaʻaongaʻi ʻo e toʻo hingoa fakaʻata. Ko e ngaahi tuʻunga ʻo e ngaue ʻi ultrasonic extractors ko e mapuleʻingofua, ʻa ia ʻoku lava ai ke taʻofi ʻa e maʻulalo ʻo e biomolecule pelepelengesi ʻo e ʻea.

Toʻo ʻUli ʻa ʻAtikisí

Ko artemisinin ko ha molecule ia ʻi loto ʻi he trichome kalava tafe mai ʻo e ʻakau Artemisia annua, ʻa ia ʻoku fakaʻaongaʻi ko e faitoʻo konatapu pea fakahaaʻi ha ivi lahi ko ha faitoʻo konatapu ki hono faitoʻo ʻo ha ngaahi mahaki kehe kau ai ʻa e kanisaa mo e SARS-Kov-2. ʻOku kau ʻi he founga tukufakaholo ʻo e toʻo hingoá ʻa e ngaahi meʻa ʻuli ʻoku fuʻu fakamomohé pea ʻoku totongi mamafa ʻaupito, pea ko e founga ia ʻoku tokolahi lelei hono faí. ʻOku fie maʻu ha founga toʻo ʻuli lelei mo lanu mata kae lava ke maʻu ha environmentally lahi ʻi he ngaahi tuʻunga lelei mo fakaʻekonomika. Ko e ultrasonic toʻo ʻuli ko ha founga toʻo hingoa lahi ia ʻe lava ke fakaʻaongaʻi ʻi hono fakatahaʻi mo e vai pe ethanol ko ha solvents ʻoku ʻikai kona. Kuo ʻosi fakamoʻoniʻi ʻa e ultrasonic toʻo ʻuli ki pununga hone artemisinin maʻolunga, koeʻuhi ke lava ʻo kaka vave ʻa e ngaohiʻanga artemisinin ki ha ngaahi tohi lalahi. ʻOku lava ke maʻu ʻa e meʻangāue ultrasonic toʻo hingoa ki he batch (batch) foaki mo e fakaʻatā tatau ʻi he lainé ki he tuʻunga fakamīsiní.

Kole 'a e fakamatala




Fakatokanga'i ange 'etau Tu'utu'uni totonu fakatautaha.


Ultrasonic extractor for artemisinin extraction under pharma-grade conditions.

ha misini to'o 'uli ultrasonic UIP2000hdT ki he kulupu (batch) foaki lalahi ʻo e artemisinin mei Artemisia annua leaves.

Ultrasonic toʻo ʻuli ʻo Artemisinin mei Artemisia annua

Ko hono ngāue ʻaki ʻo e mālohi fakaʻata ki he toʻo hingoá ʻoku māʻolunga ange ia ʻi he ngaahi founga toʻo hingoa kehé ʻi ha ngaahi meʻa lalahi kehekehe, kau ai ʻa e taimi foʻou ʻoku ʻomi aí, taimi ʻoku toʻo ʻaki e ʻulí, anga fakakaumeʻa ʻi he ʻeá, mo e ola lelei ʻo e totongí.

UP100H mo MS14 sonotrode ki hono toʻo e ʻuli ʻo e botanicals, hange ko e artemisinin mei Artemisia annua leaves

Ko e Drawbacks ʻo e Toʻo Hingoa Tukufakaholo ʻo e ʻAtá

Ko e ngaahi founga toʻo hingoa tukufakaholo ki he artemisinin ʻoku vela taimi, te ne lava ʻo maumauʻi ʻa e bioactive molecules artemisinin koeʻuhi ko e mafana ʻa e ʻea, pea ʻi ai mo ha ʻatakai maʻolunga koeʻuhi ko e solvents ʻoku fakaʻaongaʻi ʻi he mafana ʻo e ʻea. ʻIkai ngata ai, ʻoku fie maʻu ʻa e fakamaʻa lahi ʻi he mataʻutoʻuta ke toʻo ʻa e ngaahi meʻa ʻuli mei he konga ʻuli.

