Ko e koloa Fakaʻofoʻofa ʻoku maʻa e Ultrasonics

ʻoku hanga ʻe he ngaahi meʻa fakanatula, (INCIs) ʻo fakatahaʻi lelei e ongo mo e bioavailability e fotunga ʻo e innovstive e ngaahi naunau fakaʻofoʻofa ʻoku maʻa. ʻoku fakaʻaongaʻi ʻa e Ultrasonication ko ha founga lelei mo falalaʻanga ke fetuʻutaki, tuifio, movete, nano mo e ngaahi meʻa ʻoku.

Ko e ha ʻoku totonu ai ke ke Fakaʻaongaʻi e Ultrasonication ki he koloa Fakaʻofoʻofa ʻoku ke Maʻa?

Sonication is used as potent mixing and blending technology for skin care products such a creams, lotions and ointmentsKo hono fio, anga, dispersing, emulsifying ʻa e ngaahi founga mo e encapsulating bioactive molecules, ʻoku ne matuʻaki ʻaonga ia ki hono ngaohi ʻo e ngaahi kiliʻi pasita, faitoʻo kili, fakaʻofoʻofa mo e cosmeceutical naunau. ʻoku mahuʻinga ʻa e ngaahi founga pau, lelei mo homogeneous hono fakahoko ʻo e ngaahi polokalama tefito ko ʻeni ke maʻu ai ha ngaahi founga ʻoku lahi ai e ngaahi nunuʻa ʻoku maʻolunga hono ngaahi ola, ʻa e potency mo e lelei ʻo e koloa aofangatuku. ʻoku fakatupulaki ʻe he ngaahi meʻa fakatekinikale fakaonopooni ʻo e fakalakalaka ha ngaahi meʻa, ʻa ia ʻoku fie maʻu ki ai ha incorporation ki he koloa aofangatuku kae lava ke maʻu e ngaahi ola ʻoku tau loto ki ai.

Sonication – Ko ha tuʻunga lahi fau ʻo e ngaahi kole

Ko e Sonication ko ha founga lelei mo falalaʻanga ia ʻo e homogenizing-vaia mo e suspensions malohi. Encapsulating molecules ki nano-lipidic lahi ʻoku nau kau mai (e.g. liposomes, niosomes, misini ʻa e paʻanga ʻoku ʻikai ke lelei nanoparticles, nanostructured ke misini.) ko ha toe fakaʻaongaʻi mahuʻinga ʻe taha ʻo e ngaue ʻoku fakahoko maʻolunga ko e micelles.
ʻe lava ke fakaʻaongaʻi ʻa e Ultrasonication ki he ngaahi sitepu lahi ʻi hono faʻu ʻo e maʻa, fakanatula, mo e ngaahi founga lelei, mo e fakamaʻa ʻo e sino, fakaʻofoʻofa mo e kili pea fakaleleiʻi ʻa e ngaahi founga ngaue ʻoku nau fio mo encapsulating. Koeʻuhi ʻoku ʻomai ʻe he ultrasonic mixers ha anga mo ha homogenization lahi, ko hono fakaʻaongaʻi ko ia ʻo e kemikale additives ʻoku faʻa tanaki atu ia ki he tolonga ʻa e malu pea ʻikai fakaʻehiʻehi kakato mei hano taʻofi.
ʻoku ʻoatu ʻe Sonication ha ngaue lelei ʻi hono maʻu e ngaahi ola lelei ʻi he founga vave mo lelei ʻo e tupulaki, homogeneous suspensions. ʻoku ne uesia ʻe ia e tolonga ʻa e koloa, moʻui mo biocompatibility lelei.

Ultrasonic Applications

  • Hono tuifio & tuifio
  • emulsification & Nano-Emulsification
  • Ko hono fakasi'isi'i 'i he lahi 'o e kihi'i konga si'i
  • Encapsulation ʻo Molecules (liposomes, niosomes)
  • Toʻo hingoa ʻo e bioactive molecules mei botanicals

Sonication – Ko ha Faitoʻo fakamisini

Ko e Ultrasonification ko ha faitoʻo angavaivai, ʻikai hano fakafuofuaʻi, ʻa ia ʻoku ʻikai hanga ʻe he ʻea vela ʻo tukuhifo ʻa e ngaahi naunau. Ko e lahi ʻo e ngaahi meʻa hange ko e lipids, bioactive e molecules pe lolololo mahuʻinga ʻoku nau ongoʻingofua mo ʻaonga lahi ʻaki hono mapuleʻi e ngaue ki he ʻea siʻisiʻi. Hielscher Ultrasonics ʻoku totonu ke mapule'ingofua ' taina, adjustable faingofua pea ʻe lava ke tokangaʻi mo fakalele ʻaki ʻa e browser emote ʻo mapuleʻi. ʻoku hanga ʻe he polokalama ʻa e Smart ʻo fakaʻaongaʻi e ngaahi fakangatangata ki he ngaohiʻanga ʻi ha kaati SD. ʻoku hanga ʻe he ngaahi fotunga ko ʻeni ʻo fakafaingofuaʻi e founga hono fakahoko mo standardization lelei pea pehe ki hono fakaʻaongaʻi ʻo e ngaahi founga ngaue lelei ʻo e Ngaohiʻanga koloa (GMP).

