Crystallization ʻo Cannabinoids mo Sonication

Ko e Crystallization ko ha sitepu mahuʻinga ia ʻoku fie maʻu kae lava ke ngaohi crystalline FBD. ʻOku fakaʻaongaʻi lahi ʻa e ultrasonic nano-crystallization (sono-crystallization) ke teuteuʻi crystalline isolates hange ko e FBD mei ha founga ʻoku ʻikai ke fuʻu lelei. ʻI he malohi fakaʻata e ngaahi peau lalahi, ʻoku hanga ʻe hono ueʻi holo ʻo e ngaahi meʻa tasilo, ʻo fakaʻaiʻai ʻa hono faʻu ʻo e tasilo FBD Kilisitala. Ko ultrasonic crystallization ko ha founga mapuleʻingofua, lelei ʻaupito, mo vave ia ki hono ngaohi ʻo crystalline CDB fakamavaheʻi.

Ultrasonic FBD Crystallization

CBD isolate is produced from CBD oil extractKo e Crystallization ʻo e FBD ko ha founga precipitation ia ʻoku ʻi ai ʻa e foomu ʻo e FBD solids ʻi ha solovaʻanga. Koeʻuhi ke lava ʻo crystallize ʻa e FBD, kuo pau ke veteki ʻa e solute (ʻa ia ko e lolo bd) ʻi ha founga ke fakaleleiʻi ʻaki. ʻOku hoko ʻa e ngaahi peau ultrasonic ko ha Stimulus ʻi tuʻa ʻa ia ʻoku ne kamata hono faʻu ʻo e ngaahi tengaʻi ʻakau Crystal (nucleation) pea tokoni ke poupouʻi mo mapuleʻi ʻa e tupulaki Crystal.
Angamaheni ʻaki hono fakaʻaongaʻi solvents: pentane pe heptane.

ʻOku ultrasonication fefe ʻa e BD Crystallization?

Ko e Ultrasonication ko ha founga lelei ʻaupito ia ʻoku ne ʻomi ha founga homogeneous supersaturated ʻo e FBD ʻi ha solovaʻanga. ʻI he lolotonga ʻo e ultrasonic lahi ʻo e founga naʻe supersaturated, ʻe lava ke faʻu ʻe he ngaahi tengaʻi ʻakau Crystal ʻa ia ʻoku hoko ko ha tupulaki ki he CDB Kilisitala. Naʻe hanga ʻe ultrasonic hono ueʻi holo ʻo fakamalohia ʻa e feʻaveʻaki ʻi he vahaʻa ʻo e ngaahi tengaʻi ʻakau Crystal mo e founga supersaturated koeʻuhi ke tupulaki vave mo uniformly ʻa e Kilisitala. ʻOku ʻuhinga ʻeni sonication ko ha founga lelei ʻaupito ia ke poupouʻi mo puleʻi ʻaki hono fokotuʻu ʻo e FBD Kilisitala.

Sono-crystallization of cannabinoids (e.g., CBD, THC)

Seinopolo mo ultrasonicator UIP2000hdT ki sono-crystallization ʻo cannabinoids

Ko e ha e meʻa ʻoku talamai ʻ

"ʻI he taimi ʻoku fakaʻaongaʻi ai fakaʻata ki ha founga ke fakaleleiʻi ʻaki e crystallization, te ne lava ʻo uesia lahi ʻa e ngaahi koloa ʻo e crystalline. Ultrasonic irradiation holoki ʻa e taimi induction mo metastable zone pea fakalahi ʻa e vave ʻo e hono. Koeʻuhi ko e ngaahi ola ko ʻeni, ʻoku faʻa ʻomi ai ha Kilisitala iiki ange mo ha tufakiʻanga naunau hala ʻi hono fakafehoanaki atu ki he crystallization angamaheni. ʻIkai ngata ai, ʻe lava ʻe ultrasonic irradiation ʻo fakatupu fragmentation ʻa e Kilisitala lolotonga ʻa ia ʻoku fakatupu ʻe crystal collisions pe sonofragmentation. " [Kimi mo Suslick, 2018]

Kole 'a e fakamatala




Fakatokanga'i ange 'etau Tu'utu'uni totonu fakatautaha.