Ko e Ngaahi Lelei ʻo e Toʻo ʻUlí Ultrasonic Artemisinin

ʻOku ʻi ai ha ngaahi ola lelei ʻo hono fakaʻaongaʻi ʻo e malohi fakaʻata ki hono toʻo e ʻuli ʻa ia ʻoku ne fakalahi ʻa e founga toʻo ʻuli: ʻOku fakatupu ʻe he ngaue fakaʻata maʻolunga ʻa e cavitation. ʻOku hanga ʻe he cavitation ko ʻeni ʻo fakaʻaiʻai botanical toʻo e ʻuli ʻaki e fakahohaʻasi toʻotoʻo, koeʻuhi ke tukuange ʻa e biomolecules mei he matrix toʻotoʻo ʻo e fuʻu ʻakau. ʻIkai ngata ai, ʻoku fakalahi ʻe he ngaahi malohi cavitational ʻa e feʻaveʻaki fakahaʻele e biomolecules hange ko artemisinin lelei ki he ngaahi solvent takatakai. ʻE lava ke tokoni ʻa e tefitoʻi moʻoni fakangāue ʻo e toʻo ʻuli ultrasonic ki he ngaahi mālohi fakamisini ʻo e cavitation. ʻOku ʻuhinga ʻeni ko e sonication ko ha founga ia ʻoku ʻikai ko ha meʻa ke ne toʻo e kemikale. ʻOku hanga ʻe heʻete hoko ko ha founga toʻo ʻuli ultrasonic ʻo ʻai ke matuʻaki lelei ʻaupito ʻa e toʻo ʻuli koeʻuhi he ko e thermally ko ha komipauni pelepelengesi, ʻa ia ko hono ʻuhinga ko e mafana ange (e.g., 70 °C) te ne fakatupu hono decomposition. Ko ia ai, artemisia annua L. he ʻikai lava ke haka ia ʻi he vai vela ke maʻu ha artemisinin.

Ngaahi Lelei ʻo Ultrasonic Artemisinin Toʻo ʻUli

  • 'Omi ma'olunga ange
  • Ko e tu'unga ma'olunga
  • mo e vave 'o e to'o 'uli
  • Fili e solvent ʻoku ke fie fakaʻaongaʻi
  • 'ikai ha 'ea ma'ulalo
  • Ngaue ʻaki ha lauʻiʻakau foʻou mo momoa
  • Ko e ngaahi tuʻunga mapuleʻingofua tofu pe
  • totongi lelei

Solvents lanumata ki ultrasonic Artemisinin toʻo ʻuli

ʻOku kau ʻi he toʻo hingoa ʻa e fungani solvents ʻoku fakaʻaongaʻi ki he polokalama ʻa e hexane, lolo fokotuʻu ʻEta pe dichloromethane. ʻOku fenāpasi e toʻo hingoa fakaʻata mo ha faʻahinga meʻa pē ʻoku ne fakaleleiʻi ʻo kau ai ʻa e angavaivai, lanu mata solvents hangē ko e ethanol pe vaí. ʻOku lelei tatau pe ʻa e ultrasonic toʻo ʻuli ʻo e artemisinin mo e ethanol ʻi he taimi ʻoku fakafehoanaki ai ki he solvents fefeka. ʻE lava ke fakaʻaongaʻi ʻa e solubility cyclodextrins ke fakaleleiʻi ʻaki ʻa e toʻo ʻuli ʻo e vai momoko ʻo e ultrasonic.

Ko e hā e Meʻa ʻOkú ne ʻAi ke Fuʻu Lelei Hono Toʻo ʻUlí Ultrasonic Artemisinin?