Ultrasonic Emulsification mo UP200St
Ultrasonicemulsification is used to produce skin care products such as creams and lotions with a high load of active substances.

UIP1000hdT mo e Seinopolo sio'ata ki hono tokanga'i 'o e ngaahi naunau hono kili hange ko e creams, lotions mo e balms

Kole 'a e fakamatala




Fakatokanga'i ange 'etau Tu'utu'uni totonu fakatautaha.


Ko e Tefitoʻi Moʻoni ngaue ʻo e Sonication

Koeʻuhi ko e sonication ko ha faitoʻo fakamisini, ʻoku ʻikai ha kemikale additive, ʻe fepaki mo e fakakaukau ke maʻa cosmetics. ʻoku fakatefito e ngaahi founga ultrasonic hange ko e fefiofi, anga, emulsification, encapsulation mo e toʻo hingoa ʻi he tefitoʻi moʻoni ngaue ʻo e cavitation.
ʻoku tautau ʻa e ngaahi peau ultrasonic malohi ʻi ha fekumi ultrasonic processor ki he slurry. ʻoku lahi e feʻaluʻaki ʻa e ngaahi peau faka'ata ʻoku ne teke holo ʻa e tahi hou/ngaahi siakale ʻo e mafasia, ʻa ia ʻoku iku ia ki he ongo cavitation. ʻoku taki atu ʻe he cavitation pe ultrasonic ʻa e kau) ki he mafana ʻo e ʻea, ngaahi vili, ʻea fakamafana/mokomoko 'o, ngaahi malohi differentials mo e tumuʻaki ʻo e ngaahi ivi ʻo e malumalu. Ko e taimi ʻoku cavitation ai ʻa e bubbles implode ʻi he tafaʻaki ʻo e ngaahi momoʻi meʻa pe droplets, ʻoku hanga ʻe he ngaahi vakapuna Micro mo e interparticlular fo'i fakatu'utamaki na'e ʻo fakatupu ha ngaahi ola hange ko e tele e ngaahi foʻi, fakatuʻutamaki, fakatuʻutamaki, sonoporation pea pehe ki he foʻi tulutaa mo e fakahohaʻasi. ʻikai ngata ai, ʻoku faʻu ʻe he implosion ʻo e cavitation ʻi he mitia huhuʻa ha macro-turbulences mo e fefiofi. ʻoku fakafofongaʻi ʻe ultrasonic irradiation ha founga lelei ki hono fakaleleiʻi ʻo e founga feʻaveʻaki paʻanga, koeʻuhi he ko e ngaahi ola ʻo cavitation mo e ngaahi meʻa ʻoku fekauʻaki mo ia ʻi he ngaahi me'a kehe, micros mo e lahi ʻi he fakamatala fekauʻaki mo e fakamovetevete ʻo e ʻu vakapuna, sonication mo e ʻi he naunau fakamafana mo e lahi decompression.
ʻe lava ke fakatupu ʻe he fekumi-Type ultrasonicators ha amplitudes maʻolunga ʻaupito, ʻa ia ʻoku fie maʻu ke fakatupu ha meʻa ʻoku malohi cavitation. Hielscher ultrasonic ki he ngaahi ngaue lahi ultrasonic processors, ʻa ia ʻe faingofua pe ke faʻu amplitudes 200 μm ʻi he hokohoko atu hono ngaue ʻaki ʻa e 24/7. Pea naʻa mo e amplitudes maʻolunga ange, ʻoku ʻoatu ai ʻe he Hielscher ha sonotrodes maʻolunga ʻo e amplitude (probes).
ʻoku ngaue ʻaki Pressurizable ultrasonic toe kau atu mo e ngaahi selo ke fakalahi ʻa e cavitation. ʻoku fakaʻau ke fakatupu ʻauha ange ʻa e ngaahi malohi cavitation mo cavitational e tumuʻaki ʻo e ngaahi nunuʻa ʻo e ultrasonic.

Ngaahi lelei ʻo ultrasonic anga mo Emulsification

Ko hono faʻu ʻo e homogeneous mixtures, dispersions, emulsions, mo nano-emulsions naʻe fie maʻu ki ai ʻa e $3 sonification ʻoku tupu ia mei ha faʻahinga ivi pe ʻoku ne puleʻi ʻa e ngaahi meʻalea ʻoku ʻikai hano ʻaonga, ʻo ʻikai hano ʻaonga ʻo e taimi ʻoku ne fakaʻaongaʻi ki ai ʻa e ngaahi meʻangaue, founga faingofua ʻo e fakaleleiʻi e polokalama, mo e mahuʻinga ʻo e koloa. ʻoku fakatupulaki ʻe ultrasonic fefiofi, anga mo emulsification ʻa e lava ke feliliuaki ʻi hono fili ʻo e surfactant mo e ngaahi fale fakalotofonua ʻo e emulsions. (FF. Marzuki et Al. 2019)

The UIP4000hdT is a 4000 watts powerful ultrasonic inline disperser.

