ʻAonga kiate Hydrogel production ʻo fakafou ʻi Ultrasonication

Ko e Sonication ko ha founga lelei, falalaʻanga mo faingofua ia ki hono teuteuʻi ʻo e hydrogels ngaue maʻolunga. ʻOku ʻomi ʻe he hydrogels ko ʻeni ha ngaahi koloa fakaʻofoʻofa hange ko e ivi absorption, viscoelasticity, ivi fakamisini, lahi modulus, mo e ngaahi ngaue fakamoʻui pe kiate kita.

Ultrasonic Polymerization mo e fakamovetevetea ki hydrogel production

Ultrasonication is used to initiate cross-linking and polymerization during hydrogel production. Ultrasonic dispersion is used to distribute nanoparticles in hydrogels.Ko e Hydrogels ko ha hydrophilic, ngaahi netiueka polymeric ʻe tolu ʻoku lava ke nau maʻu ha vai lahi pe fluids. Hydrogels fakaʻaliʻali ha ivi makehe. ʻOku kau ʻi he ngaahi konga angamaheni ʻo e hydrgels ʻa e polyvinyl kava malohi, polyethylene glycol, ʻelemeniti ko polyacrylate, acrylate polymers, carbomers, polysaccharides pe polypeptides ʻaki ha ngaahi kulupu hydrophilic lahi, mo ha polotini fakanatula hange ko collagen, gelatine mo e fibrin.
Ko ia ʻoku ui hybrid hydrogels ʻoku ʻi ai ha ngaahi faitoʻi kehekehe, functionally, mo morphologically ngaahi naunau kehekehe, hange ko e polotini, peptides, pe nano-/microstructures.
ʻOku fakaʻaongaʻi lahi ʻa e ultrasonic matoʻo atu ko ha founga lelei mo falalaʻanga ke homogenize nano-naunau hange ko e kaponi nanotubes (CNTs, MWCNTs, SWCNTs), cellulose nano-Kilisitala, chitin nanofibres, titanium taiokisaiti, siliva nanoparticles, polotini ʻOku hoko ʻeni sonication ko ha tefitoʻi meʻangaue ke maʻu ai ha hydrogels ngaue maʻolunga mo ha ngaahi ʻulungaanga makehe.

Kole 'a e fakamatala




Fakatokanga'i ange 'etau Tu'utu'uni totonu fakatautaha.


Ultrasonic cavitation promotes the cross-linking and polymerization during hydrogel synthesis. Ultrasonic dispersion facilitates the uniform distribution of nanomaterials for hybrid hydrogel fabrication.

ultrasonicator UIP1000hdT mo e Sioʻata Seinopolo ki hydrogel synthesis

Ko e ha e fakatotolo ʻoku fakahaaʻ – Ultrasonic Hydrogel teuteu

ʻUluaki, ʻoku poupouʻi ʻe ultrasonication ʻa e polymerization mo e ngaahi toʻonga fakafehokotaki ʻi he lolotonga hydrogel hono faʻu.
Ua, kuo fakamoʻoniʻi ʻa e ultrasonication ko ha founga falalaʻanga mo lelei ki hono fokotuʻu ʻo hydrogels mo nanocomposite hydrogels.

Ultrasonic cross-linking mo e Polymerization ʻo Hydrogels

ʻOku tokoni ʻa e Ultrasonication ki hono faʻu ʻo polymeric ngaahi netiueka lolotonga hydrogel synthesis ʻo fakafou ʻi he toʻu tangata fototehina taʻetotongi. ʻOku fakatupu ʻe he ngaahi peau fakaʻata lahi ha cavitation ʻa ia ʻoku ne fakatupu ʻa e ngaahi malohi ʻo e mamani, molecular e fekau mo e tauʻataina fototehina faʻu.