Kuo pau ke mahino ʻa e tefitoʻi moʻoni ʻo e ngaue fakaʻata ke mahino ʻa e ngaahi lelei ʻo ultrasonically tokoni ki hono toʻo e ʻuli. Ko e founga toʻo ʻuli ʻo e malohi fakaʻata ʻoku ʻuhinga pe ia ki he fakaofo ʻo e cavitation. ʻOku fakatupu ʻe ultrasonic cavitation ʻa e collisions ʻi he vahaʻa ʻo e ngaahi momoʻi meʻa ʻo e botanical biomass (hange ko Artemisia annua L. leaves), ʻa ia ko e ola ia ʻo e fractioning mo hono fakasiʻisiʻi ʻo e lahi ʻo e kihiʻi konga siʻi. ʻI he taimi ʻoku cavitation ai ʻa e bubbles ʻi he fukahi vesitapolo solids, ʻoku toe fakalahi atu ʻe he sonoporation ʻa e kihiʻi konga siʻi. ʻOku hanga ʻe he lahi ʻo e feʻaveʻaki paʻanga ʻo fakafaingofuaʻi hono tukuange ʻo molecules hange ko e polotini, lipids, sugars, vaitamini, antioxidants, phyto-kemikale (e.g., artemisinin) mo e meʻakai fibres. Ultrasonically fakaleleiʻi ʻe he ngaahi malohi ʻo e mamani ʻa e kemikale ʻo e solvent ki he matrix Mopaila ʻo e meʻa botanical pea fakaleleiʻi ʻa e permeability ʻo e membranes toʻotoʻo. ʻOku fatongia ʻaki ʻe he ngaahi ngaahi meʻa kehe ko ʻeni ʻo e malohi ultrasonics ʻa e founga mahuʻinga intensification aʻusia ʻi he taimi ʻoku fakaʻaongaʻi ai ultrasonication ki botanical toʻo ʻuli.

Ultrasonic extraction is works by disrupting cell structures and promoting mass transfer

ʻOku hanga ʻe he malohi fakaʻata e ngaahi peau ʻo maumauʻi e faʻunga toʻotoʻo ʻo e botanicals, tukuange ʻa e bioactive meʻa koʻeni pea tuʻuaki ʻa e feʻaveʻaki lahi ʻi he vahaʻa ʻo e fuʻu ʻakau mo e solvent (e.g., ethanol).

Ultrasonic probe deice UP400St for the extraction of artemisinin from Artemisia annua trichomes.

Ultrasonicator UP400St (400 Watts) ki he kulupu (batch) toʻo hingoa ʻo e mīsini fakaʻatá.

Kole 'a e fakamatala




Fakatokanga'i ange 'etau Tu'utu'uni totonu fakatautaha.


Ngaahi Ola Kuo Fakamoʻoniʻi ʻi he Fekumí ultrasonic Artemisinin Extraction

Kuo fakahoko ha ngaahi ako fakasaienisi lahi kae lava ke nau vakaiʻi ʻa e lavameʻa mo e practicability ʻo ultrasonic artemisinin toʻo mei Artemisia annua leaves.

Naʻe fakahaaʻi ʻe Briars mo Paniwnyk "ʻoku hanga ʻe he fakaʻata ʻi he mafana ʻo e ʻea ʻo fakatupulaki ʻa e tukulolo ʻa e artemisinin mei he A. annua ʻi he 58% pea ʻoku ha ngali maʻa ange ʻa e ngaahi meʻa naʻe toʻo ʻi he taimi ʻoku fakafehoanaki ai ki he fakaʻuli angamaheni; ko ia ai ko hono fakaʻaongaʻi ʻo e fakaʻata lolotonga e toʻo ʻuli, ʻoku malava ai ke maʻu ha ngaahi faitoʻo ʻoku siʻisiʻi ange hono totongi. " (Briars mo e Paniwnyk, 2013)

