Hielscher Ultrasound Technology

Ultrasonic tabako bunutan

Maginoo tabako bunutan ay isang mabagal na, oras na ubos na proseso, na nagsasangkot ng paggamit ng mga nakakalason solvents sa mataas na temperatura, na gumagawa ng proseso mapanganib.
Ultrasonically pagkuha ng alkaloids mula sa tabako ay maaaring tumakbo gamit ang tubig o mild solvents sa isang mabilis na proseso ng ilang minuto. Ultrasonically nakuha alkaloids tulad ng nikotina mula sa tabako ay pinakawalan sa isang mabilis at mataas na mahusay na pamamaraan, na nagbibigay ng mataas na magbubunga ng isang buong spectrum kunin (na naglalaman ng nikotina, nornikotina, chlorogenic acid (5-caffeoylquinic acid), rutin, caffeic acid at scopoletin, solanesol etc.)

Ultrasonic pagkuha ng tabako

Ultrasonic bunutan (UAE) ay isang mabilis, mabisa, at maginhawa na paraan ng pagkuha, na kung saan ay batay sa ang application ng kapangyarihan-ultratunog. Matinding ultrasonic waves bumuo ng mabilis na maliit na kilusan at mga tunog cavitation sa solido system (eg vegetal materyal sa panunaw, hal. tabako dahon sa ethanol), na kung saan ay resulta sa isang nadagdagan mass transfer pati na rin ang isang pinabilis na proseso ng pagkuha. Sa paghahambing sa iba pang mga advanced na pamamaraan tulad ng superkritikal na likido bunutan at Ion-pares ng bunutan, ultrasonically bunutan ay makabuluhang mas pang-ekonomiya, sa, mas ligtas at mas madaling gamitin. Samakatuwid, ultrasonic bunutan ay ang ginustong pamamaraan ng bunutan upang palabasin ang bioaktibong compounds mula sa botanicals.
Ultrasonic pagkuha ng mga resulta sa isang malawak na spectrum katas, na naglalaman ng nikotina, na kung saan ay ang mga pangunahing alkaloid ng tabako sa 94 – 98% ng kabuuang alkaloid nilalaman, pati na rin ang alkaloids nornikotina, anabasine, anatabine, cotinine at myosmine.

UP100H sa MS14 sonotrode para sa pagkuha ng botanicals, tulad ng tabako

Hielscher ultrasonics ' SonoStation ay isang madaling gamitin ultrasonic setup para sa produksyon scale. (I-click upang palakihin!)

SonoStation – isang ultrasonic system na may 2 x 2kW ultrasonicators, hinalo ng mga tangke at bomba – ang isang user-friendly na sistema para sa bunutan.

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Ganap na spectrum tabako extracts sa sonication

Alkaloids tulad ng nikotina at nornikotina, chlorogenic acid, phenolics, solanesol at iba pang bioactive compounds ay maaaring mabilis, mahusay at ligtas na nakahiwalay gamit ang ultrasonic bunutan. Ang maginoo tabako bunutan nagsasangkot ang paggamit ng nakakalason solvents tulad ng heptane sa mataas na temperatura, na lumiliko ang pagkuha ng proseso sa isang mapanganib na pamamaraan. Ang buong maginoo bunutan ng proseso ay tumatagal ng presyo. 24h at sa gayon napaka panahon-ubos na.
Ultrasonic bunutan ay maaaring gumanap bilang malamig na tubig bunutan o gamit ang mild solvents tulad ng ethanol o ethanol timpla ng tubig sa temperatura o bahagyang mataas na temperatura. Ang sonication ay tumatagal ng ilang minuto, na lumiliko ang bunutan sa isang mabilis na pamamaraan. Bukod pa rito, ang paggamit ng tubig o mild solvents ang proseso ay ganap na ligtas at maginhawa.
Ang ultrasonically depleated tabako dahon ay separated mula sa nakuha compounds sa panunaw. Ang ultrasonically ginawa buong spectrum extracts ay naglalaman ng pangunahing alkaloid nikotina pati na rin ang pangalawa o menor de edad alkaloids tulad ng anabasine o 3-(2-piperidinyl) pyridine, anatabine o 3-(2-1, 2, 3, 6-tetrahydropyridyl) pyridine, cotinine o 1- metil-5-(3-pyridyl) -2-pyrrolidinone), 2, 3 '-dipyridyl o isonicoteine, N-formylnornicotine o 2-(3-pyridyl) pyrrolidinecarbaldehyde, myosmine o 3-(1-pyrrolin-2-yl) pyridine, nornikotina o 3-(pyrrolidin-2-yl) pyridine, at 𝛽-nicotyrine or 3-(1-methylpyrrol-2-yl)pyridine. The content of these alkaloids varies depending on tobacco species and tobacco products. While nicotine is the primary alkaloid with 94–98% of the total alkaloid content, nornicotine and anatabine are the two most abundant secondary alkaloids, each accounting for approx. 2% to 6% of the total alkaloid content of tobacco.