Naʻe teuteuʻi ʻe Cass et Al. (2010) ha "ʻakeliliki hydrogels naʻe teuteuʻi ʻo fakafou ʻi ultrasonic polymerization ʻo e vai soluble monomers mo macromonomers. Naʻe fakaʻaongaʻi ʻa e fakaʻata ke faʻu ʻaki ha radicals ʻi viscous aqueous monomer soluions ʻo fakaʻaongaʻi ʻa e additives glycerol, sorbitol pe suka ʻi ha polokalama ava ʻi he 37 °C. Naʻe mahuʻinga ʻa e vai soluble additives ki he polokalama hydrogel, glycerol ko e ola lelei taha ia. Naʻe teuteuʻi Hydrogels mei he monomers 2-hydroxyethyl methacrylate, poly (ethylene glycol) dimethacrylate, dextran methacrylate, ʻakelilikiʻi ʻesiti/ethylene glycol dimethacrylate mo e acrylamide/bis-acryide. " [Cass et Al. 2010] Fakaʻata tohi kole ʻo fakaʻaongaʻi ha fekumi fakaʻata naʻe maʻu ia ko ha founga lelei ki hono polymerization ʻo e vai soluble vainolo monomers pea mo hono teuteuʻi kimui ʻo hydrogels. ʻOku vave hono kamata ʻo e ultrasonically polymerization ʻi he ʻikai ke ʻi ai ha kemikale initiator.

Ultrasonic fakamovetevete ʻo Nano-Silica

Ultrasonic fakamovetevete ʻo

  • nanoparticles, e.g. TiO2
  • kaponi nanotubes (CNTs)
  • cellulose nanocrystals (FNTHF)
  • cellulose nanofibrils
  • gums, e.g. xanthan, ko e tengaʻi ʻakau poto ko e g
  • polotini
Ultrasonic nano-dispersion with the ultrasonicator UP400St


Hydrogel formation via ultrasonically-assisted gelation using the ultrasonicator UP100H

Hydrogel hono faʻu ʻo fakafou ʻi ultrasonically tokoniʻi gelation fakaʻaongaʻi ʻa e ultrasonicator UP100H

Kole 'a e fakamatala




Fakatokanga'i ange 'etau Tu'utu'uni totonu fakatautaha.


ʻOku fenapasi ʻa e Ultrasonication mo e faʻahinga polymers mo e biopolymers kotoa pe pea ʻoku lava ai ke fakamalohia hybrid hydrogels ʻaki ʻa e ngaahi naunau nano faʻunga hange ko e nanoparticles, nanocrystals pe nanofibres. ʻOku hanga ʻe hono fakamalohia ʻo e hydrogels mo e ngaahi nanomaterials kehekehe ʻo fakaʻata ke liliu mo puleʻi physicochemical mo rheo e ngaahi koloa fakamisini ʻo e nanocomposite hydrogels, koeʻuhi he ko e microstructures ko e tefitoʻi meʻa mahuʻinga ia ki he ngaahi koloa ʻoku maʻu.

Ultrasonication is applied to produce high-performance hydrogels containing nano-materials

MAKAKA ʻo e poly (acrylamide-Co-itaconic ʻesiti hydrogel ʻoku ʻi ai ʻa e MWCNTs. Naʻe ultrasonically fakamovetevete ʻa e MWCNTs ʻo fakaʻaongaʻi ʻa e ultrasonicator UP200S.
ako mo e fakatataa: Mohammadinezhada et Al., 2018

Ngaohi ʻaki ʻo poly (acrylamide-Co-itaconic ʻesiti) – MWCNT Hydrogel fakaʻaongaʻi ʻo e Sonication