Naʻe fakatotoloʻi ʻe Zhang et Al. (2017) ultrasonic artemisinin toʻo ʻuli ʻo fakaʻaongaʻi propylene glycol methyl ʻEta (PGME) ko e solovaʻanga. Ultrasonically faʻu ʻe he artemisinin ha konga naʻe toʻo analysed ʻo fakaʻaongaʻi ʻa e Ultra ngaue chromatography (UPLC). Naʻe fakaʻuhingaʻi ʻe he ngaahi ola hono ʻanalaiso ʻa e tuʻunga lelei ʻo e konga naʻe toʻo. Koeʻuhi ko e founga lelei repeatability mo e tuʻu maʻu ʻa e artemisinin, naʻe tokoni ʻa e ultrasonically ke toʻo e ʻuli ʻo fakaʻaongaʻi ʻa e lanu mata mo lelei monoether propylene glycol methyl ʻEta (PGME) ʻo hange ko hono fakahaaʻi ʻe solvent ha ngaahi faingamalie maʻongoʻonga ʻi hono toʻo e ʻuli mo e mavahe ʻa bioactivether molecules mei botanicals. Ultrasonic toʻo ʻuli ʻaki hono fakaʻaongaʻi propylene glycol methyl ʻEta (PGME) ko e ola ia ʻo e toʻo hingoa fakalukufua mo e artemisinin maʻolunga. (FF. Zhang et Al., 2017)

ʻI ha ako ʻe taha, Zhang et Al. (2020) fakahoko ʻa e ultrasonic toʻo hingoa ʻo e artemisinin ʻo fakaʻaongaʻi hydroxypropyl-β-cyclodextrin. ʻOku hanga ʻe hono tanaki atu ʻo e cyclodextrin ʻo fakaleleiʻi ʻa hono tukuange ʻo e komipauni soluble ʻoku ʻikai ke lelei pea lava ai ke fakaʻaongaʻi ʻa e vai ko ha solvent ʻaki ʻa e toʻo ʻuli lelei. Naʻe hanga ʻe ultrasonic toʻo ʻuli ʻi hono fakatahaʻi mo cyclodextrin ʻo fakalahi ʻa e lahi ʻo e paʻanga ki he 8.66 mg/g, ʻa ia ʻoku mahuʻinga ange ia ʻi he lahi ʻo e 1.70 mg/g ʻoku maʻu ʻi he vai.

Ngaue maʻolunga ultrasonic extractors ki he production Artemisini

Ultrasonic extractor UIP2000hdT (2000 watts) during botanical extraction such as artemisinin from Artemisia annua leaves.ʻOku fakaʻaongaʻi ʻa e founga toʻo ʻuli ultrasonic mei Hielscher Ultrasonics ʻi he funga ʻo e mamani ʻi he R&T, siʻisiʻi, lahi mo e ngaahi tuʻunga fakakomesiale kakato ʻi he ngaahi ngaueʻanga kehekehe hange ko e meʻakai, fakalahi ki he meʻakai mo e ngaohiʻanga fakafaitoʻo. ʻOku hanga ʻe he ngaahi meʻa toʻo ʻuli fakaʻata māʻolunga ʻo fakalahi ʻa e founga toʻo hingoá pea toe lahi ange ai hono fakaleleiʻi ʻo e tuʻunga lavameʻa fakakātoa ʻo hono toʻo e ʻulí. ʻOku ʻomi ʻe Hielscher Ultrasonics ha meʻangaue toʻo ʻuli ki ha faʻahinga voliume/founga ngaue. ʻI heʻene taukei ʻi botanical toʻo hingoa ʻi ha taʻu ʻe 25 tupu, hielscher Ultrasonics ko ho hoa falalaʻanga ia ki he ngaue maʻolunga ultrasonic toʻo ʻuli mei Artemisia annua!