Ueʻi Crystallization ʻo Cannabinoids

Ko ultrasonic crystallization (ʻoku toe ʻiloa pe ko sono-crystallization) ko ha founga ia ʻoku puleʻi ʻaki e crystallization, ʻa ia ʻoku maʻolunga ange ia ʻi he ngaahi founga angamaheni precipitation ʻaki hono faʻu vave koeʻuhi ko ha ultrasonic lahi. ʻOku fakafeʻiloaki atu ʻe he ultrasonic fakamafana mo e fefiofi ʻa e ngaahi malohi maʻolunga kinetic ki he fefiofi ʻo e FBD. ʻI heʻene pehee, ʻoku faʻu ai ha founga supersaturated ʻa ia ʻoku hanga ai ʻe ultrasonic hono ueʻi holo ʻo e paʻanga ko ia ʻo fakavaveʻi ʻa e vave ʻo e crystallization. Ko e ultrasonic crystallization ko ha founga vave ia, ʻa ia ʻe lava pe ke mapuleʻi. ʻOku malava heni ke tupulaki ʻa e lahi ʻo e teunga pea mo ha tuʻunga lelei ʻo e koloa maʻolunga. ʻOku fakaʻata ʻe ultrasonic crystallization ʻaki hano fakatonutonu ʻo e ngaahi fakangatangata sonication ki he crystallization ʻo e teunga micron-pe nano kilisitala. Tupu Kilisitala ke feʻunga mo e lahi ʻo e founga ngaue kuo fokotuʻu. ʻI hono fakaʻaongaʻi ko ia ʻo e sono-crystallization, ʻoku malava leva ke precipitate nano kilisitala, ʻa ia ʻoku ne ʻomi ha bioavailability maʻolunga ange pea ʻoku fakamahuʻingaʻi ia ʻe he kau fakatau ki ha ngaahi lelei ʻoku maʻolunga ange mo foaki ki he moʻui lelei. ʻOku ʻomi ʻe hono puleʻi totonu ʻo e ngaahi fakangatangata sono-crystallization ʻa e repeatable/reproducible ola. ʻIkai ngata ai, ʻe lava ke kakato ʻa e ultrasonic crystallization ʻo cannabinoids kaka ki ha faʻahinga tohi pe. ʻI ultrasonic crystallization ngaahi ola ʻi he tuʻunga lelei ʻo e FBD, ʻoku fakasiʻisiʻi leva ʻa e ngaahi founga ʻo e mataʻutoʻuta hange ko e fakamaʻa ki he siʻisiʻi taha.

The ultrasonicator UP200St improves the conversion rate in crstallization

He UP200St ʻe lava ke fakakau ki ha kemikale ʻoku ueʻi ke fakavaveʻi mo fakaleleiʻi crystallization.

Ultrasonication poupouʻi

  • Ueʻi Crystallization
  • Co-crystallization
  • Fili ʻo e crystallization
  • Mokomoko ʻo crystallization
  • Vaia Crystallization
  • Maʻu crystallization/precipitation

Ultrasonic Crystallizers ki he FBD

Ko Hielscher Ultrasonics ko ho hoa taukei taimi loloa ia ki he ngaue maʻolunga ultrasonic crystallization. Hielscher Ultrasonics ngaahi naunau ʻoku lahi hono ultrasonic crystallization ki he kulupu (batch) mo e hokohoko atu ʻo e ngaue ki he laine. ʻOku fokotuʻu ʻa e meʻangaue Hielscher Ultrasonics ʻ ʻi he funga ʻo e mamani ʻi he meʻakai mo e ngaue fakafaitoʻo pea fulfils ngaahi tuʻunga moʻui lelei taha. Feʻunga mo e founga standardization, hokohoko atu e tuʻunga lelei ʻo e koloa mo e ngaahi founga ngaohiʻanga koloa lelei (GMP), Hielscher ultrasonic crystallization ʻoku ʻi he laine hoʻo ngaahi taumuʻa ki he ngaahi tuʻunga moʻui maʻolunga ange.