Naʻe lava lelei hono faʻu ʻe Mohammadinezhada et Al. (2018) ha superabsorbent hydrogel composite ʻoku ʻi ai e poly (acrylamide-Co-itaconic ʻesiti) mo e kaponi kuo ʻaaʻi fakavahaʻa-taʻu (MWCNTs). Naʻe fakahoko Ultrasonication ʻa e Hielscher ultrasonic device UP200S. Naʻe tupulaki ʻa e tuʻunga malu ʻo e hydrogel ʻi he fakautuutu ʻo e MWCNTs ratios, ʻa ia ʻe lava ke pehe ko e natula hydrophobic ʻo e MWCNTs pea pehe ki he lahi ange ʻo e crosslinker density. Naʻe toe tupulaki foki mo e ivi tauhi vai (WPU) ʻo e P (AI-Co-IA) hydrogel ʻi he ʻao ʻo e MWCNT (10 uat%). ʻI he ako ko ʻeni, naʻe maʻolunga ange ʻa e ngaahi ola ʻo e ultrasonication ʻi hono tufaki ʻo e kaponi nanotubes ʻi he fukahi polymer. Naʻe tuʻu maʻu pe ʻa e MWCNTs ʻo ʻikai toe fakahohaʻasi ʻi he faʻunga polymeric. ʻIkai ngata ai, naʻe toe lahi ange ʻa e malohinga ʻo e nanocomposite naʻe maʻu pea mo hono pukepuke ʻo e vai pea mo e absorption ʻo e ngaahi naunau soluble kehe hange ko Pb (II). Naʻe maumauʻi ʻe Sonication ʻa e initiator pea fakamovetevete ʻa e MWCNTs ko ha filler fakaʻofoʻofa ʻi he ngaahi seini polymer ʻi he fakautuutu ʻa e ʻea.
ʻOku pehe ʻe he kau fai fakatotolo "he ʻikai lava ke aʻusia ʻa e ngaahi tuʻunga ko ʻeni ʻo e tali ʻi he ngaahi founga angamaheni, pea he ʻikai lava ke aʻusia ʻa e homogeneity mo e momoʻi meʻa lelei ki he tokotaha ʻoku ne tokangaʻi. ʻIkai ngata ai, sonication mavahe ʻa e founga nanoparticles ki he kihiʻi konga siʻi, ka he ʻikai lava ke fai ʻeni ʻe he fakamafana. Ko e founga ʻe taha ki hono fakasiʻisiʻi ʻo e lahi ko e ola ia ʻo e ngaahi peau malohi ʻi he ngaahi haʻi hono ua hange ko fakapaaki ʻo e ʻa ia ʻoku hanga ʻe he irradiation ko ʻeni ʻo maumauʻi ʻa e ngaahi momoʻi meʻa ʻa e aggregated pea toe lahi ange ai ʻa e ngaahi kulupu adsorptive taʻetotongi hange ko e ongo. Ko ia ai, ʻoku hoko ʻa e meʻa mahuʻinga ko ʻeni ko ha founga sonication maʻolunga ange ki he niʻihi kehe hange ko hiki fakamakinito fakaʻaongaʻi ʻi he ngaahi tohi. " [Mohammadinezhada et Al., 2018]

Ngaue maʻolunga Ultrasonicators ki hydrogel Synthesis

Hielscher Ultrasonics ʻa e meʻangaue ultrasonic ki he synthesis ʻo hydrogels. Mei he siʻisiʻi mo e kongaloto R&T mo e pailate ultrasonicators ki he ngaahi founga fakapisinisi ki he ngaohiʻanga hydrogel fakakomesiale ʻi he founga hokohoko, Hielscher Ultrasonics ʻoku ʻi ai e ngaahi fie maʻu ki hoʻo founga ngaue.
ʻE lava ʻe he ultrasonicators maaka lalahi ʻo fakahaofi ha amplitudes maʻolunga ʻaupito, ʻa ia ʻoku lava ai ke fakafehokotaki mo polymerization ʻa e ngaahi toʻonga mo e teunga ʻo e nano. Amplitudes ʻo aʻu ki 200μm ʻe faingofua pe ke lele hokohoko ʻi he tafa 24/7/365. ʻOku lava ke maʻu ha amplitudes maʻolunga ange fakapatonu ultrasonic sonotrodes.

Ko e ha Hielscher Ultrasonics?

  • Ko e lavame'a ma'olunga
  • Tuʻunga ʻo e tekinolosia fakaʻaati
  • falala'anga & robustness
  • kulupu (batch) & he
  • ki ha faʻahinga tohi pe
  • polokalama fakakomipiuta poto
  • smart features (e.g., fakamatala protocolling)
  • CIP (maʻa-ʻi he-feituʻu)

Kole mai he ʻaho ni ke maʻu ha fakamatala fakatekinikale lahi ange, totongi mo ha kupuʻi lea ʻoku ʻikai tuku kakato. ʻOku fiefia ʻemau kau ngaue taimi loloa ke talanoa mo koe!
'Oku 'omi 'e he e tepile 'i lalo ha faka'ilonga ia 'o e tu'unga 'o e ngaue ki he fakafuofua'i 'o e hotau ultrasonicators:

Kulupu (batch) 'o e tohi 'Oku tafe mai 'a e 'ea 'Oku fokotu'u atu 'a e ngaahi me'angaue
mL 'o e 1 ki he 500 10 ki he 200mL/miniti 'e UP100H
mL 'i he 10 ki he 2000 20 ki he 400mL/miniti 'e UP200Ht, UP400St
0.1 ki he 20L 0.2 ke 4L/miniti 'e UIP2000hdT
10 ki he 100L 2 ki he 10L/miniti 'e UIP4000hdT
n.a. 10 ki he 100L/miniti 'e UIP16000
n.a. lalahi fakataha'i 'o e UIP16000

Fetu'utaki mai kiate kimautolu! / Kole kiate kitautolu!