UIP4000hdT, ko ha tokotaha ultrasonicator malohi, ʻoku ngaue ʻaki ʻi he laine ʻo e dispersing pea emulsification fakaʻaongaʻi ʻa e ngaahi founga fakakomipiuta ʻo e kumi koloa

Ngaahi Meʻa ʻoku molecule lahi

ʻoku lahi ange e Submicron transdermal kuo nano mo e fakaʻaliʻali molecules. Lolotonga ʻoku tangutu ʻa e fuʻu molecules ʻi he tumuʻaki ʻo e kili pea ʻikai ke ne lava ʻo mamata ki he kili koeʻuhi ko e lahi ʻena molecules, ʻoku lava ke fakalaka atu ʻi he epidermis.
ʻoku ʻuhinga ʻeni, ʻoku ʻave ʻa e bioactive me'a ko'eni ki he ngaahi feituʻu ʻoku dermal loloto ange, ʻa ia te nau lava ai ʻo fakahoko ʻenau "ngaue" ʻaki hono tanumaki pe fakaleleiʻi ʻa e kili.
Ko ha sipinga ʻiloa ki he mahuʻinga ʻo molecular lahi ʻoku hyaluronic, ko ha ʻesiti molecule. Kapau ʻoku molcular maʻolunga ʻa e ʻesiti hyaluronic, he ʻikai lava ke hu ia ki he paa ʻo e kili ʻo tuʻu ʻi ha foʻi faiva. Molecular siʻi hifo hyaluronic e ʻesiti ʻi he tafaʻaki ʻe nima ki he feituʻu ʻoku lahi ange hono kili, pea ʻoku ʻi ai hono ngaahi nunuʻa moisturizing.
Ko ha sipinga ʻe taha ki he ʻaonga ʻo e ngaahi konga lalahi ʻoku titanium taiokisaiti mo e singiki oxide. ʻoku fakatou fakaʻaongaʻi kinaua ko ha ongo ngaue malohi ʻi he ngaahi naunau fakanatula ʻo e laʻaa (e.g. lotions, moisturizers, taʻeufi). ʻoku mahuʻinga ha kiʻi konga siʻi uniformly ke fakaʻehiʻehi ai mei clogging ʻa e kili pea taʻofi ke ʻoua naʻa ʻasi. ʻikai ko ia pe, ka ko e ngaahi momoʻi meʻa iiki ange ʻa e ola whitening mo ngingila ʻo e ngaahi screen ʻo e laʻaa pe taʻofi.

'Oku ultrasonic nano-emulsification e ola lelei 'o e emulsions, liposomes mo e misini ki he fe'unga mo e faito'o konatapu.

'Oku faka'aonga'i 'a e ultrasonic nano-emulsification ke ngaohi 'aki ha uta nano-emulsions, liposomes pea mo ha misini ke fakasi'isi'i e nanoparticles. 'Oku hanga 'e he Sonication 'o 'omi ha fo'i tulutaa 'oku 'i ai hono ngaahi naunau.

Toe fakaleleiʻi e kili ʻo e kapeti

Enhancers hono kili ʻo e kemikale, fakakau e ngaahi naunau hange ko e l-α-lecithin, urea, faʻafaʻesiti, ethanol, mo e glycols.
Ko e founga 'oku fie Ultrasonication ki ai ke fa'u liposomes 'aki ha uta lahi 'o e bioactive me'a ko'eni.

  • ʻoku kau ʻi he Vesicular kili enhancers ʻa e Vesicular e ngaahi satelaite hange ko e liposomes mo e niosomes. Ko Vesicular ʻoku fai ki ai e kau fata ʻi he ngaahi founga kuo ʻomi ke ngaue molecules. ʻoku nau ʻoange ʻa e faingamalie ke fai ha hydrophilic pea pehe foki ki he lipophilic molecules, koeʻuhi ko ʻenau taʻanga. ʻoku leva me'a encapsulated ʻa e molecules Hydrophilic ki he ʻelito ʻo e aqueous, pea ʻoku fakakau atu lipophilic molecules ʻa e misini ke ʻa e milemila. Koeʻuhi ʻoku vesicle e holisi ʻo e phospholipid ko ha meʻa ʻoku ne tokangaʻi e liposomes mo e synthetic ʻi he surfactants, ko e niosomes ʻoku nau vesicles vai pea ʻoku nau soluble lahi.
    Lau ha fakamatala lahi ange fekauʻaki mo ultrasonically liposomes!
  • Enhancers kau ʻi hono kili Enzymatic ʻo e enzymes hange ko e HMGCoA reductase mo e acetyl CoA carboxylase, ʻa ia ʻoku ne holoki ʻa e mahuʻinga enzymes ko ia ʻo e epidermal ʻoku ʻikai ke feʻunga synthesis mo liliu ʻa e ngaahi meʻa mahuʻinga Molar ʻo e kii stratum corneum lipids.
  • Ko e Urea, naʻe toe ʻiloa pe ko carbamide, ʻoku ngaue ʻaki ia ke fakalahi e absorption ʻo ha ngaahi meʻa ʻoku fakaʻaongaʻi lelei ʻi heʻene hoko ko e kili permeability.
Ultrasonic processor UIP2000hdT (2kW) 'i hono ue'i 'o e batch Seinopolo