Kole 'a e fakamatala




Fakatokanga'i ange 'etau Tu'utu'uni totonu fakatautaha.


Ngaahi lelei ʻo Hielscher Ultrasonics ʻ Cannabinoid Crystallization systems

  • Micron-mo nano-Kilisitala (adjustable)
  • Ko e lavame'a ma'olunga
  • Puleʻi moʻoni e tupulaki Crystal
  • Tupulaki ʻa e teunga Crystal
  • Fotunga tasilo
  • Hivaʻi e founga-paasi/kiʻi poulu ʻe taha
  • Repeatable, reproducible ola
  • Faingofua mo malu ke ngaue

Amplitudes maʻolunga ki Sonocrystallization

Sonication ʻi he ngaahi peau amplitude maʻolunga fakaʻata holo induction taimi lahi ange ia ʻi he sonication mo e ngaahi peau amplitude maʻulalo. [Kimi mo Suslick, 2018] ʻOku hanga ʻe he ultrasonication malohi ʻi he amplitudes maʻolunga ʻo ʻomi ha ngaahi fetoʻaki lahi, ngaahi malohi ʻo e mamani, mo hono ngaueʻi holo. Naʻe hanga ʻe he ngaahi ola macro mo macro ko ʻeni ʻi he supersaturated slurry ʻo fakaleleiʻi ʻa e feʻaveʻaki paʻanga pea toe lahi ange crystallization. Hielscher Ultrasonics’ ʻe lava ʻe he ultrasonic lalahi processors ʻo fakahaofi ha amplitudes maʻolunga ʻaupito. Amplitudes ʻo aʻu ki 200μm ʻe faingofua pe ke lele hokohoko ʻi he tafa 24/7. ʻOku lava ke maʻu ha amplitudes maʻolunga ange fakapatonu ultrasonic sonotrodes.
ʻOku langa ʻa e meʻangaue kotoa pe ki he 24/7/365 ʻoku fakaʻaongaʻi kakato ʻi he kavenga pea mo hono robustness mo falalaʻanga ke hoko ia ko e hoosi ngaue ʻi hoʻo founga sono-crystallization. ʻOku ngaohi heni ʻa e meʻangaue ultrasonic ʻa Hielscher ko ha meʻangaue falalaʻanga ʻoku ne fulfils hoʻo ngaahi fie maʻu sono crystallization.

Ko hono mapuleʻi Amplitudes ki he Crystallization maʻolunga ange

Hielscher's industrial processors of the hdT series can be comfortable and user-friendly operated via browser remote control.Ko e Hielscher kotoa pe ultrasonic processors ko e mapuleʻingofua moʻoni ia pea ʻoku falalaʻanga ai e fanga hoosi ngaue ʻi he R&D mo e faiva. Ko e amplitude ko e taha ia ʻo e ngaahi fakangatangata mahuʻinga ʻoku ne takiekina ʻa e lavameʻa mo e ola lelei ʻo e sono-crystallization. Hielscher ultrasonics kotoa pe’ processors fakaʻata ʻa e tuʻunga totonu ʻo e amplitude. ʻE lava ʻe he ultrasonic processors ʻa Hielscher ʻo fakahaofi ha amplitudes maʻolunga ʻaupito pea ʻave ʻa e malohi ultrasonic ʻoku fie maʻu ki hono fakaʻaongaʻi. Amplitudes ʻo aʻu ki 200μm ʻe faingofua pe ke lele hokohoko ʻi he tafa 24/7.
ʻOku ʻoatu ʻe he ngaahi feituʻu amplitude totonu mo hono vakaiʻi maʻu pe ʻo e ngaahi fakangatangata ʻo e founga ngaue ultrasonic ʻo fakafou ʻi he polokalama smart Software ʻa e malava ko ia ke takiekina e tali sono crystallization. ʻI he lolotonga ʻo e lele sonication kotoa pe, ʻoku lekooti leva ʻa e ngaahi fakangatangata ultrasonic kotoa pe ʻi ha kaati SD, koeʻuhi ke lava ʻo vakaiʻi mo puleʻi ʻa e lele takitaha. Tokolahi lelei sonication ki he sono lelei taha-crystallization!