Kole ki ha fakamatala lahi ange

Kataki 'o ngaue 'aki e foomu 'i lalo ke kole ha toe fakamatala ki he ultrasonic processors, faka'aonga'i mo e totongi. Te mau fiefia ke alea'i e founga 'oku mo 'i ai mo ho'omou ngaahi fie ma'u ultrasonic he polokalama!









Kataki 'o fakatokanga'i ange 'etau Tu'utu'uni totonu fakatautaha.


Ultrasonic high-shear homogenizers are used in lab, bench-top, pilot and industrial processing.

Hielscher Ultrasonics ʻa e ngaohiʻanga koloa maʻolunga ultrasonic homogenizers ki hono tuifio ʻo e ngaahi polokalama, fakamovetevetea, emulsification mo e toʻo hingoa ʻi he fale fakatotolo fakakemi, pailate mo e meʻafua ki he ngaahi meʻa fakapisinisi.

Ngaahi tohi/fakamo'oni fakafolofola



Ngaahi mo'oni'i me'a 'oku mahu'inga ke 'ilo'i

Ko e ha ʻoku Hydrogels fakaʻaongaʻi ki ai?

ʻOku fakaʻaongaʻi ʻa e Hydrogels ʻi ha ngaahi ngaueʻanga lahi hange ko e pharma ki hono ʻomi ʻo e faitoʻo konatapu (e.g. tukuange taimi, fakamatala, intravenous, kaveinga pe rectal hono ʻomi ʻo e faitoʻo konatapu), faitoʻo (e.g. hange ko e scaffolds ʻi he ʻenisinia moluu, huhu to, biomechanical naunau, kafo dressings), ngaahi naunau ki he meʻa ke tokangaʻi (e.g. fetuʻutaki ʻi, taipa, lingiʻanga napkins), ngoue (e.g. ki faitoʻo ʻinisekite formulations, granules ki hono toʻo e hauhau ʻo e ʻuli ʻi he ngaahi feituʻu momoa). , encapsulation ʻo quantum ngaahi foʻi Toti, thermodynamic toʻu tangata ʻuhila), vai malala, Sinou loi, additives meʻakai, mo ha ngaahi koloa kehe (e.g., kuluuʻi).

Fakafaʻahinga ʻo e Hydrogels

ʻI he taimi ʻoku fai ai e fakafaʻahinga ʻo e hydrogels ʻo makatuʻunga ʻi honau faʻunga fakatuʻasino ʻe lava ke fakafaʻahinga ʻo hange ko ʻeni:

  • amorphous (ʻikai ko e crystalline)
  • semicrystalline: ko ha konga faingataʻa ʻo e amorphous mo crystalline konga
  • crystalline

ʻI he taimi ʻoku tukutaha ai e tokanga ʻi polymeric taʻanga, ʻe lava foki ke toe fakafaʻahinga ʻa e hydrogels ki he ngaahi faʻahinga ʻe tolu ko ʻeni:

  • homopolymeric hydrogels
  • copolymeric hydrogels
  • multipolymeric hydrogels/IPN hydrogels

Makatuʻunga ʻi he faʻahinga crosslinking, ʻoku fakafaʻahinga ʻa e hydrogels ki he:

  • faitoʻi crosslinked netiueka: tuʻu maʻu junctions
  • ngaahi netiueka crosslinked fakaesino: niʻihi kehe junctions

ʻOku fakaiku ʻa e fōtunga fakaesinó ki he fakafaʻahingá ki he:

  • matrix
  • filimi
  • microsphere

Fakafaʻahinga ʻo makatuʻunga ʻi he totongi fakaʻuhila ki he netiueka:

  • nonionic (tuʻu pe)
  • ionic (kau ai e anionic pe cationic)
  • amphoteric electrolyte (ampholytic)
  • zwitterionic (polybetaines)

Hielscher Ultrasonics supplies high-performance ultrasonic homogenizers from lab to industrial size.

Ngaue ultrasonics maʻolunga! ʻOku ʻufiʻufi ʻe he koloa ʻa Hielscher ʻa e tuʻunga kakato mei he fale fakatotolo fakakemi ultrasonicator ʻi he ngaahi ʻiuniti ʻi ʻolunga ki he ngaahi polokalama ultrasonic lalahi.