Ultrasonic homogenizer UIP2000hdT (2kW) mo e hokohoko atu hono ue'i 'o e kulupu Seinopolo

Ultrasonically fakalakalaka Bioavailability ʻo Actives ʻi hono Tokangaʻi e kili

ʻoku fakaʻuhingaʻi ʻa e bioavailability ko e vave ko ia ke aʻu ki ha komipauni malohi ke aʻusia e feituʻu ʻo e ngaue. ʻoku fakapapauʻi ʻa e vave flux pe lahi ʻo e tokolahi ʻo e kaingalotu ʻi he micrograms/cm2houa. ʻoku angamaheni ʻaki ko e epidermis maʻulalo ʻa e taumuʻa ʻo e ngaue ki ha konga ʻoku ʻi ai e meʻa ʻoku fakataumuʻa ki ai. ʻoku actives ʻa e ngaahi fakaʻata makehe hange ko e singiki oxide pe titanium taiokisaiti, mo e ngaahi meʻa angamaheni ʻi he sunscreen lotions mo e, koeʻuhi he ʻoku ʻi ai ʻa e ngaahi meʻa ʻoku nau ngaue ai ʻi he tafaʻaki ʻo e kili, ʻa ia ʻe lava ke peluki ai ʻe he fanga kiʻi konga siʻi honau ivi lahi taha ko e.
Ko e bioavailability ʻo e ngaahi meʻa ʻoku malohi ʻoku takiekina lahi ia ʻe he faʻahinga meʻafua formulations fakaʻaongaʻi. Ko e formulations angamaheni ko ia ʻi he koloa fakaʻofoʻofa mo fakatautaha ko e vai ʻi he emulsions (O/W), ko e lolo-ki he-lolololo emulsions (u/O), vai-ki he-vai-ʻe emulsions (W/O/W), polyol-in-lolo emulsions mo e hydrogels foki. (Polyols fakaʻaongaʻi ʻa e ngaahi meʻa angamaheni formulations ko e sorbitol, mannitol, mo e ala meʻa pehee).

Ultrasonic emulsification with Hielscher's UP200Ht and sonotrode S26d14

Teuteu ultrasonic 'o ha emulsion (lanu kulokula 'a e vai / lanu engeenga lolo). Na'e liliu 'e ha ki'i taimi si'i 'o e sonication he tapa kehekehe 'o e mavahevahe vai/lolo ki ha emulsion sai pe.

Sonication ki he toe lahi ange hono kili Permeability

Ko hono kili permeability pea ʻe lava ke fakatupulaki ai hono bioavailability ʻo e ngaahi actives mo e cosmeceuticals ʻe ha taha ʻoku ne takiekina ʻa e kili pe ko e tupu ʻi he solubility ʻa e malohi ʻo e molecules.
Koeʻuhi ke holoki e paa ʻo e kili pea fakafaingofuaʻi e ngaue ʻa e molecules malohi ki he epidermis maʻulalo ange, manifold ha ngaahi meʻa hange ko e solvents, phospholipids mo surfactant vesicles naʻe fai mei phospholipids pea pehe ki exfoliants ʻe lava ke fakalakalaka ai ʻa e ke ʻoua naʻa toe hoko ia ko ha meʻa ke ne kili ai.

  • Solvents ngaue ʻaki ʻa e dimethyl isosorbide, ethoxydiglycol, ethanol, mo oleic ʻesiti. ʻoku fenapasi lelei e ngaahi solvents ko ʻeni mo ultrasonic fefiofi, anga mo emulsification founga.
  • ʻoku ʻiloa e Phospholipids ki hono fakaleleiʻi e kili ʻo e lolo mo e vai soluble e molecules. Ko e ngaahi phospholipids angamaheni ʻoku ngaue ʻaki lecithin, hydrogenated lecithin, lysolecithin, mo tocopheryl phosphate. ʻoku nau maʻu ha ngaahi lelei mei he ngaue ultrasonic ʻi hono tufaki atu ʻo e phospholipids ke tatau hangatonu mo e ʻuli.
  • Surfactant vesicles: te Surfactants lava ʻo faʻu ha multilamellar mo unilamellar vesicles mo actives. Ko Liposomes mo e misini ʻoku ʻikai fuʻu lelei ʻa e nanoparticles ko hono maʻu ko ia ha ngaahi sipinga maʻolunga ki he kili vesicles fakaha'ele bioactive me'a ko'eni ke fakataumuʻa ki ai. Ko e founga lelei mo ʻaonga taha ke fakatupu ha liposomes, nanoliposomes mo ha misini ke vave nanoparticles (SLNs) mo ha uta maʻolunga, encapsulation lavameʻa (% EE), tuʻu maʻu mo bioavailability.
  • ʻoku kau ʻi he kemikale exfoliants ʻa e lactic, glycolic, salicylic ʻesiti, mo N-acetyl-glucosamine. ʻoku kau ʻi he ha kili'i fakamakeniki ha fu'u valevale atu abrasive mei he malala, Niu ia pe kofi. ʻe lava ke fakamovetevete lelei ʻa e ngaahi meʻa ni kotoa ultrasonification.