Puleʻi ʻo e ʻea Sonication

Ko e founga crystallization ʻo e cannabinoids, ko e mafana ko ha founga mahuʻinga ia Parameter ʻoku ne takiekina ʻa e ola mo e tuʻunga lelei ʻo e FBD Kilisitala. ʻOku fakanaunau ʻa Hielscher sono-crsytallization reators ʻaki ha saketi mokomoko ʻo ke tauhi ʻa e mafana ʻo e ʻea. ʻIkai ngata ai, ʻoku hoko ʻetau polokalama fakakomipiuta sono-crsytallization ko ha polokalama fakakomipiuta fakapotopoto ʻoku ne vakaiʻi ʻa e mafana ʻo e ʻea ʻo fakafou ʻi ha pluggable mafana sensor resistance. ʻI he menu ki he tokotaha fakaʻaongaʻi, ʻe lava ke fokotuʻu ʻe he tokotaha ngaue ha mafana ʻi ʻolunga mo maʻulalo ange. ʻI he taimi pe ʻoku lahi ai e mafana ʻo e ʻea, ʻoku kiʻi longo e ultrasonicator kae ʻoua kuo toe foki mai ʻa e ʻea ki he ∆T. ʻOku ʻoatu ʻe he meʻa ni ke ke mapuleʻi totonu ʻa e founga mahuʻinga crystallization Parameter "mafana".

Ko e MultiPhaseCavitator ki he teunga Kilisitala

InsertMPC48 mo ha cannulas sai pe 48, 'a ia 'oku huhu 'aki 'a e konga hono ua 'o e emulsion hangatonu ki he ultrasonic cavitation fakasouniKo e MultiPhaseCavitator MPC48 ko ha meʻa toʻotoʻo makehe ia ʻoku ʻasi ai ʻa e 48 cannulas ke fai fanga ʻa e konga hono ua (ʻa ia ko e FBD distillate) ki he cavitational feituʻu ʻafu. ʻI heʻene pehee, ʻoku ʻi ai ha teunga ʻoku tuifio ai ʻa e FBD distillate mo e ngaahi foomu fakaleleiʻi ʻo e founga naʻe supersaturated, ʻa ia ʻe faʻu ai ʻe he nuclei ʻo e FBD Kilisitala. ʻOku fakaʻata ʻe he ultrasonic Seinopolo ʻa e mapuleʻingofua nucleation mo e tupulaki Crystal. ʻOku ʻai ʻe he MultiPhaseCavitator crystallization founga lelei ʻaupito pea fakaʻata ia koeʻuhi ko e mapuleʻi totonu ʻo e founga standardization. Ko e founga hono ngaohi ʻo e koloa ko ha konga ia ʻo e ngaahi founga ngaohiʻanga koloa lelei (GMP) pea ʻoku tokoni ia ke maʻu maʻu pe ha koloa ʻoku lelei taha.

Ultrasonic reactor FC100L1K-1S with InsertMPC48

Ultrasonic Seinopolo mo MultiPhaseCavitator ki hono fakaleleiʻi sono-crystallization

ʻulungaanga maʻolunga taha – Faʻu mo Manufactured ʻi Siamane

ʻI he hoko ʻa Hielscher ko ha pisinisi ʻa e famili mo e fakalele fakafamili, ʻoku ne fakamuʻomuʻa ʻa e ngaahi tuʻunga moʻui lelei taha ki hono ultrasonic processors. ʻOku fokotuʻutuʻu ʻa e ultrasonicators kotoa pe, manufactured mo siviʻi fakaʻauliliki ʻi homau ʻuluʻi ʻofisi ʻi Teltow ofi ki Pealini ʻi Siamane. ʻOku hanga ʻe robustness mo e ala falalaʻanga ʻo e meʻangaue ultrasonic ʻa Hielscher ʻo ʻai ke hoko ia ko ha hoosi ngaue ʻi hoʻo faiva. 24/7 ngaue ʻi he uta kakato pea ʻi he ngaahi ʻatakai ʻoku femoʻuekina, ko ha ʻulungaanga fakanatula ia ʻo e ngaue maʻolunga ʻa Hielscher ultrasonic probes mo e niʻihi ʻoku nau kau mai.