Benefits of Ultrasonic Tobacco Extraction:

  • Higher Yield
  • High Quality
  • Rapid Extraction
  • Mild, Non-thermal Process
  • Water or Solvent
  • Simple & Safe Operation

Choose from a Broad Selection of Solvents

Using ultrasonic extraction, you can select from various solvents, including water, alcohol, ethanol, methanol, ethanol-water mixtures or strong solvents such as heptane or hexane. All of the former named solvents have been already successfully tested and shown to be effective for the isolation of bioactive compounds such as alkaloids, terpenoids, phenolics and solanesol from tobacco plant materials. Sonication can be used in solvent-free cold-water extraction (e.g. to prepare organic extracts) or can be combined with a solvent of your choice.
Learn more about solvents for the ultrasonic extraction from botanicals!

Hielscher ultrasonicator UP400St with sonotrode S24d22L2 for extraction of nicotine and harmala from tobacco leaves.

Ultrasonic processor UP400St (400 watts) for the extraction of alkaloids such as nicotine and harmala from tobacco leaves.

High-Performance Ultrasound Extractors

UIP4000hdT (4kW) ultrasonic processor for the extraction of pectins in an industrial inline process.Hielscher’s ultrasonic equipment is a commonly extraction tool for the isolation of bioactive compounds from botanicals. Supplying ultrasonic extractors for all process scales, Hielscher is able to recommend you the most suitable ultrasonic system for your needs. Starting with compact, yet powerful lab systems for analysis and feasibility testing, Hielscher offers the full range from lab and pilot plant ultrasonicators up to fully industrial ultrasound reactors. Offering the full band width of ultrasonic processors, Hielscher has the ideal setup for your extraction process. Depending on your process volume and goal, ultrasonic extraction can be performed in batch or continuous flow mode. Manifold accessories such as sonotrodes, booster horns, flow cells and reactors allow to equip the ultrasonic processor to fulfil the process targets ideally.
Hielscher’s ultrasonic processors can be precisely controlled and process data are automatically recorded on the integrated SD-card of our digital ultrasonic systems. The reliable control over the process parameters ensure a consistently high product quality. The automatic data recording of the process parameters allow for an easy process standardization and the fulfilment of Good Manufacturing Practices (GMP).
The robustness of Hielscher’s ultrasonic equipment allows for 24/7 operation at heavy duty and in demanding environments. Easy and safe operation as well as low maintenance make Hielscher’s ultrasonic systems the reliable work horse in your production.

The table below gives you an indication of the approximate processing capacity of our ultrasonicators:

Batch Volume Flow Rate Recommended Devices
0.5 to 1.5mL n.a. VialTweeter
1 to 500mL 10 to 200mL/min UP100H
10 to 2000mL 20 to 400mL/min UP200Ht, UP400St
0.1 to 20L 0.2 to 4L/min UIP2000hdT
10 to 100L 2 to 10L/min UIP4000
n.a. 10 to 100L/min UIP16000
n.a. larger cluster of UIP16000

Contact us now for further information! Our well-trained staff will be glad to discuss your extraction process with you!

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Hielscher Ultrasonics manufactures high-performance ultrasonicators for sonochemical applications.

High-power ultrasonic processors from lab to pilot and industrial scale.



Facts Worth Knowing

Why is Ultrasonic Extraction so Effective?

Ultrasonically-assisted extraction (UAE) is based on coupling highly intense ultrasound waves (acoustic waves) into a liquid or slurry. The acoustic waves create alternating high pressure / low pressure cycles, which result in the phenomenon of acoustic cavitation. The phenomenon of ultrasonic or acoustic cavitation is characterized by extreme, locally confined conditions of very high pressures, temperatures and shear forces. In proximity of the imploding cavitation bubbles, temperatures of up to 5000K, pressures of 1000 atmosphere, heating-cooling rate above 1010 K/s and liquids jets with up to 280m/s velocity, which appear as very high shear force and turbulences in the cavitational zone, can be measured. The combination of these factors (pressure, heat, shear and turbulence) disrupt cells (lysis) and intensify mass transfer during the extraction process. Thereby, the liquid-solid extraction of phytoconstituents from plant cells is promoted. The ultrasonic extraction technique is widely applied for the successful and efficient extraction of flavonoids, polysaccharides, alkaloids, phytosterols, polyphenols, and pigments from plants.