ʻe lava ke fakatupulaki e Solubility ʻo e ngaahi ʻata ʻi he cosmetics ʻi hono fakakau atu e complexes, encapsulation, micron-/nano-emulsions pea pehe ki he solubilisation lelei ʻi he taha ko ia.

  • Fakakau complexation hono fakaʻaongaʻi ʻo e cyclodextrins (hange ko e ʻalifa-, gamma-, hydroxypropyl beta-cyclodextrin). ʻoku fakaʻaliʻali ʻe Cyclodextrin complexes ha ʻana ʻoku leva me'a encapsulated ai ha ngaahi meʻa bioactive. ʻoku hanga ʻe he encapsulation/complexation ʻo ʻai ke malohi me'a ko'eni vai-soluble pea mo bioavailable ai. Laukonga lahi ange kau ki ultrasonic huhu'i mai lototo'a complexation!
  • Ko Phytoglycogen ko ha fale ʻoku fakavaʻe ʻaki e ʻakau, maʻolunga density carbohydrate (polysaccharide) nanoparticle mo ha ʻana ʻoku ne lava ʻo ʻomi ha faʻahinga kehekehe ʻo e actives. Ko e Phytoglycogen octenyl succinate (PG-OS) ko ha amphiphilic carbohydrate nanoparticle, ʻa ia ʻoku ne fakalahi ʻa emulsions ha misini ke ne fakasiʻisiʻi ʻa e oxidative. Ultrasonic emulsification fakalakalaka ʻa e toʻu tangata ʻo e homogeneous, ʻo e tauhi phytoglycogen emulsions.
  • ʻoku fakaʻaongaʻi e Submicron-mo e nanoemulsions ko e ngaahi polokalama tufa ʻo e miniti, ʻa ia ʻoku me'a ko'eni ai e soluble vai pea fakangofua ke ʻave ʻa e ngaahi meʻa ʻoku fie maʻu ki he saiti ʻoku fakataumuʻa ki ai. ʻoku hanga ʻe he kiʻi nano siʻisiʻi ʻo e droplets ʻo fakalahi ʻa e permeability ʻi he paa ʻo e kili ki he loloto ange ʻo e kili.
  • ʻoku fakaʻaongaʻi ʻa e ngaahi emollients lahi ʻi he formulations ke solubilize hydrophobic/-ngaahi meʻa ʻoku ʻikai ke ne tali e vai ʻo hange ko ia ʻoku ʻikai ke tau maheni mo ia. ʻoku faʻa fakaʻaongaʻi ʻa e ngaahi emollients lahi ko ʻeni: isopropyl lauroyl sarcosinate, lauryl lactate, phenyl ethyl benzoate, dioctyl maleate, mo dioctyl isosorbide. ʻoku ʻi ai ha ngaahi sunscreens kehekehe ʻoku ʻiloa ai enhancers. ʻoku ultrasonic ʻa e fefiofi mo e dispersing ʻo fakapapauʻi ha homogeneous ʻoku fio ai ʻa e emollients mo e ngaahi ngaue malohi.

Ultrasonic Mixers ki he ngaahi naunau Fakaʻofoʻofa ʻoku Maʻa

Hange ko ia ko e ngaahi faitoʻo fakamakeniki, ʻe lava ke sonication fakaʻaongaʻi ki hono ngaohi ʻo e ngaahi faʻahinga kehekehe ʻo e naunau kuo fakamoʻoniʻi. Ko e ngaahi founga falalaʻanga ʻo e Hielscher Ultrasonics ʻ ʻoku fakaʻaongaʻi ia ʻi he faʻu ʻo e ʻulungaanga lelei cosmetics pea therapeutics ke nau fokotuʻutuʻu nano-emulsified mo liposomal leva me'a encapsulated bioactive me'a ko'eni ʻaki ha tuʻunga maʻolunga absorption lahi pea mo biocompatibility. Ke feau e ngaahi fie maʻu ʻa e kau fakatau, ʻoku ultrasonicators ʻa e ngaahi naunau Hielscher mei he fale kumi paʻanga homogenizer mo e sea ʻi ʻolunga ʻo e ultrasonicators ki he ngaahi founga maʻolunga ʻo e. ʻoku ultrasonic ʻa e founga ʻo e cosmetics mo e cosmeceuticals ʻe lava ʻo fakalele ʻaki ʻa e kulupu (batch) pe ko e hokohoko ʻo e ngaahi laine ʻo e ultrasonic ʻo fakafou ʻi he Seinopolo. ʻoku ʻi ai ha ngaahi ultrasonic sonotrodes (probes) mo Seinopolo ngaahi vaka ʻoku lava ke maʻu ke fakapapauʻi ko ha fokotuʻutuʻu tokolahi lelei ki hoʻo liposome. ʻoku fakaʻata ʻe he robustness ʻo Hielscher e meʻangaue ultrasonic ʻo e 24/7 ʻa e ngaue ʻi ha fatongia mamafa ʻi ha ngaahi ʻatakai faingataʻa pea fakapapauʻi ha siakale loloa ʻo e moʻui ʻa e misini.
Hielscher's industrial processors of the hdT series can be comfortable and user-friendly operated via browser remote control.ʻoku hanga ʻe hono mapuleʻi tatau ʻi he ngaahi founga mahuʻinga kotoa ʻo hange ko e amplitude, malohi, mafana mo e taimi sonication ʻo ʻai ke falalaʻanga mo reproducible ʻa e ultrasonic. ʻoku ʻiloʻi ʻe Hielscher Ultrasonics ʻa hono mahuʻinga ke kei hokohoko atu ʻa e totongi maʻolunga mo poupouʻi ha ngaahi founga ke fakahoko ʻaki e mo GMP (ngaahi founga ngaue lelei ʻo e Ngaohiʻanga. ʻoku hanga ʻe heʻetau ultrasonic fakaʻilekitulonika ʻo lekooti ʻa e fakangatangata kotoa pe ki he founga hono langa ʻi ha kaati SD. Lomiʻi ʻi he Digital Touch ʻoku lava ʻa e ngaahi founga ʻoku ʻasi mo e browser ke puleʻi ʻaki hono toutou vakaiʻi pea lava ke fakaleleiʻi e fakangatangata ʻo e founga ʻi he taimi kotoa pe ʻe fie maʻu ai. ʻoku hanga ʻe he founga ko ʻeni ʻo fakafuofuaʻi ʻa hono tokangaʻi mo hono mapuleʻi lelei ʻo e ngaue.
'Oku 'omi 'e he e tepile 'i lalo ha faka'ilonga ia 'o e tu'unga 'o e ngaue ki he fakafuofua'i 'o e hotau ultrasonicators:

Kulupu (batch) 'o e tohi 'Oku tafe mai 'a e 'ea 'Oku fokotu'u atu 'a e ngaahi me'angaue
mL 'o e 1 ki he 500 10 ki he 200mL/miniti 'e UP100H
mL 'i he 10 ki he 2000 20 ki he 400mL/miniti 'e UP200Ht, UP400St
0.1 ki he 20L 0.2 ke 4L/miniti 'e UIP2000hdT
10 ki he 100L 2 ki he 10L/miniti 'e UIP4000hdT
n.a. 10 ki he 100L/miniti 'e UIP16000
n.a. lalahi fakataha'i 'o e UIP16000

Fetu'utaki mai kiate kimautolu! / Kole kiate kitautolu!

Kole ki ha fakamatala lahi ange

Kataki 'o ngaue 'aki e foomu 'i lalo ke kole ha toe fakamatala ki he ultrasonic processors, faka'aonga'i mo e totongi. Te mau fiefia ke alea'i e founga 'oku mo 'i ai mo ho'omou ngaahi fie ma'u ultrasonic he polokalama!









Kataki 'o fakatokanga'i ange 'etau Tu'utu'uni totonu fakatautaha.


Hielscher Ultrasonics pilisone ngaue ma'olunga ultrasonic homogenizers ki he fakamovetevetea, emulsification mo e hingoa to'oto'o.

Ko e malohi ma'olunga ultrasonic homogenizers mei Loki fakasaienisi ki he pailate mo e Lalahi me'afua.

Ngaahi tohi/fakamo'oni fakafolofola

  • Kentish, S.; Wooster, T.; Ashokkumar, M.; Simons, L. (2008): The use of ultrasonics for nanoemulsion preparation. Innovative Food Science Emerging Technologies 9(2):170-175.
  • Zahra Hadian, Mohammad Ali Sahari, Hamid Reza Moghimi; Mohsen Barzegar (2014): Formulation, Characterization and Optimization of Liposomes Containing Eicosapentaenoic and Docosahexaenoic Acids; A Methodology Approach. Iranian Journal of Pharmaceutical Research (2014), 13 (2): 393-404.
  • Joanna Kopecka, Giuseppina Salzano, PharmDa, Ivana Campia, Sara Lusa, Dario Ghigo, Giuseppe De Rosa, Chiara Riganti (2013): Insights in the chemical components of liposomes responsible for P-glycoprotein inhibition. Nanomedicine: Nanotechnology, Biology, and Medicine 2013.
  • Harshita Krishnatreyya, Sanjay Dey, Paulami Pal, Pranab Jyoti Das, Vipin Kumar Sharma, Bhaskar Mazumder (2019): Piroxicam Loaded Solid Lipid Nanoparticles (SLNs): Potential for Topical Delivery. Indian Journal of Pharmaceutical Education and Research Vol 53, Issue 2, 2019. 82-92.
  • Kiran A. Ramisetty; R. Shyamsunder (2011): Effect of Ultrasonication on Stability of Oil in Water Emulsions. International Journal of Drug Delivery 3, 2011. 133-142.
  • Shabbar Abbas, Khizar Hayat, Eric Karangwa, Mohanad Bashari, Xiaoming Zhang (2013): An Overview of Ultrasound-Assisted Food-Grade Nanoemulsions. Food Engineering Reviews 2013.
  • Ng Sook Han, Mahiran Basri, Mohd Basyaruddin Abd Rahman, Raja Noor Zaliha Raja Abd Rahman, Abu Bakar Salleh, Zahariah Ismail (2012): Preparation of emulsions by rotor–stator homogenizer and ultrasonic cavitation for the cosmeceutical industry. Journal of Cosmetic Science 63, September/October 2012. 333–344.