Ngaue maʻolunga, Siteiti-ʻo e-Art Ultrasonicators
ʻOku fakataumuʻa ʻa e ngaahi fotunga poto ʻo Hielscher ultrasonicators ke fakapapauʻi ʻoku fai ha tafa falalaʻanga, reproducible ngaahi ola mo e anga fakakaumeʻa. ʻE lava ke faingofua hono maʻu mo dialled ʻa e ngaahi fokotuʻutuʻu ngaue ʻo fakafou ʻi he menu, ʻa ia ʻe lava ke maʻu ʻo fakafou ʻi he digital colour Touch-Display mo e browser ʻoku ʻikai lava ʻo mapuleʻi. Ko ia ai, ko e ngaahi tuʻunga kotoa ʻo e ngaue hange ko e kupenga, ivi fakakatoa, amplitude, taimi, malohi mo e mafana ʻoku hiki ia ʻi ha kaati SD. ʻOku fakaʻata koe heni ke ke toe fakaleleiʻi mo fakafehoanaki ʻa e ngaahi sonication ki muʻa pea ke lahi ange ʻa e founga toʻo ʻuli ki he lavameʻa maʻolunga taha.
ʻOku fakaʻaongaʻi ʻa e hielscher Ultrasonics systems ʻi he funga ʻo e mamani ki hono ngaohi ʻo e ngaahi meʻa botanical lelei. Hielscher faingofua pe hono fakalele ʻo e ultrasonicators lalahi amplitudes ʻi he tafa hokohoko (24/7/365). Amplitudes ʻo aʻu ki he 200μm ʻe faingofua pe hono maʻu e ngaahi meʻa angamaheni sonotrodes (ultrasonic probes/meʻatui). ʻOku lava ke maʻu ha amplitudes maʻolunga ange fakapatonu ultrasonic sonotrodes. Koeʻuhí ko ʻenau robustness mo hono tokangaʻi maʻulalo, ʻoku angamaheni ʻaki hono fakahu ʻetau founga toʻo ʻuli ultrasonic ki hono fakaʻaongaʻi ʻo e fatongia mamafa pea ʻi ha ngaahi ʻatakai ʻoku femoʻuekina.

Fetuʻutaki mai he taimi ni ke ʻilo lahi ange fekauʻaki mo ultrasonic toʻo ʻuli ʻo artemisinin mei he fuʻu ʻakau Artemisia annua. Te mau fiefia ke ʻoatu ha fakamatala fekauʻaki mo ʻemau ultrasonic toʻo hingoa mo e totongi! ʻE fiefia ʻetau kau ngaue taukei ke aleaʻi hoʻo tohi kole mo e ngaahi fie maʻu ki hoʻo ngaue mo koe!
'Oku 'omi 'e he e tepile 'i lalo ha faka'ilonga ia 'o e tu'unga 'o e ngaue ki he fakafuofua'i 'o e hotau ultrasonicators:

Kulupu (batch) 'o e tohi 'Oku tafe mai 'a e 'ea 'Oku fokotu'u atu 'a e ngaahi me'angaue
mL 'o e 1 ki he 500 10 ki he 200mL/miniti 'e UP100H
mL 'i he 10 ki he 2000 20 ki he 400mL/miniti 'e UP200Ht, UP400St
0.1 ki he 20L 0.2 ke 4L/miniti 'e UIP2000hdT
10 ki he 100L 2 ki he 10L/miniti 'e UIP4000hdT
n.a. 10 ki he 100L/miniti 'e UIP16000
n.a. lalahi fakataha'i 'o e UIP16000

Fetu'utaki mai kiate kimautolu! / Kole kiate kitautolu!

Kole ki ha fakamatala lahi ange

Kataki 'o ngaue 'aki e foomu 'i lalo ke kole ha toe fakamatala ki he ultrasonic processors, faka'aonga'i mo e totongi. Te mau fiefia ke alea'i e founga 'oku mo 'i ai mo ho'omou ngaahi fie ma'u ultrasonic he polokalama!









Kataki 'o fakatokanga'i ange 'etau Tu'utu'uni totonu fakatautaha.


Ultrasonic high-shear homogenizers are used in lab, bench-top, pilot and industrial processing.

Hielscher Ultrasonics ʻa e ngaohiʻanga koloa maʻolunga ultrasonic homogenizers ki hono tuifio ʻo e ngaahi polokalama, fakamovetevetea, emulsification mo e toʻo hingoa ʻi he fale fakatotolo fakakemi, pailate mo e meʻafua ki he ngaahi meʻa fakapisinisi.

Ngaahi tohi/fakamo'oni fakafolofola




High performance ultrasonics! Hielscher's product range covers the full spectrum from the compact lab ultrasonicator over bench-top units to full-industrial ultrasonic systems.

Hielscher Ultrasonics e ngaohiʻanga koloa maʻolunga ultrasonic homogenizers mei he Loki fakasaienisi ki he lahi ʻo e lalahi.