Ultrasonic disruptors are used for extractions from phyto sources (e.g. plants, algae, fungi)

Ultrasonic extraction from plant cells: the microscopic transverse section (TS) shows the mechanism of actions during ultrasonic extraction from cells (magnification 2000x) [resource: Vilkhu et al. 2011]

Tobacco

Various plants in the Nicotiana genus and the Solanaceae (nightshade) family are known as tobacco plants. Besides being the commonly used term for the plant, tobacco describes also the products prepared from the cured leaves of the tobacco plant. Whilst Nicotiana tabacum is the main crop use for tobacco and nicotine production, there are over 70 plant species of tobacco. N. tabacum is the dominant species used for tobacco products, however the more potent variant N. rustica can be found around the world and is used for.
Tobacco contains the stimulant alkaloid nicotine as well as harmala alkaloids. Dried and cured tobacco leaves are mainly used for smoking in cigarettes, cigars, pipes, shishas as well as e-cigarettes, e-cigars, e-pipes and vaporizers. Alternatively, they can be consumed as snuff, chewing tobacco, dipping tobacco and snus.

The tobacco plant family contains various (sub-)species, which exhibit different alkaloid and flavour profiles.
Oriental tobacco (Nicotiana tabacum L.) is a species of tobacco grown mainly in Turkey, Greece, and neighboring areas, which is used for the commercial production of cigarettes, cigars and chewing tobacco. It has a strong characteristic flavor, is relatively low in nicotine and high in reducing sugars, acids, and volatile flavor oil, which gives the tobacco products an intense aroma.

There are 67 natural species of tobacco known. Below the most common species are listed:

  • Nicotiana acuminata (Graham) Hook. – manyflower tobacco
  • Nicotiana africana Merxm.
  • Nicotiana alata Link & Otto – winged tobacco, jasmine tobacco, tanbaku (Persian)
  • Nicotiana attenuata Torrey ex S. Watson – coyote tobacco
  • Nicotiana benthamiana Domin
  • Nicotiana clevelandii A. Gray
  • Nicotiana glauca Graham – tree tobacco, Brazilian tree tobacco, shrub tobacco, mustard tree
  • Nicotiana glutinosa L.
  • Nicotiana langsdorffii Weinm.
  • Nicotiana longiflora Cav.
  • Nicotiana occidentalis H.-M. Wheeler
  • Nicotiana obtusifolia M. Martens & Galeotti – desert tobacco, punche, “tabaquillo”
  • Nicotiana otophora Griseb.
  • Nicotiana plumbaginifolia Viv.
  • Nicotiana quadrivalvis Pursh
  • Nicotiana rustica L. – Aztec tobacco, mapacho
  • Nicotiana suaveolens Lehm. – Australian tobacco
  • Nicotiana sylvestris Speg. & Comes – South American tobacco, woodland tobacco
  • Nicotiana tabacum L. – commercial tobacco grown for the production of cigarettes, cigars, chewing tobacco, etc.
  • Nicotiana tomentosiformis Goodsp.

The three species below are man-made hybrids:

  • Nicotiana × didepta N. debneyi × N. tabacum
  • Nicotiana × digluta N. glutinosa × N. tabacum
  • Nicotiana × sanderae Hort. ex Wats. N. alata × N. forgetiana

Types of Tobacco
The curing and subsequent aging process of tobacco leaves induces a slow oxidation and degradation of the present carotenoids in tobacco leaf. Due to the oxidation, certain compounds in the tobacco leaves are synthesized, which result in sweet hay, tea, rose oil, or fruity aromatic flavors, which contribute to the “smoothness” of the smoke. Starches are converted into sugars, which subsequently glycate proteins, and are oxidized into advanced glycation endproducts (AGEs). This is a caramelization process that also gives the smoke its flavor.
The preparation and curing method of tobacco influences its final aroma characteristics. Curing can be achieved by air-, fire-, flue-, and sun-curing. For example, flue-cured tobacco (e.g. from France) contains only low levels of alkaloids, whilst air-cured Burley tobacco (e.g. sourced from Guatemala) is known for its high content of alkaloids.