Ngaahi mo'oni'i me'a 'oku mahu'inga ke 'ilo'i

Ko e ha ha ngaahi meʻa Fakaʻofoʻofa ʻoku Maʻa?

Ko ha ngaahi meʻa fakaʻofoʻofa ʻa e cosmetics maʻa ʻa e fakaʻofoʻofa, ʻa ia ʻoku ngaohi ʻaki ʻa e ngaahi meʻa ʻoku ʻikai ke kona, ʻoku hoko fakanatula pe ia. Lolotonga ʻoku ʻikai ko ha uniformly fakaʻuhingaʻi mo maluʻi ʻa e ngaahi lea fakanatula, ko e ʻuhinga fakanatula pe ia focusses ʻi hono fakaʻaongaʻi ʻo e ngaahi naunau fakanatula, organically kuo tupu. Ko e ngaahi meʻa ʻe ngali fakatuʻutamaki (hange ko e endocrine disruptors) ʻoku taʻofi ia mei he ngaahi naunau ʻoku maʻa, lolotonga ia ʻoku fakahoko e maʻa ʻo e ngaahi naunau ʻoku ngaue ʻaki ki ai e koloa ʻoku mahuʻinga.
Fakatatau ki ha fakaʻuhinga ne fakamahinoʻi ʻi he ʻiunioni ʻiulope, ʻoku hoko e cosmetics fakanatula ko ha meʻa ke ne ngaohi mei he ngaahi meʻa fakanatula. Ki he preservatives mo e emulsifiers ʻoku maʻu ʻi ha ngaahi meʻa ʻoku fakanatula pe, ʻoku fusi hake ai ʻa e fakaʻuhinga ko ʻeni. ʻoku fakaʻuhingaʻi ʻa e ngaahi meʻa fakanatula ko ha ngaahi meʻa ʻoku ʻa e ʻakau, ha monumanu pe tupuʻanga ko pea pehe ki heʻenau ngaahi fengaueʻaki mo ʻenau mixtures. Ke toʻo ʻa e ʻuli pea toe fai ha ngaue ki he ngaahi founga fakatuʻasino/meʻa fakamisini, hange ko hono ʻunuakiʻi ʻi he ngaahi meʻa fakamisini, ʻoku ngofua ke fai hano fakamomoa, mo toʻo e ʻuli kuo pau ke solvents. ʻikai ko ia pe, ka ʻoku fakangofua ʻa e enzymatic mo e founga microbiological kapau ko ha enzymes fakanatula pe microorganisms ʻoku ʻikai ke fakaʻaongaʻi ki ai ʻa e genetically engineered (ʻikai ko ha GMO).
ʻoku kau ʻi he ngaahi cosmetics angamaheni mo fakanatula ʻa e ngaahi naunau fakaʻofoʻofa mo e kili, ʻa ia ʻoku ngaohi tafataha pe ki he ngaahi meʻa fakanatula, pea fakalahi pe fakaʻata ha ngaahi meʻa ke fakatolonga. ʻe makatuʻunga ʻa e fakaʻofoʻofa mo e ngaahi naunau tauhi ʻo e kili mei he ngaahi lao tatau ʻo e cosmetics.

Ko e ngaahi fie pule ko ʻeni (INCIs/Fakavahaʻapuleʻanga Nomenclature meʻafua) ʻoku faʻa fakaʻaongaʻi mo taau ke fakaʻaongaʻi ʻi he fakaʻofoʻofa maʻa formulations:

  • Solvents: konga ʻo e vai: ko e aqua, Waldensians vai hange ko e lose, etc; ethanol pe; vesitapolo glycerin mo e ala meʻa pehe.
  • Surfactants / stabilizers / emulsifiers: lecithin, phospholipids; glucosides hange ko e lauryl glucoside, decyl glucoside, caprylyl/decyl glucoside, Koko glucoside; cocamidopropyl betaine; cetearyl ʻolokaholo, mo e ala meʻa pehe.
  • Tokotaha uta lolololo/konga lolo: lolololo mo e butters hange ko ha lolo melie, avocado lolo, lolo uolonati, lolo Niu, hemp lolo, siola'a tupu ha tengaʻi ʻakau lolo, ha lolo, lolo ʻokani, castor ha tengaʻi ʻakau, pea mo ha lolo tengaʻi ʻakau, broccoli ha lolo, carrot ha tengaʻi ʻakau, mo e ha fua.
  • Butters mo e waxes: shea pata, Niu pata, mango pata, Koko pata, ʻasili ai pe ʻene hone, mo e ha fua.
  • Botanical ko ha ngaahi meʻa hange ko e lau maile ʻe taha, arnica ʻa e matalaʻiʻakau naʻe toʻo, calendula e konga naʻe toʻo mei ai, mohuku e konga kuo toʻo, vai, mo e tengaʻi ʻakau naʻe fua, nettle tincture, lesi glycerol toʻo, etc.
  • ʻoku mahuʻinga lolololo hange ko e lavender, peppermint, ʻakau ti, rosehip, pe ko e (ngaahi meʻa mahuʻinga ʻoku fakaʻaongaʻi ʻe he lolololo, kuo pau ke maʻu ia mei he koloa fakanatula, kae ʻikai ko e artificially synthsized)
  • Ko e ngaahi meʻa ʻoku tau ngaue malohi ki ai ko e fanga moisturising ia ʻoku nau ʻai ke ʻikai lelei, hange ko e anga ʻo ʻenau rejuvenating & ngaahi ola ne nau uesia ʻa e fili ʻo e toulekeleka. Ngaahi meʻa ʻoku bioactive molecules hange ko e resveratrol, hyaluronic ʻesiti, urea, vaitamini C, CoQ10, ceramides, vaitamini E/ʻalifa-tocopherol, f vaitamini, ferulic ʻesiti, retinol & retinoids, peptides, titanium taiokisaiti, singiki oxide, e malala, ʻesiti fakanatula lactic, pyrrolidone ʻesiti, carboxylic ko, D-salts, konga ʻo e kalepi, lauʻi ʻakau ʻolive, panthenol Viela, aloE mo e ala meʻa pehe.
  • Ko e ngaahi vaʻa ʻalaha mo e kaloni ʻoku fakaʻaongaʻi ʻi he cosmetics fakanatula ʻoku mahuʻinga mo lolololo, lolololo fakanatula mo ha ngaahi namu ʻoku totonu me'a ko'eni. ʻoku manakoa ha lolololo ʻoku mahuʻinga mei he lanu moli, lavender, peppermint, lemani, sandalwood, Sesimani, neroli, patchouli, Lose, pea mo e ngaahi foʻi anga ʻiloa ʻo e fika ʻi he faiva, ʻo hange ha fanga kiʻi koloa mahuʻinga.
    Ko ultrasonic toʻo e ʻuli, ko e founga maʻolunga ia ke maʻu ai e tuʻunga maʻolunga ʻoku mahuʻinga lolololo mei he botanicals. Laukonga lahi ange kau ki ultrasonic hydrodistillation 'o e lolololo mahu'inga!

Ngaahi meʻa ʻoku angamaheni ki he ngaue malohi ʻi he ngaahi meʻa fekauʻaki mo e fakavaʻe fakanatula

Panthenol ko ha meʻa ʻoku mahuʻinga, ʻa ia ʻoku ʻiloa ko hono natula vaitamini B5, pea ʻoku fakaʻaongaʻi ia ʻi he ngaahi naunau fefakatauʻaki ko e emollient mo e fakafofonga moisturizing. Formulations ʻi hono tokangaʻi ʻo e ʻulu, ʻoku tanaki atu ia ʻo hange ko humectant, emollient, glossifier, detangler mo e fakafofonga moisturizing. ʻoku lava ke Panthenol ʻo hoko ko e foomu t, pe ko ha racemic tuifio, ko e DL-Panthenol. Ko e t-panthenol ko e founga ia ʻoku sai ange, he ko e meʻa pe ʻoku ului ki ai ʻa e t-panthenol ki vaitamini B5.
polyphenols hange ko e resveratrol, quercetin, mo e rutin ko e malohi fakanatula antioxidants, ʻa ia ʻe lava ke maʻu mei he botanicals. ʻoku fakaʻaongaʻi kinautolu ʻi he cosmetics mo cosmeceuticals ke taʻofi ha ngaahi toʻonga seini oxidative ʻi he kili mo e ngaahi poupou ʻa e tangata ko ia ai ko e kili ʻo e moʻui lelei fakalukufua pea lava ke ne taʻofi ha ngaahi mahaki kili pea pehe ki ha ʻaho ne hoko ai ha taʻehoko.

Cosmetics fakaenatula

ʻoku ʻikai ha tuʻunga ia ʻo e tohi fakamoʻoni (standard) ʻoku ʻikai ʻaonga ke ʻi ai ha meʻa fakaʻofoʻofa mo ha ngaahi meʻa ʻoku ne mioʻi. ʻe lava ke maʻu ʻe ha ngaahi meʻa ʻoku ʻi ai ha ngaahi meʻa ʻoku ʻi ai ha meʻa lelei ʻo fakatatau mo e tuʻunga ʻulungaanga kehe ʻo e tohi fakamoʻoni, ʻa ia ʻoku tali ʻi ha fonua pe ngaahi feituʻu pau.
Ko e tohi fakamoʻoni maʻolunga mo fakavahaʻapuleʻanga ʻo e ʻilo ko e tuʻunga COSMOS-maheni ia (ʻoku angamaheni ʻaki ke ʻesitimeti) ʻa ia ʻoku ne fakafaikehekeheʻi ʻa e ngaahi cosmetics fakanatula (Cosmos-fakanatula) mo moʻui totonu ʻaki pe cosmetics (Cosmos-standard) pea ʻoku ne fokotuʻu ʻa e ngaahi fie maʻu takitaha ki he tohi fakamoʻoni. Ko e COSMOS ʻoku ʻi ai pe hono tokangaʻi lelei ʻo kapau ko e 95% ko e siʻisiʻi taha ia ʻo e ngaahi fuʻu ʻakau ʻoku ʻi ai pea ʻoku ʻi ai ha ngaahi meʻa ʻe 20% ʻo e ʻoku ʻi he founga totonu (10% ki hono vaimaʻa).