Fetuʻutaki mai he taimi ni ʻo fakamatala mai fekauʻaki mo hoʻo ngaahi fie maʻu sono crystallization! Te mau fokotuʻu atu ʻa e ultrasonic lelei taha crystallizer mo Seinopolo fokotuʻutuʻu!

Fetu'utaki mai kiate kimautolu! / Kole kiate kitautolu!

Kole ki ha fakamatala lahi ange

Kataki 'o ngaue 'aki e foomu 'i lalo ke kole ha toe fakamatala ki he ultrasonic processors, faka'aonga'i mo e totongi. Te mau fiefia ke alea'i e founga 'oku mo 'i ai mo ho'omou ngaahi fie ma'u ultrasonic he polokalama!









Kataki 'o fakatokanga'i ange 'etau Tu'utu'uni totonu fakatautaha.


Ngaahi tohi/fakamo'oni fakafolofola



Ngaahi mo'oni'i me'a 'oku mahu'inga ke 'ilo'i

Pentane ko solvent

n-Pentane (CAS fika 109-6-0) ko ha hydrocarbon solvent, ʻa ia ʻoku faʻa fakaʻaongaʻi ki he crystallization ʻo cannabinoids hange ko e FBD.
"n-pentane naʻe ʻikai ke fuʻu kona ʻi he ngaahi halanga vaka pe inhalation, naʻe ʻikai ko ha kili pe mata irritant pea naʻe ʻikai ke ne poupouʻi ʻa e kili sensitization. Naʻe ʻikai ke ne fakahaaʻi ʻa e fakakatoa ʻo e toxicity ʻi he ngaahi tuʻunga ʻo aʻu ki he 20000 mg m (-3), ʻa ia ʻoku fakafuofua ko e vaheua ʻe taha ʻo e fakangatangata ki lalo pea mo e tuʻunga maʻolunga taha ʻoku pehe ʻoku malu ke siviʻi. Naʻe ʻikai ke ne poupouʻi ʻa e toxicity fakalakalaka pea naʻe ʻikai mutagenic. Mei he fakamatala ko ʻeni mo e ngaahi fakamatala lolotonga, ʻoku pehe ʻoku ʻikai fie maʻu ke fakafaʻahinga ʻa n-pentane ki ha ngaahi fakatuʻutamaki ʻe ala hoko (ʻo hange ko hono fakamatalaʻi ʻe Annex VI ʻo e EU meʻa fakatuʻutamaki fakahinohino, 1993), neongo ʻoku fakahaaʻi ʻe he ngaahi koloa fakatuʻasino ʻe feʻunga ke fakatokanga ki he meʻa ʻe malava ke hoko. ʻIkai ngata ai, ʻoku ʻikai ha ʻuhinga ke fakasiʻisiʻi ai ʻa e ngaahi fokotuʻu fakangaue lolotonga. Fakaʻosi, neongo ʻoku ʻi ai ha ngaahi meʻa maluʻi fekauʻaki mo e flammability ʻo n-pentane, ka ʻoku fakahaaʻi ʻe he ʻikai ke ʻi ai ha demonstrable toxicity ʻi he tuʻunga maʻolunga ʻo e faitoʻo, ʻoku siʻisiʻi ʻa e fakatuʻutamaki ʻo e ngaahi nunuʻa kovi ʻo e moʻui lelei ki he kakai kotoa pe. " (Meki et Al. 1998)

Ultrasonic high-shear homogenizers are used in lab, bench-top, pilot and industrial processing.

Hielscher Ultrasonics ʻa e ngaohiʻanga koloa maʻolunga ultrasonic homogenizers ki hono tuifio ʻo e ngaahi polokalama, fakamovetevetea, emulsification mo e toʻo hingoa ʻi he fale fakatotolo fakakemi, pailate mo e meʻafua ki he ngaahi meʻa fakapisinisi.